| Antonelli, Massimo |
| Active, not recruiting | 4 | 520 | Europe, RoW | Non-invasive ventilation, Noninvasive ventilation, NIV, Standard care | Università Vita-Salute San Raffaele | Early Acute Respiratory Failure | 08/23 | 07/24 | | |
| Recruiting | 3 | 1252 | Europe | Albumin, Balanced, Ringer Lactate, Ringer Acetate, Crystalsol | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Istituto Di Ricerche Farmacologiche Mario Negri | Septic Shock | 12/21 | 02/22 | | |
IPERPEEP, NCT04012073: Individualized Positive End-expiratory Pressure Guided by End-expiratory Lung Volume in the Acute Respiratory Distress Syndrome |
|
|
| Recruiting | 3 | 132 | Europe | Invasive Mechanical ventilation, Neuromuscular Blocking Agents, Prone positioning, Resume of spontaneous breathing, Rescue treatments, Weaning from PEEP, Weaning from mechanical ventilation, Extubation | Fondazione Policlinico Universitario Agostino Gemelli IRCCS, ClinicalTrialCenter, FerrarioDati, General Electric | Respiratory Distress Syndrome, Adult | 12/24 | 04/25 | | |
HENIVOTpilot, NCT04502576: Helmet Noninvasive Ventilation vs. High-flow Nasal Cannula in Moderate-to-severe Acute Hypoxemic Respiratory Failure |
|
|
| Completed | N/A | 110 | Europe | Noninvasive respiratory support | Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università degli studi di Chieti, Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva | Respiratory Failure With Hypoxia | 01/21 | 12/22 | | |
NCT04033224: Use of EBPT in Critically Ill Patients With AKI and/or Multiorgan Failure |
|
|
| Recruiting | N/A | 1000 | Europe | Commercial membrane for Extracorporeal Blood Purification Therapy (EBPT) | Careggi Hospital, University of Florence | Critical Illness, Acute Kidney Injury, Sepsis, Systemic Inflammatory Response Syndrome | 12/24 | 12/24 | | |
NCT05403320: Cuff Pressure Control and Evacuation of Subglottic Secretions To Prevent Pneumonia |
|
|
| Completed | N/A | 270 | Europe, RoW | Continuous cuff pressure regulation, Intermittent cuff pressure regulation, Automatic subglottic secretion drainage, Manual subglottic secretion drainage, Tracheobronchial colonization assessment, Microaspiration assessment, VAP assessment | Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Catholic University of the Sacred Heart | Respiratory Failure | 01/24 | 04/24 | | |
NCT03807414: Development of a Web-based Multicenter Registry on the Use of oXiris Membrane for EBPTs in Critically Ill Patients |
|
|
| Active, not recruiting | N/A | 270 | Europe | oXiris | Careggi Hospital, University of Florence | Critical Illness, Acute Kidney Injury, Sepsis, Systemic Inflammatory Response Syndrome | 12/24 | 12/24 | | |
| Recruiting | N/A | 20 | Europe | Noninvasive support | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Acute Hypoxic Respiratory Failure | 12/24 | 12/24 | | |
NCT06210386: Physiology of Helmet vs. Facemask Noninvasive Ventilation |
|
|
| Recruiting | N/A | 20 | Europe | Noninvasive ventilation | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Acute Hypoxemic Respiratory Failure | 12/24 | 01/25 | | |
| Recruiting | N/A | 1200 | Europe | Noninvasive respiratory support | Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva, Catholic University of the Sacred Heart | Respiratory Failure, Hypoxemic Respiratory Failure | 12/25 | 06/26 | | |
HISTAP, NCT05637606: HIgh Versus STAndard Blood Pressure Target in Hypertensive High-risk Patients Undergoing Major Abdominal Surgery |
|
|
| Recruiting | N/A | 636 | Europe | Ephedrine, Ephedrine bolus, Norepinephrine, norepinephrine infusion, Etilefrine Hydrochloride bolus, Use of pulse pressure and stroke volume variation (PPV and SVV); use of Mini Fluid Challenge (mini_FC), Hemodynamic optimization | Humanitas Clinical and Research Center, Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva | Blood Pressure, Complication,Postoperative, Intraoperative Hypotension | 02/25 | 03/25 | | |
PACCOF, NCT06651047: PK/PD Analysis of Ceftazidime/Avibactam or Cefiderocol With or Without Fosfomycin for the Treatment of Difficult To-treat Gram-negative Infections |
|
|
| Recruiting | N/A | 120 | Europe | | University of Bologna | Gram Negative Infection, Antimicrobial Resistance (AMR) | 09/25 | 09/25 | | |
| Not yet recruiting | N/A | 20 | Europe | Noninvasive ventilation, Positive-pressure ventilation | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Respiratory Insufficiency | 10/25 | 10/25 | | |
