Texas Children's Hospital
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 645 Trials 
2018 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Williams, Christopher J
NCT06592872: Using Digital Health Technology to Prevent Bullying and Cyberbullying Among Elementary School Students

Not yet recruiting
N/A
3000
NA
Bullying prevention
Christopher Williams, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Bullying, Cyberbullying, Smoking
06/27
12/27
Dunkel, Ira
NCT00554788: Combination Chemotherapy, Autologous Stem Cell Transplant, and/or Radiation Therapy in Treating Young Patients With Extraocular Retinoblastoma

Completed
3
60
Canada, US, RoW
Autologous Bone Marrow Transplantation, ABMT, Autologous Blood and Marrow Transplantation, Autologous Bone Marrow Transplant, Autologous Marrow Transplantation, Autologous Hematopoietic Stem Cell Transplantation, AHSCT, Autologous, Autologous Hematopoietic Cell Transplantation, Autologous Stem Cell Transplant, Autologous Stem Cell Transplantation, Stem Cell Transplantation, Autologous, Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, JM8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Asta B 518, B 518, B-518, B518, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR 138719, WR- 138719, WR-138719, WR138719, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16, VP 16-213, VP 16213, VP-16, VP-16-213, VP-16213, VP16, VP16213, Filgrastim, Filgrastim Biosimilar Filgrastim-sndz, Filgrastim Biosimilar Tbo-filgrastim, Filgrastim XM02, Filgrastim-aafi, Filgrastim-ayow, Filgrastim-sndz, G-CSF, Granix, Neupogen, Neutroval, Nivestim, Nivestym, r-metHuG-CSF, Recombinant Methionyl Human Granulocyte Colony Stimulating Factor, Releuko, rG-CSF, Tbo-filgrastim, Tevagrastim, XM02, Zarxio, In Vitro-Treated Peripheral Blood Stem Cell Transplantation, in vitro-treated PBPC transplantation, in vitro-treated peripheral blood progenitor cell transplantation, Radiation Therapy, Cancer Radiotherapy, Energy Type, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation, Thiotepa, 1,1',1''-Phosphinothioylidynetrisaziridine, Girostan, N,N', N''-Triethylenethiophosphoramide, Oncotiotepa, SH 105, SH-105, SH105, STEPA, Tepadina, Tepylute, TESPA, Tespamin, Tespamine, Thio-Tepa, Thiofosfamide, Thiofozil, Thiophosphamide, Thiophosphoamide, Thiophosphoramide, Thiotef, Tifosyl, TIO TEF, Tio-tef, Triethylene Thiophosphoramide, Triethylenethiophosphoramide, Tris(1-aziridinyl)phosphine sulfide, TSPA, WR 45312, Vincristine Sulfate, Kyocristine, Leurocristine Sulfate, Leurocristine, sulfate, Oncovin, Vincasar, Vincosid, Vincrex, Vincristine, sulfate
Children's Oncology Group, National Cancer Institute (NCI)
Extraocular Retinoblastoma
06/18
12/24
NCT04201457: A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration

Recruiting
1/2
75
US
Dabrafenib, Dabrafenib mesylate, Tafinlar, Trametinib, Trametinib dimethyl sulfoxide, Mekinist, Hydroxychloroquine, Plaquenil, Plaquinol, Toremonil, Ercoquinn
Pediatric Brain Tumor Consortium, National Cancer Institute (NCI), American Lebanese Syrian Associated Charities
Low Grade Glioma (LGG) of Brain With BRAF Aberration, High Grade Glioma (HGG) of the Brain With BRAF Aberration, Low Grade Glioma of Brain With Neurofibromatosis Type 1
03/27
06/30
NCT03904862: Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery

Recruiting
1/2
66
US
CX 4945, Silmitasertib sodium
Pediatric Brain Tumor Consortium, Senhwa Biosciences, Inc., National Cancer Institute (NCI), St. Jude Children's Research Hospital, National Cancer Institute/NIH/DHHS (NCI)
Medulloblastoma, Childhood, Medulloblastoma Recurrent, Medulloblastoma
12/29
02/30
NCT03389802: Phase I Study of APX005M in Pediatric Central Nervous System Tumors

Active, not recruiting
1
32
US
APX005M treatment for recurrent or refractory primary malignant CNS tumor patients, APX005M treatment for newly diagnosed DIPG patients
Pediatric Brain Tumor Consortium, American Lebanese Syrian Associated Charities, Pyxis Oncology, Inc, Solving Kids' Cancer, Ty Louis Campbell Foundation, A Kids' Brain Tumor Cure Foundation, National Cancer Institute (NCI)
Glioblastoma Multiforme, High-grade Astrocytoma Not Otherwise Specified (NOS), CNS Primary Tumor, Not Otherwise Specified (NOS), Ependymoma, Not Otherwise Specified (NOS), Diffuse Intrinsic Pontine Gliomas (DIPG), Medulloblastoma
09/23
09/24
NCT04295759: INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas

Active, not recruiting
1
13
US
INCB7839
Pediatric Brain Tumor Consortium, National Cancer Institute (NCI), American Lebanese Syrian Associated Charities
Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, DIPG, High-grade Astrocytoma NOS, CNS Primary Tumor, NOS (Malignant Glioma)
12/23
03/25
NCT03598244: Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors

Recruiting
1
50
Canada, US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Savolitinib, AZD 6094, AZD6094, HMPL-504, Volitinib, X-Ray Imaging, Conventional X-Ray, Diagnostic Radiology, Medical Imaging, X-Ray, Plain film radiographs, Radiographic Imaging, Radiographic imaging procedure (procedure), Radiography, RG, Static X-Ray, X-Ray
National Cancer Institute (NCI)
Recurrent Diffuse Intrinsic Pontine Glioma, Recurrent Malignant Glioma, Recurrent Medulloblastoma, Recurrent Primary Central Nervous System Neoplasm, Refractory Diffuse Intrinsic Pontine Glioma, Refractory Malignant Glioma, Refractory Medulloblastoma, Refractory Primary Central Nervous System Neoplasm
06/26
06/26
NCT04978727: A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Recruiting
1
35
Canada, US
SurVaxM for patients with relapsed or progressive MB, HGG or ependymoma ages ≥10 and ≤21 years, SurVaxM for patients with relapsed or progressive MB, HGG or ependymoma ages ≥1 and <10 years, SurVaxM for patients with non-relapsed DIPG post radiation-therapy ages ≥1 and ≤21 years
Pediatric Brain Tumor Consortium, Roswell Park Cancer Institute, National Cancer Institute (NCI), American Lebanese Syrian Associated Charities
Medulloblastoma, Glioblastoma Multiforme, Anaplastic Astrocytoma, High-grade Astrocytoma NOS, Anaplastic Oligodendroglioma, Anaplastic Ependymoma, Ependymoma, Diffuse Intrinsic Pontine Glioma
08/25
06/28
NCT02359565: Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

