| Tran, David |
TVI-AST-008, NCT05685004: Study of Neoantigen-specific Adoptive T Cell Therapy for Newly Diagnosed MGMT Negative Glioblastoma Multiforme (GBM) |
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| Recruiting | 2/3 | 120 | US | TVI-Brain-1, Standard of Care, Radiotherapy, Temozolomide, Chemotherapy | TVAX Biomedical | Glioblastoma Multiforme of Brain | 12/26 | 03/27 | | |
EMPOWER, NCT04333706: A Dose Finding Phase 1 of Sarilumab Plus Capecitabine in HER2/Neu-Negative Metastatic Breast Cancer and a Single-arm, Historically-controlled Phase 2 Study of Sarilumab Plus Capecitabine in Stage I-III Triple Negative Breast Cancer With High-Risk Residual Disease |
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| Recruiting | 1/2 | 65 | US | Capecitabine, Sarilumab 150mg or 200 mg plus Capecitabine, Sarilumab 150mg plus Capecitabine | University of Southern California, National Cancer Institute (NCI) | Breast, Metastatic, Triple Negative, Cancer, Disseminated Tumor Cell | 11/25 | 11/26 | | |
| Terminated | 1 | 10 | US | LITT + Pembrolizumab, NeuroBlate System, Keytruda | University of Florida, Monteris Medical | Melanoma, Non-small Cell Lung Carcinoma (NSCLC), Renal Cell Carcinoma (RCC), Small-cell Lung Cancer, Head and Neck Squamous Cell Cancer, Classical Hodgkin Lymphoma, Primary Mediastinal Large B-Cell Lymphoma, Urothelial Carcinoma, Microsatellite Instability-High Cancer, Gastric Cancer, Esophageal Cancer, Cervical Cancer, Hepatocellular Carcinoma, Merkel Cell Carcinoma, Brain Metastases, Adult | 12/23 | 12/23 | | |
DCVax-L EAP, NCT02146066: Expanded Access Protocol for GBM Patients With Already Manufactured DCVax®-L Who Have Screen-Failed Protocol 020221 |
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| Available | N/A | | US | DCVax-L | Northwest Biotherapeutics | GBM, Glioblastoma Multiforme | | | | |
| Wymer, James |
NCT04220021: Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD |
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| Active, not recruiting | 2 | 18 | US | Metformin, Metformin hydrochloride sustained-release (SR) | University of Florida, ALS Association | C9orf72 Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia | 08/24 | 06/25 | | |
| Recruiting | N/A | 90 | US | Magnetic Resonance Imaging, Plasma neurofilament light chain (NfL) quantification | University of Minnesota, Food and Drug Administration (FDA), Minnesota Office of Higher Education | Amyotrophic Lateral Sclerosis, ALS | 08/27 | 08/28 | | |
| Recruiting | N/A | 5000 | Europe, US | | Massachusetts General Hospital, Henry Ford Health System, Northwestern University, Temple University, St. Louis University, University of Florida, University of Minnesota, Virginia Commonwealth University, Fondazione Serena Onlus - Centro Clinico NeMO Milano, Providence Health & Services, University of Pittsburgh, Istituti Clinici Scientifici Maugeri SpA | ALS, PLS, MND (Motor Neurone DIsease), Kennedy Disease, PMA - Progressive Muscular Atrophy, PBP - Progressive Bulbar Palsy | 12/30 | 12/30 | | |
| Leeman, Robert F |
NCT03314454: Alcohol Use and Mental Health - Pilot Test of Video-assisted Drinking Topography |
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| Terminated | 4 | 11 | US | Beer, Videotaped drinking session, video-assisted topography | University of Florida | Alcohol Use Disorder | 12/22 | 06/23 | | |
NCT04331704: ANCHORS Alcohol & Sexual Health Study: UH3 Project |
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| Recruiting | 4 | 88 | US | PrEP acronym (pre-exposure prophylaxis), emtricitabine/tenofovir disoproxil fumarate, Initial Web Survey, Interactive Voice Response (IVR) monitoring, Educational material on alcohol and sexual health behavior, Interactive Voice Response (IVR) assessment with personalized information, Personalized information based on web-based survey responses & standardized information | University of Florida, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Alcohol Use, Unspecified, Substance Use, Sex Behavior | 06/25 | 12/25 | | |
| Completed | N/A | 673 | US | Survey, Focus Group, Usability study | University of Florida, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | HIV-1-infection | 06/20 | 07/23 | | |
