The Second Affiliated Hospital of Guilin Medical University
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 36 Trials 
106 Trials

   

Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Deng, Yanhong
OPTICAL, NCT02572141: FOLFOX or CAPOX Perioperative Chemotherapy Versus Postoperative Chemotherapy for Locally Advanced Colon Cancer

Active, not recruiting
3
738
RoW
Perioperative chemotherapy with mFOLFOX6 or CAPOX regimens, Oxaliplatin, 5-Fluorouracil, Capecitabine, Leucovorin, Postoperative chemotherapy with mFOLFOX6 or CAPOX regimens
Sun Yat-sen University
Colon Cancer
04/21
04/23
NCT04714190: A Study of RC48-ADC in Local Advanced or Metastatic Gastric Cancer With the HER2-Overexpression

Recruiting
3
351
RoW
RC48-ADC, Recombinant Humanized anti-HER2 Monoclonal Antibody-MMAE Conjugate For Injection, Paclitaxel injection, Taxol, Irinotecan Hydrochloride Injection, CAMPTO, Apatinib Mesylate Tablets, Aitan
RemeGen Co., Ltd.
Gastric Cancer, HER2 Overexpressing Gastric Carcinoma
12/24
06/25
NCT04385550: A Study of Anlotinib Hydrochloride Capsule Combined With AK105 Injection in Subject With Advanced Gastric and Gastro-oesophageal Junction Adenocarcinoma

Not yet recruiting
3
528
RoW
Anlotinib hydrochloride capsule, AK105 injection, Paclitaxel injection, Docetaxel injection
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Advanced Gastric and Gastro-oesophageal Junction Adenocarcinoma
10/23
12/23
TRIBE-C, NCT04230187: Bevacizumab Plus MFOLFOXIRI As First-line Treatment for Patients with Unresectable Metastatic Colorectal Cancer

Active, not recruiting
3
528
RoW
mFOLFOXIRI plus Bevacizumab, Oxaliplatin, Irinotecan, 5-Fluorouracil, Leucovorin, Bevacizumab, mFOLFOX6 Plus Bevacizumab
Yanhong Deng
Colorectal Cancer
01/24
06/26
HERIZON-GEA-01, NCT05152147 / 2021-000296-36: A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers

Recruiting
3
918
Europe, Canada, Japan, RoW
Zanidatamab, ZW25, JZP598, Tislelizumab, Trastuzumab, Herceptin®, Capecitabine, Oxaliplatin, Cisplatin, 5-Fluorouracil
Jazz Pharmaceuticals, BeiGene, Ltd.
Gastric Neoplasms, Gastroesophageal Adenocarcinoma, Esophageal Adenocarcinoma
05/25
05/26
FOBEAR, NCT04215731: Neoadjuvant mFOLFOXIRI Plus Bevacizumab in Patients With High-Risk Locally Advanced Rectal Cancer

Recruiting
3
500
RoW
Neoadjuvant chemotherapy with mFOLFOXIRI plus bevacizumab, Oxaliplatin, Irinotecan, 5-Fluorouracil, Leucovorin, Bevacizumab, Restaging, Concomitant Chemoradiotherapy, Surgery, Chemoradiotherapy (only when patients with MRF involved or ycT4a/b by restaging), Induction chemotherpay with FOLFOX
Yanhong Deng
Rectal Cancer
02/26
02/26
FANTASTIC, NCT04338191: mFOLFOXIRI Versus mFOLFOX6 as Adjuvant Chemotherapy for Locally Advanced Colorectal Cancer

Recruiting
3
638
RoW
mFOLFOXIRI adjuvant chemotherapy, Oxaliplatin, Irinotecan, Leucovorin, 5-Fluorouracil, mFOLFOX6 adjuvant chemotherapy
Sun Yat-sen University
Colorectal Cancer
02/25
02/25
AFFORD, NCT05427669: Adjuvant mFOLFOXIRI vs. mFOLFOX6 in MRD Positive Stage II-III Colorectal Cancer

Not yet recruiting
3
340
NA
mFOLFOXIRI, Oxaliplatin, Irinotecan, 5-Fluorouracil, Leucovorin, mFOLFOX6
Yanhong Deng
Colorectal Cancer
07/25
07/27
MOUNTAINEER-03, NCT05253651 / 2021-002672-40: A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

Recruiting
3
400
Europe, Canada, Japan, US, RoW
tucatinib, TUKYSA, ONT-380, ARRY-380, PF-07265792, trastuzumab, Herceptin, bevacizumab, Avastin, cetuximab, Erbitux, oxaliplatin, leucovorin, levoleucovorin, fluorouracil
Seagen Inc., Merck Sharp & Dohme LLC
Colorectal Neoplasms
08/25
04/28
AZUR-2, NCT05855200: Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer

Recruiting
3
711
Europe, Canada, Japan, US, RoW
Dostarlimab, CAPEOX, FOLFOX
GlaxoSmithKline
Colonic Neoplasms, Neoplasms, Colon
12/28
12/30
NCT05019794: Infigratinib in Subjects With GC or GEJ With FGFR2 Amplification or Other Solid Tumors With Other FGFR Alterations

