Franco Locatelli
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 20 Trials 
29 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Locatelli, Franco
NCT02670564: ALL SCTped FORUM - Pharmacogenomic Study (add-on Study)

Recruiting
4
1000
Europe
Pharmacogenomics, DNA analyses, Busulfan plasma level measurements
Swiss Pediatric Oncology Group, ALL SCTped Forum
Acute Lymphoblastic Leukemia
04/21
04/26
ALLELE, NCT03394365 / 2017-002949-30: Tabelecleucel for Solid Organ or Allogeneic Hematopoietic Cell Transplant Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease (EBV+ PTLD) After Failure of Rituximab or Rituximab and Chemotherapy

Checkmark Data from ALLELE trial for post-transplant lymphoproliferative disease
Dec 2021 - Dec 2021: Data from ALLELE trial for post-transplant lymphoproliferative disease
Recruiting
3
66
Europe, Canada, US, RoW
tabelecleucel, tab-cel®, ATA129, EBV-CTL
Atara Biotherapeutics
Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications, Lymphoproliferative Disorders, Allogeneic Hematopoietic Cell Transplant, Stem Cell Transplant Complications
08/25
06/27
NCT01728155: European Low and Intermediate Risk Neuroblastoma Protocol

Completed
3
685
Europe, RoW
chemotherapy
Instituto de Investigacion Sanitaria La Fe
LOW AND INTERMEDIATE PAEDIATRIC NEUROBLASTOMA AND NEONATAL SUPRARENAL MASSES
12/22
 
TRACE, NCT04832607 / 2018-000853-29: Multivirus-specific T-cell Transfer Post SCT vs AdV, CMV and EBV Infections

Recruiting
3
149
Europe
Multivirus (CMV, EBV, AdV)-specific T cells
Prof. Tobias Feuchtinger, European Commission, Simbec-Orion Group Ltd, Merthyr Tydfil, UK, Miltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, Germany, Leiden University Medical Center, LUMC, Leiden, The Netherlands, Centre Hospitalier Universitaire de Nancy, CHU, Vandoeuvre-Lès-Nancy, France, Ghent University Hospital, UZG, Ghent, Belgium, Ospedale Pediatrico Bambino Gesù, OPBG, Rome, Italy, Newcastle University, UNEW, Newcastle, UK, Vall d'Hebron Institute of Oncology (VHIO) and Banc de Sang I Teixits (BST), Barcelona, Spain
AdV Infection, EBV Infection, CMV Infection, Stem Cell Transplant Complications
06/24
12/24
AIEOP-BFM ALL 2017, NCT03643276 / 2016-001935-12: Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia -

Recruiting
3
5000
Europe, RoW
Blinatumomab, Bortezomib, Cyclophosphamide, Cytarabine, Daunorubicin, Myocet, Dexamethasone, Doxorubicin, Etoposide, Fludarabine Phosphate, Ifosfamide, 6-Mercaptopurine, Methotrexate, Pegaspargase, Prednisolone, Prednisone, Tioguanin, Vincristine, Vindesine, Erwinase
Martin Schrappe, Deutsche Krebshilfe e.V., Bonn (Germany)
Acute Lymphoblastic Leukemia, Pediatric
07/28
07/28
FORUM, NCT01949129 / 2012-003032-22: Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia

Recruiting
2/3
1800
Europe, Canada, RoW
VP16, Etoposide, TBI, Thiotepa, Thio, Treosulfan, Treo, Fludarabine, Flu, Busulfan, Bu, ATG Thymoglobulin, ATG Thymo, Cyclophosphamide, Cy, Grafalon, Anti-human T-lymphocyte immunoglobulin
St. Anna Kinderkrebsforschung, ALL SCTped Forum, European Society for Blood and Marrow Transplantation, ALL-BFM Study Group, Assistance Publique - Hôpitaux de Paris, Dutch Childhood Oncology Group, Swiss Pediatric Oncology Group, Australian & New Zealand Children's Haematology/Oncology Group
Acute Lymphoblastic Leukaemia
06/25
04/30
NCT04785547: ALL SCTped 2012 FORUM Add-on Study Blina Post HSCT

