| Russell, Stuart J |
LUX-Dx TRENDS, NCT04790344: Evaluates Diagnostics Sensors in Heart Failure Patients Receiving Boston Scientific's Investigational ICM System. |
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| Active, not recruiting | N/A | 525 | US | Investigational LUX-Dx ICM Implant | Boston Scientific Corporation | Heart Failure | 05/26 | 06/26 | | |
| Boggess, Kim |
DECIDE, NCT06445946: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes |
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| Recruiting | 4 | 1572 | US | Metformin, Insulin | Ohio State University, Patient-Centered Outcomes Research Institute, The George Washington University Biostatistics Center | Gestational Diabetes Mellitus, Pregnancy, High Risk | 12/29 | 12/30 | | |
ASPIRIN, NCT06468202: Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: TRIAL |
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| Recruiting | 4 | 10742 | US | Aspirin 81 mg, Aspirin 162 mg | Ohio State University, Patient-Centered Outcomes Research Institute, Northwestern University, Preeclampsia Foundation | Hypertensive Disorders of Pregnancy, Preeclampsia, Gestational Hypertension | 01/29 | 02/30 | | |
| Recruiting | 3 | 8000 | US | Azithromycin Injection, Placebo, Standard of Care Preoperative antibiotics | The George Washington University Biostatistics Center, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), University of Alabama at Birmingham | Obstetrical Complications, Labor and Delivery Complication, Cesarean Delivery | 11/27 | 03/28 | | |
NCT04521712: Postpartum Glycemia in Women At Risk for Persistent Hyperglycemia |
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| Completed | N/A | 40 | US | 2-hour 75-g oral glucose tolerance test and Dexcom G6 Pro continuous glucose monitor | University of Alabama at Birmingham, University of North Carolina, Chapel Hill | Gestational Diabetes | 12/24 | 12/24 | | |
| Not yet recruiting | N/A | 300 | US | CGM device - Metformin group, CGM device - Insulin group | Ohio State University, The George Washington University Biostatistics Center, DexCom, Inc. | Gestational Diabetes Mellitus, Pregnancy, High Risk | 12/29 | 12/30 | | |
| Not yet recruiting | N/A | 564 | US | CGM | University of Alabama at Birmingham, National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Type 2 Diabetes Mellitus (T2DM), Pregnancy | 02/29 | 07/29 | | |
| Anderson, Barbara J |
| Recruiting | 3 | 3200 | Europe, Canada, US | Antiplatelet-only strategy, Oral Anticoagulant plus background antiplatelet therapy | Icahn School of Medicine at Mount Sinai, National Heart, Lung, and Blood Institute (NHLBI), Vanderbilt University Medical Center | Atrial Fibrillation, Stroke, Bleeding | 06/25 | 06/25 | | |
NCT01858168: Phase I Study of Olaparib and Temozolomide for Ewings Sarcoma or Rhabdoomyosarcoma |
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| Active, not recruiting | 1 | 93 | US | Olaparib, AZD2281, Temozolomide, Temodal, SCH52365, Temodar, Irinotecan, Camptosar | Massachusetts General Hospital | Ewing Sarcoma, Rhabdomyosarcoma | 11/24 | 12/24 | | |
| Recruiting | N/A | 200 | US | SelfWrap Bioabsorbable Perivascular Wrap, SelfWrap, Untreated AVF Control, Standard of Care | VenoStent | Chronic Kidney Diseases, End Stage Renal Disease, Arteriovenous Fistula, Hemodialysis Access Failure, ESRD, Vascular Access Complication, Renal Failure, Catheter Complications, Catheter Dysfunction, Renal Insufficiency | 06/25 | 12/27 | | |
| Recruiting | N/A | 842 | Canada, US | CardioGard Embolic Protection Cannula, Standard Aortic Cannula | Icahn School of Medicine at Mount Sinai, National Heart, Lung, and Blood Institute (NHLBI) | Delirium, Ischemic Stroke, Acute Kidney Injury, Heart Valve Disease, Coronary Artery Disease | 04/27 | 04/27 | | |
| D'Alessandro, David |