| Terminated | N/A | 24 | US | Attentional Bias Retraining (ABR), Control Training | University of Florida | Attention, Substance Use | 08/21 | 06/23 | | |
| Recruiting | N/A | 120 | US | Counseling, mHealth | University of Florida, University of Miami, University of Louisville, Florida State University, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Alcohol Use | 09/26 | 09/26 | | |
| Recruiting | N/A | 115 | US | Alcohol-related mobile health technologies, Smartphone breathalyzer, BAC estimator app and self-texting procedure, Motivational interview and psychoeducation on blood/breath alcohol concentration, M.I., Lower tech facilitation, Higher tech facilitation, Attention control psychoeducation, Attention control technology | Northeastern University, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Alcohol Use, Alcohol Drinking, Drinking Behavior | 12/24 | 02/25 | | |
| Duarte, Julio |
NCT04630093: Pilot of Preemptive Pharmacogenetics in Medically Underserved Patients |
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| Completed | N/A | 100 | US | Panel-based pharmacogenetic genotyping | University of Florida, National Center for Advancing Translational Sciences (NCATS) | Pharmacogenetic Testing | 06/22 | 06/22 | | |
NCT06201000: Effect of Genetic Polymorphisms on the Clinical Response to SGLT2 Inhibitors in Heart Failure Patients |
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| Recruiting | N/A | 282 | US | SGLT2 inhibitors (Dapagliflozin and Empagliflozin), Forxiga, Jardiance | October 6 University, University of Florida, National Heart Institute, Egypt, Beni-Suef University | Genetic Polymorphisms, Heart Failure | 07/24 | 09/24 | | |
| Not yet recruiting | N/A | 1200 | NA | Panel-based pharmacogenetic genotyping | University of Florida, National Human Genome Research Institute (NHGRI) | Pharmacogenomic Drug Interaction | 07/26 | 07/27 | | |
| Active, not recruiting | N/A | 492 | US | Panel-based pharmacogenetic genotyping | University of Florida, National Human Genome Research Institute (NHGRI) | Use of Prescription Medications, Pharmacogenetic Testing | 06/25 | 06/26 | | |
| Woods, Adam J |
| Recruiting | 3 | 7600 | US | Cognitive Training, Computerized Cognitive Stimulation | University of South Florida, National Institute on Aging (NIA) | Age-related Cognitive Decline, Alzheimer's Disease and Related Dementias | 01/26 | 01/26 | | |
NCT04018092: The Revitalize Study in Older Adults at Risk for Alzheimer's Disease |
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| Recruiting | 2 | 168 | US | Active NIR-PBM, Sham NIR-PBM | University of Florida, University of Arizona, National Institute on Aging (NIA) | Cognitive Aging, Alzheimer Disease, Protection Against | 04/25 | 04/25 | | |
| Completed | N/A | 379 | US | Cognitive Training, tDCS (active stimulation), tDCS (sham stimulation), Educational Training | University of Florida, University of Arizona, National Institute on Aging (NIA) | Aging | 04/22 | 04/22 | | |
NCT05377411: SMART Stimulation: Precision Neuromodulation of Cognition in Older Adults |
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| Completed | N/A | 33 | US | tDCS, cognitive training | University of Florida, Soterix Medical | Aging | 06/24 | 06/24 | | |
NCT03551392: Pilot Intervention With Near Infrared Stimulation |
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| Recruiting | N/A | 24 | US | Medx Console System, Low Level Light Therapy, Photobiomodulation, Transcranial Near Infrared Stimulation, Sham Medx Console System, Vielight 810 intranasal stand alone unit, Sham Vielight 810 intranasal stand alone unit | University of Florida, McKnight Brain Research Foundation, University of Arizona | Aging | 04/26 | 04/26 | | |
| Completed | N/A | 197 | US | Bariatric Surgery Candidates, Non surgical/Community volunteers | University of Florida, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Diabetes, Weightloss | 11/22 | 11/22 | | |
| Recruiting | N/A | 1305 | US | Cognitive Training, Computerized Cognitive Stimulation | University of Alabama at Birmingham, University of Florida, University of Minnesota, National Institute on Aging (NIA), Clemson University, University of California, San Francisco | Age-related Cognitive Decline, Mild Cognitive Impairment, Dementia | 08/27 | 08/27 | | |
