Universität Mainz (Johannes Gutenberg-Universität Mainz)
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 39 Trials 
66 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Leroux, Lionel
EXCELLENT, NCT02669810: (EXpanded CELL ENdocardiac Transplantation)

Completed
2
49
Europe
PROTHERACYTES, Standard Treatment for CHF post AMI
CellProthera
Acute Myocardial Infarction
03/24
03/24
FRONTIER V, NCT05323877: Safety and Performance Study of Large Hole Vascular Closure Device - France

Not yet recruiting
N/A
20
NA
Test Device (PerQseal+), PerQseal+
Vivasure Medical Limited
Large Hole Percutaneous Arterial Closure
08/22
04/23
NCT04029363: Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk

Recruiting
N/A
120
Europe, RoW
HighLife Transcatheter Mitral Valve Replacement
HighLife SAS, ICON plc
Mitral Regurgitation
03/25
06/30
PERFECT, NCT06521047: A Multicentre Observational Study to Assess Long-term Outcome of Participants in the EXCELLENT Clinical Trial

Recruiting
N/A
48
Europe
NA - Observational study
CellProthera
Acute Myocardial Infarction
03/34
03/34
VANTAGE, NCT04788888: Evaluation of TAVR Using the NAVITOR Valve in a Global Investigation

Recruiting
N/A
590
Europe, RoW
Navitor Transcatheter Aortic Valve and FlexNav Delivery System
Abbott Medical Devices
Symptomatic Severe Aortic Stenosis
06/25
02/36
BEST, NCT05454150: Balloon-Expandable Versus Self-expanding Transcatheter Heart Valve for Treatment of Symptomatic Native Aortic Valve Stenosis

Recruiting
N/A
1862
Europe
balloon-expandable valve, self-expanding valve
University Hospital, Lille, Ministry of Health, France
Aortic Valve Stenosis
07/25
07/25
NCT05601453: The ReTAVI Prospective Observational Registry

Recruiting
N/A
150
Europe, Canada, RoW
Elective redo transcatheter aortic valve implantation (redo-TAVI), redo-TAVI, redo-TAVR, Valve-in-Valve (ViV), TAV-in-TAV, TAVR-in-TAVR, Revalve
Institut für Pharmakologie und Präventive Medizin, Edwards Lifesciences
Structural Valve Deterioration, Structural Valve Degeneration, Symptomatic Patients Who Have Had Transcatheter Heart Valve (THV) Failure, Prosthetic Valve Malfunction, Prosthesis Failure
09/25
12/26
MITRA-HR, NCT03271762: Multicentre Study of MITRACLIP® Transcatheter Mitral Valve Repair in Patients With Severe Primary Mitral Regurgitation Eligible for High-risk Surgery

Recruiting
N/A
330
Europe, RoW
percutaneous mitral valve repair with MITRACLIP NT, MITRACLIP NTR/XTR, MITRACLIP G4NT/XT, MITRACLIP G4NTW/XTW, MITRACLIP, cardiac surgery
Nantes University Hospital, Ministère de la Santé, Abbott
Mitral Regurgitation
03/27
05/28
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial

Recruiting
N/A
400
Europe
Medtronic Intrepid™ TMVR TF System
Medtronic Cardiovascular
Mitral Regurgitation
08/29
12/38
Worthley, Stephen
PORTICO IDE, NCT02000115: Portico Re-sheathable Transcatheter Aortic Valve System US IDE Trial

Recruiting
N/A
1150
US, RoW
Portico transcatheter aortic valve, Commercially available transcatheter aortic valve
Abbott Medical Devices
Aortic Valve Stenosis
10/19
07/25
HighFLO, NCT04888247: Study - HighLife Trans-septal Mitral Valve Replacement (TSMVR) Feasibility Study of the Open Cell CLARITY Valve

Recruiting
N/A
30
Europe, RoW
CLARITY
HighLife SAS
Mitral Regurgitation
12/25
02/31
NCT04029363: Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk

Recruiting
N/A
120
Europe, RoW
HighLife Transcatheter Mitral Valve Replacement
HighLife SAS, ICON plc
Mitral Regurgitation
03/25
06/30
VANTAGE, NCT04788888: Evaluation of TAVR Using the NAVITOR Valve in a Global Investigation