Terminated
2
3
Europe, RoW
Blinatumomab, Blincyto
Prof. Christina Peters, Amgen
ALL, Childhood, Minimal Residual Disease
01/22
01/22
NCT04793919 / 2017-002383-40: Treatment Study for Children and Adolescents With Acute Promyelocytic Leukemia

Recruiting
2
89
Europe, RoW
Mylotarg, GO, Arsenic Trioxide, ATO, All-trans retinoic acid, ATRA
Associazione Italiana Ematologia Oncologia Pediatrica, AIEOP
Acute Promyelocytic Leukemia
10/25
10/27
XCGD-MOBI, NCT03055247 / 2015-002356-27: Combination of Ibuprofen, G-CSF and Plerixafor as Stem Cells Mobilization Regimen in Patients Affected by X-CGD

Recruiting
2
3
Europe
Ibuprofen, Myelostim, Mozobil
IRCCS San Raffaele, Fondazione Telethon
Chronic Granulomatous Disease X-linked (X-CGD)
07/23
07/23
NCT03590171: International Study for Treatment of High Risk Childhood Relapsed ALL 2010

Recruiting
2
250
Europe, RoW
Bortezomib
Charite University, Berlin, Germany, Australian & New Zealand Children's Haematology/Oncology Group, St. Anna Kinderkrebsforschung, CCRI (co-sponsor, Austria), European Organisation for Research and Treatment of Cancer - EORTC, University Hospital Motol (Co-Sponsor Czech Republic), Copenhagen University Hospital, Rigshospitalet (co-sponsor, Denmark), Turku University Central Hospital (co-sponsor, Finland), Centre Hospitalier Universitaire de Nice, Our Lady's Chilrden's Hospital (Co-Sponsor Ireland), Tel Aviv Sourasky Medical Centre (Co-Sponsor Israel), Ospedale Pediatrico Bambino (co-sponsor, Italy), Prinses Máxima Centrum (Co-Sponsor Netherlands), Oslo University Hospital (co-sponsor, Norway), Medical University of Wroclaw (Co-Sponsor Poland), Instituto Português de Oncologia de Lisboa (co-sponsor, Portugal), Karolinska University Hospital Stockholm (co-sponsor, Sweden), Spanish Society of Pediatric Hematology and Oncology (SEHOP) (Co-Sponsor Spain), University Children's Hospital, Zurich, Central Manchester University Hospitals NHS Foundation Trust (co-sponsor, UK)
Acute Lymphoblastic Leukemia (ALL)
12/27
12/27
EBVision, NCT04554914 / 2020-000177-25: A Study to Evaluate Tabelecleucel in Participants with Epstein-barr Virus-associated Diseases

Hourglass Jan 2023 - Dec 2023 : From P2 trial for Epstein-Barr virus-associated sarcoma
Recruiting
2
190
Europe, US
Tabelecleucel, tab-cel®, ATA129, EBV-CTLs
Atara Biotherapeutics
Epstein-Barr Virus (EBV)-associated Diseases, EBV+ Lymphoproliferative Disease with Primary Immunodeficiency (EBV+ PID LPD), EBV+ Lymphoproliferative Disease with Acquired (non-congenital) Immunodeficiency (EBV+ AID LPD), EBV+ Posttransplant Lymphoproliferative Disease in Central Nervous System (EBV+ CNS PTLD), EBV+ Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications, Lymphoproliferative Disorders, Allogeneic Hematopoietic Cell Transplant, Stem Cell Transplant Complications, EBV+ Sarcomas, Leiomyosarcoma
06/27
05/29
NCT03373097 / 2017-002475-26: Anti-GD2 CAR T Cells in Pediatric Patients Affected by High Risk And/or Relapsed/refractory Neuroblastoma or Other GD2-positive Solid Tumors