| Ross, Kathryn M |
NCT06508580: Optimizing Self-Monitoring Feedback for the Treatment of Obesity |
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| Active, not recruiting | N/A | 28 | US | Component 1: Calorie Goal Attainment, Component 2: Diet Quality, Component 3: Physical Activity Goal Attainment, Component 4: Goal Setting | University of Florida | Obesity, Weight Loss | 02/25 | 03/25 | | |
NCT04116853: Support and Tracking to Achieve Results (Project STAR) |
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| Active, not recruiting | N/A | 255 | US | ADAPTIVE Extended-Care Program, STATIC Extended-Care Program | University of Florida, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Obesity | 12/24 | 12/24 | | |
| Wendling, Adam |
NCT04805073: Treatment of Pruritus With Intramuscular Promethazine |
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| Completed | 4 | 110 | US | Promethazine, Phenergan, Placebo, salt water | University of Florida | Pruritus, Pregnancy Related | 05/24 | 05/24 | | |
NCT06030063: The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry |
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| Recruiting | N/A | 5000 | Canada, US | | Yale University | Cesarean Delivery, General Anesthesia | 09/28 | 09/29 | | |
| Plowman, Emily K |
NCT04220021: Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD |
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| Active, not recruiting | 2 | 18 | US | Metformin, Metformin hydrochloride sustained-release (SR) | University of Florida, ALS Association | C9orf72 Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia | 08/24 | 06/25 | | |
NCT04887415: Respiratory Strength Training in Cardiac Surgical Patients |
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| Completed | N/A | 25 | US | Respiratory Strength Training (RST) Program | University of Florida, American Speech-Language-Hearing Foundation, American Heart Association | Cardiovascular Diseases, Thoracic Diseases, Surgery, Surgery--Complications, Dysphagia | 01/23 | 01/23 | | |
NCT02962050: Delineating Swallowing Impairment and Decline in ALS |
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| Completed | N/A | 109 | US | Videofluoroscopic Swallowing Study (VFSS), VFSS, X-Ray of Swallowing, Modified Barium Swallow Study, Voluntary Peak Cough Flow Testing, Iowa Oral Performance Instrument, IOPI, Capsaicin Challenge, Reflexive Cough Testing, Pulmonary Function Testing, Eating Assessment Tool 10, EAT 10, The Center for Neurologic Study Bulbar Function Scale, CNS-BFS | University of Florida, National Institute of Neurological Disorders and Stroke (NINDS) | Amyotrophic Lateral Sclerosis | 02/23 | 02/23 | | |
NCT04464317: Dysphagia and Vocal Cord Injury Following Cardiac Surgery |
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| Withdrawn | N/A | 6000 | NA | | University of Florida | Dysphagia, Cardiovascular Diseases | 06/23 | 06/23 | | |
| Completed | N/A | 46 | US | Fiberoptic Endoscopic Evaluation of Swallowing, (FEES), Videofluoroscopic Swallowing Study, Voluntary Peak Cough Flow Testing, Iowa Oral Performance Instrument, Capsaicin Challenge, Reflexive Cough Testing, Pulmonary Function Testing, Voicing Tasks | University of Florida | Dysphagia | 09/23 | 09/23 | | |
NCT05304416: Clinical Markers of Dysphagia in Cardiac Surgical Patients |
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| Active, not recruiting | N/A | 347 | US | Fiberoptic Endoscopic Evaluation of Swallowing, FEES, Simultaneous FEES and Videofluoroscopy instrumental swallowing exam, Endofluoroscopy, Videofluoroscopy instrumental swallowing exam (VFSS), Modified barium swallow study, Voluntary Cough Peak Expiratory Flow (PEF) Testing, Reflex Cough Screen, Lingual Pressure Testing, Speech Testing | University of Florida, National Institute of Nursing Research (NINR), Ohio State University | Cardiovascular Diseases, Dysphagia | 10/26 | 12/26 | | |
| Enrolling by invitation | N/A | 580 | Canada, US | Videofluoroscopic Swallowing Study (VF) | University Health Network, Toronto, University of Florida, McMaster University, National Institute on Aging (NIA), Ohio State University | Dysphagia, Oropharyngeal | 11/26 | 07/27 | | |
