| Mourvillier, Bruno |
BICCS, NCT05681442: Beta-lactam Intermittent Versus Continuous Infusion and Combination Antibiotic Therapy in Sepsis |
|
|
| Recruiting | 4 | 600 | Europe | continuous pivotal βL-AB, CID group, intermittent pivotal βL-AB, IID control group, AG infusion most 1 dose, AMT group, AG infusion for 5 days, ACT Group | Assistance Publique - Hôpitaux de Paris | Sepsis | 09/24 | 01/25 | | |
REITAB-2, NCT05204563: Imipenem/Cilastatin-XNW4107 Versus Imipenem/Cilastatin/Relebactam for Treatment of Participants With Bacterial Pneumonia (XNW4107-302, ) |
|
|
| Recruiting | 3 | 450 | Europe, US, RoW | Combination of Imipenem/Cilastatin and XNW4107, Imipenem/Cilastatin/Relebactam, Recarbrio | Evopoint Biosciences Inc. | Hospital Acquired Bacterial Pneumonia or Ventilator-Associated Bacterial Pneumonia | 04/25 | 12/25 | | |
EMPASHOCK, NCT05879276: Effect at 3 Months of Early Empagliflozin Initiation in Cardiogenic Shock Patients on Mortality, Rehospitalization, Left Ventricular Ejection Fraction and Renal Function. |
|
|
| Not yet recruiting | 3 | 164 | Europe | Empagliflozin 10 MG | Central Hospital, Nancy, France | Cardiogenic Shock | 01/26 | 01/26 | | |
NCT04612413: A Phase 2 Study Evaluating Efficacy, Safety and Tolerability of Different Doses and Regimens of Allocetra-OTS for the Treatment of Organ Failure in Adult Sepsis Patients |
|
|
| Active, not recruiting | 2 | 160 | Europe, RoW | Allocetra-OTS, Placebo | Enlivex Therapeutics Ltd., Cato Research, Accelsiors CRO & Consultancy Services | Sepsis, Community-acquired Pneumonia, Urinary Tract Infections, Cholecystitis, Acute, Cholangitis Acute, Intraabdominal Infections | 12/24 | 03/25 | | |
PERFECCT, NCT05961488: Performance of Coronary CT Angiography to Rule Out Coronary Artery Disease After Out-of-hospital Cardiac Arrest |
|
|
| Recruiting | N/A | 200 | Europe | Coronary Calcium Score and Coronary CT angiogram | CHU de Reims | Out of Hospital Cardiac Arrest Without ST-segment Elevation | 06/27 | 01/28 | | |
| BOUADMA, Lila |
BICCS, NCT05681442: Beta-lactam Intermittent Versus Continuous Infusion and Combination Antibiotic Therapy in Sepsis |
|
|
| Recruiting | 4 | 600 | Europe | continuous pivotal βL-AB, CID group, intermittent pivotal βL-AB, IID control group, AG infusion most 1 dose, AMT group, AG infusion for 5 days, ACT Group | Assistance Publique - Hôpitaux de Paris | Sepsis | 09/24 | 01/25 | | |
| Meziani, Ferhat |
BICCS, NCT05681442: Beta-lactam Intermittent Versus Continuous Infusion and Combination Antibiotic Therapy in Sepsis |
|
|
| Recruiting | 4 | 600 | Europe | continuous pivotal βL-AB, CID group, intermittent pivotal βL-AB, IID control group, AG infusion most 1 dose, AMT group, AG infusion for 5 days, ACT Group | Assistance Publique - Hôpitaux de Paris | Sepsis | 09/24 | 01/25 | | |
| Not yet recruiting | 3 | 610 | Europe | Levosimendan 2.5 MG/ML Injectable Solution, Placebo | Central Hospital, Nancy, France | Cardiogenic Shock | 07/23 | 06/24 | | |
| Recruiting | 3 | 270 | Europe | Placebos, Dobutamine | University Hospital, Limoges, Centre d'Investigation Clinique 1415 | Sepsis, Cardiomyopathies, Hypoperfusion, Left Ventricular Systolic Dysfunction | 12/24 | 12/24 | | |
