Main Line Health / Lankenau Institute for Medical Research
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 15 Trials 
35 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Gray, William K
CT-AMT-130-02, NCT05243017: Safety and Efficacy of AMT-130 in European Adults with Early Manifest Huntington's Disease

Active, not recruiting
1/2
14
Europe
intra-striatal rAAV5-miHTT, AMT-130
UniQure Biopharma B.V.
Huntington Disease
03/29
10/29
TRANSCEND, NCT03241459: Safety and Efficacy of the SurVeil™ Drug-Coated Balloon

Active, not recruiting
N/A
446
Europe, US, RoW
Surmodics SurVeil DCB, Medtronic IN.PACT Admiral DCB
SurModics, Inc.
Peripheral Arterial Disease, Peripheral Vascular Disease, Artery Disease, Peripheral, Femoropopliteal Artery Occlusion
09/20
10/24
ConformalEFS, NCT03616028: The CONFORMAL Early Feasibility Study

Active, not recruiting
N/A
64
US
left atrial appendage closure
Conformal Medical, Inc, Yale Cardiovascular Research Group
Non-valvular Atrial Fibrillation
05/22
06/25
PERFORMANCE II, NCT04201132: Protection Against Emboli During Carotid Artery Stenting Using the Neuroguard IEP System

Active, not recruiting
N/A
305
Europe, US, RoW
Carotid artery stenting with Neuroguard IEP System
Contego Medical, Inc., Yale Cardiovascular Research Group, Advance Research Associates, CardioMed Device Consultants, LLC, Iqvia Pty Ltd, Medidata Solutions
Carotid Artery Stenosis, Carotid Artery Diseases, Carotid Stenosis
10/23
12/25
TRIOMPHE, NCT04471909: NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Recruiting
N/A
110
US, RoW
NEXUS Aortic Stent Graft System
Endospan Ltd.
Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
11/24
10/29
NCT05653336: PerQseal® Clinical Study

Recruiting
N/A
120
Europe, US
PerQseal® Closure Device System
Vivasure Medical Limited
Percutaneous Large Hole Vascular Closure
05/24
08/25
CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting
N/A
1247
Europe, Canada, US
Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System
Edwards Lifesciences
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
01/25
04/30
NCT04905017: Trisol System EFS Study

Recruiting
N/A
15
US
Transcatheter Tricuspid Valve Replacement
Trisol Medical
Tricuspid Regurgitation
01/25
07/27
NCT04482062: TRISCEND II Pivotal Trial

Active, not recruiting
N/A
1070
Europe, US
Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy
Edwards Lifesciences
Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure
06/24
12/29
NCT06212193: Innoventric Trillium™ Stent Graft Early Feasibility Study (EFS)

Recruiting
N/A
15
US
Trillium™
Innoventric LTD, Innoventric Inc.
Tricuspid Regurgitation, Tricuspid Regurgitation Functional
08/25
08/30
ALT-FLOW II, NCT05686317: Trial of the Edwards APTURE Transcatheter Shunt System

Recruiting
N/A
100
Europe, Canada, US
Edwards APTURE transcatheter shunt system, Sham procedure
Edwards Lifesciences
Heart Failure
01/26
07/30
NCT03523416: Early Feasibility Study - Edwards APTURE Transcatheter Shunt System

Active, not recruiting
N/A
71
US
Transcatheter Atrial Shunt System
Edwards Lifesciences
Heart Failure
12/23
11/28
CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting
N/A
870
Canada, US
Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy
Edwards Lifesciences
Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease
12/27
12/31
NCT03382457: Clinical Study of Edwards Cardioband FIT Valve Repair System

Recruiting
N/A
55
US
Transcatheter Tricuspid Valve Repair, Edwards Cardioband Tricuspid Valve Repair
Edwards Lifesciences
Tricuspid Regurgitation
12/26
12/31
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting
N/A
2486
Europe, Canada, US, RoW
Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS
Thomas G. Brott, M.D., National Institute of Neurological Disorders and Stroke (NINDS)
Carotid Stenosis
02/26
02/26
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
NCT05147792: The CONFORM Pivotal Trial