Active, not recruiting
1/2
42
Europe
GD2-CART01
Bambino Gesù Hospital and Research Institute
Neuroblastoma, Neuroblastoma Recurrent, GD2-positive Solid Tumors, Osteosarcoma, Ewing Sarcoma, Sarcoma
12/26
12/27
NCT04501614 / 2019-002549-39: A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Terminated
1/2
11
Europe, US, RoW
Ponatinib, Chemotherapy Agents
Takeda, Takeda Development Center Americas, Inc.
Pediatric Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ALL), Ph+ Mixed Phenotype Acute Leukemia (MPAL), Philadelphia Chromosome-Like ALL (Ph-like ALL)
12/23
07/24
NCT04787263: CD19-CAR_Lenti T Cells in Pediatric Patients Affected by Relapsed/Refractory CD19+ ALL and DLBCL or PML

Recruiting
1/2
32
Europe
CD19-CAR_Lenti T cell
Bambino Gesù Hospital and Research Institute
Acute Lymphoblastic Leukemia, Diffuse Large B Cell Lymphoma, Primary Mediastinal Lymphoma
03/25
03/38
NCT06521567: A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer

Recruiting
1/2
95
Europe, US, RoW
Cobolimab, Dostarlimab
GlaxoSmithKline
Melanoma, Hodgkin Lymphoma, High and Low Grade Glioma, Glioblastoma Multiforme (GBM), Diffuse Intrinsic Pontine Glioma (DIPG), Ependymoma, Osteosarcoma, Hepatic Tumors, Hepatoblastoma, Hepatocellular Carcinoma (HCC), Fibrolamellar Carcinoma, Rhabdomyosarcoma
10/29
01/32
CD7-CAR01, NCT06064903: CD7-CAR-T Cells in Pediatric Relapsed/Refractory CD7+ T-ALL/LL

Recruiting
1/2
26
Europe
CD7-CART01
Bambino Gesù Hospital and Research Institute
T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma
09/28
09/40
HEM-iSMART D, NCT05658640: HEM ISMART-D: Trametinib + Dexamethasone + Chemotherapy in Children with Relapsed or Refractory Hematological Malignancies

Recruiting
1/2
26
Europe, RoW
Trametinib, Dexamethasone, Cyclophosphamide, Cytarabine, Intrathecal chemotherapy
Princess Maxima Center for Pediatric Oncology, Innovative Therapies For Children with Cancer Consortium, IBFM, Fight Kids Cancer
Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory
04/29
04/29
NCT06080191: Allogeneic Second-generation CD19-CAR T Cells for Pediatric Relapsed/Refractory B-ALL

Recruiting
1
24
Europe
CD19-CAR_Lenti_ALLO
Bambino Gesù Hospital and Research Institute
B-cell Acute Lymphoblastic Leukemia
06/26
06/41
NCT05298995: GD2-CAR T Cells for Pediatric Brain Tumours

Recruiting
1
54
Europe
GD2-CART01 (iC9-GD2-CAR T-cells)
Bambino Gesù Hospital and Research Institute
Brain Tumor, Pediatric, Medulloblastoma, Childhood, Embryonal Tumor, High Grade Glioma, Diffuse Midline Glioma, Diffuse Intrinsic Pontine Glioma, Brain Tumor Adult
11/27
11/38
RAG1-SCID, NCT04797260: Phase I/II Clinical Trial Stem Cell Gene Therapy in RAG1-Deficient SCID

Recruiting
N/A
10
Europe, RoW
Gene therapy
Leiden University Medical Center, ZonMw: The Netherlands Organisation for Health Research and Development, Horizon 2020 - European Commission
Severe Combined Immunodeficiency Due to RAG1 Deficiency
12/29
12/29
HEMOGLOB-VAX, NCT05157256: Monitoring of Anti-SARS-CoV-2 (COVID 19) and Encapsulated Vaccination Patients With Thalassemic and Falcemic Syndromes