REITAB-2, NCT05204563: Imipenem/Cilastatin-XNW4107 Versus Imipenem/Cilastatin/Relebactam for Treatment of Participants With Bacterial Pneumonia (XNW4107-302, ) |
|
|
| Recruiting | 3 | 450 | Europe, US, RoW | Combination of Imipenem/Cilastatin and XNW4107, Imipenem/Cilastatin/Relebactam, Recarbrio | Evopoint Biosciences Inc. | Hospital Acquired Bacterial Pneumonia or Ventilator-Associated Bacterial Pneumonia | 04/25 | 12/25 | | |
EMPASHOCK, NCT05879276: Effect at 3 Months of Early Empagliflozin Initiation in Cardiogenic Shock Patients on Mortality, Rehospitalization, Left Ventricular Ejection Fraction and Renal Function. |
|
|
| Not yet recruiting | 3 | 164 | Europe | Empagliflozin 10 MG | Central Hospital, Nancy, France | Cardiogenic Shock | 01/26 | 01/26 | | |
NCT05962606: Safety and Efficacy of AON-D21 in Severe Community-Acquired Pneumonia. |
|
|
| Recruiting | 2 | 100 | Europe | AON-D21, Placebo | Aptarion Biotech AG | Community-acquired Pneumonia | 05/25 | 06/25 | | |
RESCUE3, NCT03783884: A Protocol Comparing Temporary Transvenous Diaphragm Pacing to Standard of Care for Weaning From Mechanical Ventilation |
|
|
| Terminated | N/A | 223 | Europe, US | Lungpacer Diaphragm Pacing Therapy, Lungpacer DPTS, AeroPace System | Lungpacer Medical Inc. | Ventilator Induced Diaphragm Dysfunction | 12/22 | 01/23 | | |
| Recruiting | N/A | 300 | Europe | Skin biopsy for genetic analyze | Hospices Civils de Lyon | Legionella | 01/24 | 01/25 | | |
| Recruiting | N/A | 520 | Europe | Biological samples will be done to evaluate the endothelial and leukocyte senescence. | University Hospital, Strasbourg, France | Shock, Cardiovascular Diseases, Infection | 02/25 | 03/25 | | |
Coro-ICU, NCT05529810: Characteristics and Consequences of Coronary Angiograms Performed in Intensive Care Patients |
|
|
| Completed | N/A | 150 | Europe | | University Hospital, Strasbourg, France | Acute Coronary Syndrome | 12/22 | 07/23 | | |
PROBIty, NCT05686577: How to Reduce Unnecessary Blood Cultures: Construction and Validation of a Predictive Score for Blood Culture Positivity in Intensive Care |
|
|
| Completed | N/A | 2411 | Europe | no intervention | University Hospital, Tours | Infection, Bacterial, Infection, Fungal, Bacteremia | 09/23 | 10/23 | | |
| ARGAUD, Laurent |
BICCS, NCT05681442: Beta-lactam Intermittent Versus Continuous Infusion and Combination Antibiotic Therapy in Sepsis |
|
|
| Recruiting | 4 | 600 | Europe | continuous pivotal βL-AB, CID group, intermittent pivotal βL-AB, IID control group, AG infusion most 1 dose, AMT group, AG infusion for 5 days, ACT Group | Assistance Publique - Hôpitaux de Paris | Sepsis | 09/24 | 01/25 | | |
| Recruiting | 3 | 270 | Europe | Placebos, Dobutamine | University Hospital, Limoges, Centre d'Investigation Clinique 1415 | Sepsis, Cardiomyopathies, Hypoperfusion, Left Ventricular Systolic Dysfunction | 12/24 | 12/24 | | |
| Recruiting | 3 | 650 | Europe, Canada, RoW | Alteplase, Placebo | Assistance Publique - Hôpitaux de Paris, Johannes Gutenberg University Mainz, Life Sciences Research Partners (D Collen Research Foundation), Canadian Institutes of Health Research (CIHR), Instituto de Salud Carlos III, International Network of VENous Thromboembolism Clinical Research Networks, Boehringer Ingelheim | Pulmonary Embolism | 09/25 | 08/27 | | |