| Recruiting | 3 | 3200 | Europe, Canada, US | Antiplatelet-only strategy, Oral Anticoagulant plus background antiplatelet therapy | Icahn School of Medicine at Mount Sinai, National Heart, Lung, and Blood Institute (NHLBI), Vanderbilt University Medical Center | Atrial Fibrillation, Stroke, Bleeding | 06/25 | 06/25 | | |
| Recruiting | N/A | 10 | US | Impella BTR | Abiomed Inc. | Heart Failure, Acute Decompensated Heart Failure | 10/23 | 01/24 | | |
| Active, not recruiting | N/A | 1017 | US | Impella 5.5 | Abiomed Inc. | Cardiogenic Shock, Acute Decompensated Heart Failure | 03/25 | 03/25 | | |
| Enrolling by invitation | N/A | 100 | US | Impella 5.5 with SmartAssist | Abiomed Inc. | Left Ventricular Dysfunction | 06/25 | 09/25 | | |
| Active, not recruiting | N/A | 350 | US | OCS Heart System | TransMedics | Transplant | 12/25 | 12/29 | | |
| Recruiting | N/A | 100000 | US | OCS Heart | TransMedics | Heart Transplant | 08/29 | 08/33 | | |
| Recruiting | N/A | 6500 | Europe, Canada, US | AtriClip LAA Exclusion System | AtriCure, Inc., Population Health Research Institute | Ischemic Stroke, Systemic Embolism | 12/31 | 04/32 | | |
| Rao, Siddhartha |
| Completed | N/A | 133 | US | AngioSafe Peripheral CTO Crossing System | AngioSafe, Inc., Veranex, Inc. | Peripheral Artery Occlusion, Peripheral Arterial Disease | 04/23 | 06/23 | | |
NCT06477965: Embo Registry; National Registry for Artery Embolization |
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| Recruiting | N/A | 1000 | US | Artery Embolization, Genicular Artery Embolization, GAE | Vascular Solutions of North Carolina | Chronic Pain, Osteoarthritis, Knee, Osteoarthritis Thumb, Osteoarthritis Shoulder, Pain, Chronic, Tendonitis Elbow, Tendonitis Shoulder, Tendonitis;Achilles, Tenosynovitis | 07/27 | 07/29 | | |
| TBD, TBD |
| Active, not recruiting | 3 | 110 | Europe, Canada, US, RoW | AL001, Placebo, Open label - AL001 | Alector Inc. | Frontotemporal Dementia | 09/25 | 10/27 | | |
| Recruiting | 2/3 | 60 | US | Monoclonal Antibody (Humanized Anti-CD52), Tacrolimus, Penile Allotransplantation | Johns Hopkins University | Amputation, Wounds and Injuries, Amputation, Traumatic, Urologic Surgical Procedures, Male, Amputation, Traumatic/Surgery, Penis/Transplantation, Penis/Surgery, Penis/Injuries, Congenital Anomaly, Male Genitalia | 06/34 | 06/39 | | |
NCT04105452: Study to Evaluate PL8177 in Subjects With Non Infectious Uveitis (NIU) |
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| Not yet recruiting | 2 | 40 | NA | PL8177 | Palatin Technologies | Non-infectious Uveitis | 05/20 | 09/20 | | |
NEO-SURG, NCT06449313: Neoadjuvant Chemo-Immunotherapy and Surgical Resection in Locally Advanced Non-small Cell Lung Cancer With N3 Lymph Node Involvement |
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| Not yet recruiting | 2 | 21 | US | Cemiplimab-Rwlc, Libtayo | Georgetown University, Regeneron Pharmaceuticals | Non-small Cell Lung Cancer Stage III | 12/27 | 09/32 | | |
| Completed | 2 | 381 | Europe, Canada, US, RoW | AL002, Placebo | Alector Inc., AbbVie | Alzheimer Disease | 08/24 | 09/24 | | |
| Active, not recruiting | 2 | 188 | Europe, Canada, US, RoW | AL002 | Alector Inc., AbbVie | Alzheimer's Disease | 09/25 | 12/25 | | |
| Recruiting | 2 | 30 | US | Deceased donor hand transplantation, Bone marrow cell-based therapy & single-drug immunosuppression. | Johns Hopkins University, Armed Forces Institute of Regenerative Medicine, U.S. Army Medical Research Acquisition Activity | Amputation, Traumatic, Wounds and Injuries, Hand Injuries | 06/36 | 06/36 | | |
| Recruiting | 2 | 15 | US | Bone marrow cell-based therapy & 1-drug immunosuppression., Deceased donor face transplantation | Johns Hopkins University | Facial Injuries, Traumatic Wounds and Injuries, Craniofacial Injuries, Craniofacial Defects, Facial Transplantation, Facial Deformity | 08/26 | 08/31 | | |
