Fondazione Policlinico Universitario Campus Bio-Medico Trials

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55 Trials

Active Trials

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Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

Giacomelli, Roberto

NCT04464434 / 2019-004718-32: Upfront Autologous HSCT Versus Immunosuppression in Early Diffuse Cutaneous Systemic Sclerosis

Recruiting

Europe

Upfront autologous HSCT

UMC Utrecht, ZonMw: The Netherlands Organisation for Health Research and Development, Boehringer Ingelheim, Miltenyi Biotec, Inc.

Systemic Sclerosis, Systemic Scleroses, Diffuse, Scleroderma, Scleroderma, Diffuse, Autologous Stem Cell Transplantation, Cyclophosphamide, Mycophenolate Mofetil, Treatment Strategy

10/27

10/30

BEconneCTD-ILD, NCT06572384: A Study of the Efficacy and Safety of Belimumab in Adults With Interstitial Lung Disease Associated With Connective Tissue Disease

Recruiting

440

Europe, Canada, Japan, US, RoW

Belimumab, BENLYSTA, GSK1550188, Placebo

GlaxoSmithKline

Lung Diseases, Interstitial

10/28

12/28

TOPAZ-2, NCT04961567 / 2020-005776-35: A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus

Recruiting

540

Europe, Canada, Japan, US, RoW

Litifilimab, BIIB059, Placebo

Biogen

Lupus Erythematosus, Systemic

09/25

03/26

OCEAN, NCT05263934 / 2021-005726-15: Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA)

Recruiting

160

Europe, Canada, Japan, US, RoW

Depemokimab, Mepolizumab, Placebo matching mepolizumab, Placebo matching depemokimab

GlaxoSmithKline

Eosinophilic Granulomatosis With Polyangiitis

05/26

06/26

empacific, NCT06284954: A Study to Evaluate Safety and Efficacy of Empasiprubart in Adults With Dermatomyositis

Recruiting

Europe, US, RoW

Empasiprubart IV, ARGX-117, Placebo IV

argenx

Dermatomyositis, Myositis

07/25

01/28

AIDA, NCT05200715: AutoInflammatory Disease Alliance Registry

Recruiting

N/A

3500

Europe, US, RoW

No intervention is foreseen by the protocol.

University of Siena

Hereditary Autoinflammatory Diseases, Schnitzler Syndrome, Behcet Syndrome, PFAPA Syndrome, Still Disease, Autoinflammatory Syndrome, Unspecified, Uveitis, Scleritis, Vexas Syndrome, Spondyloarthritis (SpA), Castleman Disease

08/26

08/30

Adlbrecht, Christopher

NCT02817360: NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients

Recruiting

2400

Europe, RoW

RAS-antagonist and beta-blocker up-to maximal dosages, Enalapril 40mg/d, Ramipril 10mg/d, Lisinopril 40mg/d, Cilazapril 5mg/d, Perindopril 8mg/d, Captopril 150mg/d, Spirapril 24mg/d, Quinapril 40mg/d, Trandolapril 4mg/d, Zofenopril 60mg/d, Fosinopril 40mg/d, Candesartan 32mg/d, Valsartan 320mg/d, Irbesartan 300mg/d, Losartan 150mg/d, Eprosartan 800mg/d, Bisoprolol 10mg/d, Metoprololsuccinat 200mg/d, Carvedilol 50mg/d (100mg/d if weight is > 85kg), Nebivolol 10mg/d, RAS-antagonist and beta-blocker none or at stable dose

Martin Huelsmann

Heart Diseases, Diabetes Mellitus, Type 2

12/25

12/26

NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

Recruiting

10000

Europe, Canada, US, RoW

Retatrutide, LY3437943, Placebo

Eli Lilly and Company

Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)

02/29

Vincenzi, Bruno

METROPHOLYS, NCT04656262 / 2018-001075-20: Low Dose Continuous Cyclophosphamide vs Standard Doxorubicin in Advanced Sarcoma Elderly Patients

Terminated

Europe

Cyclophosphamide, Endoxan, Doxorubicin

Istituto Oncologico Veneto IRCCS, Ministry of Health, Italy

Soft Tissue Sarcoma Adult

05/24

TANGENT, NCT05417789: Study of Emactuzumab for Tenosynovial Giant Cell Tumor (TGCT)

Recruiting

128

Europe, Canada, US, RoW

Emactuzumab, Placebo

SynOx Therapeutics Limited

TGCT

04/26

09/27

PANOVA-3, NCT03377491: Effect of Tumor Treating Fields (TTFields, 150 kHz) as Front-Line Treatment of Locally-advanced Pancreatic Adenocarcinoma Concomitant With Gemcitabine and Nab-paclitaxel

Completed

571

Europe, Canada, US, RoW

NovoTTF-200T, TTFields, Gemcitabine, nab paclitaxel

NovoCure Ltd.

Pancreas Adenocarcinoma

10/24

RINGSIDE, NCT04871282 / 2020-005833-34: A Study of AL102 in Patients With Progressing Desmoid Tumors

Active, not recruiting

2/3

192

Europe, US, RoW

AL102, Placebo

Immunome, Inc.

