Vanderbilt Eye Institute
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 15 Trials 
40 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Owings, Sandy A
NCT03283878: Antibiotic Prophylaxis in Patients Undergoing Elective TKA- Multi-center Trial

Active, not recruiting
4
1770
US
Cefazolin, Ancef
Duke University, American Association of Hip and Knee Surgeons, Orthopedic Research and Education Foundation
Arthropathy of Knee, Antibiotic Prophylaxis
11/24
08/25
Joos, Karen
PHACE, NCT05133245: - Prospective Genetic Investigation

Enrolling by invitation
N/A
50
US
Diagnostic study only
Vanderbilt University Medical Center
PHACE Syndrome
11/26
11/26
NCT00338065: External Influences Upon Ocular Homeostasis

Enrolling by invitation
N/A
200
US
Postural change, Water drinking
Vanderbilt University Medical Center
Intraocular Pressure
12/27
12/27
Kim, Stephen J
INSPIRE, NCT04505566: INflammatory MediatorS in the PathophysIology of Diabetic REtinopathy Study

Active, not recruiting
1
164
US
Ketorolac 0.45% ophthalmic solution, Acuvail, Placebo - Preservative-free artificial tears, Refresh, Aqueous PGE2 and inflammatory cytokines measurements
Stephen J. Kim, MD, Allergan, National Eye Institute (NEI)
Diabetic Retinopathy
12/25
12/25
Donahue, Sean P
ATS23, NCT06380517: Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

Recruiting
3
238
US
Luminopia, Eye Patch
Jaeb Center for Health Research, National Eye Institute (NEI), Pediatric Eye Disease Investigator Group
Amblyopia
12/26
05/27
Reddy, Rahul K
NCT05322070: Fluocinolone Acetonide Intravitreal Implant 0.18 mg in the Treatment of Chronic Non-Infectious Posterior Segment Uveitis

Active, not recruiting
4
125
US
Fluocinolone Acetonide Intravitreal Implant 0.18 mg, YUTIQ 0.18 mg
Alimera Sciences, CBCC Global Research
Uveitis, Posterior
11/25
11/25
Agarwal, Anita
SMART-BD, NCT06433635: Sequential Multiple Assignment Randomized Trial for Bipolar Depression

Not yet recruiting
4
2726
Canada, US
Cariprazine, Vraylar, Aripiprazole/Escitalopram combination, Abilify/ Lexapro, Quetiapine, Seroquel, Lurasidone, Latuda
Massachusetts General Hospital, Patient-Centered Outcomes Research Institute
Bipolar I Disorder, Depression
02/30
02/30
Kuchtey, Rachel
COAST, NCT04967989: Clarifying the Optimal Application of SLT Therapy Trial

Recruiting
N/A
790
Europe, Canada, US
Low Energy SLT, Standard Energy SLT
West Virginia University, University of Pittsburgh
Glaucoma and Ocular Hypertension
06/27
08/27
Kehler, Lori Ann
ATS22, NCT04378790: A Randomized Trial to Evaluate Sequential vs Simultaneous Patching

Recruiting
3
544
US
Patching, Eye Patch, Glasses, Spectacles
Jaeb Center for Health Research, National Eye Institute (NEI), Pediatric Eye Disease Investigator Group
Amblyopia
05/28
05/28
NCT00341744: Providing Access to the Visual Environment

Recruiting
N/A
795
US
Vanderbilt University, Tennessee Department of Education
Vision Impairment
12/28
12/28
Flowers, Brian
STAR-V, NCT05024695: Evaluate the Safety and Effectiveness of iSTAR Medical's MINIject™ Implant for Lowering Intraocular Pressure (IOP) in Subjects With Primary Open-angle Glaucoma.