Active, not recruiting
1
110
Canada, US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Conventional Magnetic Resonance Imaging, Conventional MRI, Diffusion Tensor Imaging, DIFFUSION TENSOR MRI, DT-MRI, DTI, Diffusion Weighted Imaging, Diffusion Weighted MRI, Diffusion-Weighted Magnetic Resonance Imaging, Diffusion-Weighted MR Imaging, Diffusion-Weighted MRI, DW-MRI, DWI, DWI MRI, DWI-MRI, MR Diffusion-Weighted Imaging, Dynamic Contrast-enhanced MR Perfusion, DCE, DCE MR Perfusion, Dynamic Contrast-enhanced Magnetic Resonance Imaging Perfusion, Dynamic Contrast-enhanced MRI Perfusion, Permeability MRI, Dynamic Susceptibility Contrast-Perfusion-Weighted Imaging, DSC, DSC-PWI, Dynamic Susceptibility Contrast Perfusion Weighted Imaging, Dynamic Susceptibility Contrast Perfusion-Weighted MR Imaging, Dynamic Susceptibility Contrast-Enhanced MR Perfusion, Magnetic Resonance Spectroscopic Imaging, 1H- Nuclear Magnetic Resonance Spectroscopic Imaging, 1H-nuclear magnetic resonance spectroscopic imaging, Magnetic Resonance Spectroscopy, MRS, MRS Imaging, MRSI, MS, Proton Magnetic Resonance Spectroscopic Imaging, Pembrolizumab, BCD-201, GME 751, GME751, Keytruda, Lambrolizumab, MK 3475, MK-3475, MK3475, Pembrolizumab Biosimilar BCD-201, Pembrolizumab Biosimilar GME751, Pembrolizumab Biosimilar QL2107, Pembrolizumab Biosimilar RPH-075, QL2107, RPH 075, RPH-075, RPH075, SCH 900475, SCH-900475, SCH900475
National Cancer Institute (NCI)
Constitutional Mismatch Repair Deficiency Syndrome, Lynch Syndrome, Malignant Glioma, Recurrent Brain Neoplasm, Recurrent Childhood Ependymoma, Recurrent Diffuse Intrinsic Pontine Glioma, Recurrent Medulloblastoma, Refractory Brain Neoplasm, Refractory Diffuse Intrinsic Pontine Glioma, Refractory Ependymoma, Refractory Medulloblastoma
12/26
12/26
NCT04903080: HER2-specific Chimeric Antigen Receptor (CAR) T Cells for Children With Ependymoma

Recruiting
1
50
US
HER2 Specific CAR T Cell
Pediatric Brain Tumor Consortium, Texas Children's Cancer Center, Baylor College of Medicine, National Cancer Institute (NCI), American Lebanese Syrian Associated Charities (ALSAC)
Ependymoma
07/28
07/43
NCT00772200: Neuropsychological and Behavioral Testing in Younger Patients With Cancer

Active, not recruiting
N/A
1200
Canada, US, RoW
Cognitive Assessment, Quality-of-Life Assessment, Quality of Life Assessment
Children's Oncology Group, National Cancer Institute (NCI)
Childhood Malignant Neoplasm
 
 
NCT05934630: Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults with Brain Tumors

Recruiting
N/A
300
US
Pediatric Brain Tumor Consortium, Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI), American Lebanese Syrian Associated Charities
Anaplastic Astrocytoma, Diffuse Brainstem Glioma, Glioblastoma Multiforme, High-grade Astrocytoma NOS, Fibrillary Astrocytoma, Low-Grade Astrocytoma, Nos, Pilocytic Astrocytoma, Choroid Plexus Carcinoma, CNS Primary Tumor, Nos, Atypical Teratoid/Rhabdoid Tumor, Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, Ependymoma, NOS, Anaplastic Oligodendroglioma, Oligodendroglioma, Nos, CNS Germ Cell Tumor, Pineoblastoma, Diffuse Leptomeningeal Glioneuronal Tumor
07/27
07/28
NCT03033992: Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG

Recruiting
N/A
80
US
Optune System (NovoTTF-200A System, Tumor Treating Fields, TTFields), Optune System (NovoTTF-200A System), Concurrent Optune and RT followed by Optune System alone
Pediatric Brain Tumor Consortium, National Cancer Institute (NCI), NovoCure Ltd., American Lebanese Syrian Associated Charities (ALSAC)
Malignant Glioma, Ependymoma, Diffuse Intrinsic Pontine Glioma
07/32
09/32
Dreyer, ZoAnn E
NCT00082745: Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors

Recruiting
N/A
3885
Europe, Canada, US, RoW
Laboratory Biomarker Analysis, Questionnaire Administration
Children's Oncology Group, National Cancer Institute (NCI)
Childhood Malignant Neoplasm
12/04
 
NCT01120353: Childhood Cancer Survivor Study

Recruiting
N/A
50000
Canada, US
St. Jude Children's Research Hospital, National Cancer Institute (NCI), Fred Hutchinson Cancer Center, Nationwide Children's Hospital, M.D. Anderson Cancer Center, University of Southern California, Children's Hospital Medical Center, Cincinnati, University of California, San Francisco
Cancer
11/26
11/26
NCT00736749: Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies

Recruiting
N/A
5000
US
Assessment of Therapy Complications, Questionnaire Administration
Children's Oncology Group, National Cancer Institute (NCI)
Hematopoietic Cell Transplantation Recipient, Leukemia, Solid Tumor
01/00
 
Berg, Stacey
PRISM-AC, NCT03668223: The PRISM Intervention: a Multi-site Randomized Controlled Trial for Adolescents and Young Adults With Advanced Cancer