| McVay, Megan A |
| Completed | N/A | 33 | US | Facilitation Intervention | University of Florida | Obesity | 07/20 | 07/20 | | |
STEADY, NCT04751656: Preventing Weight Gain Among Those Who Decline Behavioral Weight Loss Treatment |
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| Completed | N/A | 39 | US | Steady Intervention | University of Florida, National Heart, Lung, and Blood Institute (NHLBI) | Overweight and Obesity | 01/23 | 01/23 | | |
NCT04851587: EMPOWER: Empowering the Management of Pain-Obesity-Weight Through Enhanced Reward |
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| Completed | N/A | 42 | US | In-Person (or Remote) Intervention | University of Florida, National Institute on Aging (NIA) | Low Back Pain | 01/24 | 01/24 | | |
| Enrolling by invitation | N/A | 864 | US | MyHealthPath Tool, MyHealthPath Guide | University of Florida, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Obesity | 03/27 | 06/27 | | |
| Salloum, Ramzi |
NCT05081882: Reducing Tobacco-associated Lung Cancer Risk: A Randomized Clinical Trial of AB-free Kava |
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| Recruiting | 2 | 80 | US | Kava, Placebo | University of Florida, Florida Department of Health | Smoking | 11/25 | 11/26 | | |
NCT05814055: The Potential of Kava in Enabling Tobacco Cessation - Its Holistic Effects in Managing Stress and Insomnia Associated With Abstinence |
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| Recruiting | 2 | 76 | US | Placebo, AB-free kava | University of Florida, National Center for Complementary and Integrative Health (NCCIH), National Institutes of Health (NIH) | Smoking | 06/26 | 06/26 | | |
NCT05390567: Project CONTINUITY: Promoting Evidence-Based Cancer Screening Among Underserved Women |
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| Recruiting | N/A | 800 | US | Participant Choice of HPV Self-Test, Survey: Participant cancer history and cervical cancer prevention/screening knowledge, Participant Choice of Standard of Care in-clinic Pap-test | University of Florida | Cervical Cancer Screening Methods | 05/25 | 05/25 | | |
| Recruiting | N/A | 1500 | RoW | Educational materials, Phone counseling, Nicotine Replacement Therapy, Provider training, Electronic reminders | University of Florida, National Cancer Institute (NCI) | Smoking Cessation | 04/27 | 08/27 | | |
PROMOTE-UP, NCT05415761: Comparative Effectiveness of Mobile Health Smoking Cessation Approaches Among Underserved Patients in Primary Care |
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| Recruiting | N/A | 1332 | US | iCanQuit, iCanQuit+Motiv8, Florida quit line | University of Florida, Patient-Centered Outcomes Research Institute | Tobacco Use Cessation | 06/27 | 12/27 | | |
| Aggarwal, Monica |
ATTAIN-1, NCT05869903: A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities |
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| Active, not recruiting | 3 | 3000 | Europe, Japan, US, RoW | Orforglipron, LY3502970, Placebo | Eli Lilly and Company | Obesity, Overweight, Overweight or Obesity | 07/25 | 07/27 | | |
| Completed | N/A | 60 | US | Olive Oil | University of Florida | Atherosclerotic Cardiovascular Disease | 06/22 | 04/24 | | |
| Langkamp-Henken, Bobbi |
NCT04457401: Probiotic and Gastrointestinal Symptoms Due to Menstruation in Healthy Women |
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| Completed | N/A | 187 | US | Probiotic, Placebo | University of Florida, Lallemand Health Solutions | Menstrual Discomfort | 12/21 | 06/24 | | |
NRO, NCT04829760: The Effect of Psyllium and Wheat Bran on Body Weight in People With Parkinson's Disease and Constipation Symptoms |
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| Completed | N/A | 35 | US | Psyllium, Coarse wheat bran, Maltodextrin | University of Florida | Parkinson Disease | 04/24 | 04/24 | | |
| Parker, Leslie A |
NCT04006509: Prenatal Breast Pump Education of Mothers and Their Support Person |
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| Completed | N/A | 90 | US | Prenatally Delivered Lactation Educational Program, Antenatal Education | University of Florida | Preterm Birth, Breast Feeding | 05/22 | 05/22 | | |
