| PISON, Christophe |
| Recruiting | 4 | 220 | Europe | Benralizumab Prefilled Syringe, Transcriptomic | Nantes University Hospital, AstraZeneca, Ministère de la Santé - France | Asthma; Eosinophilic, Severe Asthma | 10/26 | 11/26 | | |
EXADOM, NCT03474575: Early Supported Discharge and Enhanced Homecare After Emergency Department Admission for Acute Exacerbation of COPD |
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| Completed | N/A | 84 | Europe | Prevention | University Hospital, Grenoble, AGIR à Dom | COPD | 10/23 | 12/23 | | |
| Completed | N/A | 203 | Europe | Oral anticoagulant treatment, warfarin (Coumadine®), fluindione (Préviscan®), acenocoumarol (Sintrom®) | Centre Hospitalier Universitaire de Saint Etienne | Pulmonary Arterial Hypertension | 09/22 | 09/23 | | |
| Completed | N/A | 49 | Europe | Rehabilitation, Supervised rehabilitation | Centre Hospitalier Universitaire de Saint Etienne, Ministry of Health, France | Pulmonary Arterial Hypertension | 12/22 | 01/24 | | |
| Cracowski, Claire |
MicroTC, NCT04597879: Impact of Severe Brain Injury on Neuro-vascular and Endothelial Regulation of Peripheral Microcirculation. |
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| Recruiting | N/A | 30 | Europe | | University Hospital, Grenoble | Severe Traumatic Brain Injury, Trauma | 08/21 | 03/23 | | |
| Pépin, Jean-Louis JP |
keePaOSA, NCT04875897: Efficacy and Safety of keepMED Positive Airway Pressure Device in Patients With Obstructive Sleep Apnea |
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| Not yet recruiting | N/A | 65 | NA | keepMED PAP device | keepMED Ltd., CRI-The Clinical Research Institute GmbH | Obstructive Sleep Apnea | 01/22 | 02/22 | | |
SLEEPCONNECT, NCT04054180: Multimodal Remote Monitoring and Integrated Educational Program in OSA Patients Initiating Continuous Positive Airway Pressure (CPAP): |
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| Terminated | N/A | 41 | Europe | CPAP associated with connected devices: blood pressure monitor , scales and activity monitor | University Hospital, Grenoble, SEFAM MEDICAL (Villiers les Nancy, France) | Obstructive Sleep Apnea Syndrome | 01/24 | 02/24 | | |
PWV follow-up, NCT04704401: Long-Term Follow-up in Patients Included in the Meta-analysis "Sleep Apnea Syndrome and Arterial Stiffness" |
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| Recruiting | N/A | 893 | Europe | Questionnaire | University Hospital, Grenoble | Sleep Apnea | 10/25 | 10/25 | | |
| Recruiting | N/A | 500 | Europe | Questionnaire | University Hospital, Grenoble | Sleep Apnea | 11/25 | 11/25 | | |
NCT05698602: Safety and Performance of NivolisMonitor and NivolisAnton for Monitoring Patients on Ventilatory Assistance at Home |
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| Active, not recruiting | N/A | 10 | Europe | NivolisMonitor, NivolisAnton | VIVARDIS | Respiratory Insufficiency, Respiratory Failure, Home Monitoring | 07/25 | 12/25 | | |
| Recruiting | N/A | 500 | Europe | | University Hospital, Grenoble, Act For Chronic Diseases, HP2 laboratory INSERM U1042, University Grenoble Alps | Obesity, Obstructive Sleep Apnea, Sleep | 01/24 | 01/24 | | |
| Not yet recruiting | N/A | 176 | Europe | PWV measurement | Withings | Vascular Stiffness | 05/24 | 11/24 | | |
| Recruiting | N/A | 1600 | Europe | | Institut National de la Santé Et de la Recherche Médicale, France | Cardiomyopathy, Diabetic | 10/27 | 10/27 | | |
| Recruiting | N/A | 1620 | Europe | Treatment according to standard care recommandation | University Hospital, Grenoble | Stroke, Sleep-disordered Breathing, Sleep Apnea Syndromes, Sleep Apnea, Obstructive, Sleep Apnea, Central, Fragmentation, Sleep | 06/30 | 06/35 | | |
