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10 Active 1 Inactive 11 All	Not yet recruiting Recruiting Enrolling by invitation Active, not recruiting Available No longer recruiting	Industry lead sponsor Industry collaborator Coop Other	US Canada Japan Europe RoW	N/A 1 2 3 4	Highlight changes:- Show only changed items Enrollment:

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Trial + Data / Events	Status	Ph	N	Region	Interventions	Sponsor	Conditions	Primary compl	Study compl
Feller, Erika
PROACTIVE-HF, NCT04089059: IDE Trial Heart Failure NYHA Class III	Active, not recruiting	N/A	457	Europe, US	Cordella™ Pulmonary Artery Sensor System	Endotronix, Inc.	Heart Failure NYHA Class III	04/28	04/28
NCT05934487: PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III	Recruiting	N/A	1650	US	Cordella™ Pulmonary Artery Sensor System	Endotronix, Inc.	Heart Failure NYHA Class II, Heart Failure NYHA Class III	09/27	09/29
Macaluso, Gregory
PROACTIVE-HF, NCT04089059: IDE Trial Heart Failure NYHA Class III	Active, not recruiting	N/A	457	Europe, US	Cordella™ Pulmonary Artery Sensor System	Endotronix, Inc.	Heart Failure NYHA Class III	04/28	04/28
NCT05934487: PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III	Recruiting	N/A	1650	US	Cordella™ Pulmonary Artery Sensor System	Endotronix, Inc.	Heart Failure NYHA Class II, Heart Failure NYHA Class III	09/27	09/29
Rich, Jaime
PROACTIVE-HF, NCT04089059: IDE Trial Heart Failure NYHA Class III	Active, not recruiting	N/A	457	Europe, US	Cordella™ Pulmonary Artery Sensor System	Endotronix, Inc.	Heart Failure NYHA Class III	04/28	04/28
NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN	Recruiting	N/A	1400	Europe, US, RoW	Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation	Medtronic Vascular	Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus	11/26	11/29
CATALYST, NCT04226547: Amplatzer Amulet LAAO vs. NOAC	Recruiting	N/A	2650	Europe, Canada, Japan, US, RoW	Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC	Abbott Medical Devices	Atrial Fibrillation, Stroke, Bleeding	08/27	08/30
EMPOWER CAD, NCT05755711: Equity in Modifying Plaque Of WomEn With UndeRtreated Calcified Coronary Artery Disease	Recruiting	N/A	400	Europe, US	Shockwave Medical Coronary IVL System	Shockwave Medical, Inc.	Coronary Artery Disease	04/25	04/28
NCT05934487: PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III	Recruiting	N/A	1650	US	Cordella™ Pulmonary Artery Sensor System	Endotronix, Inc.	Heart Failure NYHA Class II, Heart Failure NYHA Class III	09/27	09/29
XU, Weining
PROACTIVE-HF, NCT04089059: IDE Trial Heart Failure NYHA Class III	Active, not recruiting	N/A	457	Europe, US	Cordella™ Pulmonary Artery Sensor System	Endotronix, Inc.	Heart Failure NYHA Class III	04/28	04/28