Desmoid, Desmoid Tumor

10/25

10/26

REGISTRI, NCT02638766 / 2015-001048-12: Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GIST

Completed

Europe

regorafenib, Stivarga

Grupo Espanol de Investigacion en Sarcomas, Bayer

Gastrointestinal Stromal Tumors

08/21

STRADA, NCT03023124 / 2016-004051-78: Study With Trabectedin Versus Adriamycin Plus Dacarbazine, in Patients With Advanced Solitary Fibrous Tumor

Completed

Europe

Trabectedin, Adriamycin, Dacarbazine

Italian Sarcoma Group

Solitary Fibrous Tumors

12/24

ChonDRAgon, NCT04950075: Study of INBRX-109 in Conventional Chondrosarcoma

Recruiting

201

Europe, US, RoW

INBRX-109, Placebo

Inhibrx Biosciences, Inc

Conventional Chondrosarcoma

09/25

12/26

ERASING, NCT03840772 / 2018-004571-12: Eribulin in Advanced Solitary Fibrous Tumor

Completed

Europe

Eribulin, Intervention under investigation

Italian Sarcoma Group, Eisai Inc.

Solitary Fibrous Tumor

09/24

ACCeSs, NCT04274023 / 2016-004368-21: Study on TSR-042 in Advanced Clear Cell Sarcoma

Terminated

Europe

TSR-042

Italian Sarcoma Group, GlaxoSmithKline

Sarcoma, Clear Cell

01/24

ISG-ARTICLE, NCT04383119 / 2020-000741-13: Trial in Patients With Metastatic or Locally Advanced Leiomyosarcoma

Recruiting

100

Europe

Trabectedin, Trabectedin arm, Gemcitabine, Gemcitabine arm, No Intervention: Observational Cohort

Italian Sarcoma Group, PharmaMar

Leiomyosarcoma of Ovary, Soft Tissue Sarcoma

12/25

ISG-MCS, NCT04305548 / 2019-003733-41: Study on Trabectedin in Advanced Rearranged Mesenchymal Chondrosarcoma

Recruiting

Europe

Trabectedin

Italian Sarcoma Group, PharmaMar

Mesenchymal Chondrosarcoma

08/25

12/25

TOMAS2, NCT03838744 / 2018-004497-10: Randomized Trial in Advanced, Metastatic or Unresectable Soft Tissue Sarcoma After Failure of Standard Treatments.

Completed

130

Europe

Standard arm: Trabectedin in monotherapy, Trabectedin arm, Experimental arm: Trabectedin + Olaparib, Trabectedin+ Olaparib arm

Italian Sarcoma Group, PharmaMar, AstraZeneca

Advanced Soft Tissue Sarcoma

11/24

Breast-Sarc, NCT04749446: Study on Clinical Features and Outcomes of Breast Sarcoma

Recruiting

N/A

300

Europe

Treatment of Breast Sarcoma according clinical practice (includes drugs, surgery or any other received treatments)

Italian Sarcoma Group

Breast Sarcoma

12/25

EHE, NCT06408441: The Epithelioid Hemangioendothelioma Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN)

Recruiting

N/A

100

Europe

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, EHE Rare Cancer Charity UK

Epithelioid Hemangioendothelioma, Sarcoma,Soft Tissue

12/33

ProStars, NCT06375941: Prospective Observational Study of Localized Angiosarcoma of Any Site:

Recruiting

N/A

250

Europe

Observational

Italian Sarcoma Group

Angiosarcoma

04/29

04/34

NCT02829437: Observational Study on Endometrial Stromal Tumors

Recruiting

N/A

100

Europe

Treatment for EST

Italian Sarcoma Group

Endometrial Stromal Tumors

12/25

EPISObs, NCT03099681: An Observational Study on Epithelioid Sarcoma

Recruiting

N/A

100

Europe

Treatment for Epitheloid Sarcoma

Italian Sarcoma Group

Epithelioid Sarcoma

11/25

03/28

START-RUN1, NCT06873685: Soft Tissue Sarcoma: Motor Performance, Robotic Rehabilitation, Nutrition, and Quality of Life

Recruiting

N/A

120

Europe

Rehabilitation

Fondazione Policlinico Universitario Campus Bio-Medico, Fondazione Don Carlo Gnocchi Onlus, Istituto Nazionale Tumori IRCCS - Fondazione G. Pascale

Sarcoma, Soft Tissue

12/25

08/26

Aprile, Irene

Birehab, NCT05176600: Bimanual Robotic Exoskeletal Platform for the Treatment of the Upper Limb in Patients With Stroke. A Feasibility Study

Recruiting

N/A

Europe

Robotic rehabilitation using the Arm Light Exoskeleton Rehab Station (ALEx RS) and bimanual serious games, Robotic rehabilitation using the Arm Light Exoskeleton Rehab Station (ALEx RS) and unimanual serious games