NCT03728608: Optimal Feeding Tube Dwell Time in VLBW Infants to Reduce Feeding Tube Contamination |
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| Completed | N/A | 151 | US | Feeding tube dwell time of 48 hours, Feeding tube dwell time of 7 day | University of Florida, National Institute of Nursing Research (NINR), National Center for Advancing Translational Sciences (NCATS) | Infection | 02/23 | 05/23 | | |
NCT05147987: Improving Lactation Success in Black Mothers of Critically Ill Infants |
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| Active, not recruiting | N/A | 40 | US | Hands free wearable breast pump | University of Florida | Insufficient Lactation | 10/25 | 10/25 | | |
NCT05167318: Frequent Standardized Oral Care to Improve Health Outcomes in Premature Infants in the Neonatal Intensive Care Unit |
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| Active, not recruiting | N/A | 150 | US | frequent standardized oral care | University of Florida | Microbial Colonization, Ventilator Associated Pneumonia | 10/23 | 10/25 | | |
| Recruiting | N/A | 274 | US | Breast Pump suction pattern | University of Florida, Medela AG | Insufficient Breast Milk Syndrome | 06/25 | 07/25 | | |
NCT04097860: Improving Lactation Success in Mothers of Critically Infants |
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| Active, not recruiting | N/A | 122 | US | Text message including biomarker of breast pumping adequacy | University of Florida | Breast Pumping | 09/25 | 09/25 | | |
NCT06000761: Frequent Standardized Oral Care Using Human Milk in the Neonatal Intensive Care Unit |
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| Recruiting | N/A | 218 | US | Standardized oral Care | University of Florida, The Gerber Foundation | Ventilator Associated Pneumonia, Bronchopulmonary Dysplasia, Respiratory Disease | 09/26 | 12/26 | | |
| Ghiaseddin, Ashley |
EF-41, NCT06556563: /KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma |
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| Recruiting | 3 | 741 | Japan, US | Optune® device, TTFields, Temozolomide, Pembrolizumab, Placebo | NovoCure GmbH, Merck Sharp & Dohme LLC | Glioblastoma | 04/29 | 04/29 | | |
NCT00887146 / 2008-007295-14: Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma |
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| Active, not recruiting | 3 | 305 | Europe, Canada, US | concomitant temozolomide (TMZ), radiotherapy, procarbazine, adjuvant temozolomide (TMZ), CCNU, vincristine | Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI), European Organisation for Research and Treatment Center (EORTC), Canadian Cancer Trials Group | Brain and Central Nervous System Tumors | 10/25 | 10/25 | | |
2-THE-TOP, NCT03405792: Study Testing The Safety and Efficacy of Adjuvant Temozolomide Plus TTFields (Optune®) Plus Pembrolizumab in Patients With Newly Diagnosed Glioblastoma |
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| Active, not recruiting | 2 | 40 | US | Temozolomide (TMZ), Optune System, NovoTTF Therapy, Pembrolizumab, Keytruda | University of Florida, NovoCure Ltd. | Glioblastoma, Glioblastoma, WHO Grade IV | 11/22 | 09/25 | | |
OPTIMUS PRIME, NCT06558214: Safety and Feasibility of OPTune GIO® Integrated With MRI-gUided Laser Ablation Surgery and Pembrolizumab for Recurrent GlIoblastoMa, A randomizEd Trial |
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| Recruiting | 2 | 20 | US | Pembrolizumab, Keytruda, Optune GIO®, TTFields, NeuroBlate®, MLA, LITT | University of Florida | Recurrent Glioblastoma | 10/29 | 10/29 | | |
PNOC020, NCT04573140: A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM) |
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| Active, not recruiting | 1/2 | 52 | US | Autologous total tumor mRNA and pp65 full length (fl) lysosomal associated membrane protein (LAMP) mRNA loaded DOTAP liposome vaccine administered intravenously (RNA loaded lipid particles, RNA-LPs) | University of Florida, Pacific Pediatric Neuro-Oncology Consortium, University of California, San Francisco, CureSearch, Team Jack Foundation, Florida Department of Health, Food and Drug Administration (FDA) | Adult Glioblastoma, High Grade Glioma, WHO Grade III or IV Malignant Glioma | 07/29 | 07/30 | | |