| Not yet recruiting | N/A | 10000 | NA | Nutritional Psycho-Behavioral Reeducation Program, RNPC Program | Groupe Éthique et Santé, University Grenoble Alps, Novo Nordisk A/S, Lyon Est University | Overweight and Obesity, Cardiovascular Diseases, Metabolic Disease, Diabete Type 2, Sleep Apnea, Obstructive, NAFLD, NASH | 07/30 | 07/30 | | |
| LEVY, Patrick PL |
| Recruiting | N/A | 150 | Europe | | University Hospital, Grenoble | Chronic Obstructive Pulmonary Disease | 11/29 | 12/29 | | |
| PEPIN, Jean-Louis JL |
| Recruiting | 3 | 86 | Europe | bosentan, placebo | University Hospital, Grenoble | Ischemic Optic Neuropathy | 12/23 | 12/25 | | |
PLASTIHC, NCT05210088: PLAsticity, Security and Tolerance to Intermittent Hypoxic Conditioning Following Stroke |
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| Withdrawn | 1/2 | 40 | Europe | Hypoxia, intermittent, Hypoxic conditioning, Hypoxia, Normoxia | University Hospital, Grenoble, Agir pour les maladies chroniques | Stroke, Ischemic, Stroke Sequelae | 01/24 | 01/24 | | |
AT1Home, NCT02796534: Prevalence of Obstructive Sleep Apnea Syndrome in Type 1 Diabetic Patients Treated With Insulin Pump (At1Home) |
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| Completed | N/A | 825 | Europe | Diagnosis of sleep apnea by oxymetry | University Hospital, Grenoble, VitalAire, ResMed | Type 1 Diabetes | 07/18 | 03/23 | | |
| Active, not recruiting | N/A | 395 | Europe | No intervention | University Hospital, Grenoble | COVID-19 | 03/22 | 06/26 | | |
CONNECTOSOM, NCT04777799: Effectiveness and Acceptability of a Digital Solution to Train Specific EEG Frequencies With Neurofeedback for Improving Sleep |
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| Terminated | N/A | 14 | Europe | URGOnight | AdministrateurDRC, Urgotech, University Hospital, Grenoble | Insomnia, Sleep Disorder | 06/22 | 06/22 | | |
TMIRA, NCT04650412: Integrated Care of Co-morbidities vs Standard Care After AHRF in the Intensive Care Unit |
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| Terminated | N/A | 188 | Europe | Bundle of comorbidities care | CTU, Dan Adler is not working anymore at UGeneva, and nobody replaced him. This study is stopped | Acute Hypercapnic Respiratory Failure | 07/22 | 07/22 | | |
EXADOM, NCT03474575: Early Supported Discharge and Enhanced Homecare After Emergency Department Admission for Acute Exacerbation of COPD |
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| Completed | N/A | 84 | Europe | Prevention | University Hospital, Grenoble, AGIR à Dom | COPD | 10/23 | 12/23 | | |
PWV follow-up, NCT04704401: Long-Term Follow-up in Patients Included in the Meta-analysis "Sleep Apnea Syndrome and Arterial Stiffness" |
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| Recruiting | N/A | 893 | Europe | Questionnaire | University Hospital, Grenoble | Sleep Apnea | 10/25 | 10/25 | | |
| Withdrawn | N/A | 45 | NA | CPAP or nasal dilators | University Hospital, Grenoble | Obstructive Sleep Apnea Syndrome, Gut Microbiota | 11/23 | 11/23 | | |
| Recruiting | N/A | 500 | Europe | Questionnaire | University Hospital, Grenoble | Sleep Apnea | 11/25 | 11/25 | | |
| Completed | N/A | 1083 | Europe | | University Hospital, Grenoble, AGIR à Dom | Obstructive Sleep Apnea, Respiratory Failure | 08/22 | 08/22 | | |
OLIGO-SAS, NCT05758324: Study Evaluating the Effect of a Specific Trace Metal Complex Versus Placebo on the Severity of Apnea in Patients With Obstructive Sleep Apnea Syndrome |
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| Not yet recruiting | N/A | 42 | Europe | Nutri PNEA, Placebo | Laboratoires Pronutri, Clin-Experts | Apnea, Obstructive | 01/24 | 01/24 | | |
