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Trial + Data / Events	Status	Ph	N	Region	Interventions	Sponsor	Conditions	Primary compl	Study compl
Ying, Kejing
NCT04398940: A Study of TQ-B3139 Capsules in Subjects With MET-Altered Advanced Non-small Cell Lung Cancer	Recruiting	2	71	RoW	TQ-B3139	Chia Tai Tianqing Pharmaceutical Group Co., Ltd.	Non Small Cell Lung Cancer	01/22	10/22
TRIDENT-1, NCT03093116 / 2016-003616-13: A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements Jan 2025 - Jan 2025 : Approval in EU for adv ROS1+ve NSCLC, adv NTRK+ve solid tumors Jul 2023 - Dec 2023 : Approval for ROS1+ NSCLC Jan 2023 - Dec 2023 : Data readout from P1/2 TRIDENT-1 trial for ROS1 NSCLC and NTRK+ solid tumors Jan 2023 - Dec 2023: Approval in US for 2L NSCLC Top line data across ROS1-positive TKI-naïve and TKI-pretreated NSCLC cohorts in TRIDENT-1 trial Apr 2022 - Apr 2022: Top line data across ROS1-positive TKI-naïve and TKI-pretreated NSCLC cohorts in TRIDENT-1 trial NMPA granted in patients with for the treatment of patients with ROS1-positive NSCLC Feb 2022 - Feb 2022: NMPA granted in patients with for the treatment of patients with ROS1-positive NSCLC Presentation of Trident -1 data for the treatment of NSCLC in AACR-NCI-EORTC 2021 Oct 2021 - Oct 2021: Presentation of Trident -1 data for the treatment of NSCLC in AACR-NCI-EORTC 2021 Granted in patients with NTRK-positive, TKI-pretreated advanced solid tumors Oct 2021 - Oct 2021: Granted in patients with NTRK-positive, TKI-pretreated advanced solid tumors Granted for ROS1-positive advanced NSCLC Aug 2021 - Aug 2021: Granted for ROS1-positive advanced NSCLC For TKI-naive ROS1-positive NSCLC from TRIDENT-1 study Jan 2021 - Jan 2021: For TKI-naive ROS1-positive NSCLC from TRIDENT-1 study For ROS1+ve metastatic NSCLC based on TRIDENT-1 study Dec 2020 - Dec 2020: For ROS1+ve metastatic NSCLC based on TRIDENT-1 study For 2L treatment of patients with advanced solid tumors Aug 2020 - Aug 2020: For 2L treatment of patients with advanced solid tumors Interim data from P2 portion of P1/2 TRIDENT-1 trial for ROS-1 positive NSCLC and NTRK-positive solid tumors Aug 2020 - Aug 2020: Interim data from P2 portion of P1/2 TRIDENT-1 trial for ROS-1 positive NSCLC and NTRK-positive solid tumors From TRIDENT-1 trial [screenshot] Sep 2019 - Sep 2019: From TRIDENT-1 trial [screenshot] From P1 portion of P1/2 TRIDENT-1 trial for ROS-1 positive NSCLC and NTRK-positive solid tumors Jun 2019 - Jun 2019: From P1 portion of P1/2 TRIDENT-1 trial for ROS-1 positive NSCLC and NTRK-positive solid tumors From P1 portion of P1/2 TRIDENT-1 trial at ASCO 2019 [screenshot] May 2019 - May 2019: From P1 portion of P1/2 TRIDENT-1 trial at ASCO 2019 [screenshot] FromTRIDENT-1 trial for ROS-1 positive NSCLC and NTRK-positive solid tumors [screenshot] Sep 2018 - Sep 2018: FromTRIDENT-1 trial for ROS-1 positive NSCLC and NTRK-positive solid tumors [screenshot] Interim data for ROS1 fusion +ve NSCLC Sep 2018 - Sep 2018: Interim data for ROS1 fusion +ve NSCLC From TRIDENT-1 trial in patients with advanced ALK/ROS1/NTRK+ Cancers at ASCO 2018 [screenshot] Jun 2018 - Jun 2018: From TRIDENT-1 trial in patients with advanced ALK/ROS1/NTRK+ Cancers at ASCO 2018 [screenshot] More	Recruiting	1/2	500	Europe, Canada, Japan, US, RoW	Oral repotrectinib (TPX-0005), repotrectinib	Turning Point Therapeutics, Inc., Zai Lab (Shanghai) Co., Ltd.	Locally Advanced Solid Tumors, Metastatic Solid Tumors	02/28	02/28
Ma, Guofeng
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