RENEW, NCT04963413: Feasibility of CMV RNA-Pulsed Dendritic Cells Vaccines for the Treatment of Newly Diagnosed Glioblastoma Patients. |
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| Terminated | 1 | 6 | US | Autologous DCs derived from PBMC loaded with RNA encoding the human CMV matrix protein pp65-flLAMP plus GM-CSF | University of Florida, Immunomic Therapeutics, Inc. | Glioblastoma | 09/23 | 09/23 | | |
ADAGiO, NCT06254326: Adoptive Cellular Therapy for the TreAtment of Recurrent OliGodendrogliOma (OG) Adult Patients |
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| Active, not recruiting | 1 | 12 | US | TTRNA-DC vaccines with GM-CSF, Autologous Hematopoietic Stem cells (HSCs), TTRNA-xALT, Td vaccine | University of Florida, Oligo Nation, Inc | Recurrent Oligodendroglioma, Progressive Oligodendroglioma | 12/27 | 06/28 | | |
NCT06389591: RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM) |
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| Active, not recruiting | 1 | 24 | US | pp65 RNA loaded lipid particles, pp65 RNA-LPs (Drug Product 1 or DP1), RNA loaded lipid particles, RNA-LPs (Drug Product 2 or DP2) | University of Florida, National Cancer Institute (NCI) | Recurrent Glioblastoma | 12/27 | 12/28 | | |
IMPACT, NCT05353530: Phase I Study of IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma |
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| Recruiting | 1 | 18 | US | Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells, 8R-70CAR T cells | University of Florida, United States Department of Defense, AM Rosen Foundation | Glioblastoma Multiforme, Glioblastoma | 12/27 | 12/42 | | |
| Steshyn, Jennifer |
| Active, not recruiting | 2/3 | 1500 | US | ABBV-CLS-7262, DNL343 | Merit E. Cudkowicz, MD, Massachusetts General Hospital | Amyotrophic Lateral Sclerosis | 07/25 | 04/26 | | |
| Recruiting | N/A | 90 | US | Magnetic Resonance Imaging, Plasma neurofilament light chain (NfL) quantification | University of Minnesota, Food and Drug Administration (FDA), Minnesota Office of Higher Education | Amyotrophic Lateral Sclerosis, ALS | 08/27 | 08/28 | | |
| Recruiting | N/A | 5000 | Europe, US | | Massachusetts General Hospital, Henry Ford Health System, Northwestern University, Temple University, St. Louis University, University of Florida, University of Minnesota, Virginia Commonwealth University, Fondazione Serena Onlus - Centro Clinico NeMO Milano, Providence Health & Services, University of Pittsburgh, Istituti Clinici Scientifici Maugeri SpA | ALS, PLS, MND (Motor Neurone DIsease), Kennedy Disease, PMA - Progressive Muscular Atrophy, PBP - Progressive Bulbar Palsy | 12/30 | 12/30 | | |
| Gunnett, Amy |
NCT04805073: Treatment of Pruritus With Intramuscular Promethazine |
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| Completed | 4 | 110 | US | Promethazine, Phenergan, Placebo, salt water | University of Florida | Pruritus, Pregnancy Related | 05/24 | 05/24 | | |
NCT05486416: Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery |
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| Completed | 3 | 466 | Europe, US | HSK3486, Propofol, Diprivan | Haisco-USA Pharmaceuticals, Inc. | General Anesthesia | 07/24 | 07/24 | | |
| Recruiting | 2 | 90 | US | Standard dosing of methadone, Aliquots of methadone titrated to apnea | University of Florida | Pain, Postoperative | 05/25 | 05/25 | | |
NCT05067257: Study to Assess Epidural Resiniferatoxin for the Treatment of Intractable Pain Associated With Advanced Cancer |
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| Suspended | 2 | 120 | US | Resiniferatoxin, RTX, Placebo | Sorrento Therapeutics, Inc. | Pain, Intractable, Pain Cancer, Pain | 06/27 | 12/27 | | |
| Recruiting | 2 | 122 | US | NRD135SE.1, NRD135s.E1, a small chemical entity for treatment of neuropathic pain, Placebo | James P. Rathmell, MD, New York University, National Institute of Neurological Disorders and Stroke (NINDS), Icahn School of Medicine at Mount Sinai | Painful Diabetic Neuropathy | 01/25 | 01/25 | | |