Active, not recruiting
N/A
195
US
Promoting Resilience in Stress Management (PRISM)
Dana-Farber Cancer Institute, Children's Hospital Los Angeles, Baylor College of Medicine, University of Pittsburgh Medical Center, Seattle Children's Hospital, National Cancer Institute (NCI)
Cancer, Quality of Life, Anxiety, Depression, Hope, Coping Skills, Communication
01/24
03/25
Lee, Brendan
EDS-OXY, NCT05405257: Oxytocin for Hypermobile Ehlers-Danlos Syndrome

Recruiting
1/2
20
US
Oxytocin, Placebo
Baylor College of Medicine
Hypermobile Ehlers-Danlos Syndrome, Pain Assessment
05/25
05/25
NCT03064048: Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD

Completed
N/A
16
US
Neo-ASA, Placebo
Baylor College of Medicine, Rare Diseases Clinical Research Network, Neogenis Laboratories
Argininosuccinate Lyase Deficiency, Urea Cycle Disorder, Urea Cycle Disorders, Inborn, Argininosuccinic Aciduria
01/23
01/23
NCT02450851: Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

Recruiting
N/A
20000
US
National Human Genome Research Institute (NHGRI)
Genetic Disease
12/28
12/28
Belfort, Michael Anthony
NCT02230072: Fetoscopic Meningomyelocele Repair Study

Active, not recruiting
1
60
US
fetoscopy, Karl Storz, Tuttlingen, Germany, Richard Wolf Medical Instruments, Corp., Karl Storz Endoscopy-America, Inc., Cook Medical, Inc., Lexion Medical, LLC., Terumo Pinnacle
Baylor College of Medicine
Neural Tube Defect
02/25
02/25
NCT03794011: Patch vs. No Patch Fetoscopic Meningomyelocele Repair Study

Active, not recruiting
1
38
US
fetoscopy, Richard Wolf Medical Instruments, Corp., Karl Storz Endoscopy-America, Inc., Cook Medical, Inc., Lexion Medical, LLC., Terumo Pinnacle, Pare Surgical, Inc., Medtronic Neurosurgery, Canon Medical, Applied Medical
Baylor College of Medicine
Neural Tube Defects
08/26
08/26
FETO, NCT00881660: Fetal Endotracheal Occlusion () in Severe and Extremely Severe Congenital Diaphragmatic Hernia

Completed
N/A
20
US
Goldballoon Detachable Balloon and delivery microcatheter, GOLDBAL4 or GOLDBAL2 Goldballoon, BALTACCIBDPE100 delivery microcatheter
Michael A Belfort, Baylor College of Medicine
Congenital Diaphragmatic Hernia
04/23
04/23
NCT02315521: Standardized Prenatal Clinical Care for LUTO

Recruiting
N/A
50
US
Fetal Intervention for LUTO, Fetal vesico-amniotic shunting, Fetal cystoscopy
Baylor College of Medicine
Urethral Obstruction
11/26
11/26
NCT05672849: Safety and Efficacy of Devices Used in Fetoscopic Neural Tube Defect Repair Cases

Recruiting
N/A
100
US
Modified Surgical Instruments/Devices (Sheaths and Irrigator)
Michael A Belfort, Baylor College of Medicine
Neural Tube Defects
12/27
12/27
NCT03980717: Fetal Endotracheal Occlusion (FETO) in the Resolution of Pulmonary Hypertension in Fetuses With Severe CDH

Recruiting
N/A
80
US
Goldbal Detachable Balloon and delivery microcatheter, GOLDBAL4 or GOLDBAL2 Goldballoon, BALTACCIBDPE100 delivery microcatheter
Michael A Belfort, Baylor College of Medicine
Congenital Diaphragmatic Hernia
12/28
12/30
NCT06022510: Safety and Efficacy of Fetoscopes Used in Fetoscopic Selective Laser Photocoagulation

Not yet recruiting
N/A
300
US
Fetoscopy Sets for Anterior and Posterior Placentas, Karl Storz Miniature Straight Forward Telescope 0 Degrees Set - Straight or 11506 AAK, Karl Storz Miniature Straight Forward Telescope 0 Degrees Set - Curved or 11508 AAK
Michael A Belfort, Baylor College of Medicine
Twin Monochorionic Diamniotic Placenta
12/28
12/28
NCT05704257: Fetal Repair of Complex Gastroschisis: a Safety and Feasibility Trial

Recruiting
N/A
10
US
fetoscopy
Baylor College of Medicine
Gastroschisis
12/29
12/29
NCT05263076: Uterine Transplant for Women With Absolute Uterine Factor Infertility (AUFI)

Recruiting
N/A
10
US
Uterine Transplant
John Goss
Mayer Rokitansky Kuster Hauser Syndrome, Absence of Uterus, Infertility of Uterine Origin
12/30
12/30
Sanchez, Pablo J
NCT01702805: Transfusion of Prematures Trial

Active, not recruiting
3
1824
US
Liberal Cell Transfusion, Restricted red cell transfusion
NICHD Neonatal Research Network, National Heart, Lung, and Blood Institute (NHLBI), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infant, Newborn, Diseases, Infant, Extremely Low Birth Weight, Infant, Small for Gestational Age, Bronchopulmonary Dysplasia (BPD), Anemia
01/20
08/25
NCT01353313: Hydrocortisone for BPD

Active, not recruiting
3
800
US
Hydrocortisone, Placebo
NICHD Neonatal Research Network, National Center for Research Resources (NCRR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Heart, Lung, and Blood Institute (NHLBI), National Center for Advancing Translational Sciences (NCATS)
Infant, Newborn, Infant, Small for Gestational Age, Infant, Very Low Birth Weight, Infant, Premature, Bronchopulmonary Dysplasia
09/20
01/25
MoCHA, NCT03340727: Moderately Preterm Infants With Caffeine at Home for Apnea () Trial

Terminated
3
827
US
Caffeine Citrate, Placebo
NICHD Neonatal Research Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Apnea of Prematurity
01/23
03/23
BiB, NCT04545866: The Budesonide in Babies () Trial