Recruiting
N/A
975
Europe, Canada, US
MINIject™ Implant
iSTAR Medical
Glaucoma
07/27
07/29
VENICE, NCT05280366: STREAMLINE®SURGICAL SYSTEM Compared to iStent Inject W® in Patients With Open-Angle Glaucoma

Active, not recruiting
N/A
150
US, RoW
Streamline Surgical System, iStent Inject W
New World Medical, Inc.
Open Angle Glaucoma
06/26
06/26
COAST, NCT04967989: Clarifying the Optimal Application of SLT Therapy Trial

Recruiting
N/A
790
Europe, Canada, US
Low Energy SLT, Standard Energy SLT
West Virginia University, University of Pittsburgh
Glaucoma and Ocular Hypertension
06/27
08/27
Shieh, Christine
NCT05555589: Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

Recruiting
3
70
US
RGN-259, Tβ4, Thymosin Beta 4, Timbetasin, Placebo, Vehicle Control
ReGenTree, LLC
Neurotrophic Keratopathy
07/24
11/24
alLEViate, NCT03953703: Levocarnitine for Dry Eye in Sjogren's Syndrome

Enrolling by invitation
2
15
US
Levocarnitine, Placebo
Vanderbilt University Medical Center
Sjogren's Syndrome, Keratoconjunctivitis Sicca
08/25
09/25
Stone, Merisa
NCT05555589: Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

Recruiting
3
70
US
RGN-259, Tβ4, Thymosin Beta 4, Timbetasin, Placebo, Vehicle Control
ReGenTree, LLC
Neurotrophic Keratopathy
07/24
11/24
Gangaputra, Sapna
NCT03816397: Adalimumab in JIA-associated Uveitis Stopping Trial

Active, not recruiting
4
87
Europe, US, RoW
Adalimumab, HUMIRA, Placebo
Nisha Acharya, Children's Hospital of Philadelphia, Children's Hospital Medical Center, Cincinnati, Children's Mercy Hospital Kansas City, National Eye Institute (NEI), Great Ormond Street Hospital for Children NHS Foundation Trust, University Hospitals Bristol and Weston NHS Foundation Trust, Alder Hey Children's NHS Foundation Trust, Newcastle-upon-Tyne Hospitals NHS Trust, Sheffield Children's NHS Foundation Trust, Cambridge University Hospitals NHS Foundation Trust, Royal Children's Hospital, Norfolk and Norwich University Hospitals NHS Foundation Trust, Vanderbilt University Medical Center, University of California, Davis, University of Texas at Austin, University of Miami, University Hospitals, Leicester, University of Utah, Colorado Retina Associates, Manchester University NHS Foundation Trust
Uveitis, JIA
01/25
04/25
ADVISE, NCT03828019: Adalimumab vs. Conventional Immunosuppression for Uveitis Trial

Completed
3
227
Europe, US, RoW
Adalimumab (ADA), Adalimumab, Humira, Conventional immunosuppression (CON), Azathioprine, Imuran , Cyclosporine, Methotrexate, Rheumatrex, Mycophenolate, CellCept, Cyclosporine, Sandimmune, Neoral, Tacrolimus, Prograf
JHSPH Center for Clinical Trials
Uveitis
04/24
09/24
NAC Attack, NCT05537220: Oral N-acetylcysteine for Retinitis Pigmentosa

Recruiting
3
438
Europe, Canada, US, RoW
N-acetylcysteine, Placebo
Johns Hopkins University, National Eye Institute (NEI), Duke University, Emory University, Massachusetts Eye and Ear Infirmary, Mayo Clinic, Medical College of Wisconsin, Retina Foundation of the Southwest, Stanford University, University of California, Davis, University of Florida, University of Iowa, University of Miami, University of Michigan, University of Minnesota, University of Oklahoma, University of Southern California, University of Utah, University of Washington, University of Wisconsin, Madison, Vanderbilt University, Vitreo Retinal Associates, PA, University of Houston, Medical University of Graz, McGill University, Universität Tübingen, Centro Medico ABC, Radboud University Medical Center, University of Amsterdam, University Hospital, Basel, Switzerland, University College London Hospitals, Northwestern University, University of Pennsylvania
Retinitis Pigmentosa
12/28
12/28
NCT05414994: Assessment of the Ocular Microbiome in Health and Disease

Recruiting
N/A
500
US
Eye swab
Vanderbilt University Medical Center
Microbial Colonization, Eye Diseases, Ophthalmopathy
09/27
12/27
Gee, Nancy
PreDICT, NCT04125134: Predicting the Success of Dry Eye Disease Interventions Using Clinical Tests