SIJ, NCT06415461: A Study Assessing the Safety of Cord Blood Product in Sacroiliac Joint Syndrome |
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| Recruiting | 1 | 9 | US | PremierMaxCB®-Platinum (CFL001); | University of Florida, Cord for Life, Inc. | Sacroiliac; Backache, Pain, Back | 06/25 | 12/25 | | |
NCT03310528: Gastric Ultrasound for Estimation of the Aspiration Risk Study |
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| Recruiting | N/A | 200 | US | Interview questionnaire, Gastric ultrasound exam | University of Florida | Respiratory Aspiration of Gastric Contents | 07/25 | 07/26 | | |
NCT06030063: The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry |
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| Recruiting | N/A | 5000 | Canada, US | | Yale University | Cesarean Delivery, General Anesthesia | 09/28 | 09/29 | | |
| Zarrinpar, Ali |
| Completed | 2 | 60 | US | Indocyanine green, ICG, PINPOINT Endoscopic Fluorescence, NIRF | University of Florida, Society of University Surgeons | Cholecystitis, Hepatocellular Carcinoma, Liver Metastases | 09/22 | 04/23 | | |
| Recruiting | 2 | 1500 | US | Remdesivir, GS-5734, Imatinib Mesylate, Dexamethasone, Cenicriviroc, Icatibant, Firazyr, Apremilast, Otezla, dornase alfa, Pulmozyme, Celecoxib, celebrex, Famotidine, Pepcid, IC14, Aviptadil, Zyesami, narsoplimab, OMS721, Cyproheptadine, periactin, Cyclosporine, CsA | QuantumLeap Healthcare Collaborative, University of California, San Francisco, University of Pennsylvania, Emory University, University of Alabama at Birmingham, University of Colorado, Denver, University of Southern California, Yale University, Wake Forest University Health Sciences, Sanford Health, Long Beach Memorial Medical Center, Georgetown University, University of California, Davis, Hoag Memorial Hospital Presbyterian, Main Line Health, DHR Health Institute for Research and Development, University of California, Irvine, Corewell Health, Kaiser Permanente, University of Michigan, West Virginia University, University of Miami, University Hospitals Cleveland Medical Center, Virtua Health, M.D. Anderson Cancer Center | COVID-19 | 07/28 | 07/30 | | |
NCT06050252: Durvalumab With Gemcitabine and Cisplatin for the Treatment of High-Risk Resectable Liver Cancer Before Surgery |
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| Recruiting | 2 | 27 | US | Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Durvalumab, Imfinzi, Immunoglobulin G1, Anti-(Human Protein B7-H1) (Human Monoclonal MEDI4736 Heavy Chain), Disulfide with Human Monoclonal MEDI4736 Kappa-chain, Dimer, MEDI 4736, MEDI-4736, MEDI4736, Gemcitabine, dFdC, dFdCyd, Difluorodeoxycytidine, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Resection, Surgical Resection | National Cancer Institute (NCI) | Resectable Intrahepatic Cholangiocarcinoma | 02/26 | 02/26 | | |
| Active, not recruiting | 2 | 201 | US | Epclusa | University of Pennsylvania, Gilead Sciences, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | End Stage Renal Disease | 06/25 | 01/26 | | |
NCT06217094: Study of NP-101 in Patients With Unresectable Hepatocellular Carcinoma (HCC) Undergoing Y-90 Treatment |
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| Not yet recruiting | 1 | 18 | US | NP-101 (3 g), NP-101 (4.8 g), NP-101 (6 g) | University of Florida, Novatek, Florida Department of Health | Hepatocellular Carcinoma | 07/26 | 09/29 | | |
| Recruiting | 1 | 12 | US | Irinotecan, Sonidegib, Sorafenib | University of Florida, Sun Pharmaceutical Industries Ltd | Hepatocellular Carcinoma | 04/26 | 04/26 | | |
| Not yet recruiting | N/A | 34 | US | Phenotypic Personalized Medicine Dosing, Standard of Care Dosing | University of Florida | Kidney Transplant Rejection | 08/26 | 01/27 | | |
TGI, NCT06063213: Using Transcriptional Assessment of Immune Response to Assess Immunosuppression After Liver Transplantation |
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| Recruiting | N/A | 40 | US | | University of Florida, Transplant Genomics, Inc. | Transplant Complication | 10/26 | 10/26 | | |
| Active, not recruiting | N/A | 5000 | US | Prospera | Natera, Inc., University of Maryland | Kidney Transplant Rejection | 10/26 | 10/27 | | |