Active, not recruiting
3
1160
US
budesonide (Pulmicort nebulizing suspension)., Pulmicort nebulizing suspension., surfactant (poractant alfa;Curosurf), poractant alfa;Curosurf
NICHD Neonatal Research Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Bronchopulmonary Dysplasia (BPD), Respiratory Distress Syndrome, Prematurity; Extreme, Neonatal
09/24
12/26
NCT03456336: Management of the PDA Trial

Active, not recruiting
3
836
US
Active Treatment, Expectant Management
NICHD Neonatal Research Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infant, Premature, Patent Ductus Arteriosus, Infant, Newborn, Diseases, Patent Ductus Arteriosus After Premature Birth
04/25
05/27
NCT02951130: Milrinone in Congenital Diaphragmatic Hernia

Active, not recruiting
2
66
US
Milrinone, Milrinone Lactate Injection, Primacor, Placebo (5% Dextrose), D5W
NICHD Neonatal Research Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Congenital Diaphragmatic Hernia, Persistent Pulmonary Hypertension of the Newborn, Hypoxemic Respiratory Failure, Pulmonary Hypoplasia
09/24
03/25
NCT06061081: A Study to Investigate the Antiviral Effect, Safety, Tolerability and Pharmacokinetics of VH3739937 in in Treatment-Naive Adults Living With HIV-1

Suspended
2
26
Europe, US, RoW
VH3739937, Placebo
ViiV Healthcare
HIV Infections
11/24
11/24
NCT04318587: Assessment of Donor Derived Cell Free DNA and Utility in Lung Transplantation

Terminated
N/A
40
US
Allosure
Pablo Sanchez, CareDx
Lung Transplant Failure and Rejection
12/22
12/23
NeoPlaTT, NCT06676904: Neonatal Platelet Transfusion Threshold Trial

Not yet recruiting
N/A
2433
US
Higher Platelet Transfusion Threshold, Liberal Transfusion Threshold, Lower Platelet Transfusion Threshold, Restrictive Transfusion Threshold
NICHD Neonatal Research Network, National Heart, Lung, and Blood Institute (NHLBI)
Thrombocytopenia, Neonatal, Platelet Transfusion, Infant, Newborn, Diseases, Infant, Extremely Low Birth Weight, Infant, Small for Gestational Age, Thrombosis
01/31
04/31
NCT03927833: Cycled Phototherapy

Recruiting
N/A
1700
US
Phototherapy lights
NICHD Neonatal Research Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Hyper Bilirubinemia, Premature Infant
07/25
07/25
NCT05547698: A Study of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation

Recruiting
N/A
228
Europe, US
Off-pump lung transplantation, Venoarterial ECMO lung transplantation
Mayo Clinic
Lung Transplant
09/25
09/25
NCT06082453: Modernizing Perinatal Syphilis Testing

Recruiting
N/A
924
US
Quantitative polymerase chain reaction (qPCR) assay for detection of Treponema pallidum, Aptima Treponema pallidum transcription-mediated amplification (TMA) assay for detection of Treponema pallidum, Center for Disease Control (CDC) Sexually Transmitted Infections (STI) 2021 Treatment Guidelines for diagnosis of syphilis
The University of Texas Health Science Center, Houston, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Syphilis
11/27
11/27
NCT00063063: Generic Database of Very Low Birth Weight Infants

Recruiting
N/A
80000
US
NICHD Neonatal Research Network, National Center for Research Resources (NCRR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
03/30
03/30
NCT00009633: Follow-up Visit of High Risk Infants

Recruiting
N/A
68000
US
NICHD Neonatal Research Network, National Center for Research Resources (NCRR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
03/30
03/30
Wearden, Mary
NCT05685745: Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset

Recruiting
N/A
5000
Europe, Canada, Japan, US
The University of Texas Health Science Center, Houston, Nationwide Children's Hospital, University of Iowa, University of Alabama at Birmingham, Jichi Medical University, Saitama Medical University
Infant, Extremely Premature, Obstetric Labor, Premature, Premature Birth, Intensive Care, Neonatal, Intensive Care Units, Neonatal
01/28
01/28
Blaney, Susan
NCT00006238: Phenylbutyrate in Treating Children With Progressive or Recurrent Cancer of the Central Nervous System

Active, not recruiting
2
US
sodium phenylbutyrate
Texas Children's Cancer Center, National Cancer Institute (NCI)
Brain and Central Nervous System Tumors
 
 
Whitehead, William E
NCT02425761: The CSF Shunt Entry Site Trial

Active, not recruiting
3
448
Canada, US
Ventriculoperitoneal shunt insertion surgery
Baylor College of Medicine, Patient-Centered Outcomes Research Institute, University of Alabama at Birmingham, University of British Columbia, University of Pittsburgh, University of Toronto, University of Utah, University of Washington, Vanderbilt University, Washington University School of Medicine, Hydrocephalus Association, Ohio State University, Johns Hopkins University, University of Calgary, University of Colorado, Denver, University of Southern California
Hydrocephalus
12/20
12/20
ESTHI, NCT04177914: HCRN Endoscopic Versus Shunt Treatment of Hydrocephalus in Infants

Recruiting
3
176
Canada, US
Endoscopic Third Ventriculostomy with Choroid Plexus Cauterization (ETV+CPC), Ventriculoperitoneal Shunt
University of Utah, University of Alabama at Birmingham, University of British Columbia, University of Pittsburgh, The Hospital for Sick Children, Seattle Children's Hospital, Vanderbilt University Medical Center, Washington University School of Medicine, Nationwide Children's Hospital, Johns Hopkins University, University of Calgary, University of Colorado, Denver, Children's Hospital Los Angeles, National Institutes of Health (NIH), Hydrocephalus Association, Penn State University, National Institute of Neurological Disorders and Stroke (NINDS), Baylor College of Medicine, University of Florida, Orlando Health, Inc., Virginia Commonwealth University
Hydrocephalus
05/27
08/27
NCT00670735: HCRN Core Data Project: Characterizing Patient Populations in the Hydrocephalus Clinical Research Network (HCRN)

Recruiting
N/A
1400
Canada, US
University of Utah, National Institute of Neurological Disorders and Stroke (NINDS)
Pediatric Hydrocephalus
12/29
12/29
FIT, NCT03811821: Fecal Incontinence Treatment () Study