| Recruiting | 2 | 30 | US | Gemcitabine, Gemzar, Nab paclitaxel, Abraxane, Proglumide, Milid, Placebo, Avicel capsules | Georgetown University | Metastatic Pancreatic Cancer | 07/27 | 11/27 | | |
| Recruiting | N/A | 40 | US | Genepro Generation 3 Protein, Whey Protein | Musclegen Research, Inc., WakeMed Bariatric Surgery & Weight Loss Center | Absorption; Disorder, Protein, Protein Malabsorption, Protein Intolerance | 01/21 | 02/21 | | |
PATHFINDER I, NCT04229563: Post-Market Registry of AURYON™ Atherectomy Device in Subjects Affected With Infrainguinal Peripheral Artery Disease |
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| Active, not recruiting | N/A | 104 | US | AURYON™ System | Angiodynamics, Inc. | Infrainguinal Peripheral Artery Disease, Peripheral Arterial Disease, PAD | 03/21 | 04/23 | | |
CAR, NCT06215105: Complex Aneurysm Registry - Real-World Evidence Data Collection Intracranial Aneurysm Treatment Devices |
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| Enrolling by invitation | N/A | 750 | US | Intracranial Aneurysm Devices | Microvention-Terumo, Inc. | Aneurysm Cerebral | 01/29 | 01/29 | | |
NCT05876078: DORAYA-HF OUS Assessment of the Doraya Catheter for the Treatment of ADHF Patients With Insufficient Response to Diuretics |
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| Recruiting | N/A | 35 | Europe, RoW | Doraya catheter | Revamp Medical Ltd. | Acute Decompensated Heart Failure | 12/25 | 04/26 | | |
| Not yet recruiting | N/A | 529 | NA | KAMRA Inlay | AcuFocus, Inc. | Presbyopia | 01/26 | 01/26 | | |
NCT03400345: Human Upper Extremity Allotransplantation: F/U Protocol |
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| Recruiting | N/A | 60 | US | | Johns Hopkins University | Amputation, Traumatic, Wounds and Injury, Hand Injuries | 07/36 | 07/36 | | |
| Recruiting | N/A | 3000 | Europe, RoW | The Paradise Ultrasound Renal Denervation System | ReCor Medical, Inc. | Hypertension | 12/30 | 12/31 | | |
| Recruiting | N/A | 500000 | US | No intervention | RAD-AID International, BioClinica, Inc., Google Inc. | COVID-19 | 03/25 | 03/25 | | |
| DeMeo, Stephen D |
| Recruiting | N/A | 3000 | Canada, US | Personalized Intubation Safety (PINS) Bundle, PINS Bundle | Children's Hospital of Philadelphia, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Infant, Intubation Complication | 04/27 | 06/27 | | |
| Recruiting | N/A | 150000 | Europe, Canada, Japan, US, RoW | | Children's Hospital of Philadelphia, Agency for Healthcare Research and Quality (AHRQ) | Failed or Difficult Intubation, Sequela, Intubation; Difficult, Intubation Complication | 01/30 | 01/30 | | |
| Silver, Marc |
NCT04496518: Personalized Therapy Study - Intrinsic Antitachycardia Pacing Post-Approval Study (iATP PAS) |
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| Active, not recruiting | N/A | 2200 | Europe, US | Intrinsic Antitachycardia Pacing (iATP) Therapy | Medtronic | Ventricular Tachycardia | 01/25 | 01/27 | | |
NCT04489225: Personalized Therapy Study - HFRS (TriageHF) Post Approval Study |
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| Active, not recruiting | N/A | 2200 | Europe, US | Observational | Medtronic | Heart Failure | 01/25 | 01/27 | | |
ASQ, NCT04024943: Personalized Therapy Study - Attain Stability Quad Post-Approval Study |
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| Active, not recruiting | N/A | 1092 | Europe, US | Quadripolar LV Lead, Medtronic CRT-P, Medtronic CRT-D | Medtronic | Heart Failure | 01/27 | 04/27 | | |
| Norton, Rhonda |
| Completed | 4 | 30 | US | CardiaMend with the Addition of Amiodarone | WakeMed Health and Hospitals, Helios Cardio Inc | Post Operative Atrial Fibrillation | 02/24 | 02/24 | | |