Checkmark NMPA cleared CTA to conduct the Phase 2a trial for metastatic gastric cancer or GE junction adenocarcinoma with FGFR2 gene amplification
Dec 2020 - Dec 2020: NMPA cleared CTA to conduct the Phase 2a trial for metastatic gastric cancer or GE junction adenocarcinoma with FGFR2 gene amplification
Recruiting
2a
80
RoW
Infigratinib, BGJ398
LianBio LLC
Gastric Cancer, Gastroesophageal Junction Adenocarcinoma, Solid Tumor
12/22
12/23
NCT05130021: A Clincal Study of Max-40279-01 in Patients With Advanced Colorectal Cancer

Not yet recruiting
2
130
RoW
MAX-40279-01, regorafenib
Maxinovel Pty., Ltd.
Metastatic Colorectal Cancer
05/22
10/23
PCOX, NCT03638297: PD-1 Antibody Combined With COX Inhibitor in MSI-H/dMMR or High TMB Colorectal Cancer

Recruiting
2
29
RoW
PD-1 antibody + cox inhibitor
Sun Yat-sen University
Colorectal Cancer
08/22
08/25
NCT04603040: A Study to Evaluate the Efficacy and Safety of Toripalimab Injection in the Treatment of Recurrent or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Who Have Failed at Least Two Prior Lines of Therapy and Are Positive Specific Markers

Recruiting
2
100
RoW
Toripalimab, Tuoyi
Shanghai Junshi Bioscience Co., Ltd.
Recurrent or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Who Have Failed at Least Two Prior Lines of Therapy
12/22
03/23
NCT04030260: Regorafenib and PD-1 Antibody in Combination With Radiotherapy for pMMR/MSS Metastatic Colorectal Cancer

Recruiting
2
28
RoW
Regorafenib and PD-1 antibody in Combination with Radiotherapy, Regorafenib, PD-1 antibody, Radiation therapy
Sun Yat-sen University
Colorectal Cancer Metastatic, MSS
02/23
07/23
PICC, NCT03926338: Toripalimab With or Without Celecoxib as Neoadjuvant Therapy in Resectable dMMR/MSI-H Colorectal Cancer

Recruiting
2
150
RoW
Cohort 1: Neoadjuvant treatment with toripalimab plus celecoxib for 3 months, Toripalimab, Celecoxib, Cohort 1: Neoadjuvant treatment with toripalimab monotherapy for 3 months, Cohort 2: Neoadjuvant treatment with toripalimab plus celecoxib for 6 months, Cohort 2: Neoadjuvant treatment with toripalimab monotherapy for 6 months
Sun Yat-sen University
Colorectal Cancer, Mismatch Repair-deficient (dMMR), Microsatellite Instability-high (MSI-H), Neoadjuvant Therapy
04/27
04/30
NCT05148195: A Phase II Study of Envofolimab and BD0801 With/Without Chemotherapy in Patients With Advanced Solid Tumors

Terminated
2
86
RoW
Envofolimab, BD0801, Docetaxel, Irinotecan, Leucovorin calcium, 5-Fluorouridine
Jiangsu Simcere Pharmaceutical Co., Ltd.
Advanced Solid Tumor
07/23
07/23
NCT06206278: Evaluation of Infigratinib in Patients With Locally Advanced or Metastatic Gastric Cancer or GEJ Adenocarcinoma

Terminated
2
6
RoW
Infigratinib, BGJ398, BBP-831
LianBio LLC
Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
05/24
05/24
NCT05068206: A Clinical Study to Compare the Efficacy and Safety of AK105 Plus Anlotinib and Capecitabine/Oxaliplatin (CapeOx) , Anlotinib Plus CapeOx, Bevacizumab Plus CapeOx

Recruiting
2
120
RoW
AK105 injection, Anlotinib hydrochloride capsule, CapeOX, Bevacizumab
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Unresectable Metastatic Colorectal Cancer
12/23
06/24
NAUTICALCRC, NCT05004350: A Study Evaluating the Combination of Encorafenib and Cetuximab Versus Irinotecan/Cetuximab or Infusional 5-fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab in Chinese Patients With BRAF V600E Mutant Metastatic Colorectal Cancer.

Active, not recruiting
2
103
RoW
Encorafenib, Braftovi®, PF-07263896, W0090, LGX818, ONO-7702, Cetuximab, Erbitux®, C225, FOLFIRI, Folinic acid + Fluorouracil + Irinotecan
Pierre Fabre Medicament, Merck KGaA, Darmstadt, Germany
BRAF V600E, Metastatic Colorectal Cancer
12/23
01/25
NCT03941574: A Clinical Study to Evaluate HLX10 Monotherapy for the Treatment of MSI-H or dMMR Solid Tumors That Failed to Respond to Standard Therapy

Recruiting
2
108
RoW
HLX10
Shanghai Henlius Biotech
MSI-H Solid Malignant Tumor
05/24
06/26
SINCERE, NCT05933980: Toripalimab,Celecoxib and Regorafenib in the Treatment of Refractory Advanced Colorectal Cancer