Active, not recruiting
N/A
271
US
Biofeedback, Injection
Mayo Clinic, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of North Carolina, Chapel Hill, Colon and Rectal Surgery Associates, Ltd., Augusta University, RTI International, University of Alabama at Birmingham, University of Michigan
Fecal Incontinence, Bowel Incontinence
05/24
12/25
NCT05672849: Safety and Efficacy of Devices Used in Fetoscopic Neural Tube Defect Repair Cases

Recruiting
N/A
100
US
Modified Surgical Instruments/Devices (Sheaths and Irrigator)
Michael A Belfort, Baylor College of Medicine
Neural Tube Defects
12/27
12/27
Abrams, Steven A
AMISTAD, NCT04801134: Interventions to Manage Food Insecurity and Inappropriate Feeding Practices Related to the COVID-19 Pandemic

Not yet recruiting
N/A
50
US
Education, Community Resources
University of Texas at Austin, Perrigo Company
Food Insecurity, Children, Only, Covid19
03/22
05/22
Brenner, Malcolm K
CASPALLO, NCT00710892: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene

Active, not recruiting
1
10
US
Allodepleted T Cells
Baylor College of Medicine, The Methodist Hospital Research Institute, Center for Cell and Gene Therapy, Baylor College of Medicine
Acute Lymphoblastic Leukemia, Non-Hodgkin's Lymphoma, Myelodysplastic Syndrome, Chronic Myeloid Leukemia
11/11
07/26
DOTTI, NCT01494103: Administration of Donor T Cells With the Caspase-9 Suicide Gene

Active, not recruiting
1
15
US
iCaspase9-transduced T cells, AP1903, AP1903 Dimerizer Drug
Baylor College of Medicine, The Methodist Hospital Research Institute, Center for Cell and Gene Therapy, Baylor College of Medicine
Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, Acute Myeloid Leukemia, Chronic Myelogenous Leukemia, Non Hodgkin Lymphoma, Hemophagocytic Lymphohistiocytosis, Familial Hemophagocytic Lymphohistiocytosis, Hemophagocytic Syndrome, Epstein Barr Virus Infection, X-linked Lymphoproliferative Disease
05/29
05/29
Krance, Robert K
NCT01656603: Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation

Recruiting
2
9999
US
unlicensed CBU
New York Blood Center
Infusion Reactions
12/25
12/25
EXCESS, NCT01189786: Ex Vivo T-Cell Depletion of Mobilized Peripheral Blood Stem Cells Via CD34-Selection

Recruiting
N/A
241
US
CliniMACS CD34 Reagent system
Baylor College of Medicine, Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital Research Institute
Stem Cell Transplant, Allogeneic
10/25
11/26
NCT01351545: A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

Recruiting
N/A
99999
US
A multicenter access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs)
Center for International Blood and Marrow Transplant Research, National Marrow Donor Program
Hematologic Malignancies, Inherited Disorders of Metabolism, Inherited Abnormalities of Platelets, Histiocytic Disorders, Acute Myelogenous Leukemia (AML or ANLL), Acute Lymphoblastic Leukemia (ALL), Other Acute Leukemia, Chronic Myelogenous Leukemia (CML), Myelodysplastic (MDS) / Myeloproliferative (MPN) Diseases, Other Leukemia, Hodgkin Lymphoma, Non-hodgkin Lymphoma, Multiple Myeloma/ Plasma Cell Disorder (PCD), Inherited Abnormalities of Erythrocyte Differentiation or Function, Disorders of the Immune System, Autoimmune Diseases, Severe Aplastic Anemia
10/41
10/41
Carrum, George
NCT03870750: Identifying Best Approach in Improving Quality of Life and Survival After a Donor Stem Cell Transplant in Older, Medically Infirm, or Frail Patients With Blood Diseases

Active, not recruiting
2/3
455
US
Supportive Palliative Care, Comfort Care, palliation, palliative care, palliative therapy, Palliative Treatment, Symptom Management, Symptoms Management, PA-Palliative Therapy, Clinical Management, Best Practice, standard of care, standard therapy, Allogeneic Hematopoietic Stem Cell Transplantation, Allogeneic Hematopoietic Cell Transplantation, Allogeneic Stem Cell Transplantation, HSC, HSCT, Stem Cell Transplantation, Questionnaire Administration, Quality-of-Life Assessment, Quality of Life Assessment, Survey Administration
Fred Hutchinson Cancer Center, National Cancer Institute (NCI), National Institutes of Health (NIH)
Hematopoietic and Lymphoid Cell Neoplasm, Non-Neoplastic Hematologic and Lymphocytic Disorder
12/25
12/25
ACCESS, NCT04904588: HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide

Recruiting
2
300
US
Busulfan, Busulfex®, Fludarabine, Fludara®, Total-body irradiation, TBI, Cyclophosphamide, Cytoxan®, Melphalan, PBSC Hematopoietic Stem Cell Transplantation (HSCT), PBSC HSCT, PBSC HCT, PBSC Transplantation, Bone Marrow Hematopoietic Stem Cell Transplantation, BM HSCT, BM HCT, Bone Marrow Transplantation, Post-transplant Cyclophosphamide, Mesna, Mesnex®, Tacrolimus, Mycophenolate Mofetil, MMF, Cellcept®, Patient-Reported Outcomes
Center for International Blood and Marrow Transplant Research, National Marrow Donor Program
Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia, Mixed Phenotype Acute Leukemia, Acute Leukemia, Myelodysplastic Syndromes, Chronic Myelogenous Leukemia, Chronic Lymphocytic Leukemia, Lymphoma
07/24
07/24
BMTCTN1903, NCT04975698: HIV Antigen-specific T-cells Targeting Conserved Epitopes (HST-NEETs)

Active, not recruiting
2
12
US
HST-NEETs, Bone Marrow Transplant
Catherine Bollard, National Heart, Lung, and Blood Institute (NHLBI), Blood and Marrow Transplant Clinical Trials Network, National Cancer Institute (NCI), National Marrow Donor Program, Children's National Research Institute
HIV Associated Lymphoma
06/25
06/26
TETRAVI, NCT04013802: Multivirus CTL for Treatment of EBV, CMV, Adenovirus, and BK Infections Post Allogeneic SCT.