| Recruiting | 3 | 3200 | Europe, Canada, US | Antiplatelet-only strategy, Oral Anticoagulant plus background antiplatelet therapy | Icahn School of Medicine at Mount Sinai, National Heart, Lung, and Blood Institute (NHLBI), Vanderbilt University Medical Center | Atrial Fibrillation, Stroke, Bleeding | 06/25 | 06/25 | | |
NCT05614869: Continuous Treatment With PREVENA Therapy for 14 Days |
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| Recruiting | N/A | 353 | US | Prevena Plus Incision Management System with Prevena Dressings | KCI USA, Inc, Solventum US LLC, 3M | Abdominal Surgery, Orthopedic Surgery, Cardiovascular Surgery, Vascular Surgery | 03/27 | 05/27 | | |
| Recruiting | N/A | 6500 | Europe, Canada, US | AtriClip LAA Exclusion System | AtriCure, Inc., Population Health Research Institute | Ischemic Stroke, Systemic Embolism | 12/31 | 04/32 | | |
| Woodard, Elizabeth |
| Recruiting | N/A | 150000 | Europe, Canada, Japan, US, RoW | | Children's Hospital of Philadelphia, Agency for Healthcare Research and Quality (AHRQ) | Failed or Difficult Intubation, Sequela, Intubation; Difficult, Intubation Complication | 01/30 | 01/30 | | |
| Wood, Frances |
| Completed | 3 | 3506 | Europe, Canada, US, RoW | Red Blood Cell Transfusion | Rutgers, The State University of New Jersey, University of Pittsburgh, National Heart, Lung, and Blood Institute (NHLBI) | Myocardial Infarction, Anemia | 05/23 | 10/23 | | |
| Withdrawn | N/A | 60 | US | SSO2 Downstream System, PCI + Impella | TherOx | Cardiogenic Shock, STEMI | 01/24 | 06/25 | | |
| Williams, Judson |
| Completed | 4 | 30 | US | CardiaMend with the Addition of Amiodarone | WakeMed Health and Hospitals, Helios Cardio Inc | Post Operative Atrial Fibrillation | 02/24 | 02/24 | | |
| Recruiting | 3 | 3200 | Europe, Canada, US | Antiplatelet-only strategy, Oral Anticoagulant plus background antiplatelet therapy | Icahn School of Medicine at Mount Sinai, National Heart, Lung, and Blood Institute (NHLBI), Vanderbilt University Medical Center | Atrial Fibrillation, Stroke, Bleeding | 06/25 | 06/25 | | |
| Recruiting | N/A | 6500 | Europe, Canada, US | AtriClip LAA Exclusion System | AtriCure, Inc., Population Health Research Institute | Ischemic Stroke, Systemic Embolism | 12/31 | 04/32 | | |
| Dewan, Maya |
| Active, not recruiting | N/A | 5 | US | SAMURAI PICU Bundle, SAMURAI Bundle | Children's Hospital Medical Center, Cincinnati, Children's Hospital of Philadelphia, Agency for Healthcare Research and Quality (AHRQ) | In-hospital Cardiac Arrest, Cardiopulmonary Resuscitation | 01/29 | 01/29 | | |
| Recruiting | N/A | 5000 | Europe, Canada, Japan, US, RoW | | Children's Hospital of Philadelphia, Zoll Medical Corporation | Cardiac Arrest, Cardiopulmonary Arrest | 01/28 | 01/30 | | |
| Recruiting | N/A | 150000 | Europe, Canada, Japan, US, RoW | | Children's Hospital of Philadelphia, Agency for Healthcare Research and Quality (AHRQ) | Failed or Difficult Intubation, Sequela, Intubation; Difficult, Intubation Complication | 01/30 | 01/30 | | |
| Treasure, Charles |
| Recruiting | 3 | 1328 | Europe, Canada, US, RoW | Plozasiran Injection, ARO-APOC3, Placebo | Arrowhead Pharmaceuticals | Hypertriglyceridemia | 07/26 | 10/26 | | |
| Recruiting | 3 | 405 | Europe, Canada, US, RoW | Plozasiran Injection, ARO-APOC3, Placebo | Arrowhead Pharmaceuticals | Severe Hypertriglyceridemia | 07/26 | 10/26 | | |
| Active, not recruiting | 3 | 14013 | Europe, Canada, US, RoW | Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL, KJX839, Placebo in 1.5ml | Novartis Pharmaceuticals | Primary Prevention of Atherosclerotic Cardiovascular Disease | 04/29 | 04/29 | | |
LUX-Dx TRENDS, NCT04790344: Evaluates Diagnostics Sensors in Heart Failure Patients Receiving Boston Scientific's Investigational ICM System. |
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| Active, not recruiting | N/A | 525 | US | Investigational LUX-Dx ICM Implant | Boston Scientific Corporation | Heart Failure | 05/26 | 06/26 | | |