Recruiting
2
44
RoW
Rego+Tori+Cele, Bayer AG, Innovent Biologics
Sun Yat-sen University
Colorectal Cancer, Liver Metastases, MSS
09/25
12/25
China AZUR-1, NCT06640049: A Study of Dostarlimab in Participants With Untreated Locally Advanced Rectal Cancer in China

Recruiting
2
23
RoW
Dostarlimab, GSK4057190A, TSR-042
GlaxoSmithKline
Neoplasms, Rectal
12/28
03/31
NCT05472948: Surufatinib and Sintilimab in Combination With Capecitabine for Metastatic Adenocarcinoma of Small Intestine or Appendix Carcinoma

Recruiting
2
36
RoW
Surufatinib, SULANDA, Sintilimab, IBI308, Capecitabine, Capecitabine tablets
Sun Yat-sen University
Adenocarcinoma of Small Intestine, Appendix Carcinoma, Metastatic
11/24
11/25
CAMCO2, NCT05360277: Maintenance Tislelizumab + Capecitabine to Treat Metastatic Colorectal Cancer

Recruiting
2
52
RoW
Tislelizumab + Capecitabine, Best supportive care
Yanhong Deng
Metastatic Colorectal Cancer,NED
02/25
11/27
OPTICAL-2, NCT05571644: Neoadjuvant Treatment With mFOLFOXIRI Plus Cadonilimab (AK104) Versus mFOLFOX6 in Locally Advanced Colorectal Cancer

Recruiting
2
143
RoW
mFOLFOXIRI + Cadonilimab, Oxaliplatin, Irinotecan, 5-Fluorouracil, Leucovorin, Cadonilimab (AK104), mFOLFOX6, mFOLFOXIRI
Sun Yat-sen University
Colorectal Cancer
12/24
12/25
DETECT, NCT05578287: RC48 Plus Tislelizumab, Low-dose Capecitabine and Celecoxib for HER2-positive Metastatic Colorectal Cancer

Recruiting
2
29
RoW
Anti-HER2 ADC, Disitamab Vedotin, Tislelizumab, Capecitabin, Celecoxib
Sun Yat-sen University
Colorectal Cancer
12/24
12/25
NCT05934331: A LM-302 Combined With Toripalimab Phase II Study

Recruiting
2
276
RoW
LM302+Toripalimab, LM302+JS001
LaNova Medicines Zhejiang Co., Ltd.
Gastric Cancer, Pancreatic Cancer
07/25
01/26
CEIL, NCT05959356: Cetuximab and Envafolimab Plus mFOLFOXIRI as First-line Treatment for RAS/BRAF Wild-type, MSS, Unresectable Left-side Metastatic Colorectal Cancer

Recruiting
2
198
RoW
Cetuximab + Envafolimab + mFOLFOXIRI, Cetuximab or c225, Envafolimab, Irinotecan, Oxaliplatin, Leucovorin, 5-FU, Cetuximab + mFOLFOX6/FOLFIRI
Sun Yat-sen University
Metastatic Colorectal Cancer
12/25
12/27
TranStar102, NCT04495296: A Trial to Evaluate Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of TST001 in Advanced or Metastatic Solid Tumors

Recruiting
1/2
320
RoW
TST001, Oxaliplatin, Capecitabine, Paclitaxel, Gemcitabine, Cisplatin, Nivolumab
Suzhou Transcenta Therapeutics Co., Ltd., Bristol-Myers Squibb
Advanced Cancer
02/25
05/25
NCT05775900: Efficacy and Safety of Triweekly Cetuximab in Combination With Capecitabine as First-line Maintenance Treatment for KRAS/BRAF Wild-type Metastatic Colorectal Cancer

Recruiting
1/2
24
RoW
Cetuximab, Erbitux, Capecitabine, Capecitabine Tablets
Sun Yat-sen University
Metastatic Colorectal Cancer
12/24
12/24
CSPC-DEY-CRC-K06, NCT06434090: Liposomal Irinotecan Plus Bevacizumab in Irinotecan-refractory Metastatic Colorectal Cancer

Not yet recruiting
1/2
74
RoW
Liposomal irinotecan, Bevacizumab, avastin
Sun Yat-sen University
Colorectal Cancer
06/25
07/26
NCT06500676: A Study of GFH375 in Patients with Advanced Solid Tumors with KRAS G12D Mutations

Recruiting
1/2
290
RoW
GFH375
Genfleet Therapeutics (Shanghai) Inc.
KRAS G12D Mutations, Advanced Solid Tumors
07/28
12/28
NCT05176665: EMB-01 in Patients With Advanced/Metastatic Gastrointestinal Cancers

Recruiting
1/2
152
US, RoW
EMB-01, FIT-013a
Shanghai EpimAb Biotherapeutics Co., Ltd., Labcorp Corporation of America Holdings, Inc
Neoplasms, Neoplasm Metastasis, Metastatic Gastrointestinal Carcinoid Tumor
12/25
12/25
CSWOG-C03, NCT05426005: Cadonilimab for PD-1/PD-L1 Blockade-refractory, MSI-H/dMMR, Advanced Colorectal Cancer