Wearable Robotics srl., Fondazione Don Carlo Gnocchi Onlus

Stroke

09/22

ACEGENDER, NCT04766645: ACE2 Gender Differences in Stroke With COVID-19

Completed

N/A

Europe

Robotic assisted intervention, epigenetic analyses, biochemical analyses

Fondazione Don Carlo Gnocchi Onlus

Neurologic Manifestations

12/22

01/23

iMotore, NCT05238389: AI-based Upper Limb Rehabilitation Therapy With MOTORE

Completed

N/A

Europe

AI-based upper limb robotic therapy, MOTORE

Fondazione Don Carlo Gnocchi Onlus

Stroke

03/23

Nutristroke, NCT04923165: Nutritional Status in Subacute Stroke Patients Under Rehabilitation

Completed

N/A

119

Europe

robotic assisted intervention, biochemical analyses, BIA, hand grip, nutritional assessment, MNA

Fondazione Don Carlo Gnocchi Onlus

Stroke

04/23

StrokeFit4, NCT06547827: Rehabilitation With and Without Robot and Allied Digital Technologies in Stroke Patients

Recruiting

N/A

596

Europe

robotic rehabilitation, traditional rehabilitation

Fondazione Don Carlo Gnocchi Onlus, Istituti Clinici Scientifici Maugeri SpA, IRCCS National Neurological Institute "C. Mondino" Foundation, Ospedale Policlinico San Martino, Università di Pavia, Scuola Superiore Sant'Anna di Pisa

Stroke

01/26

07/26

NCT06649968: Clinical Validation of an Instrumented Glove for Sensorimotor Rehabilitation

Recruiting

N/A

Europe

DESC-Glove (active), DESC-Glove (sham), Traditional rehabilitation

Christian Cipriani

Stroke

07/26

Agilik@home, NCT06622655: Clinical Improvement Due to the Home Use of Agilik in Children With Cerebral Palsy

Recruiting

N/A

Europe

Powered orthosis

IRCCS Eugenio Medea, IRCCS Fondazione Stella Maris, Fondazione Don Carlo Gnocchi Onlus, Istituto Neurologico Nazionale IRCCS Casimiro Mondino, Pavia, Italy

Cerebral Palsy (CP)

07/26

Fit4MR-ChrMND, NCT06881979: High-Tech Rehabilitation Pathway for Chronic Adult Neuromuscular Diseases - Fit4MedRob-Chronic MND Project

Not yet recruiting

N/A

Europe

High-tech rehabilitative treatment, Rehabilitation

Istituti Clinici Scientifici Maugeri SpA, Ospedale Policlinico San Martino, Genova, Azienda Ospedaliero-Universitaria di Modena, Fondazione Don Carlo Gnocchi Onlus

Amyotrophic Lateral Sclerosis, Chronic Inflammatory Demyelinating Neuropathy, Charcot-Marie-Tooth Disease

03/26

START-RUN1, NCT06873685: Soft Tissue Sarcoma: Motor Performance, Robotic Rehabilitation, Nutrition, and Quality of Life

Recruiting

N/A

120

Europe

Rehabilitation

Fondazione Policlinico Universitario Campus Bio-Medico, Fondazione Don Carlo Gnocchi Onlus, Istituto Nazionale Tumori IRCCS - Fondazione G. Pascale

Sarcoma, Soft Tissue

12/25

08/26

ONEHEALTH, NCT06896877: Nutritional Status and Emotional Well-being of the Worker-consumer in the Food Supply Chain.

Not yet recruiting

N/A

Fondazione Don Carlo Gnocchi Onlus

Healthy

12/25

Fit4MR-AcMND, NCT06822231: High-Tech Rehabilitation Pathway for Acute Adult Neuromuscular Diseases - Fit4MedRob-Acute MND Project

Not yet recruiting

N/A

124

Europe

High-tech rehabilitative treatment, Rehabilitation

Istituti Clinici Scientifici Maugeri SpA, Azienda Ospedaliero-Universitaria di Modena, Fondazione Don Carlo Gnocchi Onlus, Ospedale Policlinico San Martino, Genova

Critical Illness Myopathy, Guillain Barré Syndrome, Critical Illness Polyneuromyopathy (CIPNM)

02/26

Nutristroke2, NCT06096350: Nutritional Status in Subacute Stroke Patients Under Rehabilitation 2.0

Recruiting

N/A

Europe

robotic assisted intervention, hematochemical analysis, BIA, hand grip, nutritional assessment, MNA,, stool sampling, urine sampling, indirect calorimetry analysis

Fondazione Don Carlo Gnocchi Onlus

Stroke

07/25

12/25

Hanusch, Ursula

NCT02817360: NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients

Recruiting

2400

Europe, RoW

Martin Huelsmann

Heart Diseases, Diabetes Mellitus, Type 2

12/25

12/26

NCT06292013: A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

Recruiting

12500

Europe, Canada, Japan, US, RoW

Lepodisiran Sodium, LY3819469, Placebo

Eli Lilly and Company

Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a)

03/29

NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

Recruiting

10000

Europe, Canada, US, RoW

Retatrutide, LY3437943, Placebo

Eli Lilly and Company

Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)