Recruiting
1
47
US
HLA-matched VSTs
Baylor College of Medicine, The Methodist Hospital Research Institute
Viral Infection
05/25
05/25
NCT03601442: CTL019 Out of Specification MAP for ALL or DLBCL Patients

Available
N/A
Canada, US, RoW
CTL019, tisagenlecleucel, Kymriah
Novartis Pharmaceuticals
Acute Lymphoblastic Leukemia (ALL), Diffuse Large B-cell Lymphoma (DLBCL)
 
 
HAPLOTAB, NCT05236764: Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion

Recruiting
N/A
47
US
CliniMACS
Baylor College of Medicine, Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital Research Institute
Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia in Remission, Myelodysplastic Syndromes, Chronic Myeloid Leukemia, Hemophagocytic Lymphohistiocytoses, Primary Immunodeficiency Diseases, Hemoglobinopathies, Severe Aplastic Anemia, Cytopenia, Bone Marrow Failure Syndrome, Severe Chronic Active Epstein-Barr Virus Infection
10/26
08/30
Heslop, Helen E
NCT05305040: Study of Posoleucel (ALVR105,Viralym-M) for Multi-Virus Prevention in Patients Post-Allogeneic Hematopoietic Cell Transplant

Terminated
2/3
451
Europe, Canada, US, RoW
Posoleucel (ALVR105), Viralym-M, Placebo
AlloVir
Adenovirus Infection, BK Virus Infection, Cytomegalovirus Infections, Epstein-Barr Virus Infections, Human Herpes Virus-6 Infection, JC Virus Infection
01/24
01/24
CHARIOT, NCT04268706: Phase 2 Study Evaluating Autologous CD30.CAR-T Cells in Patients With Relapsed/Refractory Hodgkin Lymphoma

Active, not recruiting
2
97
US
CD30.CAR-T, Fludarabine, Fludara, Bendamustine, Bendeka
Tessa Therapeutics
Hodgkin Lymphoma, Adult, Hodgkin Disease Recurrent, Hodgkin Disease Refractory, Hodgkin Disease, Pediatric
05/25
03/37
ACTION, NCT05352828: Autologous CD30.CAR-T in Combination With Nivolumab in cHL Patients After Failure of Frontline Therapy

Active, not recruiting
1b
15
US
Nivolumab, Opdivo, Autologous CD30.CAR-T, CD30-directed CAR-T cells, Fludarabine, Fludara, Bendamustine, Bendeka, Treanda
Tessa Therapeutics, Bristol-Myers Squibb
Classical Hodgkin Lymphoma, Hodgkin Disease Refractory, Hodgkin Disease Recurrent
12/25
12/37
CARCD30, NCT01192464: EBV CTLs Expressing CD30 Chimeric Receptors For CD 30+ Lymphoma

Active, not recruiting
1
18
US
autologous CAR.CD30 EBV specific-CTLs, CD30 EBV CTL
Baylor College of Medicine, Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital Research Institute
Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma
05/12
10/33
NCT00368082: Autologous/Allogeneic TGFbeta-resistant LMP-specific CTL, Lymphoma (TGF-beta)

Active, not recruiting
1
8
US
TGFbeta resistant LMP-specific CTLs, TGF-b Resistant LMP2A-Specific Cytotoxic T-Lymphocytes
Baylor College of Medicine, The Methodist Hospital Research Institute, Center for Cell and Gene Therapy, Baylor College of Medicine
Lymphoma, Hodgkin's Disease, Relapse, Lymphoma, Non-Hodgkin
09/13
07/31
NCT02065362: TGF-beta Resistant Cytotoxic T-lymphocytes in Treatment of EBV-positive Nasopharyngeal Carcinoma / RESIST-NPC

Active, not recruiting
1
14
US
DNR.NPC-specific T cells, DNR.NPC-specific T cells + cyclophosphamide + fludarabine
Baylor College of Medicine, National Cancer Institute (NCI), Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital Research Institute
EBV-positive Nasopharyngeal Carcinoma
03/17
02/33
GRALE, NCT01555892: Cytotoxic T-Lymphocytes for EBV-positive Lymphoma,

Recruiting
1
136
US
EBV-specific T cells: A, LMP, BARF1 and EBNA1 specific CTLs, EBV-specific T cells: B
Baylor College of Medicine, The Methodist Hospital Research Institute, Center for Cell and Gene Therapy, Baylor College of Medicine, National Institutes of Health (NIH), National Cancer Institute (NCI)
Hodgkin's Disease, Non-Hodgkin's Lymphoma, Lymphoproliferative Disease, Lymphoma
03/26
07/26
NCT02287311: Most Closely Matched 3rd Party Rapidly Generated LMP, BARF1 And EBNA1 Specific CTL, EBV-Positive Lymphoma (MABEL)

Active, not recruiting
1
38
US
MABEL CTLs, LMP, BARF-1 and EBNA1 specific cytotoxic T lymphocytes, MABEL Cytotoxic T cells, Cyclophosphamide, Cytoxan, Fludarabine, Fludara
Baylor College of Medicine, Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital Research Institute
Hodgkin Disease, Non-Hodgkin Lymphoma, Severe Chronic Active Epstein Barr Virus, T/NK-lymphoproliferative Disease, Nasopharyngeal Carcinoma, Smooth Muscle Tumor
01/24
03/29
NCT06598332: 5-Azacytidine with Steroids for Gastrointestinal GVHD (5-AZA for GVHD)

Not yet recruiting
1
20
US
5-Azacytidine
Baylor College of Medicine, The Methodist Hospital Research Institute, Center for Cell and Gene Therapy, Baylor College of Medicine
Graft-Versus-Host Disease(GVHD)
03/28
02/29
EAP CHALLAH, NCT01945619: Allogeneic Virus-Specific Cytotoxic T-Lymphocytes(CTL), Persistent/Recurrent Viral Infection Post-HSCT

No Longer Available
N/A
US
Trivirus-Specific CTLs
Baylor College of Medicine, Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital Research Institute, Children's Hospital Los Angeles, Duke University, Hackensack Meridian Health, New York Medical College, University of Texas Southwestern Medical Center, Children's National Research Institute, Johns Hopkins All Children's Hospital
EBV Infection, CMV Infection, Adenoviral Infection
 
 
Bollard, Catherine
SUN-RAY, NCT06358638: Sickle Cell Disease Transplant Using a Nonmyeloablative Approach for Patients With Anti-donor Red Cell AntibodY