Recruiting
1/2
28
RoW
Cadonilimab
Sun Yat-sen University
Colorectal Cancer Stage IV, Mismatch Repair-deficient (dMMR), Microsatellite Instability-high (MSI-H)
07/25
07/27
NCT04689100: Efficacy and Safety of JMT101 in Patients With Advanced Solid Tumor

Recruiting
1
259
RoW
JMT101, FOLFIRI(Irinotecan, Leucovorin Calcium, and Fluorouracil); mFOLFOX6((Oxaliplatin, Leucovorin Calcium, and Fluorouracil);, FOLFIRI; mFOLFOX6; Irinotecan;
Shanghai JMT-Bio Inc., CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Advanced Solid Tumor
12/21
06/22
NCT04930354: ECP-1014 Treatment for Patients With Solid Tumor Cancers

Recruiting
1
29
RoW
ECP-1014, GIBH-1014
Euclises Pharmaceuticals, Inc.
Solid Tumor
09/23
12/23
CSG-1906-101, NCT05857332: SG1906 for CLDN18.2-Positive Solid Tumors

Recruiting
1
60
RoW
SG1906
Hangzhou Sumgen Biotech Co., Ltd.
Locally Advanced Unresectable or Metastatic Solid Tumors
02/25
08/25
NCT06036862: Utilization of Transanal Endoscopy in the Treatment of Anastomotic Stenosis

Recruiting
N/A
50
RoW
Transanal and transabdominal combined endoscopic resection of rectal stenosis and anal reconstruction
Sun Yat-sen University
Anastomotic Stenosis
12/26
12/26
NCT06043999: Salvage Chemotherapy Versus Total Mesorectal Resection for Local Resection Rectal Cancer Patients

Recruiting
N/A
392
RoW
Radical total mesorectal excision, Salavge Adjuvant Chemoradiotherapy
Sun Yat-sen University
Chemotherapy Effect, Rectal Cancer
12/28
12/28
Song, Erwei
NCT04335006: A Phase 3 Study Comparing Carelizumab Plus Nab-paclitaxel and Apatinib, Carelizumab Plus Nab-paclitaxel, and Nab-paclitaxel in Patients With Advanced Triple Negative Breast Cancer.

Terminated
3
80
RoW
Carelizumab, SHR-1210, Nab-paclitaxel, Apatinib
Jiangsu HengRui Medicine Co., Ltd.
Breast Cancer, Triple Negative Breast Cancer
04/23
04/23
NCT06313463: Study Of Capecitabine Combined With Camrelizumab For Non-pCR TNBC With TLS After Neoadjuvant Chemoterapy

Recruiting
3
375
RoW
Carrellizumab + Capecitabine, Placebo + Capecitabine
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Neoplasms
09/31
12/35
NCT06316531: A Study Comparing BL-M07D1 With T-DM1 in Patients With Unresectable Locally Advanced or Metastatic HER2-positive Breast Cancer

Recruiting
3
268
RoW
BL-M07D1, T-DM1
Sichuan Baili Pharmaceutical Co., Ltd., Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.
HER2-positive Breast Cancer
05/26
05/26
HLX11-BC301, NCT05346224 / 2022-002189-34: A Study to Evaluate the Efficacy and Safety of HLX11 vs. EU-Perjeta® in the Neoadjuvant Therapy of HER2-Positive and HR-Negative Early-stage or Locally Advanced Breast Cancer

Active, not recruiting
3
900
RoW
HLX11, Recombinant anti-HER2 domain II humanized monoclonal antibody injection, EU-Perjeta®
Shanghai Henlius Biotech, Shanghai Henlius Biotech, Inc.
Breast Cancer, Breast Neoplasms, HER2-positive Breast Cancer
11/24
12/25
SHR-A1811-III-301, NCT05424835: A Trial of SHR-A1811versus Pyrotinib in Combination With Capecitabine in HER2-Positive, Unresectable and/or Metastatic Breast Cancer Subjects Previously Treated With Trastuzumab and Taxane

Active, not recruiting
3
381
RoW
SHR-A1811, Pyrotinib in combination with Capecitabine.
Jiangsu HengRui Medicine Co., Ltd.
HER2-Positive, Unresectable and/or Metastatic Breast Cancer Subjects Previously Treated With Trastuzumab and Taxane
12/26
12/27
JSKN003-302, NCT06079983: JSKN003 Versus Treatment Of Physician'S Choice For HER2-low, Unresectable and/or Metastatic Breast Cancer Subjects

Not yet recruiting
3
400
RoW
JSKN003, Capecitabine tablets, Gemcitabine hydrochloride for injection, Vinorelbine tartrate injection, Paclitaxel for injection (albumin-bound type), Docetaxel injection, Eribulin mesylate injection
Jiangsu Alphamab Biopharmaceuticals Co., Ltd
Breast Cancer
04/25
03/29
NCT02062489: Evaluation of Tamoxifen's Efficacy for ER/PR Negative,ER-beta Positive Operable Breast Cancer Patients