02/29

ACHIEVE-4, NCT05803421: A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk

Active, not recruiting

2749

Europe, US, RoW

Orforglipron, LY3502970, Insulin Glargine

Eli Lilly and Company

Type 2 Diabetes, Obesity, Overweight or Obesity, Overweight, Cardiovascular Diseases, Chronic Kidney Disease

09/25

01/26

SURMOUNT-MMO, NCT05556512: A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

Active, not recruiting

15374

Europe, Canada, Japan, US, RoW

Tirzepatide, LY3298176, Placebo

Eli Lilly and Company

Obesity, Overweight

10/27

TREASURE-CKD, NCT05536804 / 2021-005273-47: A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes

Recruiting

140

Europe, Canada, US, RoW

Tirzepatide, Placebo

Eli Lilly and Company, Eli Lilly and Company

Overweight, Obesity, Chronic Kidney Disease, Type 2 Diabetes, T2D

09/26

10/26

Potestà, Cinzia

NCT02584478 / 2021-003871-32: Phase 1/2a/3 Evaluation of Adding AL3818 to Standard Platinum-Based Chemotherapy in Subjects With Recurrent or Metastatic Endometrial, Ovarian, Fallopian, Primary Peritoneal or Cervical Carcinoma (AL3818-US-002)

Active, not recruiting

294

Europe, US, RoW

AL3818, Anlotinib Hydrochloride, Anlotinib, Catequentinib, Paclitaxel, Pegylated Liposomal Doxorubicin (PLD), Topotecan, Daily Topotecan, Weekly Topotecan, Carboplatin, Paraplatin, Taxol

Advenchen Laboratories, LLC, Advenchen Laboratories, LLC

Endometrial Carcinoma, Ovarian Carcinoma, Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma, Cervical Carcinoma

10/24

12/24

START-RUN1, NCT06873685: Soft Tissue Sarcoma: Motor Performance, Robotic Rehabilitation, Nutrition, and Quality of Life

Recruiting

N/A

120

Europe

Rehabilitation

Fondazione Policlinico Universitario Campus Bio-Medico, Fondazione Don Carlo Gnocchi Onlus, Istituto Nazionale Tumori IRCCS - Fondazione G. Pascale

Sarcoma, Soft Tissue

12/25

08/26

Vadalà, Gianluca

DREAM, NCT05066334 / 2019-002749-40: Efficacy of Intradiscal Injection of Autologous BM-MSC in Subjects With Chronic LBP Due to Multilevel Lumbar IDD

Recruiting

Europe

Autologous BM-MSC, Treated, Sham, Untreated

Campus Bio-Medico University, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Center for Outcomes Research and Clinical Epidemiology, Italy

Intervertebral Disc Degeneration, Chronic Low-back Pain

05/22

06/23

ACTIVE, NCT04759105 / 2019-004476-19: Efficacy of Intradiscal Injection of Autologous BM-MSC in Worker Patients Affected by Chronic LBP Due to Multilevel IDD

Active, not recruiting

Europe

Autologous BM-MSC, Treated, Sham Procedure, Sham

Campus Bio-Medico University, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Center for Outcomes Research and Clinical Epidemiology, Italy

Intervertebral Disc Degeneration, Chronic Low-back Pain

12/24

ENCANTO, NCT06576583: Implantation of Engineered Cartilage Grafts for Treatment of Patellofemoral Osteoarthritis Versus Surgical Comparators.

Recruiting

150

Europe, RoW

Engineered cartilage graft (N-TEC), Autologous Matrix Induced Chondrogenesis (AMIC), Patellofemoral Arthroplasty (PFA)

University Hospital, Basel, Switzerland, Clinical Trial Unit, University Hospital Basel, Switzerland, Wuerzburg University Hospital, Medical University of Vienna, Videoreha, University of Oulu, Theracell Laboratories, Promove-Biotec GmbH, Maastricht University, Foundation National Reumafonds, Angry@Arthritis, University of Miami, Geistlich Pharma AG, European Union

Patellofemoral Osteoarthritis

01/29

01/30

Tuccinardi, Dario

NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

Recruiting

10000

Europe, Canada, US, RoW

Retatrutide, LY3437943, Placebo

Eli Lilly and Company

Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)

02/29

SURMOUNT-MMO, NCT05556512: A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

Active, not recruiting

15374

Europe, Canada, Japan, US, RoW

Tirzepatide, LY3298176, Placebo

Eli Lilly and Company

Obesity, Overweight

10/27

DIAFLASH, NCT06098040: Long-Term Feedback Effect of FGM in Newly-Diagnosed T2D Patients

Active, not recruiting

N/A

Europe

flash glucose monitoring continuous, capillary blood test, flash glucose monitoring intermittent

Campus Bio-Medico University

Type 2 Diabetes

06/25

09/25

Bruni, Vincenzo

REPABS-BPG, NCT06614257: REduced Pain After Bariatric Surgery - Gastric Bypass

Completed

N/A

Europe

LG-TAP block with local anesthetic, Port site infiltration, LG-TAP block with saline solution