Suspended
N/A
1600
US, RoW
CLAAS, WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder
Conformal Medical, Inc
Atrial Fibrillation, Stroke
08/26
08/30
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
10/26
09/36
Chikowski, Ann Marie
NCT05163548: PerQseal®+ Early Feasibility Study

Completed
N/A
15
US
PerQseal Plus Device, Vascular Closure Device
Vivasure Medical Limited
Percutaneous Large Hole Vascular Closure
07/22
07/22
NCT04905017: Trisol System EFS Study

Recruiting
N/A
15
US
Transcatheter Tricuspid Valve Replacement
Trisol Medical
Tricuspid Regurgitation
01/25
07/27
NCT04943172: The Hancock Jaffe Surgical Antireflux Venous Valve Endoprosthesis Study

Recruiting
N/A
75
US
Hancock-Jaffe bioprosthetic venous valve (VenoValve®)
Hancock Jaffe Laboratiores, Inc, AXIOM Real Time Metrics, Syntactx
Deep Venous Insufficiency (Diagnosis)
03/24
03/28
Yadav, Pradeep
NCT03904147: TRILUMINATE Pivotal Trial

Active, not recruiting
N/A
572
Europe, Canada, US
TriClipTM Device
Abbott Medical Devices
Tricuspid Regurgitation
11/22
04/29
NCT04029337: An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System

Recruiting
N/A
30
US
Transcatheter Mitral Valve Replacement
HighLife SAS
Mitral Regurgitation
12/24
12/27
NCT04905017: Trisol System EFS Study

Recruiting
N/A
15
US
Transcatheter Tricuspid Valve Replacement
Trisol Medical
Tricuspid Regurgitation
01/25
07/27
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting
N/A
958
Canada, US
Tendyne Mitral Valve System, MitraClip System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
05/24
06/28
NCT05061004: Cephea Early Feasibility Study

Recruiting
N/A
50
Canada, US
Cephea Mitral Valve System
Abbott Medical Devices
Mitral Regurgitation
03/26
03/31
NCT04482062: TRISCEND II Pivotal Trial

Active, not recruiting
N/A
1070
Europe, US
Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy
Edwards Lifesciences
Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure
06/24
12/29
NCT05913908: EFS of the DUO System for Tricuspid Regurgitation

Recruiting
N/A
15
US
DUO Transcatheter Tricuspid Coaptation Valve System, DUO System
CroiValve Limited
Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases
12/25
10/29
TRICURE EFS, NCT06506942: The Study

Recruiting
N/A
10
US
Transcatheter Tricuspid Valve Replacement, TRiCares Topaz Tricuspid Valve Replacement System
TRiCares
Tricuspid Valve Regurgitation, Heart Valve Diseases, Cardiovascular Diseases
10/25
10/30
MITRAL-II, NCT04408430: The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).

Recruiting
N/A
210
US
Transseptal ViMAC, ViMAC
Mayra Guerrero
Mitral Annular Calcification, Mitral Stenosis, Mitral Regurgitation, Mitral Valve Disease
12/24
12/24
CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting
N/A
870
Canada, US
Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy
Edwards Lifesciences
Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease
12/27
12/31
NCT03382457: Clinical Study of Edwards Cardioband FIT Valve Repair System

Recruiting
N/A
55
US
Transcatheter Tricuspid Valve Repair, Edwards Cardioband Tricuspid Valve Repair
Edwards Lifesciences
Tricuspid Regurgitation
12/26
12/31
NCT05172973: ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

Recruiting
N/A
200
Canada, US
SAPIEN X4 THV
Edwards Lifesciences
Aortic Valve Insufficiency, Aortic Valve Stenosis
12/25
02/34
COMPLETE TAVR, NCT04634240: Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement

Recruiting
N/A
4000
Canada, US
Percutaneous Coronary Intervention (PCI)
University of British Columbia
Aortic Stenosis, Coronary Artery Disease, Coronary Stenosis
04/26
04/26
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
10/26
09/36

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