Recruiting
3
688
RoW
Tamoxifen, Nolvadex, Placebo
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer
05/25
05/26
NCT03351062: Efficacy of Tamoxifen Versus Toremifene in CYP2D6 IM/PM of Premenopausal Patients With ER-positive Early Breast Cancer

Recruiting
3
844
RoW
Tamoxifen, Tamoxifen citrate, Toremifene, fareston
Chinese Anti-Cancer Association, Fudan University, Henan Cancer Hospital, The First Hospital of Jilin University, Southwest Hospital, China, First Hospital of China Medical University, Guangdong Provincial People's Hospital, Harbin Medical University, First Affiliated Hospital of Chongqing Medical University, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Jiangsu Provincial People's Hospital, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Zhejiang Cancer Hospital, Tianjin Medical University Cancer Institute and Hospital, Union hospital of Fujian Medical University, Hebei Tumor Hospital, Hunan Cancer Hospital, Affiliated Hospital of Qinghai University, Wuhan TongJi Hospital, Hainan People's Hospital, The Third Affiliated Hospital of Kunming Medical College., The Third Affiliated Hospital of Nanchang University
Breast Cancer Female
12/25
12/25
NCT05463601: Mecapegfilgrastim for the Prevention of Dalpiciclib -Induced Neutropenia in Advanced Breast Cancer

Recruiting
2
132
RoW
Mecapegfilgrastim, dalpiciclib, exemestane, fulvestrant, letrozole, tamoxifen
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Jiangsu HengRui Medicine Co., Ltd.
Metastatic Breast Cancer
12/23
12/24
MA-BC-II-018, NCT04872985: Pyrotinib in Combination with Neoadjuvant Chemotherapy in HR+/HER2-, HER4 High Expression Breast Cancer Patients: a Phase II Trial

Recruiting
2
140
RoW
Pyrotinib, Epirubicin, E, Doxorubicin Hydrochloride Liposome Injection, A, Cyclophosphamide, C, Docetaxel, T, Nab paclitaxel, Placebo
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Jiangsu HengRui Medicine Co., Ltd.
Breast Cancer, Hormone-receptor Positive Breast Cancer
12/25
12/28
NCT05812326: PD-1 Knockout Anti-MUC1 CAR-T Cells in the Treatment of Advanced Breast Cancer

Completed
1/2
15
RoW
AJMUC1- PD-1 gene knockout anti-MUC1 CAR-T cells, Therapeutic T cells
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou Anjie Biomedical Technology Co., Ltd.
Advanced Breast Cancer, Breast Neoplasm Malignant Female
11/22
11/22
NCT05981014: Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes as Neoadjuvant Therapy for HER2-Negative Breast Cancer

Recruiting
1/2
196
RoW
Sentinel Lymph Node Biopsy (SLNB), SLNB, Doxorubicin, Epirubicin, Cyclophosphamide, Fludarabine, Tumor-draining lymph node-derived lymphocyte (LNL), LNL, Interleukin-2, IL-2, Nab-paclitaxel
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Neoplasms
12/30
05/35
NCT05981001: Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes for Advanced HER2-Negative Breast Cancer

Recruiting
1/2
170
RoW
Surgery for harvesting tumor-draining lymph nodes, Cyclophosphamide, Fludarabine, Tumor-draining lymph node-derived lymphocyte (LNL), LNL, Interleukin-2, IL-2, Camrelizumab, SHR-1210, Nab-paclitaxel, Gemcitabine, Carboplatin
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Neoplasms
04/32
04/35
GNC-035-103, NCT05160545: A Study of GNC-035, a Tetra-specific Antibody, in Participants With Locally Advanced or Metastatic Breast Cancer

Recruiting
1
29
RoW
GNC-035
Sichuan Baili Pharmaceutical Co., Ltd., Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.
Breast Cancer
06/25
12/25
NCT05339685: A Study of BL-M02D1 in Patients With Locally Advanced or Metastatic Triple Negative Breast Cancer or Other Solid Tumors

Recruiting
1
26
RoW
BL-M02D1
Sichuan Baili Pharmaceutical Co., Ltd., SystImmune Inc., Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.
Breast Cancer
12/24
12/24
NCT05461768: A Study of BL-M07D1 in Patients With Locally Advanced or Metastatic HER2 Positive/Low Expression Breast Cancer and Other Solid Tumors

Recruiting
1
26
RoW
BL-M07D1
Sichuan Baili Pharmaceutical Co., Ltd., SystImmune Inc., Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.
Breast Cancer, Locally Advanced or Metastatic Solid Tumor
06/25
12/25
NCT06364501: Phase 1 Trial of KH801

Not yet recruiting
1
17
RoW
KH801
Beijing Kanghong Biopharmaceutical Co., Ltd.
Advanced Solid Tumors
05/26
05/30
NCT06530082: A Single Arm Clinical Study of Dendritic Cell Vaccine Loaded With Circular RNA Encoding Cryptic Peptide for Patients With HER2-negative Advanced Breast Cancer