Fondazione Policlinico Universitario Campus Bio-Medico

Pain, Postoperative Pain, Acute Pain, Analgesia, Bariatric Surgery Candidate, Anesthesia

03/24

REPABS-SG, NCT06383234: REduced Pain After Bariatric Surgery - Sleeve Gastrectomy

Completed

N/A

110

Europe

LG-TAP block with local anesthetic, LG-TAP block with saline solution, Port site infiltration

Fondazione Policlinico Universitario Campus Bio-Medico

Pain, Postoperative Pain, Acute Pain, Analgesia, Bariatric Surgery Candidate, Anesthesia

09/23

Longo, Umile Giuseppe

AI-TKA, NCT06634654: An Artificial Intelligence-based Approach in Total Knee Arthroplasty: from Inflammatory Responses to Personalized Medicine

Recruiting

N/A

197

Europe

Total Knee Arthroplasty, Multifaceted diagnostic assessments, Follow-ups, Genetic screening

Fondazione Policlinico Universitario Campus Bio-Medico

Knee Osteoarthritis

12/25

12/29

Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

Giacomelli, Roberto

NCT04464434 / 2019-004718-32: Upfront Autologous HSCT Versus Immunosuppression in Early Diffuse Cutaneous Systemic Sclerosis

Recruiting

Europe

Upfront autologous HSCT

UMC Utrecht, ZonMw: The Netherlands Organisation for Health Research and Development, Boehringer Ingelheim, Miltenyi Biotec, Inc.

Systemic Sclerosis, Systemic Scleroses, Diffuse, Scleroderma, Scleroderma, Diffuse, Autologous Stem Cell Transplantation, Cyclophosphamide, Mycophenolate Mofetil, Treatment Strategy

10/27

10/30

BEconneCTD-ILD, NCT06572384: A Study of the Efficacy and Safety of Belimumab in Adults With Interstitial Lung Disease Associated With Connective Tissue Disease

Recruiting

440

Europe, Canada, Japan, US, RoW

Belimumab, BENLYSTA, GSK1550188, Placebo

GlaxoSmithKline

Lung Diseases, Interstitial

10/28

12/28

Recruiting

540

Europe, Canada, Japan, US, RoW

Litifilimab, BIIB059, Placebo

Biogen

Lupus Erythematosus, Systemic

09/25

03/26

OCEAN, NCT05263934 / 2021-005726-15: Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA)

Recruiting

160

Europe, Canada, Japan, US, RoW

Depemokimab, Mepolizumab, Placebo matching mepolizumab, Placebo matching depemokimab

GlaxoSmithKline

Eosinophilic Granulomatosis With Polyangiitis

05/26

06/26

empacific, NCT06284954: A Study to Evaluate Safety and Efficacy of Empasiprubart in Adults With Dermatomyositis

Recruiting

Europe, US, RoW

Empasiprubart IV, ARGX-117, Placebo IV

argenx

Dermatomyositis, Myositis

07/25

01/28

AIDA, NCT05200715: AutoInflammatory Disease Alliance Registry

Recruiting

N/A

3500

Europe, US, RoW

No intervention is foreseen by the protocol.

University of Siena

Hereditary Autoinflammatory Diseases, Schnitzler Syndrome, Behcet Syndrome, PFAPA Syndrome, Still Disease, Autoinflammatory Syndrome, Unspecified, Uveitis, Scleritis, Vexas Syndrome, Spondyloarthritis (SpA), Castleman Disease

08/26

08/30

Adlbrecht, Christopher

NCT02817360: NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients

Recruiting

2400

Europe, RoW

Martin Huelsmann

Heart Diseases, Diabetes Mellitus, Type 2

12/25

12/26

NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

Recruiting

10000

Europe, Canada, US, RoW

Retatrutide, LY3437943, Placebo

Eli Lilly and Company

Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)

02/29

Vincenzi, Bruno

METROPHOLYS, NCT04656262 / 2018-001075-20: Low Dose Continuous Cyclophosphamide vs Standard Doxorubicin in Advanced Sarcoma Elderly Patients

Terminated

Europe

Cyclophosphamide, Endoxan, Doxorubicin

Istituto Oncologico Veneto IRCCS, Ministry of Health, Italy

Soft Tissue Sarcoma Adult

05/24

TANGENT, NCT05417789: Study of Emactuzumab for Tenosynovial Giant Cell Tumor (TGCT)

Recruiting

128

Europe, Canada, US, RoW

Emactuzumab, Placebo

SynOx Therapeutics Limited

TGCT

04/26

09/27

PANOVA-3, NCT03377491: Effect of Tumor Treating Fields (TTFields, 150 kHz) as Front-Line Treatment of Locally-advanced Pancreatic Adenocarcinoma Concomitant With Gemcitabine and Nab-paclitaxel

Completed

571

Europe, Canada, US, RoW

NovoTTF-200T, TTFields, Gemcitabine, nab paclitaxel

NovoCure Ltd.