Active, not recruiting
N/A
1000
Europe
Società Italiana Talassemie ed Emoglobinopatie
SARS-CoV-2 Infection, Thalasemmie, SCD
12/30
12/30
Zecca, Marco P
AIEOP-BFM ALL 2017, NCT03643276 / 2016-001935-12: Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia -

Recruiting
3
5000
Europe, RoW
Blinatumomab, Bortezomib, Cyclophosphamide, Cytarabine, Daunorubicin, Myocet, Dexamethasone, Doxorubicin, Etoposide, Fludarabine Phosphate, Ifosfamide, 6-Mercaptopurine, Methotrexate, Pegaspargase, Prednisolone, Prednisone, Tioguanin, Vincristine, Vindesine, Erwinase
Martin Schrappe, Deutsche Krebshilfe e.V., Bonn (Germany)
Acute Lymphoblastic Leukemia, Pediatric
07/28
07/28
NCT04793919 / 2017-002383-40: Treatment Study for Children and Adolescents With Acute Promyelocytic Leukemia

Recruiting
2
89
Europe, RoW
Mylotarg, GO, Arsenic Trioxide, ATO, All-trans retinoic acid, ATRA
Associazione Italiana Ematologia Oncologia Pediatrica, AIEOP
Acute Promyelocytic Leukemia
10/25
10/27
NCT06861257: Treosulfan Therapeutic Drug Monitoring in Pediatric Hematopoietic Stem Cell Transplant Recipients

Recruiting
N/A
70
Europe
Fondazione IRCCS Policlinico San Matteo di Pavia
Pediatric Hematopoietic Stem Cell Transplantation, Malignant Disorders, Non-malignant Disorders
12/25
12/25
CopAt, NCT06858163: Coping and Attachment in Pediatric Oncohematology

Recruiting
N/A
60
Europe
Fondazione IRCCS Policlinico San Matteo di Pavia, Fondazione Soleterre - Strategie di Pace ONLUS, Università Pavia - Dipartimento di Scienze del Sistema Nervoso e del Comportamento, Università Cattolica Milano - Unità di ricerca sul Trauma, Dipartimento di Psicologia
Pediatric Cancer, Coping Behavior, Relationship, Parent Child
12/26
12/26
NCT04621201: Genomic Profiles Analysis in Children, Adolescents and Young Adult With Sarcomas

Recruiting
N/A
120
Europe
observation and biopsy
Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna, Associazione Italiana Ematologia Oncologia Pediatrica
Diagnosed or Relapsed/Refractory Sarcomas
12/24
12/26
Bernardo, Maria Ester
HURCULES, NCT06149403: A Study to Investigate the Efficacy and Safety of OTL-203 in Subjects with MPS-IH Compared with Standard of Care with Allogeneic HSCT

Active, not recruiting
3
41
Europe, US
Experimental: OTL-203, Active Comparator: Allo-HSCT
Orchard Therapeutics
MPS-IH (Hurler Syndrome)
03/28
03/31
NCT06861257: Treosulfan Therapeutic Drug Monitoring in Pediatric Hematopoietic Stem Cell Transplant Recipients

Recruiting
N/A
70
Europe
Fondazione IRCCS Policlinico San Matteo di Pavia
Pediatric Hematopoietic Stem Cell Transplantation, Malignant Disorders, Non-malignant Disorders
12/25
12/25
NCT04386538: Effect of a Low Starch Diet in Patients With Ankylosing Spondylitis

Recruiting
N/A
150
Europe
Low Starch Diet (LSD), General healthy eating
Universidade do Porto, Portuguese Institute of Rheumatology, Centro de Investigação Interdisciplinar Egas Moniz
Spondyloarthritis, Ankylosing Spondylitis
09/22
12/22
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Locatelli, Franco
NCT02670564: ALL SCTped FORUM - Pharmacogenomic Study (add-on Study)