| Recruiting | N/A | 126 | Europe | Lower tract respiratory samples, Multiplex PCR assay (Film-array Pneumonia Panel Plus), Lower respiratory tract standard culture, Blood sample standard culture | Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Catholic University of the Sacred Heart | HAP - Hospital Acquired Pneumonia, VAP - Ventilator Associated Pneumonia | 04/25 | 04/25 | | |
| Russo, Andrea |
CHANGE AFIB, NCT05130268: Early Dronedarone Versus Usual Care to Improve Outcomes in Persons With Newly Diagnosed Atrial Fibrillation |
|
|
| Active, not recruiting | 4 | 3000 | US | Dronedarone, Multaq | American Heart Association, Duke Clinical Research Institute, Sanofi | Atrial Fibrillation | 06/24 | 12/24 | | |
NCT05187273: Hemodynamic Optimization Based on a Dynamic Elastance Protocol |
|
|
| Completed | N/A | 46 | Europe | Elastance Group | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Fluid Management | 08/22 | 12/23 | | |
NCT01600040: Proton Beam Teletherapy for Post-Hysterectomy Cancers of the Uterus and Cervix |
|
|
| Completed | N/A | 22 | US | Proton radiation therapy | Massachusetts General Hospital, National Cancer Institute (NCI) | Uterine Cancer, Cervical Cancer | 10/22 | 08/23 | | |
NCT05481047: Prevention or Treatment of Arterial Hypotension and Oxygen Cerebral Saturation During Major Abdominal Surgery |
|
|
| Completed | N/A | 48 | Europe | HPI | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Hypotension During Surgery, Hemodynamic Instability | 04/23 | 03/24 | | |
| Recruiting | N/A | 88 | Europe | arterial dp/dtmax | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Intraoperative Hemodyamic Monitoring | 02/25 | 02/25 | | |
HERMES, NCT06439732: Impact of Using an Hemodynamic Monitoring System on Anesthetic Consumption During Abdominal Surgery |
|
|
| Not yet recruiting | N/A | 84 | NA | Acumen IQ cuff | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Hypotension During Surgery | 07/25 | 07/26 | | |
| Recruiting | N/A | 500 | Europe, US, RoW | Medtronic Astra/Azure DR MRI IPG with AVIM therapy Activated, BackBeat CNT, Medtronic Astra/Azure DR MRI IPG with AVIM therapy Deactivated | Orchestra BioMed, Inc, Medtronic | Hypertension, Hypertension, Systolic, Hypertension,Essential | 10/25 | 06/28 | | |
| Completed | N/A | 973 | US | Non-Interventional | Medtronic Cardiac Rhythm and Heart Failure | Atrial Fibrillation | 01/24 | 01/24 | | |
| Dell'Anna, Antonio Maria |
IPERPEEP, NCT04012073: Individualized Positive End-expiratory Pressure Guided by End-expiratory Lung Volume in the Acute Respiratory Distress Syndrome |
|
|
| Recruiting | 3 | 132 | Europe | Invasive Mechanical ventilation, Neuromuscular Blocking Agents, Prone positioning, Resume of spontaneous breathing, Rescue treatments, Weaning from PEEP, Weaning from mechanical ventilation, Extubation | Fondazione Policlinico Universitario Agostino Gemelli IRCCS, ClinicalTrialCenter, FerrarioDati, General Electric | Respiratory Distress Syndrome, Adult | 12/24 | 04/25 | | |
| Recruiting | N/A | 297 | Europe | Bedside Echocardiography, Spontaneuos breathing trial, Bedside Echocardiography_1, Baseline Echo_1, Bedside Echocardiography_2, Echo_2, Bedside Echocardiography_3, Echo_3, Bedside Echocardiography_4, Echo_4 | Humanitas Clinical and Research Center | Critical Illness, Diastolic Dysfunction, Diastolic Heart Failure, Weaning Failure, Mechanical Ventilation Complication | 06/22 | 06/22 | | |
CRYSID, NCT03507062: Effect of Crystalloids With Different SID on pH, and Urinary Electrolytes During General Anesthesia |
|
|
| Completed | N/A | 45 | Europe | 0.9% saline administration, Ringer's lactate administration, Plasmalyte-like solution administration | Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Cristina Dominedò, Marco Rossi, Rossano Festa, Nicoletta Filetici, Marta Cicetti, Domenico Luca Grieco, Massimo Antonelli | SID, Acid-Base Imbalance | 06/22 | 07/23 | | |
| Recruiting | N/A | 20 | Europe | Noninvasive support | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Acute Hypoxic Respiratory Failure | 12/24 | 12/24 | | |
ECOVEN, NCT06156072: Ultrasound-guided Blood Sampling Drawing for Microbiological Analysis in the Critically Ill |
|
|
| Not yet recruiting | N/A | 100 | NA | Ultrasound-guided venipuncture | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Sepsis, Septic Shock, Infections, Diagnosis | 06/25 | 12/25 | | |
HEART-CORE, NCT03113435: Patient Management During Major Abdominal Surgery: an Oxygen Consumption Protocol Compared to Standard Approach |