Pancreas Adenocarcinoma

10/24

RINGSIDE, NCT04871282 / 2020-005833-34: A Study of AL102 in Patients With Progressing Desmoid Tumors

Active, not recruiting

2/3

192

Europe, US, RoW

AL102, Placebo

Immunome, Inc.

Desmoid, Desmoid Tumor

10/25

10/26

REGISTRI, NCT02638766 / 2015-001048-12: Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GIST

Completed

Europe

regorafenib, Stivarga

Grupo Espanol de Investigacion en Sarcomas, Bayer

Gastrointestinal Stromal Tumors

08/21

STRADA, NCT03023124 / 2016-004051-78: Study With Trabectedin Versus Adriamycin Plus Dacarbazine, in Patients With Advanced Solitary Fibrous Tumor

Completed

Europe

Trabectedin, Adriamycin, Dacarbazine

Italian Sarcoma Group

Solitary Fibrous Tumors

12/24

ChonDRAgon, NCT04950075: Study of INBRX-109 in Conventional Chondrosarcoma

Recruiting

201

Europe, US, RoW

INBRX-109, Placebo

Inhibrx Biosciences, Inc

Conventional Chondrosarcoma

09/25

12/26

ERASING, NCT03840772 / 2018-004571-12: Eribulin in Advanced Solitary Fibrous Tumor

Completed

Europe

Eribulin, Intervention under investigation

Italian Sarcoma Group, Eisai Inc.

Solitary Fibrous Tumor

09/24

ACCeSs, NCT04274023 / 2016-004368-21: Study on TSR-042 in Advanced Clear Cell Sarcoma

Terminated

Europe

TSR-042

Italian Sarcoma Group, GlaxoSmithKline

Sarcoma, Clear Cell

01/24

ISG-ARTICLE, NCT04383119 / 2020-000741-13: Trial in Patients With Metastatic or Locally Advanced Leiomyosarcoma

Recruiting

100

Europe

Trabectedin, Trabectedin arm, Gemcitabine, Gemcitabine arm, No Intervention: Observational Cohort

Italian Sarcoma Group, PharmaMar

Leiomyosarcoma of Ovary, Soft Tissue Sarcoma

12/25

ISG-MCS, NCT04305548 / 2019-003733-41: Study on Trabectedin in Advanced Rearranged Mesenchymal Chondrosarcoma

Recruiting

Europe

Trabectedin

Italian Sarcoma Group, PharmaMar

Mesenchymal Chondrosarcoma

08/25

12/25

TOMAS2, NCT03838744 / 2018-004497-10: Randomized Trial in Advanced, Metastatic or Unresectable Soft Tissue Sarcoma After Failure of Standard Treatments.

Completed

130

Europe

Standard arm: Trabectedin in monotherapy, Trabectedin arm, Experimental arm: Trabectedin + Olaparib, Trabectedin+ Olaparib arm

Italian Sarcoma Group, PharmaMar, AstraZeneca

Advanced Soft Tissue Sarcoma

11/24

Breast-Sarc, NCT04749446: Study on Clinical Features and Outcomes of Breast Sarcoma

Recruiting

N/A

300

Europe

Treatment of Breast Sarcoma according clinical practice (includes drugs, surgery or any other received treatments)

Italian Sarcoma Group

Breast Sarcoma

12/25

EHE, NCT06408441: The Epithelioid Hemangioendothelioma Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN)

Recruiting

N/A

100

Europe

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, EHE Rare Cancer Charity UK

Epithelioid Hemangioendothelioma, Sarcoma,Soft Tissue

12/33

ProStars, NCT06375941: Prospective Observational Study of Localized Angiosarcoma of Any Site:

Recruiting

N/A

250

Europe

Observational

Italian Sarcoma Group

Angiosarcoma

04/29

04/34

NCT02829437: Observational Study on Endometrial Stromal Tumors

Recruiting

N/A

100

Europe

Treatment for EST

Italian Sarcoma Group

Endometrial Stromal Tumors

12/25

EPISObs, NCT03099681: An Observational Study on Epithelioid Sarcoma

Recruiting

N/A

100

Europe

Treatment for Epitheloid Sarcoma

Italian Sarcoma Group

Epithelioid Sarcoma

11/25

03/28

START-RUN1, NCT06873685: Soft Tissue Sarcoma: Motor Performance, Robotic Rehabilitation, Nutrition, and Quality of Life

Recruiting

N/A

120

Europe

Rehabilitation

Fondazione Policlinico Universitario Campus Bio-Medico, Fondazione Don Carlo Gnocchi Onlus, Istituto Nazionale Tumori IRCCS - Fondazione G. Pascale

Sarcoma, Soft Tissue

12/25

08/26

Aprile, Irene

Birehab, NCT05176600: Bimanual Robotic Exoskeletal Platform for the Treatment of the Upper Limb in Patients With Stroke. A Feasibility Study