Recruiting
4
1000
Europe
Pharmacogenomics, DNA analyses, Busulfan plasma level measurements
Swiss Pediatric Oncology Group, ALL SCTped Forum
Acute Lymphoblastic Leukemia
04/21
04/26
ALLELE, NCT03394365 / 2017-002949-30: Tabelecleucel for Solid Organ or Allogeneic Hematopoietic Cell Transplant Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease (EBV+ PTLD) After Failure of Rituximab or Rituximab and Chemotherapy

Checkmark Data from ALLELE trial for post-transplant lymphoproliferative disease
Dec 2021 - Dec 2021: Data from ALLELE trial for post-transplant lymphoproliferative disease
Recruiting
3
66
Europe, Canada, US, RoW
tabelecleucel, tab-cel®, ATA129, EBV-CTL
Atara Biotherapeutics
Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications, Lymphoproliferative Disorders, Allogeneic Hematopoietic Cell Transplant, Stem Cell Transplant Complications
08/25
06/27
NCT01728155: European Low and Intermediate Risk Neuroblastoma Protocol

Completed
3
685
Europe, RoW
chemotherapy
Instituto de Investigacion Sanitaria La Fe
LOW AND INTERMEDIATE PAEDIATRIC NEUROBLASTOMA AND NEONATAL SUPRARENAL MASSES
12/22
 
TRACE, NCT04832607 / 2018-000853-29: Multivirus-specific T-cell Transfer Post SCT vs AdV, CMV and EBV Infections

Recruiting
3
149
Europe
Multivirus (CMV, EBV, AdV)-specific T cells
Prof. Tobias Feuchtinger, European Commission, Simbec-Orion Group Ltd, Merthyr Tydfil, UK, Miltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, Germany, Leiden University Medical Center, LUMC, Leiden, The Netherlands, Centre Hospitalier Universitaire de Nancy, CHU, Vandoeuvre-Lès-Nancy, France, Ghent University Hospital, UZG, Ghent, Belgium, Ospedale Pediatrico Bambino Gesù, OPBG, Rome, Italy, Newcastle University, UNEW, Newcastle, UK, Vall d'Hebron Institute of Oncology (VHIO) and Banc de Sang I Teixits (BST), Barcelona, Spain
AdV Infection, EBV Infection, CMV Infection, Stem Cell Transplant Complications
06/24
12/24
AIEOP-BFM ALL 2017, NCT03643276 / 2016-001935-12: Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia -

Recruiting
3
5000
Europe, RoW
Blinatumomab, Bortezomib, Cyclophosphamide, Cytarabine, Daunorubicin, Myocet, Dexamethasone, Doxorubicin, Etoposide, Fludarabine Phosphate, Ifosfamide, 6-Mercaptopurine, Methotrexate, Pegaspargase, Prednisolone, Prednisone, Tioguanin, Vincristine, Vindesine, Erwinase
Martin Schrappe, Deutsche Krebshilfe e.V., Bonn (Germany)
Acute Lymphoblastic Leukemia, Pediatric
07/28
07/28
FORUM, NCT01949129 / 2012-003032-22: Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia

Recruiting
2/3
1800
Europe, Canada, RoW
VP16, Etoposide, TBI, Thiotepa, Thio, Treosulfan, Treo, Fludarabine, Flu, Busulfan, Bu, ATG Thymoglobulin, ATG Thymo, Cyclophosphamide, Cy, Grafalon, Anti-human T-lymphocyte immunoglobulin
St. Anna Kinderkrebsforschung, ALL SCTped Forum, European Society for Blood and Marrow Transplantation, ALL-BFM Study Group, Assistance Publique - Hôpitaux de Paris, Dutch Childhood Oncology Group, Swiss Pediatric Oncology Group, Australian & New Zealand Children's Haematology/Oncology Group
Acute Lymphoblastic Leukaemia
06/25
04/30
NCT04785547: ALL SCTped 2012 FORUM Add-on Study Blina Post HSCT