RICO, NCT04392401: COVID-19 - Study of the Kinetics of the Immune Response During the Intensive Care Unit Stay in Adult Patients Infected With SARS-CoV-2: Multicentric Non Interventional Study |
|
|
| Recruiting | N/A | 200 | Europe | Collection of blood samples in order to create a biocollection | Hospices Civils de Lyon, BioMérieux | Intensive Care Unit, SARS-Cov-2 | 05/22 | 05/22 | | |
CovidEP, NCT04751643: Therapeutic Plasma Exchange to Alleviate Hyperinflammatory Condition During Severe Covid-19 Infections |
|
|
| Recruiting | N/A | 132 | Europe | Therapeutic plasma exchange : 3 sessions in 3 consecutive days (day 1 to day 3), Usual treatments in intensive care unit according to the current state of knowledge | Hospices Civils de Lyon | Intensive Care Units, ARDS, Human, Covid19 | 12/22 | 12/22 | | |
VT4COVID, NCT04349618: Ultraprotective Ventilation Without Extracorporeal Circulation During COVID 19 Pneumonia |
|
|
| Recruiting | N/A | 200 | Europe | PROTECTIVE VENTILATION, ULTRAPROTECTIVE VENTILATION | Hospices Civils de Lyon | Acute Respiratory Distress Syndrome, COVID19, Sars-CoV2, Pneumonia | 04/23 | 04/23 | | |
| Active, not recruiting | N/A | 1346 | Europe, RoW | Family members of patients admitted to the ICU, Health care professionals, Patients | Nantes University Hospital, Assistance Publique - Hôpitaux de Paris, Assistance Publique Hopitaux De Marseille | Stress Disorders, Post-Traumatic, Family Members | 01/24 | 07/24 | | |
| Recruiting | N/A | 300 | Europe | Skin biopsy for genetic analyze | Hospices Civils de Lyon | Legionella | 01/24 | 01/25 | | |
EXSUPEEP, NCT05147636: EXtubation With SUctioning or With Positive End-Expiratory Pressure in Intensive Care Unit |
|
|
| Recruiting | N/A | 424 | Europe | Extubation with PEEP, Endotracheal Aspiration | Centre Hospitalier de Bourg en Bresse, Direction Générale de l'Offre de Soins, Hospices Civils de Lyon | Extubation in Intensive Care Unit | 12/24 | 01/25 | | |
IDBIORIV, NCT06219135: Evaluation of the Performance of the Method in Pathogen Identification and Antibiotic Susceptibility Testing in Patients With Sepsis |
|
|
| Recruiting | N/A | 1372 | Europe | no intervention - Contamination group, blood sample - Bacteraemia group | Hospices Civils de Lyon | Sepsis | 01/26 | 05/26 | | |
| Recruiting | N/A | 220 | Europe | Remote ischemic conditioning, No remote ischemic conditioning | Hospices Civils de Lyon | Out-Of-Hospital Cardiac Arrest | 06/26 | 10/26 | | |
| LOUIS, Guillaume |
BICCS, NCT05681442: Beta-lactam Intermittent Versus Continuous Infusion and Combination Antibiotic Therapy in Sepsis |
|
|
| Recruiting | 4 | 600 | Europe | continuous pivotal βL-AB, CID group, intermittent pivotal βL-AB, IID control group, AG infusion most 1 dose, AMT group, AG infusion for 5 days, ACT Group | Assistance Publique - Hôpitaux de Paris | Sepsis | 09/24 | 01/25 | | |
| Not yet recruiting | 3 | 610 | Europe | Levosimendan 2.5 MG/ML Injectable Solution, Placebo | Central Hospital, Nancy, France | Cardiogenic Shock | 07/23 | 06/24 | | |
EMPASHOCK, NCT05879276: Effect at 3 Months of Early Empagliflozin Initiation in Cardiogenic Shock Patients on Mortality, Rehospitalization, Left Ventricular Ejection Fraction and Renal Function. |