SUNSAS, NCT05057975: Validation of an Integrated Digital Solution (SUNrise®) Versus Polysomnography for Obstructive Sleep Apnea Diagnosis |
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| Completed | N/A | 848 | Europe | Sunrise, polysomnography | Sunrise, ICUREsearch | Obstructive Sleep Apnea | 10/24 | 10/24 | | |
NCT02346305: Cohort of Respiratory Failure Patients Treated for the First Time With Non-Invasive Ventilation at Home |
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| Recruiting | N/A | 3000 | Europe | Non-invasive ventilation | Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche | Respiratory Insufficiency | 12/24 | 12/24 | | |
| Recruiting | N/A | 400 | Europe | Connected actimeter to measure physical activity in OSA patients, Connected BORA Band to measure physical activity in COPD patients only, IPAQ to evaluated physical activity, Connected scale to measure weight, Connected tensiometer to measure arterial pressure, Connected BORA Band to measure oxygen saturation in COPD patients only, Connected BORA Band to measure heart rate in COPD patients only, Connected BORA Band to measure respiratory rate in COPD patients only, EXASCORE to evaluated COPD severity, Epworth scale to evaluate sleepiness, Pichot scale to evaluate fatigue, Usability questionnaire, SF36 questionnaire | University Hospital, Grenoble, EFCR Department and Sleep Laboratory, Grenoble Alpes University Hospital, Pneumology Department, Verdun Hospital, BIOSENCY compagny, SEFAM compagnie, ADOR - Territorial Support Network, Device and Tools for Primary Care Teams, PULSY - Regional Support Group for the Development of e-health, eMeuse-Santé consortium | Sleep Apnea, Obstructive, Chronic Obstructive Pulmonary Disease | 12/24 | 02/25 | | |
| Recruiting | N/A | 150 | Europe | | University Hospital, Grenoble | Chronic Obstructive Pulmonary Disease | 11/29 | 12/29 | | |
| Doutreleau, Stéphane |
PLASTIHC, NCT05210088: PLAsticity, Security and Tolerance to Intermittent Hypoxic Conditioning Following Stroke |
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| Withdrawn | 1/2 | 40 | Europe | Hypoxia, intermittent, Hypoxic conditioning, Hypoxia, Normoxia | University Hospital, Grenoble, Agir pour les maladies chroniques | Stroke, Ischemic, Stroke Sequelae | 01/24 | 01/24 | | |
| Terminated | N/A | 65 | Europe | Questionnaires, blood test, Maximal effort test, actigraphy, Neuromuscular evaluation, stool analysis, food diary | Centre Hospitalier Universitaire de Saint Etienne, University of Saint-Etienne, Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques | Chronic Fatigue Syndrome, Intensive Care Unit, Muscle | 07/21 | 08/21 | | |
| Recruiting | N/A | 64 | Europe | Hypoxia and/or Exercise | University Hospital, Grenoble | Hypoxia, Cerebral Hypoxia, Brain Diseases, Exercise, Aging, Cognitive Decline, Healthy Aging | 03/24 | 09/24 | | |
| Recruiting | N/A | 40 | Europe | Medical air, Hyperoxia | University Hospital, Grenoble | Pulmonary Disease, Chronic Obstructive, Heart Failure | 12/25 | 12/25 | | |
| Recruiting | N/A | 180 | Europe | Internal discourses, Non internal discourses | University Hospital, Grenoble | Physical Exertion | 11/25 | 11/25 | | |
| Recruiting | N/A | 150 | Europe | | University Hospital, Grenoble | Chronic Obstructive Pulmonary Disease | 11/29 | 12/29 | | |
| Cracowski, Jean-Luc |
| Terminated | 1/2 | 4 | Europe | Treprostinil iontophoresis, Remodulin® placebo iontophoresis | University Hospital, Grenoble | Diabetic Foot Ulcer | 12/21 | 12/21 | | |
MicroTC, NCT04597879: Impact of Severe Brain Injury on Neuro-vascular and Endothelial Regulation of Peripheral Microcirculation. |