Terminated
2
3
Europe, RoW
Blinatumomab, Blincyto
Prof. Christina Peters, Amgen
ALL, Childhood, Minimal Residual Disease
01/22
01/22
NCT04793919 / 2017-002383-40: Treatment Study for Children and Adolescents With Acute Promyelocytic Leukemia

Recruiting
2
89
Europe, RoW
Mylotarg, GO, Arsenic Trioxide, ATO, All-trans retinoic acid, ATRA
Associazione Italiana Ematologia Oncologia Pediatrica, AIEOP
Acute Promyelocytic Leukemia
10/25
10/27
XCGD-MOBI, NCT03055247 / 2015-002356-27: Combination of Ibuprofen, G-CSF and Plerixafor as Stem Cells Mobilization Regimen in Patients Affected by X-CGD

Recruiting
2
3
Europe
Ibuprofen, Myelostim, Mozobil
IRCCS San Raffaele, Fondazione Telethon
Chronic Granulomatous Disease X-linked (X-CGD)
07/23
07/23
NCT03590171: International Study for Treatment of High Risk Childhood Relapsed ALL 2010

Recruiting
2
250
Europe, RoW
Bortezomib
Charite University, Berlin, Germany, Australian & New Zealand Children's Haematology/Oncology Group, St. Anna Kinderkrebsforschung, CCRI (co-sponsor, Austria), European Organisation for Research and Treatment of Cancer - EORTC, University Hospital Motol (Co-Sponsor Czech Republic), Copenhagen University Hospital, Rigshospitalet (co-sponsor, Denmark), Turku University Central Hospital (co-sponsor, Finland), Centre Hospitalier Universitaire de Nice, Our Lady's Chilrden's Hospital (Co-Sponsor Ireland), Tel Aviv Sourasky Medical Centre (Co-Sponsor Israel), Ospedale Pediatrico Bambino (co-sponsor, Italy), Prinses Máxima Centrum (Co-Sponsor Netherlands), Oslo University Hospital (co-sponsor, Norway), Medical University of Wroclaw (Co-Sponsor Poland), Instituto Português de Oncologia de Lisboa (co-sponsor, Portugal), Karolinska University Hospital Stockholm (co-sponsor, Sweden), Spanish Society of Pediatric Hematology and Oncology (SEHOP) (Co-Sponsor Spain), University Children's Hospital, Zurich, Central Manchester University Hospitals NHS Foundation Trust (co-sponsor, UK)
Acute Lymphoblastic Leukemia (ALL)
12/27
12/27
EBVision, NCT04554914 / 2020-000177-25: A Study to Evaluate Tabelecleucel in Participants with Epstein-barr Virus-associated Diseases

Hourglass Jan 2023 - Dec 2023 : From P2 trial for Epstein-Barr virus-associated sarcoma
Recruiting
2
190
Europe, US
Tabelecleucel, tab-cel®, ATA129, EBV-CTLs
Atara Biotherapeutics
Epstein-Barr Virus (EBV)-associated Diseases, EBV+ Lymphoproliferative Disease with Primary Immunodeficiency (EBV+ PID LPD), EBV+ Lymphoproliferative Disease with Acquired (non-congenital) Immunodeficiency (EBV+ AID LPD), EBV+ Posttransplant Lymphoproliferative Disease in Central Nervous System (EBV+ CNS PTLD), EBV+ Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications, Lymphoproliferative Disorders, Allogeneic Hematopoietic Cell Transplant, Stem Cell Transplant Complications, EBV+ Sarcomas, Leiomyosarcoma
06/27
05/29
NCT03373097 / 2017-002475-26: Anti-GD2 CAR T Cells in Pediatric Patients Affected by High Risk And/or Relapsed/refractory Neuroblastoma or Other GD2-positive Solid Tumors