Recruiting
2
12
US
Daratumumab, Darzalex, Alemtuzumab, Campath-1H, Sirolimus, Rapamune, Total Body Irradiation, TBI
Children's National Research Institute, Alberta Children's Hospital, The Hospital for Sick Children, Levine Children's Hospital, Ann & Robert H Lurie Children's Hospital of Chicago, Nationwide Children's Hospital, Children's Hospital at Montefiore, Doris Duke Charitable Foundation, Janssen Pharmaceuticals
Sickle Cell Disease
09/44
09/54
NCT01945814: Allogeneic Multivirus - Directed Cytotoxic T Lymphocytes (CTL)

Active, not recruiting
1
27
US
CTL for CMV seropositive donors, CTL for CMV naïve donors
Catherine Bollard
EBV, CMV, Adenovirus
10/18
04/25
NCT02510417: Allogeneic Virus-specific T Cell Lines (VSTs)

Active, not recruiting
1
31
US
VSTs
Catherine Bollard
Viral Infections After HSCT
04/25
04/25
ALCI2, NCT01956084: Cytotoxic T Cells to Treat Relapsed EBV-positive Lymphoma

Completed
1
10
US
LMP1/2 CTLs (Group A), LMP1/2 CTLs (Group B)
Catherine Bollard
Hodgkin Disease, Non Hodgkin Lymphoma, Lymphoepithelioma, Severe Chronic Active EBV Infection Syndrome (SCAEBV), Leiomyosarcoma
11/17
10/19
Fisher, Michael
NCT04576117: A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma

Recruiting
3
300
Canada, US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Selumetinib Sulfate, AZD-6244 Hydrogen Sulfate, AZD6244 Hydrogen Sulfate, AZD6244 Hydrogen Sulphate, Koselugo, Selumetinib Sulphate, Vinblastine Sulfate, 29060 LE, 29060-LE, Exal, Velban, Velbe, Velsar, VINCALEUKOBLASTINE
National Cancer Institute (NCI)
Recurrent Low Grade Astrocytoma, Recurrent WHO Grade 2 Glioma, Refractory Low Grade Astrocytoma, Refractory Low Grade Glioma, Refractory WHO Grade 1 Glioma
12/26
12/26
NCT04166409: A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

Recruiting
3
220
Canada, US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, JM8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Selumetinib Sulfate, AZD-6244 Hydrogen Sulfate, AZD6244 Hydrogen Sulfate, AZD6244 Hydrogen Sulphate, Koselugo, Selumetinib Sulphate, Vincristine Sulfate, Kyocristine, Leurocristine Sulfate, Leurocristine, sulfate, Oncovin, Vincasar, Vincosid, Vincrex, Vincristine, sulfate
National Cancer Institute (NCI)
Low Grade Astrocytoma, Low Grade Glioma, Metastatic Low Grade Astrocytoma, Metastatic Low Grade Glioma
12/26
12/26
NCT03871257: A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma

Recruiting
3
290
Canada, US
Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, JM8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Selumetinib Sulfate, AZD-6244 Hydrogen Sulfate, AZD6244 Hydrogen Sulfate, AZD6244 Hydrogen Sulphate, Koselugo, Selumetinib Sulphate, Vincristine Sulfate, Kyocristine, Leurocristine Sulfate, Leurocristine, sulfate, Oncovin, Vincasar, Vincosid, Vincrex, Vincristine, sulfate
National Cancer Institute (NCI)
Low Grade Glioma, Neurofibromatosis Type 1, Visual Pathway Glioma
05/27
05/27
NCT06161974: Study of Olutasidenib and Temozolomide in HGG

Not yet recruiting
2
60
Europe, Canada, US, RoW
Olutasidenib + TMZ
Rigel Pharmaceuticals, Nationwide Children's Hospital
High Grade Glioma, Astrocytoma, Astrocytoma, Grade III, Astrocytoma, Grade IV, Diffuse Intrinsic Pontine Glioma, WHO Grade III Glioma, WHO Grade IV Glioma, Metastatic Brain Tumor, Diffuse Midline Glioma, H3 K27M-Mutant, Thalamus Tumor, Spinal Tumor, IDH1 Mutation, IDH1 R132, IDH1 R132C, IDH1 R132H, IDH1 R132S, IDH1 R132G, IDH1 R132L, Oligodendroglioma
06/29
06/35
NCT05233397: ACTEMRA® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma

Recruiting
2
38
Canada, US, RoW
Tocilizumab, ACTEMRA®
Nationwide Children's Hospital, Children's Hospital Colorado
Adamantinomatous Craniopharyngioma, Recurrent Adamantinomatous Craniopharyngioma
12/25
12/27
INSPIRE-NF1, NCT06541847: A Phase 2, Open-Label Study to Evaluate the Safety and Effects of HLX-1502 in Patients with Neurofibromatosis Type 1

Recruiting
2
20
US
HLX-1502
Healx Limited
Neurofibromatosis Type 1
07/26
08/27
NF111, NCT04544007: A Phase II Trial of Poly-ICLC for Low-Grade Gliomas

Recruiting
2
20
US
Poly ICLC
University of Alabama at Birmingham, Children's Healthcare of Atlanta, Children's Hospital Los Angeles
NF1, Low-grade Glioma
02/26
02/27
NCT05286788: MEKTOVI® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma

Recruiting
2
38
Canada, US, RoW
Binimetinib Oral Tablet [Mektovi], MEKTOVI
Nationwide Children's Hospital, Children's Hospital Colorado
Adamantinous Craniopharyngioma, Recurrent Adamantinomatous Craniopharyngioma
04/25
04/27
LEAHRN, NCT02724579: Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma

