| Grupp, Stephan A |
| Recruiting | 3 | 1400 | Europe, Canada, Japan, US, RoW | Previously treated CAR-T patients | Novartis Pharmaceuticals, University of Pennsylvania | Long Term Safety of Patients Receiving CAR-T in an Eligible Clinical Trial or Managed Access Program | 02/36 | 02/36 | | |
| Recruiting | 2 | 50 | Canada, US | Prednisone | John Levine | Acute Graft vs Host Disease, Allogeneic Bone Marrow Transplantation, Adverse Effects | 03/25 | 03/25 | | |
NCT04276870: Orphan Indications for CD19 Redirected Autologous T Cells |
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| Recruiting | 2 | 81 | US | Murine CART19 | Stephan Grupp MD PhD, University of Pennsylvania | Pediatric and Young Adult Patientswith Hypodiploid or t(17;19) B-ALL, Infants With Very High Risk KMT2A B-ALL, Patients With Central Nervous System Relapse Who Did Not Receive Cranial Radiation or Bone Marrow Transplantation | 03/28 | 03/37 | | |
| Recruiting | 2 | 140 | US | Alpha Beta T cell depletion | Children's Hospital of Philadelphia | Leukemia, Lymphoma, Myelodysplasia | 10/25 | 10/26 | | |
NCT05480449: Autologous HuCART19 T Cells Manufactured Using the CliniMACS Prodigy Platform for Pediatric B-ALL (huCART19 Prodigy) |
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| Recruiting | 1/2 | 89 | US | Autologous Humanized CD19-Directed Chimeric Antigen Receptor T-Cells (huCART19) | Stephan Grupp MD PhD, Children's Hospital of Philadelphia | B Cell Acute Lymphoblastic Leukemia (B-ALL), B Lineage Lymphoblastic Lymphoma | 09/27 | 09/29 | | |
| Recruiting | 1 | 100 | US | Transplant of stem cells with CD3+/CD19+ depletion (CliniMACs), CliniMACs | Children's Hospital of Philadelphia | Leukemia, Inborn Errors of Metabolism, Bone Marrow Failure Syndromes, Immunodeficiencies, Immunodysregulation Polyendocrinopathy Enteropathy X-linked Syndrome | 01/25 | 01/27 | | |
| Recruiting | 1 | 15 | US | CART22 cells transduced with a lentiviral vector to express anti-CD22 scFv TCRz:41BB | University of Pennsylvania, Children's Hospital of Philadelphia | B Cell Leukemias, B Cell Lymphomas | 12/37 | 12/37 | | |
NCT03601442: CTL019 Out of Specification MAP for ALL or DLBCL Patients |
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| Available | N/A | | Canada, US, RoW | CTL019, tisagenlecleucel, Kymriah | Novartis Pharmaceuticals | Acute Lymphoblastic Leukemia (ALL), Diffuse Large B-cell Lymphoma (DLBCL) | | | | |
NCT03047746: Unrelated And Partially Matched Related Donor PSCT w/ T Cell Receptor (TCR) αβ Depletion for Patients With BMF |
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| Recruiting | N/A | 50 | US | CliniMACs | Children's Hospital of Philadelphia | Acquired Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, Inherited Bone Marrow Failure Syndromes | 03/25 | 03/26 | | |
| Leahy, Allison Barz |
NCT05480449: Autologous HuCART19 T Cells Manufactured Using the CliniMACS Prodigy Platform for Pediatric B-ALL (huCART19 Prodigy) |
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| Recruiting | 1/2 | 89 | US | Autologous Humanized CD19-Directed Chimeric Antigen Receptor T-Cells (huCART19) | Stephan Grupp MD PhD, Children's Hospital of Philadelphia | B Cell Acute Lymphoblastic Leukemia (B-ALL), B Lineage Lymphoblastic Lymphoma | 09/27 | 09/29 | | |
| Varghese, Melissa |
NCT05480449: Autologous HuCART19 T Cells Manufactured Using the CliniMACS Prodigy Platform for Pediatric B-ALL (huCART19 Prodigy) |
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| Recruiting | 1/2 | 89 | US | Autologous Humanized CD19-Directed Chimeric Antigen Receptor T-Cells (huCART19) | Stephan Grupp MD PhD, Children's Hospital of Philadelphia | B Cell Acute Lymphoblastic Leukemia (B-ALL), B Lineage Lymphoblastic Lymphoma | 09/27 | 09/29 | | |
NCT05674175: Co-administration of CART22-65s and huCART19 for B-ALL |
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| Recruiting | 1/2 | 93 | US | Autologous, humanized anti-CD22 CAR T cell therapy (CART22-65s), CART22-65s, Autologous, humanized anti-CD19 CAR T cell therapy (huCART19), huCART19 | Stephan Grupp MD PhD, University of Pennsylvania | B-cell Acute Lymphoblastic Leukemia, B Lineage Lymphoblastic Lymphoma | 01/27 | 01/29 | | |
| Recruiting | 1 | 30 | US | GPC2 CAR T cells | Stephan Grupp MD PhD, Children's Hospital of Philadelphia, Tmunity Therapeutics, University of Pennsylvania | Refractory Neuroblastoma, Relapsed Neuroblastoma, High-risk Neuroblastoma | 01/25 | 01/26 | | |