Not yet recruiting
1
48
NA
CircFam53B-219aa DC vaccine, camrelizumab
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Neoplasms
04/26
01/27
SHR-4602-I-101, NCT05819684: A Study of SHR-4602 in Subjects With Advanced Malignant Solid Tumors

Recruiting
1
133
RoW
SHR-4602 for injection
Suzhou Suncadia Biopharmaceuticals Co., Ltd.
Advanced Solid Tumor
05/25
05/26
NCT06121570: Phase I Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes as Neoadjuvant Therapy for HER2-Negative Breast Cancer

Recruiting
1
24
RoW
Sentinel Lymph Node Biopsy (SLNB), SLNB, Doxorubicin, Epirubicin, Cyclophosphamide, Fludarabine, Tumor-draining lymph node-derived lymphocyte (LNL), LNL, Interleukin-2, IL-2, Nab-paclitaxel
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Neoplasms
08/26
08/31
NCT06121557: Phase I Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes for Advanced HER2-Negative Breast Cancer

Recruiting
1
24
RoW
Surgery for harvesting tumor-draining lymph nodes, Cyclophosphamide, Fludarabine, Tumor-draining lymph node-derived lymphocyte (LNL), LNL, Interleukin-2, IL-2, Camrelizumab, SHR-1210, Chemotherapeutic drug, ADC or PARP inhibitor
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Neoplasms
12/26
12/31
NCT03724903: Ductal Lavage Versus Corticosteroids Therapy for Idiopathic Granulomatous Mastitis

Completed
N/A
140
RoW
Ductal lavage, Corticosteroid therapy
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Granulomatous Mastitis
04/23
04/23
NCT06319157: Minimal Access Versus Conventional Latissimus Dorsi Flap Harvest for Breast Reconstruction

Recruiting
N/A
94
RoW
minimal access breast reconstruction with a latissimus dorsi muscle flap, conventional breast reconstruction with a latissimus dorsi muscle flap
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Neoplasms
11/28
11/28
NCT04076111: Patterns of Breast Cancer Management and Prognosis of Breast Cancer in China

Not yet recruiting
N/A
20000
RoW
Fengxi Su
Breast Cancer
12/25
12/25
Coordinator
NCT05070455: An Open Label, Multicenter Study to Evaluate the Pharmacokinetics, Efficacy and Safety of ASCENIV™ (IGIV) in Pediatric Subjects With Primary Immunodeficiency Diseases (PIDD)

Recruiting
4
12
US
Asceniv™
ADMA Biologics, Inc.
Primary Immune Deficiency
03/23
06/23
VRDN-001-302, NCT06179875: An Open-label Study for Participants Who Are Non-responders at the End of Treatment Assessment on the VRDN-001-101 and VRDN-001-301 Pivotal Studies

Recruiting
3
143
Europe, US
Intervention/Treatment
Viridian Therapeutics, Inc.
Thyroid Eye Disease
07/25
03/26
RECOVER, NCT05184335: Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia

Recruiting
3
690
US
Brilaroxazine, RP5063, Placebo
Reviva Pharmaceuticals
Schizophrenia
02/25
02/25
STRIVE, NCT06384547: A Randomized, Active Controlled, Safety and Tolerability Study of VRDN-001 in Participants With Thyroid Eye Disease (TED)

Recruiting
3
212
US
VRDN-001 10 mg/kg, VRDN-001 3 mg/kg
Viridian Therapeutics, Inc.
Thyroid Eye Disease
05/25
01/26
REVEAL-1, NCT06625411: An Efficacy, Safety, and Tolerability Study of VRDN-003 in Participants with Active Thyroid Eye Disease (TED)

Recruiting
3
84
US
VRDN-003, Placebo
Viridian Therapeutics, Inc.
Thyroid Eye Disease
03/26
11/26
REVEAL-2, NCT06625398: An Efficacy, Safety, and Tolerability Study of VRDN-003 in Participants with Chronic Thyroid Eye Disease (TED)

Recruiting
3
126
US
VRDN-003, Placebo
Viridian Therapeutics, Inc.
Thyroid Eye Disease
04/26
12/26
THRIVE-2, NCT06021054: An Efficacy, Safety, and Tolerability Study of Veligrotug (VRDN-001), in Participants with Chronic Thyroid Eye Disease (TED)

Active, not recruiting
3
188
Europe, US, RoW
Veligrotug (VRDN-001), Placebo
Viridian Therapeutics, Inc.
Thyroid Eye Disease
12/24
09/25
NCT04222062: A Study Comparing GLIADEL to Stereotactic Radiosurgery in Metastatic Brain Disease

Recruiting
2
100
US
Carmustine 7.7Mg Wafer, GLIADEL
University of Nebraska, Arbor Pharmaceuticals, Inc.
Brain Tumor - Metastatic
12/25
12/26
NCT06107686: A Study of YL202 in Selected Patients with Advanced Solid Tumors

Recruiting
2
200
RoW
YL202 should be intravenously infused
MediLink Therapeutics (Suzhou) Co., Ltd.
NSCLC, Breast Cancer, HNSCC, Locally Advanced or Metastatic Solid Tumors
11/26
11/28
NCT06057922: A Study YL201 in Patients With Selected Advanced Solid Tumors