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| Recruiting | N/A | 30 | Europe | | University Hospital, Grenoble | Severe Traumatic Brain Injury, Trauma | 08/21 | 03/23 | | |
NivOSe, NCT03749577: Nutritional Strategies to Increase Nitric Oxide Signaling in Raynaud's Phenomenon |
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| Recruiting | N/A | 30 | Europe | L-citrulline, Beetroot juice, L-citrulline placebo, Denitrated beetroot juice | University Hospital, Grenoble, University Hospital, Rouen | Raynaud Phenomenon | 04/22 | 06/22 | | |
| PEPIN, Jean Louis |
| Recruiting | N/A | 400 | Europe | CPAP, MAD | ResMed | OSA | 10/22 | 10/26 | | |
| Tamisier, Renaud |
| Recruiting | 3 | 86 | Europe | bosentan, placebo | University Hospital, Grenoble | Ischemic Optic Neuropathy | 12/23 | 12/25 | | |
PLASTIHC, NCT05210088: PLAsticity, Security and Tolerance to Intermittent Hypoxic Conditioning Following Stroke |
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| Withdrawn | 1/2 | 40 | Europe | Hypoxia, intermittent, Hypoxic conditioning, Hypoxia, Normoxia | University Hospital, Grenoble, Agir pour les maladies chroniques | Stroke, Ischemic, Stroke Sequelae | 01/24 | 01/24 | | |
| Active, not recruiting | N/A | 395 | Europe | No intervention | University Hospital, Grenoble | COVID-19 | 03/22 | 06/26 | | |
| Completed | N/A | 7 | Europe | Activated Inspire® Upper Airway Stimulation System, Inactivated Inspire® Upper Airway Stimulation System | University Hospital, Grenoble, Inspire Medical Systems, Inc. | Obstructive Sleep Apnea Syndrome | 12/21 | 10/23 | | |
STIMOBIII, NCT02210585: Study of Neuromuscular Electrical Stimulation to Increase Spontaneous Physical Activity in Obesity Patient |
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| Completed | N/A | 73 | Europe | Rehabilitation | University Hospital, Grenoble | Obesity, Number of Steps Per Day < 7000 | 05/24 | 05/24 | | |
| Recruiting | N/A | 62 | Europe | Physical activity intervention | University Hospital, Grenoble, HP2 Laboratory | Obstructive Sleep Apnea | 10/26 | 10/26 | | |
| Terminated | N/A | 65 | Europe | Questionnaires, blood test, Maximal effort test, actigraphy, Neuromuscular evaluation, stool analysis, food diary | Centre Hospitalier Universitaire de Saint Etienne, University of Saint-Etienne, Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques | Chronic Fatigue Syndrome, Intensive Care Unit, Muscle | 07/21 | 08/21 | | |
PWV follow-up, NCT04704401: Long-Term Follow-up in Patients Included in the Meta-analysis "Sleep Apnea Syndrome and Arterial Stiffness" |
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| Recruiting | N/A | 893 | Europe | Questionnaire | University Hospital, Grenoble | Sleep Apnea | 10/25 | 10/25 | | |
| Recruiting | N/A | 500 | Europe | Questionnaire | University Hospital, Grenoble | Sleep Apnea | 11/25 | 11/25 | | |
| Recruiting | N/A | 500 | Europe | | University Hospital, Grenoble, Act For Chronic Diseases, HP2 laboratory INSERM U1042, University Grenoble Alps | Obesity, Obstructive Sleep Apnea, Sleep | 01/24 | 01/24 | | |
SUNSAS, NCT05057975: Validation of an Integrated Digital Solution (SUNrise®) Versus Polysomnography for Obstructive Sleep Apnea Diagnosis |
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| Completed | N/A | 848 | Europe | Sunrise, polysomnography | Sunrise, ICUREsearch | Obstructive Sleep Apnea | 10/24 | 10/24 | | |
| Recruiting | N/A | 70 | Europe | Deem 3 Headband | University Hospital, Grenoble, Dreem, AGIR à Dom | Sleep Apnea, Obstructive Sleep Apnea | 11/25 | 12/25 | | |
| Recruiting | N/A | 250 | Europe | Videoconsultation | University Hospital, Grenoble, University Hospital, Angers | Obstructive Sleep Apnea | 03/26 | 03/26 | | |
| Recruiting | N/A | 150 | Europe | | University Hospital, Grenoble | Chronic Obstructive Pulmonary Disease | 11/29 | 12/29 | | |