Recruiting
4
66
US
Preservative-free Refresh Optive Advanced Lubricant Eye Drops
Tufts Medical Center
Dry Eye
12/25
12/25
DEcIDED, NCT04527887: Intracanalicular Dexamethasone Insert for the Treatment of Inflammation and Discomfort in Dry Eye Disease

Terminated
4
54
US
Dextenza (IDI) (Sustained Release Dexamethasone), (0.4 mg), ProLong™ collagen plugs
Tufts Medical Center, Ocular Therapeutix, Inc.
Dry Eye
11/23
12/24
NCT05555589: Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

Recruiting
3
70
US
RGN-259, Tβ4, Thymosin Beta 4, Timbetasin, Placebo, Vehicle Control
ReGenTree, LLC
Neurotrophic Keratopathy
07/24
11/24
NCT05551156: The Role of Therapy Dogs in Reducing Depression, Anxiety, and Loneliness Among Hospitalized Children

Recruiting
N/A
60
US
Animal-assisted interaction, Conversational interaction
Virginia Commonwealth University, Purina Mills, Inc
Hospitalized Children
12/24
12/24
NCT05089201: A Pilot Study to Examine the Impact of a Therapy Dog Intervention on Loneliness and Related Health Outcomes in Vulnerable Populations

Completed
N/A
72
US
Animal-assisted interaction, Conversational control
Virginia Commonwealth University, Waltham Petcare Science Institute, Human Animal Bond Research Institute (HABRI)
Loneliness, Depression, Anxiety, Quality of Life
01/24
01/24
NCT05653921: Prospective Study to Validate the Imaging Biomarker for NCP (R33)

Recruiting
N/A
438
US
In vivo confocal microscopy (IVCM)
Tufts Medical Center, National Institute of Neurological Disorders and Stroke (NINDS)
Dry Eye Syndromes, Corneal Disease
05/25
07/25
BIRC-02, NCT04469140: Non Exudative AMD Imaged With SS-OCT- Extension

Recruiting
N/A
450
US, RoW
SS-OCT imaging, Zeiss PlexElite, PlexElite 9000, Swept Source OCT, Optical Coherence Tomography Angiography
Boston Image Reading Center
Dry Macular Degeneration
08/25
08/25
Groth, Sylvia
NCT04175444: Establishing a Normative Database in Pediatric Population of the Head-mounted visuALL Field Analyzer

Completed
N/A
50
US
VisuALL Field Analyzer, visual field testing strategy, head mounted device, Olleyes, Humphrey Field Analyzer, standard of care visual field test
Vanderbilt University Medical Center
Visual Field Defect, Peripheral
07/20
12/22
Nicholson, Crystal
ADVISE, NCT03828019: Adalimumab vs. Conventional Immunosuppression for Uveitis Trial

Completed
3
227
Europe, US, RoW
Adalimumab (ADA), Adalimumab, Humira, Conventional immunosuppression (CON), Azathioprine, Imuran , Cyclosporine, Methotrexate, Rheumatrex, Mycophenolate, CellCept, Cyclosporine, Sandimmune, Neoral, Tacrolimus, Prograf
JHSPH Center for Clinical Trials
Uveitis
04/24
09/24
NCT05555589: Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

Recruiting
3
70
US
RGN-259, Tβ4, Thymosin Beta 4, Timbetasin, Placebo, Vehicle Control
ReGenTree, LLC
Neurotrophic Keratopathy
07/24
11/24
Carter, Marybeth
NCT05999630: Artificial Tears to Prevent Nasolacrimal Duct Obstruction in Patients Treated with Radioactive Iodine for Thyroid Cancer

Recruiting
3
100
US
Artificial Tears Methylcellulose
Vanderbilt University Medical Center
Nasolacrimal Duct Obstruction, Thyroid Cancer
12/27
12/27
NAC Attack, NCT05537220: Oral N-acetylcysteine for Retinitis Pigmentosa