Active, not recruiting
1/2
42
Europe
GD2-CART01
Bambino Gesù Hospital and Research Institute
Neuroblastoma, Neuroblastoma Recurrent, GD2-positive Solid Tumors, Osteosarcoma, Ewing Sarcoma, Sarcoma
12/26
12/27
NCT04501614 / 2019-002549-39: A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Terminated
1/2
11
Europe, US, RoW
Ponatinib, Chemotherapy Agents
Takeda, Takeda Development Center Americas, Inc.
Pediatric Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ALL), Ph+ Mixed Phenotype Acute Leukemia (MPAL), Philadelphia Chromosome-Like ALL (Ph-like ALL)
12/23
07/24
NCT04787263: CD19-CAR_Lenti T Cells in Pediatric Patients Affected by Relapsed/Refractory CD19+ ALL and DLBCL or PML

Recruiting
1/2
32
Europe
CD19-CAR_Lenti T cell
Bambino Gesù Hospital and Research Institute
Acute Lymphoblastic Leukemia, Diffuse Large B Cell Lymphoma, Primary Mediastinal Lymphoma
03/25
03/38
NCT06521567: A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer

Recruiting
1/2
95
Europe, US, RoW
Cobolimab, Dostarlimab
GlaxoSmithKline
Melanoma, Hodgkin Lymphoma, High and Low Grade Glioma, Glioblastoma Multiforme (GBM), Diffuse Intrinsic Pontine Glioma (DIPG), Ependymoma, Osteosarcoma, Hepatic Tumors, Hepatoblastoma, Hepatocellular Carcinoma (HCC), Fibrolamellar Carcinoma, Rhabdomyosarcoma
10/29
01/32
CD7-CAR01, NCT06064903: CD7-CAR-T Cells in Pediatric Relapsed/Refractory CD7+ T-ALL/LL

Recruiting
1/2
26
Europe
CD7-CART01
Bambino Gesù Hospital and Research Institute
T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma
09/28
09/40
HEM-iSMART D, NCT05658640: HEM ISMART-D: Trametinib + Dexamethasone + Chemotherapy in Children with Relapsed or Refractory Hematological Malignancies

Recruiting
1/2
26
Europe, RoW
Trametinib, Dexamethasone, Cyclophosphamide, Cytarabine, Intrathecal chemotherapy
Princess Maxima Center for Pediatric Oncology, Innovative Therapies For Children with Cancer Consortium, IBFM, Fight Kids Cancer
Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory
04/29
04/29
NCT06080191: Allogeneic Second-generation CD19-CAR T Cells for Pediatric Relapsed/Refractory B-ALL

Recruiting
1
24
Europe
CD19-CAR_Lenti_ALLO
Bambino Gesù Hospital and Research Institute
B-cell Acute Lymphoblastic Leukemia
06/26
06/41
NCT05298995: GD2-CAR T Cells for Pediatric Brain Tumours

Recruiting
1
54
Europe
GD2-CART01 (iC9-GD2-CAR T-cells)
Bambino Gesù Hospital and Research Institute
Brain Tumor, Pediatric, Medulloblastoma, Childhood, Embryonal Tumor, High Grade Glioma, Diffuse Midline Glioma, Diffuse Intrinsic Pontine Glioma, Brain Tumor Adult
11/27
11/38
RAG1-SCID, NCT04797260: Phase I/II Clinical Trial Stem Cell Gene Therapy in RAG1-Deficient SCID

Recruiting
N/A
10
Europe, RoW
Gene therapy
Leiden University Medical Center, ZonMw: The Netherlands Organisation for Health Research and Development, Horizon 2020 - European Commission
Severe Combined Immunodeficiency Due to RAG1 Deficiency
12/29
12/29
HEMOGLOB-VAX, NCT05157256: Monitoring of Anti-SARS-CoV-2 (COVID 19) and Encapsulated Vaccination Patients With Thalassemic and Falcemic Syndromes