| Recruiting | N/A | 1620 | Europe | Treatment according to standard care recommandation | University Hospital, Grenoble | Stroke, Sleep-disordered Breathing, Sleep Apnea Syndromes, Sleep Apnea, Obstructive, Sleep Apnea, Central, Fragmentation, Sleep | 06/30 | 06/35 | | |
| Recruiting | N/A | 300 | Europe | SFRMS/SPLF CPAP-telemonitoring diagnosis/therapeutic algorithm. | University Hospital, Montpellier, ADENE, Montpellier, AGIR à dom, Meylan, ASTEN sante, Pays de la Loire, ELIA medical, Cesson-Sévigné | Obstructive Sleep Apnea | 12/21 | 12/23 | | |
| Recruiting | N/A | 400 | Europe | CPAP, MAD | ResMed | OSA | 10/22 | 10/26 | | |
| Launois, Sandrine H |
SESAME, NCT06578390: Efficacy Investigation of the Medical Device Apneal® on Smartphone for Sleep Apnea-Hypopnea Syndrome Diagnosis |
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| Recruiting | N/A | 500 | Europe | Apneal device | Mitral | Sleep Apnea Syndromes | 04/25 | 04/25 | | |
| Detante, Olivier |
| Not yet recruiting | 2 | 60 | Europe | OTR4132, Placebo | Organ, Tissue, Regeneration, Repair and Replacement, Euraxi Pharma | Endovascular Thrombectomy, Ischemic Cerebrovascular Accident | 03/26 | 03/26 | | |
PLASTIHC, NCT05210088: PLAsticity, Security and Tolerance to Intermittent Hypoxic Conditioning Following Stroke |
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| Withdrawn | 1/2 | 40 | Europe | Hypoxia, intermittent, Hypoxic conditioning, Hypoxia, Normoxia | University Hospital, Grenoble, Agir pour les maladies chroniques | Stroke, Ischemic, Stroke Sequelae | 01/24 | 01/24 | | |
| Recruiting | 1 | 95 | Europe | Adipose derived Stem Cell, ADSC, placebo | University Hospital, Grenoble, Horizon 2020 - European Commission, University Grenoble Alps, Servicio Madrileño de Salud, Madrid, Spain, St. Anne's University Hospital Brno, Czech Republic, Andaluz Health Service, University of Glasgow, University of Eastern Finland, Etablissement Français du Sang, Tampere University, Histocell SL, Spain, Medfiles CRO, Finland, Institut National de la Santé Et de la Recherche Médicale, France, Hospices Civils de Lyon, Association Groupe ESSEC, NOVADISCOVERY SAS, France, Finovatis, Centre Hospitalier Universitaire de Besancon, Assistance Publique - Hôpitaux de Paris, University Hospital, Toulouse, University Hospital, Bordeaux, University Hospital, Caen, Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León, Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Servicio de Salud de Castilla La Mancha, Albacete, Spain, Servizo Galego de Saude, Santiago de Compostela, Spain, Pirkanmaa Hospital District, Tampere, Finland, Hospital Vall d'Hebron, Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta, CH Sainte-Anne, Paris, France | Stroke | 07/25 | 07/27 | | |
| Recruiting | N/A | 52 | Europe | Hippotherapy, Conventional Neurorehabilitation | Alliance Equiphoria, Boehringer Ingelheim, Centre Hospitalier Sud Francilien, Centre Hospitalier de Béziers, University Hospital, Grenoble | Cerebrovascular Accident, Neurorehabilitation, Neuroplasticity, Hippotherapy, Silent Neurofunctional Barriers, Functional Deficit, Cognitive Deficit, Psychological Trauma, Autonomy, Quality of Life, Caregiver Burnout | 11/25 | 03/26 | | |
MATRISS, NCT04083001: An Open, Study to Assess the Safety of RGTA® (OTR4132) in Patients With Acute Ischemic Stroke (AIS) |
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| Completed | N/A | 19 | Europe | OTR4132MD | Organ, Tissue, Regeneration, Repair and Replacement, European Commission, Euraxi Pharma | Stroke, Acute | 06/24 | 06/24 | | |