|
|
| Recruiting | N/A | 76 | Europe | Oxygen consumption optimization | Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Flavia Torrini, Alessandra Bisanti, Eleonora Filipponi, Domenica Luca Grieco, Massimo Antonelli, Liliana Sollazzi, Valter Perilli, Andrea Russo, Pierpaolo Ciocchetti | Hemodynamic Instability | 07/24 | 12/24 | | |
| Not yet recruiting | N/A | 20 | Europe | Noninvasive ventilation, Positive-pressure ventilation | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Respiratory Insufficiency | 10/25 | 10/25 | | |
| Bongiovanni, Filippo |
IPERPEEP, NCT04012073: Individualized Positive End-expiratory Pressure Guided by End-expiratory Lung Volume in the Acute Respiratory Distress Syndrome |
|
|
| Recruiting | 3 | 132 | Europe | Invasive Mechanical ventilation, Neuromuscular Blocking Agents, Prone positioning, Resume of spontaneous breathing, Rescue treatments, Weaning from PEEP, Weaning from mechanical ventilation, Extubation | Fondazione Policlinico Universitario Agostino Gemelli IRCCS, ClinicalTrialCenter, FerrarioDati, General Electric | Respiratory Distress Syndrome, Adult | 12/24 | 04/25 | | |
| Recruiting | N/A | 20 | Europe | Noninvasive support | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Acute Hypoxic Respiratory Failure | 12/24 | 12/24 | | |
| Not yet recruiting | N/A | 20 | Europe | Noninvasive ventilation, Positive-pressure ventilation | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Respiratory Insufficiency | 10/25 | 10/25 | | |
| Grieco, Domenico Luca |
IPERPEEP, NCT04012073: Individualized Positive End-expiratory Pressure Guided by End-expiratory Lung Volume in the Acute Respiratory Distress Syndrome |
|
|
| Recruiting | 3 | 132 | Europe | Invasive Mechanical ventilation, Neuromuscular Blocking Agents, Prone positioning, Resume of spontaneous breathing, Rescue treatments, Weaning from PEEP, Weaning from mechanical ventilation, Extubation | Fondazione Policlinico Universitario Agostino Gemelli IRCCS, ClinicalTrialCenter, FerrarioDati, General Electric | Respiratory Distress Syndrome, Adult | 12/24 | 04/25 | | |
HENIVOTpilot, NCT04502576: Helmet Noninvasive Ventilation vs. High-flow Nasal Cannula in Moderate-to-severe Acute Hypoxemic Respiratory Failure |
|
|
| Completed | N/A | 110 | Europe | Noninvasive respiratory support | Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università degli studi di Chieti, Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva | Respiratory Failure With Hypoxia | 01/21 | 12/22 | | |
INSPIRE, NCT06344234: Non-invasive Assessment of Inspiratory Effort and Tidal Distension During Non-invasive Ventilation |
|
|
| Recruiting | N/A | 60 | Europe | End-inspiratory Maneuvers, End-Expiratory Occlusion Maneuvers, Esophageal pressure monitoring, Diaphragmatic ultrasounds | University of Bari | Respiratory Disease, Artificial Respiration | 05/26 | 06/26 | | |
| Recruiting | N/A | 20 | Europe | Noninvasive support | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Acute Hypoxic Respiratory Failure | 12/24 | 12/24 | | |
NCT06210386: Physiology of Helmet vs. Facemask Noninvasive Ventilation |
|
|
| Recruiting | N/A | 20 | Europe | Noninvasive ventilation | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Acute Hypoxemic Respiratory Failure | 12/24 | 01/25 | | |
| Recruiting | N/A | 1200 | Europe | Noninvasive respiratory support | Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva, Catholic University of the Sacred Heart | Respiratory Failure, Hypoxemic Respiratory Failure | 12/25 | 06/26 | | |
| Recruiting | N/A | 740 | Europe, Canada, US, RoW | Respiratory Mechanics, Standard Ventilation Strategy | Unity Health Toronto, Canadian Institutes of Health Research (CIHR), University of Toronto, Applied Health Research Centre | ARDS | 11/25 | 03/26 | | |
| Not yet recruiting | N/A | 20 | Europe | Noninvasive ventilation, Positive-pressure ventilation | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Respiratory Insufficiency | 10/25 | 10/25 | | |
| Recruiting | N/A | 470 | Europe, RoW | Left ventricular septal pacing, Right ventricular pacing | Maastricht University, ZonMw: The Netherlands Organisation for Health Research and Development, Medtronic | Cardiac Pacing, Pacing-Induced Cardiomyopathy, Conduction System Pacing, Left Ventricular Septal Pacing, Atrioventricular Block | 05/25 | 05/25 | | |
| Valerio, Gallotta |
| No trials found |