Active, not recruiting
2
45
Canada, US, RoW
Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Asta B 518, B 518, B-518, B518, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR 138719, WR- 138719, WR-138719, WR138719, Laboratory Biomarker Analysis, Lomustine, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea, 1-Nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-, Belustin, Belustine, CCNU, Cecenu, CeeNU, Chloroethylcyclohexylnitrosourea, Citostal, Gleostine, Lomeblastin, Lomustinum, Lucostin, Lucostine, N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea, Prava, RB-1509, WR-139017, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Radiation Therapy, Cancer Radiotherapy, Energy Type, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation, Vincristine, LCR, Leurocristine, VCR, Vincrystine, Vincristine Sulfate, Kyocristine, Leurocristine Sulfate, Leurocristine, sulfate, Oncovin, Vincasar, Vincosid, Vincrex, Vincristine, sulfate
Children's Oncology Group, National Cancer Institute (NCI)
Medulloblastoma
06/27
06/27
NCT02840409 / 2017-001982-26: Vinblastine +/- Bevacizumab in Children With Unresectable or Progressive Low Grade Glioma (LGG)

Active, not recruiting
2
109
Canada, US, RoW
Vinblastine, Bevacizumab, Avastin
The Hospital for Sick Children, Hoffmann-La Roche
Low Grade Glioma
07/24
08/26
NCT05096481: PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

Recruiting
2
120
US
PEP-CMV, Temozolomide, TMZ, Tetanus Diphtheria Vaccine, Td
Nationwide Children's Hospital
High Grade Glioma, Diffuse Intrinsic Pontine Glioma, Recurrent Medulloblastoma
06/28
06/30
NCT05843253: Study of Ribociclib and Everolimus in HGG and DIPG

Recruiting
2
100
Europe, Canada, US, RoW
Ribociclib, Kisqali, Everolimus, Afinitor
Nationwide Children's Hospital, Novartis
High Grade Glioma, Diffuse Intrinsic Pontine Glioma, Anaplastic Astrocytoma, Glioblastoma, Glioblastoma Multiforme, Diffuse Midline Glioma, H3 K27M-Mutant, Metastatic Brain Tumor, WHO Grade III Glioma, WHO Grade IV Glioma
08/28
08/34
NCT05839379: Targeted Pediatric High-Grade Glioma Therapy

Recruiting
2
450
Europe, Canada, US, RoW
Nationwide Children's Hospital
High Grade Glioma, Diffuse Intrinsic Pontine Glioma, Anaplastic Astrocytoma, Glioblastoma, Glioblastoma Multiforme, Diffuse Midline Glioma, H3 K27M-Mutant, Metastatic Brain Tumor, WHO Grade III Glioma, WHO Grade IV Glioma
08/29
08/34
NCT05253131: Trial of Selumetinib and Bromodomain Inhibitor With Durvalumab for Sarcomas

Not yet recruiting
2
41
US
Selumetinib, BI, Durvalumab
University of Alabama at Birmingham, United States Department of Defense
MPNST, NF1, Sarcoma
06/30
06/31
NCT05278208: Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

Recruiting
1/2
65
US
LUTATHERA® (Lutetium Lu 177 dotatate), Lutathera
Nationwide Children's Hospital, Children's Hospital Medical Center, Cincinnati
High Grade Glioma, Meningioma, Embryonal Tumor, Medulloblastoma, Anaplastic Ependymoma, Recurrent Diffuse Intrinsic Pontine Glioma, Recurrent Malignant Glioma, Recurrent Medulloblastoma, Recurrent Primary Central Nervous System Neoplasm, Refractory Diffuse Intrinsic Pontine Glioma, Refractory Malignant Glioma, Refractory Medulloblastoma, Refractory Primary Central Nervous System Neoplasm
11/27
11/27
NCT03605550: A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma

Active, not recruiting
1
64
US
PTC596, Radiotherapy
Nationwide Children's Hospital, PTC Therapeutics
High Grade Glioma, Diffuse Intrinsic Pontine Glioma
03/24
03/29
NCT06333899: Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

Not yet recruiting
1
15
Europe, Canada, US, RoW
Lorlatinib, LOBRENA, Lorlatinib with chemotherapy1, Lorlatinib with chemotherapy 2, Lorlatinib post Radiation
Nationwide Children's Hospital, Pfizer
High Grade Glioma, Diffuse Intrinsic Pontine Glioma, Anaplastic Astrocytoma, Infant Type Hemispheric Glioma, Glioblastoma, Glioblastoma Multiforme, WHO Grade III Glioma, WHO Grade IV Glioma, Diffuse Midline Glioma, H3K27-altered
09/27
09/34
CONNECT1903, NCT04655404: A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

Recruiting
1
15
Europe, Canada, US, RoW
Larotrectinib, Larotrectinib surgical
Nationwide Children's Hospital
High Grade Glioma, Diffuse Intrinsic Pontine Glioma
12/25
12/25
EASY-AS, NCT04204915: The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study

Recruiting
N/A
2844
Europe, RoW
Aortic valve replacement
University of Leicester, University of Auckland, New Zealand, University Hospitals, Leicester, The University of Western Australia
Aortic Stenosis
04/31
04/31
Shneider, Benjamin
NCT02055768: Safety and Efficacy Study of the Intestinal Bile Acid Transport (IBAT) in the Reduction of Pruritus in ALGS

Not yet recruiting
2
24
US, Canada
LUM001 70 ug/kg/day, Intestinal Bile Acid Transport (IBAT) Inhibitor, Placebo, LUM001 140 ug/kg/day
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Lumena Pharmaceuticals, Inc.
Pruritus, Alagille Syndrome
02/15
05/15
NCT02922751: FibroScan™ in Pediatric Cholestatic Liver Disease (FORCE)

Completed
N/A
552
Canada, US
Liver Stiffness Measurement (LSM), FibroScan™
Arbor Research Collaborative for Health, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Biliary Atresia, Alagille Syndrome, Alpha1 Anti-Trypsin Deficiency, Portal Hypertension, Liver Fibrosis, Cholestasis
12/22
12/22
PROBE, NCT00061828: A Prospective Database of Infants With Cholestasis

Recruiting
N/A
1000
Canada, US
Arbor Research Collaborative for Health, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Biliary Atresia, Neonatal Cholestasis
05/29
05/29
BASIC, NCT00345553: Biliary Atresia Study in Infants and Children

Recruiting
N/A
1265
Canada, US
Arbor Research Collaborative for Health, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Biliary Atresia
05/29
05/29
LOGIC, NCT00571272: Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis

Suspended
N/A
1675
Canada, US
Arbor Research Collaborative for Health, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Liver Diseases, Alagille Syndrome, Alpha 1-Antitrypsin Deficiency
05/29
05/29
 

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