ACTRIS, NCT02841098: " Endarterectomy Combined With Optimal Medical Therapy (OMT) vs OMT Alone in Patients With Asymptomatic Severe Atherosclerotic Carotid Artery Stenosis at Higher-than-average Risk of Ipsilateral Stroke " |
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| Completed | N/A | 43 | Europe | Carotid endarterectomy (CEA) combined with optimal medical therapy (OMT), Optimal medical therapy alone | Centre Hospitalier St Anne, Hôpitaux Universitaires Paris Ile-de-Franc Ouest | Asymptomatic Carotid Artery Stenosis | 01/22 | 01/22 | | |
| Recruiting | N/A | 400 | Europe | Cognitive tasks | University Hospital, Grenoble, Grenoble Institut des Neurosciences | Focal Brain Injury, Cognition | 02/30 | 02/30 | | |
| Recruiting | N/A | 1620 | Europe | Treatment according to standard care recommandation | University Hospital, Grenoble | Stroke, Sleep-disordered Breathing, Sleep Apnea Syndromes, Sleep Apnea, Obstructive, Sleep Apnea, Central, Fragmentation, Sleep | 06/30 | 06/35 | | |
| EPAULARD, Olivier |
NCT02701608: Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus |
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| Recruiting | 3 | 324 | Europe | Levofloxacin, Fluoroquinolones, Rifampicin, Conventional IV treatment of staphylococci IE following European guidelines 2015 including cloxacilline, oxacilline,gentamicine,vancomycine,rifampicine | University Hospital, Tours | Infective Endocarditis | 05/24 | 09/24 | | |
NCT02701595: Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus |
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| Recruiting | 3 | 324 | Europe | Amoxicillin, Conventional IV treatment of streptococci/enterococci IE following European guidelines 2015 including amoxicillin, gentamicin, amicillin, vancomycin, penicillin G, ceftriaxone, netilmicin | University Hospital, Tours | Infective Endocarditis | 05/24 | 09/24 | | |
| Withdrawn | 2b | 250 | Europe | DILTIAZEM TEVA 60 mg or placebo | Hospices Civils de Lyon, Signia Therapeutics | COVID-19 | 10/24 | 12/24 | | |
NanoDxCoV19, NCT04597216: Exploration of Feasability of Blood and Saliva Proteomic Analysis Through Harvesting by Silica Matrix (NanoDx-CoV-19) |
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| Recruiting | N/A | 200 | Europe | sample of blood and saliva | University Hospital, Grenoble | Covid19 | 12/20 | 12/21 | | |
| Not yet recruiting | N/A | 170 | NA | serology | University Hospital, Grenoble | Covid19 | 09/21 | 12/21 | | |
| Completed | N/A | 242 | Europe | Questionnaire | Centre Hospitalier Annecy Genevois | Pre-Exposure Prophylaxis, HIV Seronegativity, Drug Combination | 04/22 | 04/22 | | |
| Completed | N/A | 164 | Europe | Clinical Pathway | University Hospital, Grenoble | Hip Prosthesis Infection | 02/24 | 02/24 | | |
| Recruiting | N/A | 1000 | Europe | anonymous self-administered online questionnaire | University Hospital, Grenoble | HIV Pre-exposure Prophylaxis Use, Adult | 09/24 | 09/24 | | |
QUANTIFOT, NCT06341543: Quantiferon CMV to Identify Treatment Need for Asymptomatic CMV Infection After Solid Organ Transplant |
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| Recruiting | N/A | 288 | Europe | Quantiferon CMV (assay that determine the presence of CMV-specific T lymphocytes)., Communication of the result of the QF-CMV to the clinician in charge | University Hospital, Grenoble | Cytomegalovirus Infections, Heart Transplantation, Kidney Transplantation, Lung Transplantation, Liver Transplantation | 10/26 | 10/26 | | |
| PIN, Isabelle |
| Recruiting | 2/3 | 135 | Europe, RoW | Posaconazole 100 MG [Noxafil], gastro-resistant tablets Noxafil® 100 mg, Posaconazole 40 MG/ML, 105 ml Noxafil® 40 mg/ml oral suspension | Bambino Gesù Hospital and Research Institute, University of Exeter, Radboud University, Consorzio per Valutazioni Biologiche e Farmacologiche | Cystic Fibrosis, Aspergillosis | 04/23 | 11/23 | | |