Active, not recruiting
N/A
1000
Europe
Società Italiana Talassemie ed Emoglobinopatie
SARS-CoV-2 Infection, Thalasemmie, SCD
12/30
12/30
Zecca, Marco P
AIEOP-BFM ALL 2017, NCT03643276 / 2016-001935-12: Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia -

Recruiting
3
5000
Europe, RoW
Blinatumomab, Bortezomib, Cyclophosphamide, Cytarabine, Daunorubicin, Myocet, Dexamethasone, Doxorubicin, Etoposide, Fludarabine Phosphate, Ifosfamide, 6-Mercaptopurine, Methotrexate, Pegaspargase, Prednisolone, Prednisone, Tioguanin, Vincristine, Vindesine, Erwinase
Martin Schrappe, Deutsche Krebshilfe e.V., Bonn (Germany)
Acute Lymphoblastic Leukemia, Pediatric
07/28
07/28
NCT04793919 / 2017-002383-40: Treatment Study for Children and Adolescents With Acute Promyelocytic Leukemia

Recruiting
2
89
Europe, RoW
Mylotarg, GO, Arsenic Trioxide, ATO, All-trans retinoic acid, ATRA
Associazione Italiana Ematologia Oncologia Pediatrica, AIEOP
Acute Promyelocytic Leukemia
10/25
10/27
NCT06861257: Treosulfan Therapeutic Drug Monitoring in Pediatric Hematopoietic Stem Cell Transplant Recipients

Recruiting
N/A
70
Europe
Fondazione IRCCS Policlinico San Matteo di Pavia
Pediatric Hematopoietic Stem Cell Transplantation, Malignant Disorders, Non-malignant Disorders
12/25
12/25
CopAt, NCT06858163: Coping and Attachment in Pediatric Oncohematology

Recruiting
N/A
60
Europe
Fondazione IRCCS Policlinico San Matteo di Pavia, Fondazione Soleterre - Strategie di Pace ONLUS, Università Pavia - Dipartimento di Scienze del Sistema Nervoso e del Comportamento, Università Cattolica Milano - Unità di ricerca sul Trauma, Dipartimento di Psicologia
Pediatric Cancer, Coping Behavior, Relationship, Parent Child
12/26
12/26
NCT04621201: Genomic Profiles Analysis in Children, Adolescents and Young Adult With Sarcomas

Recruiting
N/A
120
Europe
observation and biopsy
Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna, Associazione Italiana Ematologia Oncologia Pediatrica
Diagnosed or Relapsed/Refractory Sarcomas
12/24
12/26
Bernardo, Maria Ester
HURCULES, NCT06149403: A Study to Investigate the Efficacy and Safety of OTL-203 in Subjects with MPS-IH Compared with Standard of Care with Allogeneic HSCT

Active, not recruiting
3
41
Europe, US
Experimental: OTL-203, Active Comparator: Allo-HSCT
Orchard Therapeutics
MPS-IH (Hurler Syndrome)
03/28
03/31
NCT06861257: Treosulfan Therapeutic Drug Monitoring in Pediatric Hematopoietic Stem Cell Transplant Recipients

Recruiting
N/A
70
Europe
Fondazione IRCCS Policlinico San Matteo di Pavia
Pediatric Hematopoietic Stem Cell Transplantation, Malignant Disorders, Non-malignant Disorders
12/25
12/25
NCT04386538: Effect of a Low Starch Diet in Patients With Ankylosing Spondylitis

Recruiting
N/A
150
Europe
Low Starch Diet (LSD), General healthy eating
Universidade do Porto, Portuguese Institute of Rheumatology, Centro de Investigação Interdisciplinar Egas Moniz
Spondyloarthritis, Ankylosing Spondylitis
09/22
12/22

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