Recruiting
N/A
590
Europe, RoW
Navitor Transcatheter Aortic Valve and FlexNav Delivery System
Abbott Medical Devices
Symptomatic Severe Aortic Stenosis
06/25
02/36
Bardeleben, Ralph Von
CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting
N/A
1247
Europe, Canada, US
Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System
Edwards Lifesciences
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
01/25
04/30
Reshape-HF2, NCT02444338: A Clinical Evaluation of the Safety and Effectiveness of the MitraClip System in the Treatment of Clinically Significant Functional Mitral Regurgitation

Completed
N/A
505
Europe, RoW
MitraClip, standard of care
University Medical Center Goettingen, University Medical Center Goettingen
Mitral Valve Insufficiency
04/24
04/24
CATALYST, NCT04226547: Amplatzer Amulet LAAO Vs. NOAC

Recruiting
N/A
2650
Europe, Canada, Japan, US, RoW
Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC
Abbott Medical Devices
Atrial Fibrillation, Stroke, Bleeding
08/27
08/30
CHOICE-MI, NCT04688190: CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry

Recruiting
N/A
800
Europe, Canada, US, RoW
Universitätsklinikum Hamburg-Eppendorf, Montreal Heart Institute, University Hospital, Bordeaux
Mitral Regurgitation
03/25
12/30
RESOLVE-MR, NCT04818502: Real World Study of the Tendyne™ Mitral Valve System to Treat Mitral Regurgitation

Active, not recruiting
N/A
200
Europe, RoW
Tendyne™ Mitral Valve System, Transcatheter Mitral Valve Implantation (TMVI)
Abbott Medical Devices
Mitral Valve Regurgitation
05/25
05/29
VANTAGE, NCT04788888: Evaluation of TAVR Using the NAVITOR Valve in a Global Investigation

Recruiting
N/A
590
Europe, RoW
Navitor Transcatheter Aortic Valve and FlexNav Delivery System
Abbott Medical Devices
Symptomatic Severe Aortic Stenosis
06/25
02/36
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial

Recruiting
N/A
400
Europe
Medtronic Intrepid™ TMVR TF System
Medtronic Cardiovascular
Mitral Regurgitation
08/29
12/38
Mieghem, Nicolas M Van
NCT05491200 / 2021-005499-20: Comparison Of Reduced DAPT Followed by P2Y12 Inhibitor Monotherapy With Prasugrel vs stAndard Regimen in STEMI Patients

Recruiting
4
1608
Europe, RoW
Prasugrel based short DAPT, Prasugrel based standard DAPT, OCT guided revascularization, Angio guided revascularization
Research Maatschap Cardiologen Rotterdam Zuid, Abbott Medical Devices
ST Elevated Myocardial Infarction, Dual Antiplatelet Therapy
08/26
08/28
REDOX TAVI, NCT04171726: Rotterdam EDOXaban Leaflet Evaluation in Patients After Transcatheter Aortic Valve Implantation

Recruiting
3
100
Europe
Edoxaban
Erasmus Medical Center, Daiichi Sankyo, Inc.
Aortic Valve Stenosis
06/23
09/23
SURTAVI, NCT01586910: Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement ().

Active, not recruiting
N/A
1746
Europe, Canada, US
Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI), Surgical Aortic Valve Replacement (SAVR), Medtronic CoreValve® Evolut R System Transcatheter Aortic Valve Implantation (TAVI)
Medtronic Cardiovascular
Severe Aortic Stenosis
07/18
11/26
NCT04147884: A Feasibility Study of the Millipede Transcatheter Annuloplasty Ring System in Patients With Functional Mitral Regurgitation

Active, not recruiting
N/A
4
US, RoW
Millipede Transcatheter Annuloplasty Ring System (Millipede System)
Boston Scientific Corporation
Mitral Regurgitation Functional, Mitral Valve Disease, Cardiovascular Diseases
12/21
11/26
THRONE, NCT04052256: The Heartflow Coronary Disease Progression Evaluation Study

Recruiting
N/A
250
Europe
Coronary computed tomography angiography
Erasmus Medical Center
Coronary Artery Disease
10/22
10/23
NCT03621501: Direct Complete Versus Staged Complete Revascularization in Patients Presenting With Acute Coronary Syndromes and Multivessel Disease

Active, not recruiting
N/A
1525
Europe
Percutaneous coronary intervention, PCI
Erasmus Medical Center, Biotronik SE & Co. KG
Acute Coronary Syndrome
10/22
10/26
PLUTO-II, NCT06204783: Real-time Pressure Volume Loop Monitoring as a Guide for Enhanced Understanding of Changes in Elemental Cardiovascular Physiology During Therapeutic Strategies Aiming for Hemodynamic Optimization. Cohort II: Structural Heart Interventions