Recruiting
3
438
Europe, Canada, US, RoW
N-acetylcysteine, Placebo
Johns Hopkins University, National Eye Institute (NEI), Duke University, Emory University, Massachusetts Eye and Ear Infirmary, Mayo Clinic, Medical College of Wisconsin, Retina Foundation of the Southwest, Stanford University, University of California, Davis, University of Florida, University of Iowa, University of Miami, University of Michigan, University of Minnesota, University of Oklahoma, University of Southern California, University of Utah, University of Washington, University of Wisconsin, Madison, Vanderbilt University, Vitreo Retinal Associates, PA, University of Houston, Medical University of Graz, McGill University, Universität Tübingen, Centro Medico ABC, Radboud University Medical Center, University of Amsterdam, University Hospital, Basel, Switzerland, University College London Hospitals, Northwestern University, University of Pennsylvania
Retinitis Pigmentosa
12/28
12/28
COAST, NCT04967989: Clarifying the Optimal Application of SLT Therapy Trial

Recruiting
N/A
790
Europe, Canada, US
Low Energy SLT, Standard Energy SLT
West Virginia University, University of Pittsburgh
Glaucoma and Ocular Hypertension
06/27
08/27
Veach, Lindsay
IIH EVOLVE, NCT05347147 / 2021-006664-24: A Trial to Determine the Efficacy and Safety of Presendin in IIH

Terminated
3
14
Europe, US, RoW
Presendin, Placebo
Invex Therapeutics Ltd., Premier Research Group plc, University Hospitals Birmingham Neuro Ophthalmology Reading Centre, Birmingham, UK, Iowa Visual Field Reading Centre, Iowa, USA
Idiopathic Intracranial Hypertension
09/23
10/23
NAC Attack, NCT05537220: Oral N-acetylcysteine for Retinitis Pigmentosa

Recruiting
3
438
Europe, Canada, US, RoW
N-acetylcysteine, Placebo
Johns Hopkins University, National Eye Institute (NEI), Duke University, Emory University, Massachusetts Eye and Ear Infirmary, Mayo Clinic, Medical College of Wisconsin, Retina Foundation of the Southwest, Stanford University, University of California, Davis, University of Florida, University of Iowa, University of Miami, University of Michigan, University of Minnesota, University of Oklahoma, University of Southern California, University of Utah, University of Washington, University of Wisconsin, Madison, Vanderbilt University, Vitreo Retinal Associates, PA, University of Houston, Medical University of Graz, McGill University, Universität Tübingen, Centro Medico ABC, Radboud University Medical Center, University of Amsterdam, University Hospital, Basel, Switzerland, University College London Hospitals, Northwestern University, University of Pennsylvania
Retinitis Pigmentosa
12/28
12/28
Shieh, Christina
NCT05555589: Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

Recruiting
3
70
US
RGN-259, Tβ4, Thymosin Beta 4, Timbetasin, Placebo, Vehicle Control
ReGenTree, LLC
Neurotrophic Keratopathy
07/24
11/24
Sauer, Theodor
COAST, NCT04967989: Clarifying the Optimal Application of SLT Therapy Trial

Recruiting
N/A
790
Europe, Canada, US
Low Energy SLT, Standard Energy SLT
West Virginia University, University of Pittsburgh
Glaucoma and Ocular Hypertension
06/27
08/27
Finn, Avni P
Protocol AF, NCT04661358: Fenofibrate for Prevention of DR Worsening

Recruiting
3
560
US
Fenofibrate, Placebo
Jaeb Center for Health Research, National Institutes of Health (NIH), National Eye Institute (NEI), Juvenile Diabetes Research Foundation, Roche Pharma AG, The Leona M. and Harry B. Helmsley Charitable Trust
Diabetic Retinopathy
04/29
04/29
NCT06311617: Retinal Vascular Changes During Pregnancy

Recruiting
N/A
90
US
Optical coherence tomography
Vanderbilt University Medical Center
Pregnancy
01/27
01/27
Protocol AM, NCT05145491: Randomized Trial Comparing Immediate Vs. Deferred Surgery for Symptomatic ERM

Recruiting
N/A
400
US
Immediate Vitrectomy, Deferred Vitrectomy
Jaeb Center for Health Research, National Institutes of Health (NIH), National Eye Institute (NEI), Juvenile Diabetes Research Foundation
Epiretinal Membrane
12/26
12/26
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Owings, Sandy A
NCT03283878: Antibiotic Prophylaxis in Patients Undergoing Elective TKA- Multi-center Trial