Recruiting
1/2
640
RoW
YL201 for Injection
MediLink Therapeutics (Suzhou) Co., Ltd.
Advanced Solid Tumor
10/26
10/27
BLAAC PD, NCT06719583: Black and African Americans Connections to Parkinson's Disease

Recruiting
N/A
2000
US
Michael J. Fox Foundation for Parkinson's Research, National Institutes of Health (NIH), University of Chicago, University of Alabama at Birmingham, Rush University, Washington University School of Medicine, Medical University of South Carolina, University Hospitals Cleveland Medical Center, Louisiana State University Health Sciences Center Shreveport, University of Florida, University of Maryland, The University of Texas Health Science Center, Houston, Ochsner Health System
Parkinson Disease
12/26
12/26
NCT06186596: Self-Administered Intralesional Injections for Acne

Recruiting
N/A
150
US
Triamcinolone delivered via injection assistance device
ACOM Labs
Acne Vulgaris
01/24
01/24
NCT05879198: Train Your Brain: A Pilot Project to Improve Memory and Decision Making

Completed
N/A
24
US
Computer-based Intervention
Henry Ford Health System, National Institutes of Health (NIH), National Institute on Drug Abuse (NIDA)
Behavior, Health
09/23
09/23
PRIMA-102, NCT05936970: Prospective, Multi-Center, Observational, Whole Blood Specimen Collection Study in Participants with Rheumatoid Arthritis with Inadequate Response or Intolerance to a DMARD Starting a New BDMARD or TsDMARD Treatment +/- CsDMARD

Recruiting
N/A
1410
US
Aqtual, Inc.
Rheumatoid Arthritis
06/25
12/25
NCT04642898: Increasing Treatment Efficacy Using SMART Methods for Personalizing Care

Completed
N/A
66
US
Standard UP Treatment, Capitalization UP Treatment, Compensation UP Treatment
Shannon E. Sauer-Zavala, National Institute of Mental Health (NIMH)
Anxiety Disorders, Post Traumatic Stress Disorder, Obsessive-Compulsive Disorder
06/24
06/24
NCT03594994: Metabolic Effects of Sleep Extension in People With Obesity

Completed
N/A
40
US
Sleep extension
Washington University School of Medicine
Insulin Resistance, Obesity
07/24
07/24
NCT06242704: Train Your Brain 2.0 - Improving Memory and Decision Making Among Youth

Recruiting
N/A
72
US
Working Memory Training, Working Memory
Henry Ford Health System
Behavior, Health
08/26
08/26
NCT04587518: Five Factor Model Treatment for Borderline Personality Disorder

Completed
N/A
100
US
Personality-Based Cognitive Behavioral Therapy
Shannon E. Sauer-Zavala
Borderline Personality Disorder
05/24
05/24
NCT05100836: SURPASS Impella 5.5 Study

Active, not recruiting
N/A
1017
US
Impella 5.5
Abiomed Inc.
Cardiogenic Shock, Acute Decompensated Heart Failure
12/24
12/24
ELEVATE-HF, NCT06592508: Evaluation Of A Virtual Cardiology Program To Improve Outcomes After Acute Decompensated Heart Failure

Recruiting
N/A
180
US
Remote Virtual Cardiology Program
Duke University, Ventricle Health
Heart Failure; With Decompensation
08/26
08/26
NCT03701828: Liver Health and Metabolic Function in People With Obesity

Enrolling by invitation
N/A
30
US
Weight loss surgery, Sleeve gastrectomy, Roux-en-Y, biliopancreatic diversion
Washington University School of Medicine
Non-Alcoholic Fatty Liver Disease
11/24
03/25
PsOWell, NCT05631223: Use of Telemedicine to Address 'Off Target' Symptoms in Psoriatic Arthritis (PsA)

Recruiting
N/A
87
US
Telemedicine
University of Pennsylvania
Psoriatic Arthritis
02/25
02/25
EIR, NCT05489133: Early Psychological Intervention After Rape

Recruiting
N/A
200
Europe
Modified prolonged exposure, Brief intervention, cognitive behavioral therapy
St. Olavs Hospital, Norwegian University of Science and Technology, The Research Council of Norway, Norwegian Women's Public Health Association (Norske Kvinners Sanitetsforening), National Centre for Emergency Primary Health Care, NORCE, UiT The Arctic University of Norway
Post Traumatic Stress Disorder, Rape Sexual Assault, Sexual Dysfunctions, Psychological, Pelvic Floor Myalgia, Pelvic Pain Syndrome, Depression, Anxiety, Sleep Disturbance, Activity, Motor, Cortisol Deficiency
05/25
12/27
CHOICES3, NCT05292781: Sickle Cell Disease Parenting CHOICES

Recruiting
N/A
506
US
CHOICES, eBook
University of Florida, National Human Genome Research Institute (NHGRI)
Sickle Cell Disease, Sickle Cell Trait
06/25
06/25
EXTEND, NCT05120544: Expanding Technology-Enabled Nurse Delivered Chronic Disease Care