Recruiting
N/A
157
Europe
Pressure volume (PV) loop measurement
Erasmus Medical Center
Heart Failure, Valvular Heart Disease, Aortic Stenosis, Mitral Insufficiency, Tricuspid Insufficiency
05/24
05/25
POLESTAR, NCT03910751: Trial - An International Multi-center Early Discharge TAVI Program

Active, not recruiting
N/A
252
Europe, Canada
Transcatheter Aortic Valve Implantation with ACURATE Neo Aortic Bioprosthesis
Erasmus Medical Center, Boston Scientific Corporation
Aortic Valve Stenosis
12/22
02/24
ART-VR, NCT05069987: Anxiety Reduction in TAVI Using Virtual Reality Trial

Recruiting
N/A
150
Europe
Virtual Reality Immersion
Erasmus Medical Center
Aortic Stenosis, Severe, Anxiety
12/22
05/23
NCT04799769: Safety and Performance Study of Large Hole Vascular Closure Device - FRONTIER V Study

Recruiting
N/A
90
Europe
Percutaneous arterial closure device
Vivasure Medical Limited
Percutaneous Arteriotomy Closure
01/23
03/23
PRECISE TAVI, NCT04473443: Addition of Computer Simulations to Minimize Adverse Events After Transcatheter Aortic Valve Implantation

Recruiting
N/A
200
Europe
FEops HEARTguideTM
Erasmus Medical Center, Feops
Aortic Valve Stenosis, Bicuspid Cardiac Valve
02/23
06/23
NCT02661451: Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

Active, not recruiting
N/A
178
Europe, Canada, US
SAPIEN 3 THV, Optimal Heart Failure Therapy
Cardiovascular Research Foundation, New York, Cardialysis BV, Avania
Aortic Valve Stenosis
02/23
02/25
POTUS, NCT05374733: Coronary Physiology Peri-Transcatheter Left-sided Valvular Interventions

Recruiting
N/A
150
Europe
Coronary Physiology assessment
Erasmus Medical Center
Aortic Valve Stenosis, Mitral Regurgitation, Coronary Artery Disease, Fractional Flow Reserve
03/23
03/23
PLUTO-I, NCT05909280: Real-time Pressure Volume Loop Monitoring as a Guide for Enhanced Understanding of Changes in Elemental Cardiovascular Physiology During Therapeutic Strategies Aiming for Hemodynamic Optimization. Cohort I: Veno-arterial Extracorporeal Membrane Oxygenation

Recruiting
N/A
20
Europe
Pressure-volume loop measurements
Erasmus Medical Center
Extracorporeal Membrane Oxygenation, Cardio/Pulm: Heart Failure
11/24
12/24
NCT06181240: Modification of Coronary Calcium With Laser Based Intravascular Lithotripsy for Coronary Artery Disease (FRACTURE)

Recruiting
N/A
400
Europe
Intravascular lithotripsy
Bolt Medical
Coronary Artery Disease, Coronary Artery Calcification
04/25
03/26
IABP ON-TIME, NCT06414187: Clinical Effects of Intra-aortic Balloon Support in Early Acute Coronary Syndrome and Non-Acute Coronary Syndrome Related Cardiogenic Shock

Not yet recruiting
N/A
400
Europe
Intra-Aortic Balloon Pump
Erasmus Medical Center, Arrow International LCC (Subsidiary of Teleflex Inc.)
Cardiogenic Shock
06/27
06/27
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF): the CORCINCH-HF Study

Recruiting
N/A
400
Europe, US, RoW
AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy
Ancora Heart, Inc.
Heart Failure with Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy
12/26
12/30
DTU-STEMI, NCT03947619: Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction: the STEMI-DTU Trial

Active, not recruiting
N/A
527
Europe, Canada, US
Impella CP® placement prior to reperfusion with Primary PCI
Abiomed Inc.
ST Elevation (STEMI) Myocardial Infarction of Anterior Wall
09/24
10/30
PROVE, NCT05539573: ACURATE neo2™ - Post Market Safety and Performance Surveillance in Aortic Stenosis

Active, not recruiting
N/A
1043
Europe
Planned TAVI with the ACURATE neo2™ aortic bioprosthesis and ACURATE neo2™ transfemoral delivery system.
University of Leipzig, National University of Ireland, Galway
Aortic Stenosis
04/25
04/25
VANTAGE, NCT04788888: Evaluation of TAVR Using the NAVITOR Valve in a Global Investigation