Active, not recruiting
4
1770
US
Cefazolin, Ancef
Duke University, American Association of Hip and Knee Surgeons, Orthopedic Research and Education Foundation
Arthropathy of Knee, Antibiotic Prophylaxis
11/24
08/25
Joos, Karen
PHACE, NCT05133245: - Prospective Genetic Investigation

Enrolling by invitation
N/A
50
US
Diagnostic study only
Vanderbilt University Medical Center
PHACE Syndrome
11/26
11/26
NCT00338065: External Influences Upon Ocular Homeostasis

Enrolling by invitation
N/A
200
US
Postural change, Water drinking
Vanderbilt University Medical Center
Intraocular Pressure
12/27
12/27
Kim, Stephen J
INSPIRE, NCT04505566: INflammatory MediatorS in the PathophysIology of Diabetic REtinopathy Study

Active, not recruiting
1
164
US
Ketorolac 0.45% ophthalmic solution, Acuvail, Placebo - Preservative-free artificial tears, Refresh, Aqueous PGE2 and inflammatory cytokines measurements
Stephen J. Kim, MD, Allergan, National Eye Institute (NEI)
Diabetic Retinopathy
12/25
12/25
Donahue, Sean P
ATS23, NCT06380517: Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

Recruiting
3
238
US
Luminopia, Eye Patch
Jaeb Center for Health Research, National Eye Institute (NEI), Pediatric Eye Disease Investigator Group
Amblyopia
12/26
05/27
Reddy, Rahul K
NCT05322070: Fluocinolone Acetonide Intravitreal Implant 0.18 mg in the Treatment of Chronic Non-Infectious Posterior Segment Uveitis

Active, not recruiting
4
125
US
Fluocinolone Acetonide Intravitreal Implant 0.18 mg, YUTIQ 0.18 mg
Alimera Sciences, CBCC Global Research
Uveitis, Posterior
11/25
11/25
Agarwal, Anita
SMART-BD, NCT06433635: Sequential Multiple Assignment Randomized Trial for Bipolar Depression

Not yet recruiting
4
2726
Canada, US
Cariprazine, Vraylar, Aripiprazole/Escitalopram combination, Abilify/ Lexapro, Quetiapine, Seroquel, Lurasidone, Latuda
Massachusetts General Hospital, Patient-Centered Outcomes Research Institute
Bipolar I Disorder, Depression
02/30
02/30
Kuchtey, Rachel
COAST, NCT04967989: Clarifying the Optimal Application of SLT Therapy Trial

Recruiting
N/A
790
Europe, Canada, US
Low Energy SLT, Standard Energy SLT
West Virginia University, University of Pittsburgh
Glaucoma and Ocular Hypertension
06/27
08/27
Kehler, Lori Ann
ATS22, NCT04378790: A Randomized Trial to Evaluate Sequential vs Simultaneous Patching

Recruiting
3
544
US
Patching, Eye Patch, Glasses, Spectacles
Jaeb Center for Health Research, National Eye Institute (NEI), Pediatric Eye Disease Investigator Group
Amblyopia
05/28
05/28
NCT00341744: Providing Access to the Visual Environment

Recruiting
N/A
795
US
Vanderbilt University, Tennessee Department of Education
Vision Impairment
12/28
12/28
Flowers, Brian
STAR-V, NCT05024695: Evaluate the Safety and Effectiveness of iSTAR Medical's MINIject™ Implant for Lowering Intraocular Pressure (IOP) in Subjects With Primary Open-angle Glaucoma.