Recruiting

N/A

Europe

Wearable Robotics srl., Fondazione Don Carlo Gnocchi Onlus

Stroke

09/22

ACEGENDER, NCT04766645: ACE2 Gender Differences in Stroke With COVID-19

Completed

N/A

Europe

Robotic assisted intervention, epigenetic analyses, biochemical analyses

Fondazione Don Carlo Gnocchi Onlus

Neurologic Manifestations

12/22

01/23

iMotore, NCT05238389: AI-based Upper Limb Rehabilitation Therapy With MOTORE

Completed

N/A

Europe

AI-based upper limb robotic therapy, MOTORE

Fondazione Don Carlo Gnocchi Onlus

Stroke

03/23

Nutristroke, NCT04923165: Nutritional Status in Subacute Stroke Patients Under Rehabilitation

Completed

N/A

119

Europe

robotic assisted intervention, biochemical analyses, BIA, hand grip, nutritional assessment, MNA

Fondazione Don Carlo Gnocchi Onlus

Stroke

04/23

StrokeFit4, NCT06547827: Rehabilitation With and Without Robot and Allied Digital Technologies in Stroke Patients

Recruiting

N/A

596

Europe

robotic rehabilitation, traditional rehabilitation

Stroke

01/26

07/26

NCT06649968: Clinical Validation of an Instrumented Glove for Sensorimotor Rehabilitation

Recruiting

N/A

Europe

DESC-Glove (active), DESC-Glove (sham), Traditional rehabilitation

Christian Cipriani

Stroke

07/26

Agilik@home, NCT06622655: Clinical Improvement Due to the Home Use of Agilik in Children With Cerebral Palsy

Recruiting

N/A

Europe

Powered orthosis

IRCCS Eugenio Medea, IRCCS Fondazione Stella Maris, Fondazione Don Carlo Gnocchi Onlus, Istituto Neurologico Nazionale IRCCS Casimiro Mondino, Pavia, Italy

Cerebral Palsy (CP)

07/26

Fit4MR-ChrMND, NCT06881979: High-Tech Rehabilitation Pathway for Chronic Adult Neuromuscular Diseases - Fit4MedRob-Chronic MND Project

Not yet recruiting

N/A

Europe

High-tech rehabilitative treatment, Rehabilitation

Istituti Clinici Scientifici Maugeri SpA, Ospedale Policlinico San Martino, Genova, Azienda Ospedaliero-Universitaria di Modena, Fondazione Don Carlo Gnocchi Onlus

Amyotrophic Lateral Sclerosis, Chronic Inflammatory Demyelinating Neuropathy, Charcot-Marie-Tooth Disease

03/26

START-RUN1, NCT06873685: Soft Tissue Sarcoma: Motor Performance, Robotic Rehabilitation, Nutrition, and Quality of Life

Recruiting

N/A

120

Europe

Rehabilitation

Fondazione Policlinico Universitario Campus Bio-Medico, Fondazione Don Carlo Gnocchi Onlus, Istituto Nazionale Tumori IRCCS - Fondazione G. Pascale

Sarcoma, Soft Tissue

12/25

08/26

ONEHEALTH, NCT06896877: Nutritional Status and Emotional Well-being of the Worker-consumer in the Food Supply Chain.

Not yet recruiting

N/A

Fondazione Don Carlo Gnocchi Onlus

Healthy

12/25

Fit4MR-AcMND, NCT06822231: High-Tech Rehabilitation Pathway for Acute Adult Neuromuscular Diseases - Fit4MedRob-Acute MND Project

Not yet recruiting

N/A

124

Europe

High-tech rehabilitative treatment, Rehabilitation

Istituti Clinici Scientifici Maugeri SpA, Azienda Ospedaliero-Universitaria di Modena, Fondazione Don Carlo Gnocchi Onlus, Ospedale Policlinico San Martino, Genova

Critical Illness Myopathy, Guillain Barré Syndrome, Critical Illness Polyneuromyopathy (CIPNM)

02/26

Nutristroke2, NCT06096350: Nutritional Status in Subacute Stroke Patients Under Rehabilitation 2.0

Recruiting

N/A

Europe

robotic assisted intervention, hematochemical analysis, BIA, hand grip, nutritional assessment, MNA,, stool sampling, urine sampling, indirect calorimetry analysis

Fondazione Don Carlo Gnocchi Onlus

Stroke

07/25

12/25

Hanusch, Ursula

NCT02817360: NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients

Recruiting

2400

Europe, RoW

Martin Huelsmann

Heart Diseases, Diabetes Mellitus, Type 2

12/25

12/26

NCT06292013: A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

Recruiting

12500

Europe, Canada, Japan, US, RoW

Lepodisiran Sodium, LY3819469, Placebo

Eli Lilly and Company

Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a)

03/29

NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

Recruiting

10000

Europe, Canada, US, RoW

Retatrutide, LY3437943, Placebo

Eli Lilly and Company

Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)

02/29

ACHIEVE-4, NCT05803421: A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk

Active, not recruiting

2749

Europe, US, RoW

Orforglipron, LY3502970, Insulin Glargine

Eli Lilly and Company

Type 2 Diabetes, Obesity, Overweight or Obesity, Overweight, Cardiovascular Diseases, Chronic Kidney Disease