Recruiting
N/A
590
Europe, RoW
Navitor Transcatheter Aortic Valve and FlexNav Delivery System
Abbott Medical Devices
Symptomatic Severe Aortic Stenosis
06/25
02/36
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting
N/A
450
Europe, Canada, US
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Occlutech International AB
Stroke, Patent Foramen Ovale, PFO
11/25
10/26
NCT05149755: Evolut™ EXPAND TAVR II Pivotal Trial

Recruiting
N/A
650
Europe, Canada, Japan, US, RoW
Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT)
Medtronic Cardiovascular
Moderate Aortic Valve Stenosis
02/26
12/34
BASELINE, NCT04843072: Balloon vs. Self Expanding Transcatheter Valve for Degenerated Bioprosthesis

Recruiting
N/A
400
Europe, Canada, US
Evolut R/PRO bioprosthesis, Edwards Sapien S3/Ultra bioprosthesis
Erasmus Medical Center
Valve Heart Disease
05/26
05/26
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial

Recruiting
N/A
400
Europe
Medtronic Intrepid™ TMVR TF System
Medtronic Cardiovascular
Mitral Regurgitation
08/29
12/38
SAVI-AoS, NCT04514250: Stress Aortic Valve Index for Assessing Risk in Aortic Valve Stenosis Patients

Active, not recruiting
N/A
52
Europe, US
Catharina Ziekenhuis Eindhoven
Aortic Valve Stenosis
10/24
10/28
UNLOAD-HF, NCT05064202: Unloading in Heart Failure Cardiogenic Shock

Not yet recruiting
N/A
456
Europe
Impella 5.5, Inotropes
Amsterdam UMC, location VUmc, Abiomed Inc.
Cardiogenic Shock
10/27
07/28
TRACE-NL, NCT05628779: Evaluating Edge-to-edge Transcatheter Tricuspid Valve Repair in Patients With Severe Symptomatic Tricuspid Regurgitation

Enrolling by invitation
N/A
150
Europe
TriClip TTVr system (Abbott Vascular), PASCAL TTVr system (Edwards Lifesciences)
St. Antonius Hospital, ZonMw: The Netherlands Organisation for Health Research and Development
Tricuspid Valve Regurgitation, Nonrheumatic, Cardiac Catheterization, Heart Failure, Right Sided, Valve Regurgitation, Tricuspid
11/27
11/27
ATLAS TAVI, NCT04914481: Anatomic Stenosis Severity as a Prognostic Marker in Patients With Low-Flow Low-Gradient Aortic Stenosis Undergoing TAVI

Recruiting
N/A
1500
Europe, Canada, RoW
Universitätsklinikum Hamburg-Eppendorf, Institut universitaire de cardiologie et de pneumologie de Québec
Low-Flow, Low-Gradient Aortic Stenosis
12/22
12/25
Ruge, Hendrik
APPIRED-III, NCT03050476 / 2016-002663-33: Preventing Systemic Inflammation After Cardiac Surgery With Alkaline Phosphatase

Recruiting
2/3
1250
Europe, RoW
RESCAP®, placebo
Alloksys Life Sciences B.V., Aix Scientifics
Systemic Inflammation, Cardiopulmonary-bypass
09/25
03/26
CHOICE-MI, NCT04688190: CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry

Recruiting
N/A
800
Europe, Canada, US, RoW
Universitätsklinikum Hamburg-Eppendorf, Montreal Heart Institute, University Hospital, Bordeaux
Mitral Regurgitation
03/25
12/30
RESOLVE-MR, NCT04818502: Real World Study of the Tendyne™ Mitral Valve System to Treat Mitral Regurgitation

Active, not recruiting
N/A
200
Europe, RoW
Tendyne™ Mitral Valve System, Transcatheter Mitral Valve Implantation (TMVI)
Abbott Medical Devices
Mitral Valve Regurgitation
05/25
05/29
VANTAGE, NCT04788888: Evaluation of TAVR Using the NAVITOR Valve in a Global Investigation

Recruiting
N/A
590
Europe, RoW
Navitor Transcatheter Aortic Valve and FlexNav Delivery System
Abbott Medical Devices
Symptomatic Severe Aortic Stenosis
06/25
02/36
VISTA, NCT06008080: Post-Market Clinical Follow Up Study with Navitor Valve

