Universitäts-Kinderspital beider Basel (UKBB) Trials

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Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

Gaab, Jens

OLP-POP, NCT04339023: Open-Label Placebo Treatment for Acute Postoperative Pain

Completed

N/A

Europe

Open-Label Placebo, treatment as usual

University Hospital, Basel, Switzerland

Postoperative Pain

01/23

NCT04130126: Feasibility and Effects of Taking Cold Showers: A Randomized Controlled Study

Completed

N/A

350

Europe

Taking cold showers

University Hospital, Basel, Switzerland

Sick Leave

03/23

12/23

MICS, NCT05497713: Mindset Interventions to Facilitate Taking Cold Showers

Active, not recruiting

N/A

476

Europe

Mindsets

Jens Gaab

Psychological

02/24

12/24

BOLPAP, NCT05819476: Boosting Open-Label Placebo Effects in Acute Induced Pain in Healthy Adults

Recruiting

N/A

141

Europe

OLP-injection, Scripted Evidence-based treatment rationale, Experimental model of acute pain

University Hospital, Basel, Switzerland

Acute Pain

04/24

Khanna, Nina

NCT04836260: Preemptive Use of Convalescent Plasma for High-risk Patients With COVID-19

Recruiting

100

Europe

SARS-CoV-2 convalescent plasma

University Hospital, Geneva, University Hospital, Basel, Switzerland, Ospedale Regionale di Lugano, Hôpital Fribourgeois

Covid19, Immuno-Deficiency, Old Age; Debility

12/21

NCT02007356: A Study to Assess Safety and Feasibility of Direct Infusions of Donor-derived Virus-specific T-cells in Recipients of Hematopoietic Stem Cell Transplantation With Post-transplant Viral Infections Using the Cytokine Capture System®

Recruiting

Europe

IFN-γ positive selected T-cells

University Hospital, Basel, Switzerland

Adenovirus Infection, EBV, Cytomegalovirus Infections, Cytokine Capture System, Allogenic Disease

12/26

OPTICOV, NCT05587894: OPtimisation of Antiviral Therapy in Immunocompromised COVID-19 Patients: a Randomized Factorial Controlled Strategy Trial

Recruiting

256

Europe

Paxlovid 5 days, Nirmatrevlir/ritonavir, Paxlovid 10 days, Veklury, remdesivir

ANRS, Emerging Infectious Diseases, University Hospital, Geneva

COVID-19, Immunodeficiency

03/25

05/25

ESPECT, NCT05688241: EBV-Tscm Cytotoxic T Cells (CTLs) for EBV- Driven Lymphomas/ Diseases

Not yet recruiting

1/2

Europe

Donor-derived ex-vivo expanded EBV Tscm CTL

University Hospital, Basel, Switzerland

EBV Lymphoma, Post-transplant Lymphoproliferative Disease (PTLD)

12/25

BIMI, NCT04720144: Breakthrough Invasive Mold Infections Under Posaconazole Prophylaxis

Recruiting

N/A

300

Europe

Centre Hospitalier Universitaire Vaudois

Invasive Mold Infections, Breakthrough Invasive Mold Infections, Hematologic Malignancy, Hematologic Diseases

09/22

PTX3 AML, NCT03828773: PTX3-targeted Antifungal Prophylaxis

Recruiting

N/A

320

Europe

Posaconazole, Noxafil, Fluconazole, Diflucan

Bochud Pierre-Yves, Swiss National Science Foundation

Candidiasis, Fungal Infection, Acute Myeloid Leukemia, Genetic Predisposition, Aspergillosis

11/25

AntiResist, NCT05017766: NCCR : New Approaches to Combat Antibiotic-resistant Bacteria

Recruiting

N/A

8000

Europe

analysis of antimicrobial resistance

University Hospital, Basel, Switzerland, Swiss National Science Foundation

Antimicrobial Resistance (AMR)

12/24

Weid, Nicolas X von der

NCT02670564: ALL SCTped FORUM - Pharmacogenomic Study (add-on Study)

Recruiting

1000

Europe

Pharmacogenomics, DNA analyses, Busulfan plasma level measurements

Swiss Pediatric Oncology Group, ALL SCTped Forum

Acute Lymphoblastic Leukemia

04/21

04/26

HR-NBL2, NCT04221035 / 2019-001068-31: High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)

Recruiting

800

Europe, RoW

Vincristine, L01CA02, Carboplatin, LO1XA02, Etoposide, L01CB01, Vindesine, L01CA03, Dacarbazine, L01AX04, Ifosfamide, Doxorubicin, L01DB01, Busulfan, L01AB01, Melphalan, L01AA03, Thiotepa, L01AC01, Radiotherapy, Dinutuximab Beta, L01XC16, Cisplatin, L01XA01, Temozolomide 100 MG, Irinotecan, Cyclophosphamid

Gustave Roussy, Cancer Campus, Grand Paris, PHRC, Solving Kids' Cancer Europe, Neuroblastoma UK, , BSPHO, Instituto de Investigación Sanitaria La Fe, Deutsche Krebshilfe