09/25

01/26

SURMOUNT-MMO, NCT05556512: A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

Active, not recruiting

15374

Europe, Canada, Japan, US, RoW

Tirzepatide, LY3298176, Placebo

Eli Lilly and Company

Obesity, Overweight

10/27

TREASURE-CKD, NCT05536804 / 2021-005273-47: A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes

Recruiting

140

Europe, Canada, US, RoW

Tirzepatide, Placebo

Eli Lilly and Company, Eli Lilly and Company

Overweight, Obesity, Chronic Kidney Disease, Type 2 Diabetes, T2D

09/26

10/26

Potestà, Cinzia

Active, not recruiting

294

Europe, US, RoW

AL3818, Anlotinib Hydrochloride, Anlotinib, Catequentinib, Paclitaxel, Pegylated Liposomal Doxorubicin (PLD), Topotecan, Daily Topotecan, Weekly Topotecan, Carboplatin, Paraplatin, Taxol

Advenchen Laboratories, LLC, Advenchen Laboratories, LLC

Endometrial Carcinoma, Ovarian Carcinoma, Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma, Cervical Carcinoma

10/24

12/24

START-RUN1, NCT06873685: Soft Tissue Sarcoma: Motor Performance, Robotic Rehabilitation, Nutrition, and Quality of Life

Recruiting

N/A

120

Europe

Rehabilitation

Fondazione Policlinico Universitario Campus Bio-Medico, Fondazione Don Carlo Gnocchi Onlus, Istituto Nazionale Tumori IRCCS - Fondazione G. Pascale

Sarcoma, Soft Tissue

12/25

08/26

Vadalà, Gianluca

DREAM, NCT05066334 / 2019-002749-40: Efficacy of Intradiscal Injection of Autologous BM-MSC in Subjects With Chronic LBP Due to Multilevel Lumbar IDD

Recruiting

Europe

Autologous BM-MSC, Treated, Sham, Untreated

Campus Bio-Medico University, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Center for Outcomes Research and Clinical Epidemiology, Italy

Intervertebral Disc Degeneration, Chronic Low-back Pain

05/22

06/23

ACTIVE, NCT04759105 / 2019-004476-19: Efficacy of Intradiscal Injection of Autologous BM-MSC in Worker Patients Affected by Chronic LBP Due to Multilevel IDD

Active, not recruiting

Europe

Autologous BM-MSC, Treated, Sham Procedure, Sham

Campus Bio-Medico University, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Center for Outcomes Research and Clinical Epidemiology, Italy

Intervertebral Disc Degeneration, Chronic Low-back Pain

12/24

ENCANTO, NCT06576583: Implantation of Engineered Cartilage Grafts for Treatment of Patellofemoral Osteoarthritis Versus Surgical Comparators.

Recruiting

150

Europe, RoW

Engineered cartilage graft (N-TEC), Autologous Matrix Induced Chondrogenesis (AMIC), Patellofemoral Arthroplasty (PFA)

Patellofemoral Osteoarthritis

01/29

01/30

Tuccinardi, Dario

NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

Recruiting

10000

Europe, Canada, US, RoW

Retatrutide, LY3437943, Placebo

Eli Lilly and Company

Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)

02/29

SURMOUNT-MMO, NCT05556512: A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

Active, not recruiting

15374

Europe, Canada, Japan, US, RoW

Tirzepatide, LY3298176, Placebo

Eli Lilly and Company

Obesity, Overweight

10/27

DIAFLASH, NCT06098040: Long-Term Feedback Effect of FGM in Newly-Diagnosed T2D Patients

Active, not recruiting

N/A

Europe

flash glucose monitoring continuous, capillary blood test, flash glucose monitoring intermittent

Campus Bio-Medico University

Type 2 Diabetes

06/25

09/25

Bruni, Vincenzo

REPABS-BPG, NCT06614257: REduced Pain After Bariatric Surgery - Gastric Bypass

Completed

N/A

Europe

LG-TAP block with local anesthetic, Port site infiltration, LG-TAP block with saline solution

Fondazione Policlinico Universitario Campus Bio-Medico

Pain, Postoperative Pain, Acute Pain, Analgesia, Bariatric Surgery Candidate, Anesthesia

03/24

REPABS-SG, NCT06383234: REduced Pain After Bariatric Surgery - Sleeve Gastrectomy

Completed

N/A

110

Europe

LG-TAP block with local anesthetic, LG-TAP block with saline solution, Port site infiltration

Fondazione Policlinico Universitario Campus Bio-Medico

Pain, Postoperative Pain, Acute Pain, Analgesia, Bariatric Surgery Candidate, Anesthesia

09/23

Longo, Umile Giuseppe

AI-TKA, NCT06634654: An Artificial Intelligence-based Approach in Total Knee Arthroplasty: from Inflammatory Responses to Personalized Medicine

Recruiting

N/A

197

Europe

Total Knee Arthroplasty, Multifaceted diagnostic assessments, Follow-ups, Genetic screening

Fondazione Policlinico Universitario Campus Bio-Medico

Knee Osteoarthritis

12/25

12/29

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