| Recruiting | N/A | 160 | Europe | SIMEOX | Physio-Assist, Icadom | Pulmonary Cystic Fibrosis | 12/24 | 06/25 | | |
| Bouzat, Pierre |
HAP-DEX, NCT06269900: Dexamethasone for Treating Severe Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype |
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| Recruiting | 3 | 450 | Europe | Dexamethasone, Placebo | Nantes University Hospital | Hospital Acquired Pneumonia | 03/26 | 08/26 | | |
T-STORHM, NCT04431999: Evaluation of a Transfusion Therapy Using Whole Blood in the Management of Coagulopathy in Patients With Acute Traumatic Hemorrhage |
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| Recruiting | 3 | 200 | Europe | Whole blood transfusion, Fractionated blood products transfusion | Direction Centrale du Service de Santé des Armées, TIMC-IMAG, Floralis | Trauma, Acute Hemorrhage, Coagulopathy | 09/24 | 09/25 | | |
| Not yet recruiting | 3 | 1218 | Europe | direct IV injection, combination of Ketamine and Propofol | Nantes University Hospital | Rapid Sequence Induction | 03/27 | 04/27 | | |
RADIOMIC-TBI, NCT04058379: Artificial Intelligence Analysis of Initial Scan Evolution of Traumatic Brain Injured Patient to Predict Neurological Outcome |
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| Active, not recruiting | N/A | 30 | Europe | CT scan | University Hospital, Grenoble | Trauma, Brain | 04/21 | 10/21 | | |
ALPACA, NCT06248736: Description of Lactulose Administration by Balloon Rectal Tube in Severe Hepatic Encephalopathy |
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| Completed | N/A | 25 | Europe | | University Hospital, Grenoble | Hepatic Encephalopathy | 08/24 | 08/24 | | |
| Completed | N/A | 1066 | Europe, RoW | Quantification of IV drugs wastage | Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer, Sainte-Anne Military Teaching Hospital | Drug Use | 03/23 | 03/23 | | |
| Terminated | N/A | 65 | Europe | Questionnaires, blood test, Maximal effort test, actigraphy, Neuromuscular evaluation, stool analysis, food diary | Centre Hospitalier Universitaire de Saint Etienne, University of Saint-Etienne, Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques | Chronic Fatigue Syndrome, Intensive Care Unit, Muscle | 07/21 | 08/21 | | |
| Recruiting | N/A | 984 | Europe, RoW | Transcranial Doppler (TCD) | University Hospital, Grenoble | Mild Traumatic Brain Injury | 05/25 | 07/26 | | |
OPTI-TWO, NCT05893030: Prevention of Organ Dysfunction and Mortality by Monitoring the Administration of Opioids and Hypnotics in Patients at High Postoperative Risk |
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| Recruiting | N/A | 1132 | Europe | anesthesia guided by sedation and analgesia monitoring, anesthesia performed according only to the clinical judgment of the anesthetist as usual practice | Centre Hospitalier Universitaire de Saint Etienne, Direction Générale de l'Offre de Soins | Sedation and Analgesia Monitoring | 01/27 | 12/27 | | |
| gauvrit, jean-yves |
Tension, NCT03094715: Efficacy and Safety of Thrombectomy in Stroke With Extended Lesion and Extended Time Window |
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| Terminated | N/A | 253 | Europe, Canada, RoW | Thrombectomy, Mechanical thrombectomy, Best medical care, Control group | University Hospital Heidelberg, Karolinska University Hospital, Eppdata GmbH Hamburg, Germany, Aarhus University Hospital, Medical University Innsbruck, Groupe Hospitalier Pitie-Salpetriere, Oslo University Hospital, University Hospital, Martin, Charles University, Czech Republic, Hospices Civils de Lyon, CHU de Reims, Epidemiological and Clinical Research Information Network, STROKE ALLIANCE FOR EUROPE, International Consortium for Health Outcome Measurement, Inc., Europan Society for Minimally Invasive Neurological Therapy, Universitätsklinikum Hamburg-Eppendorf | Stroke, Acute, Cerebral Stroke, Cerebrovascular Stroke, Apoplexy; Brain | 05/23 | 11/23 | | |