|
|
| Not yet recruiting | 3 | 164 | Europe | Empagliflozin 10 MG | Central Hospital, Nancy, France | Cardiogenic Shock | 01/26 | 01/26 | | |
| Completed | N/A | 1058 | Europe | | Centre Hospitalier Régional Metz-Thionville | SARS CoV 2 Infection | 05/23 | 05/23 | | |
NCT04494074: Fever Control Using External Cooling in Mechanically Ventilated Patients With Septic Shock |
|
|
| Recruiting | N/A | 820 | Europe | External Cooling | Centre Hospitalier Intercommunal Creteil | Septic Shock | 12/26 | 12/26 | | |
| DAHYOT-FIZELIER, Claire |
BICCS, NCT05681442: Beta-lactam Intermittent Versus Continuous Infusion and Combination Antibiotic Therapy in Sepsis |
|
|
| Recruiting | 4 | 600 | Europe | continuous pivotal βL-AB, CID group, intermittent pivotal βL-AB, IID control group, AG infusion most 1 dose, AMT group, AG infusion for 5 days, ACT Group | Assistance Publique - Hôpitaux de Paris | Sepsis | 09/24 | 01/25 | | |
| Recruiting | 3 | 272 | Europe | 56 days of weight-adjusted L-Carnitine treatment, 10 days of intravenous placebo (isotonic saline) | Centre Hospitalier Universitaire de Nīmes | Severe Sepsis, Shock, Septic, Acute Kidney Injury | 05/25 | 05/26 | | |
| Active, not recruiting | 3 | 700 | Europe | Inhaled sedation with sevoflurane, intravenous sedation with propofol | University Hospital, Clermont-Ferrand | Acute Respiratory Distress Syndrome | 10/23 | 10/24 | | |
NCT03481569: Population Pharmacokinetic-pharmacodynamic (PK-PD) Study of 9 Broad-Spectrum Anti-infective Agents in the Cerebro Spinal Fluid (CSF) of Brain Injured Patients With an External Ventricular Drainage (EVD). |
|
|
| Completed | 1 | 176 | Europe | Blood and cerebrospinal fluid pharmacocinetic samples on one of the nine antibiotics prescribed in routine use | Poitiers University Hospital | Infection | 07/23 | 07/23 | | |
| Recruiting | N/A | 660 | Europe | Extubation readiness clinical score, Standard of care | University Hospital, Clermont-Ferrand, AZUREA Network (www.azurea.org), ANARLF Network, Direction Générale de l'Offre de Soin (DGOS) | Mechanical Ventilator Weaning, Acute Brain Injury, Altered Level of Consciousness, Mechanical Ventilation, Airway Control | 02/27 | 10/27 | | |
| SACCHERI, Clément |
BICCS, NCT05681442: Beta-lactam Intermittent Versus Continuous Infusion and Combination Antibiotic Therapy in Sepsis |
|
|
| Recruiting | 4 | 600 | Europe | continuous pivotal βL-AB, CID group, intermittent pivotal βL-AB, IID control group, AG infusion most 1 dose, AMT group, AG infusion for 5 days, ACT Group | Assistance Publique - Hôpitaux de Paris | Sepsis | 09/24 | 01/25 | | |
| Recruiting | N/A | 150 | Europe | | Centre Hospitalier Universitaire de Nice | COVID, ARDS, Quality of Life | 06/25 | 12/25 | | |
| ARRIVE, François |
BICCS, NCT05681442: Beta-lactam Intermittent Versus Continuous Infusion and Combination Antibiotic Therapy in Sepsis |
|
|
| Recruiting | 4 | 600 | Europe | continuous pivotal βL-AB, CID group, intermittent pivotal βL-AB, IID control group, AG infusion most 1 dose, AMT group, AG infusion for 5 days, ACT Group | Assistance Publique - Hôpitaux de Paris | Sepsis | 09/24 | 01/25 | | |