Recruiting
N/A
975
Europe, Canada, US
MINIject™ Implant
iSTAR Medical
Glaucoma
07/27
07/29
VENICE, NCT05280366: STREAMLINE®SURGICAL SYSTEM Compared to iStent Inject W® in Patients With Open-Angle Glaucoma

Active, not recruiting
N/A
150
US, RoW
Streamline Surgical System, iStent Inject W
New World Medical, Inc.
Open Angle Glaucoma
06/26
06/26
COAST, NCT04967989: Clarifying the Optimal Application of SLT Therapy Trial

Recruiting
N/A
790
Europe, Canada, US
Low Energy SLT, Standard Energy SLT
West Virginia University, University of Pittsburgh
Glaucoma and Ocular Hypertension
06/27
08/27
Shieh, Christine
NCT05555589: Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

Recruiting
3
70
US
RGN-259, Tβ4, Thymosin Beta 4, Timbetasin, Placebo, Vehicle Control
ReGenTree, LLC
Neurotrophic Keratopathy
07/24
11/24
alLEViate, NCT03953703: Levocarnitine for Dry Eye in Sjogren's Syndrome

Enrolling by invitation
2
15
US
Levocarnitine, Placebo
Vanderbilt University Medical Center
Sjogren's Syndrome, Keratoconjunctivitis Sicca
08/25
09/25
Stone, Merisa
NCT05555589: Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

Recruiting
3
70
US
RGN-259, Tβ4, Thymosin Beta 4, Timbetasin, Placebo, Vehicle Control
ReGenTree, LLC
Neurotrophic Keratopathy
07/24
11/24
Gangaputra, Sapna
NCT03816397: Adalimumab in JIA-associated Uveitis Stopping Trial

Active, not recruiting
4
87
Europe, US, RoW
Adalimumab, HUMIRA, Placebo
Nisha Acharya, Children's Hospital of Philadelphia, Children's Hospital Medical Center, Cincinnati, Children's Mercy Hospital Kansas City, National Eye Institute (NEI), Great Ormond Street Hospital for Children NHS Foundation Trust, University Hospitals Bristol and Weston NHS Foundation Trust, Alder Hey Children's NHS Foundation Trust, Newcastle-upon-Tyne Hospitals NHS Trust, Sheffield Children's NHS Foundation Trust, Cambridge University Hospitals NHS Foundation Trust, Royal Children's Hospital, Norfolk and Norwich University Hospitals NHS Foundation Trust, Vanderbilt University Medical Center, University of California, Davis, University of Texas at Austin, University of Miami, University Hospitals, Leicester, University of Utah, Colorado Retina Associates, Manchester University NHS Foundation Trust
Uveitis, JIA
01/25
04/25
ADVISE, NCT03828019: Adalimumab vs. Conventional Immunosuppression for Uveitis Trial

Completed
3
227
Europe, US, RoW
Adalimumab (ADA), Adalimumab, Humira, Conventional immunosuppression (CON), Azathioprine, Imuran , Cyclosporine, Methotrexate, Rheumatrex, Mycophenolate, CellCept, Cyclosporine, Sandimmune, Neoral, Tacrolimus, Prograf
JHSPH Center for Clinical Trials
Uveitis
04/24
09/24
NAC Attack, NCT05537220: Oral N-acetylcysteine for Retinitis Pigmentosa

Recruiting
3
438
Europe, Canada, US, RoW
N-acetylcysteine, Placebo
Johns Hopkins University, National Eye Institute (NEI), Duke University, Emory University, Massachusetts Eye and Ear Infirmary, Mayo Clinic, Medical College of Wisconsin, Retina Foundation of the Southwest, Stanford University, University of California, Davis, University of Florida, University of Iowa, University of Miami, University of Michigan, University of Minnesota, University of Oklahoma, University of Southern California, University of Utah, University of Washington, University of Wisconsin, Madison, Vanderbilt University, Vitreo Retinal Associates, PA, University of Houston, Medical University of Graz, McGill University, Universität Tübingen, Centro Medico ABC, Radboud University Medical Center, University of Amsterdam, University Hospital, Basel, Switzerland, University College London Hospitals, Northwestern University, University of Pennsylvania
Retinitis Pigmentosa
12/28
12/28
NCT05414994: Assessment of the Ocular Microbiome in Health and Disease

Recruiting
N/A
500
US
Eye swab
Vanderbilt University Medical Center
Microbial Colonization, Eye Diseases, Ophthalmopathy
09/27
12/27
Gee, Nancy
PreDICT, NCT04125134: Predicting the Success of Dry Eye Disease Interventions Using Clinical Tests

