| Ciulla, Thomas |
NCT05131646: Extension Study to Evaluate the Long-term Outcomes of Subjects in the CLS-AX CLS1002-101 Study |
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| Completed | N/A | 15 | US | CLS-AX, axitinib injectable suspension | Clearside Biomedical, Inc. | Neovascular Age-related Macular Degeneration | 01/23 | 01/23 | | |
| Maturi, Raj K |
AO, NCT05904028: Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD |
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| Recruiting | 3 | 600 | US | Intravitreal injections of 6 mg faricimab on a Treat and Extend schedule, Intravitreal injections of 6 mg faricimab on a home optical coherence tomography-guided treatment schedule, Home OCT | Jaeb Center for Health Research, National Institutes of Health (NIH), National Eye Institute (NEI), Juvenile Diabetes Research Foundation | Neovascular Age-related Macular Degeneration | 07/27 | 07/27 | | |
| Recruiting | 3 | 560 | US | Fenofibrate, Placebo | Jaeb Center for Health Research, National Institutes of Health (NIH), National Eye Institute (NEI), Juvenile Diabetes Research Foundation, Roche Pharma AG, The Leona M. and Harry B. Helmsley Charitable Trust | Diabetic Retinopathy | 04/29 | 04/29 | | |
| Recruiting | 2 | 128 | US | Tonabersat, Placebo | Jaeb Center for Health Research, National Institutes of Health (NIH), National Eye Institute (NEI), Juvenile Diabetes Research Foundation | Diabetic Macular Edema | 11/24 | 05/25 | | |
SIGLEC, NCT05839041: A Multiple Dose Study of AVD-104 for Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD) |
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| Recruiting | 2 | 300 | US | AVD-104, Avacincaptad | Aviceda Therapeutics, Inc. | Geographic Atrophy of the Macula, Macular Degeneration | 06/25 | 06/26 | | |
| Recruiting | 2 | 72 | US | 4D-150 IVT, Aflibercept IVT, Eylea | 4D Molecular Therapeutics | Diabetic Macular Edema, Diabetic Retinopathy | 02/28 | 07/28 | | |
| Recruiting | 1/2 | 150 | US | 4D-150 IVT, Aflibercept IVT | 4D Molecular Therapeutics | Neovascular (Wet) Age-Related Macular Degeneration | 11/24 | 11/25 | | |
| Recruiting | N/A | 400 | US | Immediate Vitrectomy, Deferred Vitrectomy | Jaeb Center for Health Research, National Institutes of Health (NIH), National Eye Institute (NEI), Juvenile Diabetes Research Foundation | Epiretinal Membrane | 12/26 | 12/26 | | |
| Chaudhry, Nauman |
SIGLEC, NCT05839041: A Multiple Dose Study of AVD-104 for Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD) |
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| Recruiting | 2 | 300 | US | AVD-104, Avacincaptad | Aviceda Therapeutics, Inc. | Geographic Atrophy of the Macula, Macular Degeneration | 06/25 | 06/26 | | |
| Brown, Erin |
FINNEN, NCT04464629: Assessing the Efficacy and Safety of DEXTENZA in Pseudo Phakic Patients Undergoing Gas Bubble Repair and Laser Following Retinal Detachment |
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| Terminated | 4 | 7 | US | Dextenza, Prednisolone Acetate | Midwest Eye Institute, Ocular Therapeutix, Inc. | Retinal Detachment | 01/23 | 01/23 | | |
NCT04417530: Phase 2 Trial to Evaluate Belzupacap Sarotalocan (AU-011) Via Suprachoroidal Administration in Subjects With Primary Indeterminate Lesions and Small Choroidal Melanoma |
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| Active, not recruiting | 2 | 22 | US | AU-011, Suprachoroidal Microinjector, PDT Laser | Aura Biosciences | Uveal Melanoma, Ocular Melanoma, Choroidal Melanoma | 05/24 | 05/25 | | |
iACT, NCT06111820: Evaluation of Training Curriculum and Service of Improving Access to Community Therapies |
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| Recruiting | N/A | 330 | RoW | Improving Access to Community Therapies (iACT), Manualised Acceptance and Commitment Therapy (ACT), Low-intensity Acceptance and Commitment Therapy (LIACT) | Mind Mental Health Hong Kong Limited, Chinese University of Hong Kong | Depression, Anxiety, Mental Health Issue, Stress, Distress, Emotional | 09/24 | 09/24 | | |
NCT05405374: OSTEOAMP Lumbar Fusion Intra-Patient Controlled Study |
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| Recruiting | N/A | 101 | US | OSTEOAMP, Infuse | Bioventus LLC | Lumbar Spine Disease, Lumbar Spondylolisthesis, Lumbar Spine Instability, Lumbar Spondylosis, Degenerative Disc Disease | 10/24 | 10/25 | | |
NCT05638191: Nerve Transfer Surgery to Restore Upper-limb Function After Cervical Spinal Cord Injury |
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| Recruiting | N/A | 60 | Canada | | University of British Columbia, Queen's University, Dalhousie University, University of Toronto, Wings for Life | Spinal Cord Injury, Spinal Cord Injury at C5-C7 Level, SCI - Spinal Cord Injury, Upper Extremity Paralysis, Upper Extremity Dysfunction, Tetraplegia, Upper Extremity Paresis, Cervical Spinal Cord Injury | 01/24 | 01/26 | | |
| Finnen, Neil |
FINNEN, NCT04464629: Assessing the Efficacy and Safety of DEXTENZA in Pseudo Phakic Patients Undergoing Gas Bubble Repair and Laser Following Retinal Detachment |
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| Terminated | 4 | 7 | US | Dextenza, Prednisolone Acetate | Midwest Eye Institute, Ocular Therapeutix, Inc. | Retinal Detachment | 01/23 | 01/23 | | |
NCT05230537: A Masked, Placebo-controlled Study to Assess Iptacopan in Age-related Macular Degeneration |
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| Recruiting | 2 | 146 | Europe, US, RoW | Iptacopan (LNP023), Placebo | Novartis Pharmaceuticals | Age-Related Macular Degeneration | 10/26 | 10/26 | | |
| Ruiz, Sarah |
SIGLEC, NCT05839041: A Multiple Dose Study of AVD-104 for Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD) |
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| Recruiting | 2 | 300 | US | AVD-104, Avacincaptad | Aviceda Therapeutics, Inc. | Geographic Atrophy of the Macula, Macular Degeneration | 06/25 | 06/26 | | |
| German, Emma |
SIGLEC, NCT05839041: A Multiple Dose Study of AVD-104 for Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD) |
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| Recruiting | 2 | 300 | US | AVD-104, Avacincaptad | Aviceda Therapeutics, Inc. | Geographic Atrophy of the Macula, Macular Degeneration | 06/25 | 06/26 | | |
| Minturn, John |
AL, NCT05844982: Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy |
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| Recruiting | 3 | 600 | US | Faricimab, fluocinolone acetonide | Jaeb Center for Health Research, National Eye Institute (NEI), National Institutes of Health (NIH), Alimera Sciences, Genentech, Inc. | Radiation Retinopathy, Visual Impairment | 11/26 | 11/28 | | |
| Carlos, Soila |
SIGLEC, NCT05839041: A Multiple Dose Study of AVD-104 for Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD) |
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| Recruiting | 2 | 300 | US | AVD-104, Avacincaptad | Aviceda Therapeutics, Inc. | Geographic Atrophy of the Macula, Macular Degeneration | 06/25 | 06/26 | | |