Active, not recruiting
N/A
220
US
EXTEND Plus, EXTEND
Duke University, National Institute of Nursing Research (NINR)
Diabetes Mellitus, Type 2, Hypertension
10/25
10/25
Roubec, Jaromir
HLX10-020-SCLC302, NCT05353257 / 2022-002226-27: A Study to Evaluate the Efficacy and Safety of Serplulimab in Combination With Chemotherapy and Concurrent Radiotherapy in Patients With Limited-Stage Small Cell Lung Cancer

Active, not recruiting
3
511
Europe, US, RoW
HLX10, Serplulimab, carboplatin/cisplatin-etoposide, Thoracic radiotherapy, Placebo, Prophylactic Cranial Irradiation (PCI)
Shanghai Henlius Biotech, Shanghai Henlius Biotech, Inc.
Limited-Stage Small Cell Lung Cancer
07/25
12/26
SUNRAY-01, NCT06119581: A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

Recruiting
3
1016
Europe, Canada, Japan, US, RoW
LY3537982, Olomorasib, Pembrolizumab, Placebo, Cisplatin, Carboplatin, Pemetrexed
Eli Lilly and Company, Loxo Oncology, Inc.
Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis
10/26
10/29
LIBRETTO-432, NCT04819100 / 2020-005191-35: A Study of Selpercatinib After Surgery or Radiation in Participants With Non-Small Cell Lung Cancer (NSCLC)

Recruiting
3
170
Europe, Canada, Japan, US, RoW
Selpercatinib, LY3527723, LOXO-292, Placebo
Loxo Oncology, Inc., Eli Lilly and Company
Carcinoma, Non-Small-Cell Lung
05/27
08/32
NCT03917381 / 2018-003402-63: GEN1046 Safety Trial in Patients With Malignant Solid Tumors

Active, not recruiting
1/2
429
Europe, US, RoW
Acasunlimab, GEN1046, DuoBody®-PD-L1x4-1BB, Acasunlimab in combination with docetaxel (in a single expansion cohort), Acasunlimab in combination with pembrolizumab (in a separate expansion cohort), Acasunlimab in combination with pembrolizumab and standard chemotherapy (in separate expansion cohorts)
Genmab, BioNTech SE
Solid Tumors, Non-small Cell Lung Cancer, Urothelial Carcinoma, Endometrial Carcinoma, Triple Negative Breast Cancer, Squamous Cell Carcinoma of the Head and Neck, Cervical Cancer
02/26
02/26
Yi, Shanyong
NCT04237805 / 2013-001045-14: A Phase I/II Clinical Study of SAF-189s in Non-small Cell Lung Cancer (NSCLC) Patients

Recruiting
1/2
280
RoW
SAF-189s, foritinib succinate
Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.
Advanced Cancer, Advanced Solid Tumor, Lung Cancer, Nonsmall Cell
12/22
03/26
KL264-01, NCT04152499: Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies

Recruiting
1/2
1300
Canada, US, RoW
SKB264
Klus Pharma Inc.
Epithelial Ovarian Cancer, Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Urothelial Carcinoma, Non-Small Cell Lung Cancer, Small-Cell Lung Cancer, Endometrial Carcinoma, Head and Neck Squamous Cell Carcinoma, Breast Cancer
08/25
07/26
Li, Bihui
NCT06300177: D-1553 Tablet Versus Docetaxel Injection for KRAS G12C Mutation-positive Locally Advanced or Metastatic Non-small Cell Lung Cancer After Prior Standard Therapy Failure

Recruiting
3
522
RoW
D-1553 Tablet, Docetaxel injection
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Non Small Cell Lung Cancer
10/26
12/27
NCT05020769: SI-B001 Combined With Osimertinib Mesylate Tablets in the Treatment of Recurrent Metastatic Non-small Cell Lung Cancer.

Recruiting
2/3
14
RoW
SI-B001, Osimertinib
Sichuan Baili Pharmaceutical Co., Ltd.
Non-small Cell Lung Cancer
06/25
06/25
NCT06206278: Evaluation of Infigratinib in Patients With Locally Advanced or Metastatic Gastric Cancer or GEJ Adenocarcinoma

Terminated
2
6
RoW
Infigratinib, BGJ398, BBP-831
LianBio LLC
Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
05/24
05/24
NCT05044897: A Clinical Study to Evaluate the Efficacy and Safety of SI-B001 in the Treatment of Recurrent and Metastatic HNSCC

Recruiting
2
30
RoW
SI-B001
Sichuan Baili Pharmaceutical Co., Ltd.
Head and Neck Squamous Cell Carcinoma
06/25
06/25
NCT05020457: SI-B001 Combined With Chemotherapy in the Treatment of EGFR/ALK WT Recurrent or Metastatic NSCLC.

Recruiting
2
60
RoW
SI-B001, AP or TP, AP chemotherapy regimen was pemetrexed combined with cisplatin, and TP chemotherapy regimen was paclitaxel combined with cisplatin., Docetaxel
Sichuan Baili Pharmaceutical Co., Ltd.
Non Small Cell Lung Cancer
06/25
06/25
 

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