Recruiting
4
66
US
Preservative-free Refresh Optive Advanced Lubricant Eye Drops
Tufts Medical Center
Dry Eye
12/25
12/25
DEcIDED, NCT04527887: Intracanalicular Dexamethasone Insert for the Treatment of Inflammation and Discomfort in Dry Eye Disease

Terminated
4
54
US
Dextenza (IDI) (Sustained Release Dexamethasone), (0.4 mg), ProLong™ collagen plugs
Tufts Medical Center, Ocular Therapeutix, Inc.
Dry Eye
11/23
12/24
NCT05555589: Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

Recruiting
3
70
US
RGN-259, Tβ4, Thymosin Beta 4, Timbetasin, Placebo, Vehicle Control
ReGenTree, LLC
Neurotrophic Keratopathy
07/24
11/24
NCT05551156: The Role of Therapy Dogs in Reducing Depression, Anxiety, and Loneliness Among Hospitalized Children

Recruiting
N/A
60
US
Animal-assisted interaction, Conversational interaction
Virginia Commonwealth University, Purina Mills, Inc
Hospitalized Children
12/24
12/24
NCT05089201: A Pilot Study to Examine the Impact of a Therapy Dog Intervention on Loneliness and Related Health Outcomes in Vulnerable Populations

Completed
N/A
72
US
Animal-assisted interaction, Conversational control
Virginia Commonwealth University, Waltham Petcare Science Institute, Human Animal Bond Research Institute (HABRI)
Loneliness, Depression, Anxiety, Quality of Life
01/24
01/24
NCT05653921: Prospective Study to Validate the Imaging Biomarker for NCP (R33)

Recruiting
N/A
438
US
In vivo confocal microscopy (IVCM)
Tufts Medical Center, National Institute of Neurological Disorders and Stroke (NINDS)
Dry Eye Syndromes, Corneal Disease
05/25
07/25
BIRC-02, NCT04469140: Non Exudative AMD Imaged With SS-OCT- Extension

Recruiting
N/A
450
US, RoW
SS-OCT imaging, Zeiss PlexElite, PlexElite 9000, Swept Source OCT, Optical Coherence Tomography Angiography
Boston Image Reading Center
Dry Macular Degeneration
08/25
08/25
Groth, Sylvia
NCT04175444: Establishing a Normative Database in Pediatric Population of the Head-mounted visuALL Field Analyzer

Completed
N/A
50
US
VisuALL Field Analyzer, visual field testing strategy, head mounted device, Olleyes, Humphrey Field Analyzer, standard of care visual field test
Vanderbilt University Medical Center
Visual Field Defect, Peripheral
07/20
12/22
Nicholson, Crystal
ADVISE, NCT03828019: Adalimumab vs. Conventional Immunosuppression for Uveitis Trial

Completed
3
227
Europe, US, RoW
Adalimumab (ADA), Adalimumab, Humira, Conventional immunosuppression (CON), Azathioprine, Imuran , Cyclosporine, Methotrexate, Rheumatrex, Mycophenolate, CellCept, Cyclosporine, Sandimmune, Neoral, Tacrolimus, Prograf
JHSPH Center for Clinical Trials
Uveitis
04/24
09/24
NCT05555589: Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

Recruiting
3
70
US
RGN-259, Tβ4, Thymosin Beta 4, Timbetasin, Placebo, Vehicle Control
ReGenTree, LLC
Neurotrophic Keratopathy
07/24
11/24
Carter, Marybeth
NCT05999630: Artificial Tears to Prevent Nasolacrimal Duct Obstruction in Patients Treated with Radioactive Iodine for Thyroid Cancer

Recruiting
3
100
US
Artificial Tears Methylcellulose
Vanderbilt University Medical Center
Nasolacrimal Duct Obstruction, Thyroid Cancer
12/27
12/27
NAC Attack, NCT05537220: Oral N-acetylcysteine for Retinitis Pigmentosa