High-Risk Neuroblastoma, Patient With Insufficient Response Chemoimmunotherapy

11/26

11/32

AIEOP-BFM ALL 2017, NCT03643276 / 2016-001935-12: Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia -

Recruiting

5000

Europe, RoW

Blinatumomab, Bortezomib, Cyclophosphamide, Cytarabine, Daunorubicin, Myocet, Dexamethasone, Doxorubicin, Etoposide, Fludarabine Phosphate, Ifosfamide, 6-Mercaptopurine, Methotrexate, Pegaspargase, Prednisolone, Prednisone, Tioguanin, Vincristine, Vindesine, Erwinase

Martin Schrappe, Deutsche Krebshilfe e.V., Bonn (Germany)

Acute Lymphoblastic Leukemia, Pediatric

07/28

FORUM, NCT01949129 / 2012-003032-22: Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia

Recruiting

2/3

1800

Europe, Canada, RoW

VP16, Etoposide, TBI, Thiotepa, Thio, Treosulfan, Treo, Fludarabine, Flu, Busulfan, Bu, ATG Thymoglobulin, ATG Thymo, Cyclophosphamide, Cy, Grafalon, Anti-human T-lymphocyte immunoglobulin

St. Anna Kinderkrebsforschung, ALL SCTped Forum, European Society for Blood and Marrow Transplantation, ALL-BFM Study Group, Assistance Publique - Hôpitaux de Paris, Dutch Childhood Oncology Group, Swiss Pediatric Oncology Group, Australian & New Zealand Children's Haematology/Oncology Group

Acute Lymphoblastic Leukaemia

06/25

04/30

Kid-MaCareOnco, NCT04308642: Study to Evaluate Blood and Urine Kidney Injury Markers to Facilitate Early Detection of Renal Adverse Drug Events in Pediatric Cancer Patients Treated With Nephrotoxic Chemotherapy

Completed

N/A

Europe

blood test for renal biomarkers, urine test for renal biomarkers

University Hospital, Basel, Switzerland, Stiftung für Krebskranke Kinder

Kidney Impairment

12/23

Cardio-Onco, NCT03790943: Cardiac Dysfunction in Childhood Cancer Survivors

Recruiting

N/A

500

Europe

cardiac assessment

University of Bern, University Hospital, Basel, Switzerland, University Children's Hospital Basel, Insel Gruppe AG, University Hospital Bern, Cantonal Hospital of St. Gallen, Luzerner Kantonsspital, University Hospital, Geneva

Cardiac Dysfunction, Cardiovascular Diseases, Childhood Cancer

12/23

01/24

PrepAIR, NCT05606588: Preventing Sensory and Motor Dysfunctions in Children Receiving Neurotoxic Chemotherapy

Recruiting

N/A

131

Europe

Playful sensorimotor training

University of Basel, University Hospital Inselspital, Berne, Kantonsspital Aarau, Ostschweizer Kinderspital, University Hospital Heidelberg, University Hospital Freiburg, Krebsforschung Schweiz, Bern, Switzerland, Clinical Trial Unit, University Hospital Basel, Switzerland, Charite University, Berlin, Germany, National Center for Tumor Diseases, Heidelberg

Chemotherapy-induced Peripheral Neuropathy, Pediatric Cancer

03/25

03/26

NCT02512250: Swiss Hemophilia Registry

Recruiting

N/A

900

Europe

Registry

Swiss Hemophilia Network

Hemophilia and Other Severe Bleeding Disorders

12/25

SCCSS-FU, NCT04732273: The Swiss Childhood Cancer Survivor Study - Follow-up (SCCSS-FollowUp)

Recruiting

N/A

3000

Europe

Physical examination, diagnostic tests, laboratory tests, Personal history, questionnaire

University of Bern

Late Effect, Childhood Cancer

01/71

SWISS-Pearl, NCT05427136: Early Pulmonary Dysfunction in Childhood Cancer Patients

Recruiting

N/A

140

Europe

Lung function measurements, Breath Analysis, Magnetic resonance imaging (MRI), Standardized interview to assess respiratory symptoms, Data collection for assessment of clinical parameters and cumulative doses to chemotherapy, radiation, surgery and HSCT, Collection of genetic samples

University Children's Hospital Basel

Pulmonary Dysfunction

06/51

Diesch, Tamara

ACCS, NCT04284189: Aftercare of Childhood Cancer Survivors in Switzerland

Recruiting

N/A

140

Europe

Transition model

Kantonsspital Aarau, University Children's Hospital Basel, Luzerner Kantonsspital

Childhood Cancer, Survivorship, Transition

04/25

08/30

Furlano, Raoul

NCT03146884: Swiss Autoimmune Hepatitis Cohort Study

Recruiting

N/A

500

Europe

Fondazione Epatocentro Ticino

Hepatitis, Autoimmune

12/22

NCT03146936: Swiss Primary Sclerosing Cholangitis Cohort Study

Recruiting

N/A

120

Europe

Fondazione Epatocentro Ticino

Cholangitis, Sclerosing

12/22

NCT04714021: CO2 vs Air Insufflation in Children Undergoing PEG

Recruiting

N/A

120

Europe, RoW

CO2, air

University Medical Centre Ljubljana, European Society of Pediatric Gastroenterology, Hepatology and Nutrition