Recruiting
N/A
1000
Europe, Japan
Navitor Transcatheter Aortic Valve, FlexNav Delivery System, Navitor Loading System
Abbott Medical Devices
Aortic Stenosis
01/26
12/30
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial

Recruiting
N/A
400
Europe
Medtronic Intrepid™ TMVR TF System
Medtronic Cardiovascular
Mitral Regurgitation
08/29
12/38
TENDER, NCT04898335: Tendyne European Experience Registry

Recruiting
N/A
400
Europe
Tendyne Mitral Valve System
Klinikum der Universitaet Muenchen
Mitral Regurgitation
12/26
12/27
Podichetty, Vinny
NCT02097420: HALO: A Single Arm Prospective Investigation of the SJM™ Masters HP™ 15mm Rotatable Mechanical Heart Valve

Completed
N/A
23
US
Mitral valve replacement SJM™ Masters HP™ 15mm Rotatable Mechanical Heart Valve
Abbott Medical Devices
Mitral Valve Disease, Damaged Mitral Valve, Malfunctioning Mitral Heart Valve, Mitral Valve Replacement
03/19
07/23
NCT03752866: CONFIDENCE Registry to Assess Safety and Performance of Portico System to Treat Patients With Severe Aortic Stenosis.

Completed
N/A
1001
Europe, RoW
Portico™ Valve, Portico Delivery System(s) and Loading System(s), Portico™ Valve, FlexNav Delivery System(s) and Loading System(s)
Abbott Medical Devices
Symptomatic Degenerative Aortic Stenosis, Severe Aortic Stenosis
11/21
07/22
NCT04011722: Portico Next Generation Approval Study

Active, not recruiting
N/A
333
Europe, US, RoW
Portico™ NG (Navitor) Valve and FlexNav™ Delivery System, Navitor Titan Valve (35mm) Valve and Large FlexNav™ Delivery System
Abbott Medical Devices
Symptomatic Severe Aortic Stenosis
01/23
12/27
NCT03016169: Trifecta™ GT Post Market Clinical Follow-up

Completed
N/A
358
Europe, Canada, US
Trifecta GT (Glide Technology) Valve
Abbott Medical Devices
Aortic Valve Disease, Aortic Valve Disorder
04/23
08/23
ABT-CIP-10387, NCT05171712: Portico and Navitor India Clinical Trial

Active, not recruiting
N/A
30
RoW
Transcatheter Aortic Valve Replacement
Abbott Medical Devices
Aortic Valve Stenosis, Aortic Valve Failure, Aortic Insufficiency, Aortic Stenosis
02/25
06/25
NCT05002088: Portico Valve-in-Valve Retrospective Registry

Completed
N/A
71
Europe, RoW
Transcatheter Aortic Valve Replacement
Abbott Medical Devices
Aortic Valve Stenosis, Aortic Valve Failure, Aortic Insufficiency, Aortic Stenosis
12/23
12/23
VANTAGE, NCT04788888: Evaluation of TAVR Using the NAVITOR Valve in a Global Investigation

Recruiting
N/A
590
Europe, RoW
Navitor Transcatheter Aortic Valve and FlexNav Delivery System
Abbott Medical Devices
Symptomatic Severe Aortic Stenosis
06/25
02/36
VISTA, NCT06008080: Post-Market Clinical Follow Up Study with Navitor Valve

Recruiting
N/A
1000
Europe, Japan
Navitor Transcatheter Aortic Valve, FlexNav Delivery System, Navitor Loading System
Abbott Medical Devices
Aortic Stenosis
01/26
12/30
ENVISION, NCT05932615: IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation

Enrolling by invitation
N/A
1500
Canada, US
Navitor Transcatheter Aortic Valve Implantation (TAVI) System, Any Commercially Available Transcatheter Aortic Valve (CAV) System
Abbott Medical Devices
Aortic Valve Stenosis, Heart Valve Diseases, Aortic Valve Disease, Heart Disease Structural Disorder
04/27
04/36
ARB-PMCF, NCT04761120: Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study

Recruiting
N/A
550
Europe, US
Abbott SJM Rigid Saddle Ring, Abbott SJM Séguin Ring, Abbott SJM Tailor Ring, Abbott SJM Tailor Band
Abbott Medical Devices
Mitral Regurgitation, Tricuspid Regurgitation, Valvular Heart Disease
11/30
03/31

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