Recruiting
3
438
Europe, Canada, US, RoW
N-acetylcysteine, Placebo
Johns Hopkins University, National Eye Institute (NEI), Duke University, Emory University, Massachusetts Eye and Ear Infirmary, Mayo Clinic, Medical College of Wisconsin, Retina Foundation of the Southwest, Stanford University, University of California, Davis, University of Florida, University of Iowa, University of Miami, University of Michigan, University of Minnesota, University of Oklahoma, University of Southern California, University of Utah, University of Washington, University of Wisconsin, Madison, Vanderbilt University, Vitreo Retinal Associates, PA, University of Houston, Medical University of Graz, McGill University, Universität Tübingen, Centro Medico ABC, Radboud University Medical Center, University of Amsterdam, University Hospital, Basel, Switzerland, University College London Hospitals, Northwestern University, University of Pennsylvania
Retinitis Pigmentosa
12/28
12/28
COAST, NCT04967989: Clarifying the Optimal Application of SLT Therapy Trial

Recruiting
N/A
790
Europe, Canada, US
Low Energy SLT, Standard Energy SLT
West Virginia University, University of Pittsburgh
Glaucoma and Ocular Hypertension
06/27
08/27
Veach, Lindsay
IIH EVOLVE, NCT05347147 / 2021-006664-24: A Trial to Determine the Efficacy and Safety of Presendin in IIH

Terminated
3
14
Europe, US, RoW
Presendin, Placebo
Invex Therapeutics Ltd., Premier Research Group plc, University Hospitals Birmingham Neuro Ophthalmology Reading Centre, Birmingham, UK, Iowa Visual Field Reading Centre, Iowa, USA
Idiopathic Intracranial Hypertension
09/23
10/23
NAC Attack, NCT05537220: Oral N-acetylcysteine for Retinitis Pigmentosa

Recruiting
3
438
Europe, Canada, US, RoW
N-acetylcysteine, Placebo
Johns Hopkins University, National Eye Institute (NEI), Duke University, Emory University, Massachusetts Eye and Ear Infirmary, Mayo Clinic, Medical College of Wisconsin, Retina Foundation of the Southwest, Stanford University, University of California, Davis, University of Florida, University of Iowa, University of Miami, University of Michigan, University of Minnesota, University of Oklahoma, University of Southern California, University of Utah, University of Washington, University of Wisconsin, Madison, Vanderbilt University, Vitreo Retinal Associates, PA, University of Houston, Medical University of Graz, McGill University, Universität Tübingen, Centro Medico ABC, Radboud University Medical Center, University of Amsterdam, University Hospital, Basel, Switzerland, University College London Hospitals, Northwestern University, University of Pennsylvania
Retinitis Pigmentosa
12/28
12/28
Shieh, Christina
NCT05555589: Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

Recruiting
3
70
US
RGN-259, Tβ4, Thymosin Beta 4, Timbetasin, Placebo, Vehicle Control
ReGenTree, LLC
Neurotrophic Keratopathy
07/24
11/24
Sauer, Theodor
COAST, NCT04967989: Clarifying the Optimal Application of SLT Therapy Trial

Recruiting
N/A
790
Europe, Canada, US
Low Energy SLT, Standard Energy SLT
West Virginia University, University of Pittsburgh
Glaucoma and Ocular Hypertension
06/27
08/27
Finn, Avni P
Protocol AF, NCT04661358: Fenofibrate for Prevention of DR Worsening

Recruiting
3
560
US
Fenofibrate, Placebo
Jaeb Center for Health Research, National Institutes of Health (NIH), National Eye Institute (NEI), Juvenile Diabetes Research Foundation, Roche Pharma AG, The Leona M. and Harry B. Helmsley Charitable Trust
Diabetic Retinopathy
04/29
04/29
NCT06311617: Retinal Vascular Changes During Pregnancy

Recruiting
N/A
90
US
Optical coherence tomography
Vanderbilt University Medical Center
Pregnancy
01/27
01/27
Protocol AM, NCT05145491: Randomized Trial Comparing Immediate Vs. Deferred Surgery for Symptomatic ERM

Recruiting
N/A
400
US
Immediate Vitrectomy, Deferred Vitrectomy
Jaeb Center for Health Research, National Institutes of Health (NIH), National Eye Institute (NEI), Juvenile Diabetes Research Foundation
Epiretinal Membrane
12/26
12/26

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