Gastrostomy

01/23

BOUGIE-PED, NCT06675825: An Innovative Endoscopic Cap for Dilating Benign Esophageal Strictures in Children

Recruiting

N/A

Europe

BougieCap, Esophageal dilation, Savary-Bougie (A) or balloon dilation (B), Dilation of esophageal stricture

University Children's Hospital, Zurich

Esophageal Stenosis, Esophageal Dilation

12/26

Paccou, Emmanuelle

Lutre-UP, NCT04390646: GnRH Therapy on Cognition in Down Syndrome

Recruiting

2/3

Europe

GnRH, gonadorelin acetate, Lutrelef, 0.9% NaCl

Nelly Pitteloud

Down Syndrome, Cognitive Decline, Alzheimer Disease, Early Onset, Olfaction Disorders

12/28

NCT01601171: Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate

Recruiting

N/A

2000

Europe

Centre Hospitalier Universitaire Vaudois, Swiss National Science Foundation

Kallmann Syndrome, Hypogonadotropic Hypogonadism, Hypothalamic Amenorrhea, Polycystic Ovarian Syndrome, Precocious Puberty, Cleft Lip and Palate, Cleft Palate, Cleft Lip

03/25

03/30

MiniNO, NCT05058781: Minipuberty in Infants Born With Potential Hypogonadism Hypogonadotrope

Recruiting

N/A

100

Europe

Centre Hospitalier Universitaire Vaudois

DSD, CHH

12/26

12/30

Sinues, Pablo

EBECA, NCT04461821: Exhaled Breath Analysis by Secondary Electrospray Ionization - Mass Spectrometry in Children and Adolescents

Recruiting

N/A

3600

Europe

Real-time SESI-MS breath analysis, Off-line breath analysis, Blood analysis, Saliva analysis, Urine analysis

University Children's Hospital Basel, Swiss National Science Foundation, Fondation Botnar (Switzerland)

Respiratory Diseases, Neurological Disorders, Type 1 Diabetes

07/30

Chybicka, Alicja

FORUM, NCT01949129 / 2012-003032-22: Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia

Recruiting

2/3

1800

Europe, Canada, RoW

VP16, Etoposide, TBI, Thiotepa, Thio, Treosulfan, Treo, Fludarabine, Flu, Busulfan, Bu, ATG Thymoglobulin, ATG Thymo, Cyclophosphamide, Cy, Grafalon, Anti-human T-lymphocyte immunoglobulin

Acute Lymphoblastic Leukaemia

06/25

04/30

EBECA, NCT04461821: Exhaled Breath Analysis by Secondary Electrospray Ionization - Mass Spectrometry in Children and Adolescents

Recruiting

N/A

3600

Europe

Real-time SESI-MS breath analysis, Off-line breath analysis, Blood analysis, Saliva analysis, Urine analysis

University Children's Hospital Basel, Swiss National Science Foundation, Fondation Botnar (Switzerland)

Respiratory Diseases, Neurological Disorders, Type 1 Diabetes

07/30

Benninger, Sabina Kroiss

HR-NBL2, NCT04221035 / 2019-001068-31: High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)

Recruiting

800

Europe, RoW

Gustave Roussy, Cancer Campus, Grand Paris, PHRC, Solving Kids' Cancer Europe, Neuroblastoma UK, , BSPHO, Instituto de Investigación Sanitaria La Fe, Deutsche Krebshilfe

High-Risk Neuroblastoma, Patient With Insufficient Response Chemoimmunotherapy

11/26

11/32

Krieg, Andreas

TANGENT, NCT05417789: Study of Emactuzumab for Tenosynovial Giant Cell Tumor (TGCT)

Recruiting

128

Europe, Canada, US, RoW

Emactuzumab, Placebo

SynOx Therapeutics Limited

TGCT

04/26

09/27

MOTION, NCT05059262 / 2020-004883-25: Study of Vimseltinib for Tenosynovial Giant Cell Tumor

Active, not recruiting

120

Europe, Canada, US, RoW

vimseltinib, DCC-3014, Placebo

Deciphera Pharmaceuticals LLC, Deciphera Pharmaceuticals, LLC

Tenosynovial Giant Cell Tumor, Pigmented Villonodular Synovitis, Giant Cell Tumor of Tendon Sheath, Tenosynovial Giant Cell Tumor, Diffuse, Tenosynovial Giant Cell Tumor, Localized

08/23

07/26

Furlanetto, Tamara Diesch-

ESPECT, NCT05688241: EBV-Tscm Cytotoxic T Cells (CTLs) for EBV- Driven Lymphomas/ Diseases

Not yet recruiting

1/2

Europe

Donor-derived ex-vivo expanded EBV Tscm CTL

University Hospital, Basel, Switzerland

EBV Lymphoma, Post-transplant Lymphoproliferative Disease (PTLD)

12/25

Widmer, Michèle

NCT06648408: Ballet Training in Children With Idiopathic Coxa Antetorta

Recruiting

N/A

Europe

Balett Training

University Children's Hospital Basel

Femoral Anteversion

04/25



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