| Terry, Ellen |
| Completed | N/A | 99 | US | Cognitive-Behavioral Intervention, Pain Education | University of Florida, National Institute of Neurological Disorders and Stroke (NINDS) | Osteoarthritis, Knee | 12/23 | 12/23 | | |
| Lattinville, Brandi |
NCT04805073: Treatment of Pruritus With Intramuscular Promethazine |
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| Completed | 4 | 110 | US | Promethazine, Phenergan, Placebo, salt water | University of Florida | Pruritus, Pregnancy Related | 05/24 | 05/24 | | |
NCT05025787: A Study to Evaluate the Safety and Efficacy of CNTX-6970 in Subjects With Knee Osteoarthritis Pain. |
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| Completed | 2 | 77 | US | CNTX-6970, Placebo | Maurizio Fava, MD | Knee Osteoarthritis | 06/24 | 06/24 | | |
NCT05476276: EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy |
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| Recruiting | 2 | 122 | US | ISA specific | James P. Rathmell, MD, New York University, Icahn School of Medicine at Mount Sinai, National Institute of Neurological Disorders and Stroke (NINDS) | Painful Diabetic Neuropathy | 01/25 | 01/25 | | |
| Recruiting | 2 | 122 | US | NRD135SE.1, NRD135s.E1, a small chemical entity for treatment of neuropathic pain, Placebo | James P. Rathmell, MD, New York University, National Institute of Neurological Disorders and Stroke (NINDS), Icahn School of Medicine at Mount Sinai | Painful Diabetic Neuropathy | 01/25 | 01/25 | | |
| Ranum, Laura |
NCT04220021: Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD |
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| Active, not recruiting | 2 | 18 | US | Metformin, Metformin hydrochloride sustained-release (SR) | University of Florida, ALS Association | C9orf72 Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia | 08/24 | 06/25 | | |
| Terrell, Joshua Drug |
| Active, not recruiting | N/A | 1643 | US | DNA sample collection | University of Florida, University of North Carolina, Chapel Hill, National Heart, Lung, and Blood Institute (NHLBI), University of Maryland, Baltimore | Coronary Artery Disease, Percutaneous Coronary Intervention | 07/24 | 07/25 | | |
| Active, not recruiting | N/A | 492 | US | Panel-based pharmacogenetic genotyping | University of Florida, National Human Genome Research Institute (NHGRI) | Use of Prescription Medications, Pharmacogenetic Testing | 06/25 | 06/26 | | |
| Patel, Bhavana |
| Recruiting | N/A | 60 | US | Deep brain stimulation effect on apraxia | University of Florida | Deep Brain Stimulation, Parkinson Disease, Apraxia, Motor | 05/25 | 06/25 | | |
| Recruiting | N/A | 106 | US | Tele-neurohub | University of Florida, National Institute on Aging (NIA) | Lewy Body Dementia With Behavioral Disturbance, Lewy Body Parkinson Disease, Lewy Body Disease | 05/26 | 05/26 | | |
| Cates, Jonathan |
NCT04805073: Treatment of Pruritus With Intramuscular Promethazine |
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| Completed | 4 | 110 | US | Promethazine, Phenergan, Placebo, salt water | University of Florida | Pruritus, Pregnancy Related | 05/24 | 05/24 | | |
| Morrison, Deborah |
NCT04220021: Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD |
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| Active, not recruiting | 2 | 18 | US | Metformin, Metformin hydrochloride sustained-release (SR) | University of Florida, ALS Association | C9orf72 Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia | 08/24 | 06/25 | | |
| Amaris, Manuel |
Reflux Band, NCT03886961: The Effect of the ™ Upper Esophageal Sphincter (UES) Assist Device on Reflux for Lung Transplant Recipients |
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| Recruiting | N/A | 20 | US | Reflux Band, Reflux Band™ Upper Esophageal Sphincter (UES) Assist Device | University of Florida, Somna Therapeutics, L.L.C. | Lung Transplant, GERD | 03/25 | 03/25 | | |
| Hone, Liana |
| Active, not recruiting | N/A | 53 | US | Control App Version, Standard App Version, Experimental, Feedback App Version | University of Florida, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Drinking, Alcohol, Drinking Behavior | 05/23 | 05/24 | | |