| Recruiting | N/A | 119 | Europe | Implantation of an eCLIPs™ device, eCLIPs™ Electrolytic Bifurcation Systems | Evasc Medical Systems Corp., European Cardiovascular Research Center | Intracranial Aneurysm | 04/25 | 04/26 | | |
| LEROY, Vincent |
| Active, not recruiting | 3 | 238 | Europe, Canada, Japan, US, RoW | Linerixibat, Placebo | GlaxoSmithKline | Pruritus | 10/24 | 01/25 | | |
NATiV3, NCT04849728: A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( ) |
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| Recruiting | 3 | 1000 | Europe, Canada, US, RoW | IVA337, Lanifibranor, Placebo | Inventiva Pharma | NASH - Nonalcoholic Steatohepatitis | 09/25 | 09/26 | | |
| Active, not recruiting | 3 | 871 | Europe, Canada, Japan, US, RoW | Bepirovirsen, Placebo | GlaxoSmithKline, GlaxoSmithKline Research & Development Limited | Chronic Hepatitis B, Hepatitis B, Chronic | 11/25 | 05/26 | | |
| Active, not recruiting | 2b | 357 | Europe, Canada, US, RoW | belapectin, GR-MD-02, galactoarabino rhamnogalacturonate, Placebo | Galectin Therapeutics Inc., Galectin Therapeutics Inc | Prevention of Esophageal Varices, NASH - Nonalcoholic Steatohepatitis, Cirrhosis | 12/24 | 12/24 | | |
DHELIVER, NCT04229901: Study to Evaluate the Efficacy and Safety of HepaStem in Patients With Acute on Chronic Liver Failure (ACLF) |
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| Terminated | 2 | 133 | Europe, RoW | HepaStem, Placebo | Cellaion SA | Acute on Chronic Liver Failure | 05/24 | 05/24 | | |
| Active, not recruiting | 2 | 72 | Europe, RoW | Obeticholic acid, Bezafibrate 200 MG, OCA Placebo, Bezafibrate 200 mg Placebo, Bezafibrate 400 MG, Bezafibrate 400 mg Placebo, OCA, Bezafibrate | Intercept Pharmaceuticals | Primary Biliary Cholangitis | 10/25 | 10/25 | | |
NCT05276297 / 2021-003567-10: A Study on the Safety, Efficacy and Immune Response Following Sequential Treatment With an Anti-sense Oligonucleotide Against Chronic Hepatitis B (CHB) and Chronic Hepatitis B Targeted Immunotherapy (CHB-TI) in CHB Patients Receiving Nucleos(t)Ide Analogue (NA) Therapy |
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| Active, not recruiting | 2 | 184 | Europe, RoW | GSK3228836, Bepirovirsen, GSK3528869A, Control | GlaxoSmithKline, GlaxoSmithKline Biologicals | Hepatitis B, Chronic | 02/26 | 02/26 | | |
NCT03866187 / 2017-001452-55: Safety, Efficacy, Immunogenicity Study of GSK Biologicals' HBV Viral Vector and Adjuvanted Proteins Vaccine (GSK3528869A) in Adult Patients With Chronic Hepatitis B Infection |
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| Terminated | 1/2 | 135 | Europe, RoW | ChAd155-hIi-HBV low dose formulation, ChAd155-hIi-HBV high dose formulation, HBc-HBs/AS01B-4 low dose formulation, HBc-HBs/AS01B-4 high dose formulation, MVA-HBV low dose formulation, MVA-HBV high dose formulation, Placebo | GlaxoSmithKline, GlaxoSmithKline Biologicals | Hepatitis B, Chronic | 10/24 | 10/24 | | |
| Recruiting | N/A | 132 | Europe | Blood Sampling, Liver biopsy | University Hospital, Grenoble, Institut National de la Santé Et de la Recherche Médicale, France, Etablissement Français du Sang | HBV, NASH - Nonalcoholic Steatohepatitis | 12/21 | 12/22 | | |
| Recruiting | N/A | 720 | Europe | Post-transplant addiction intervention | University Hospital, Montpellier | Alcohol Associated Liver Disease, Liver Transplantation | 09/26 | 09/28 | | |
