| Jain, Sandeep |
| Terminated | 3 | 409 | Europe, US, RoW | Reparixin, Repertaxin L-lysine salt, Placebo, Matched placebo | Dompé Farmaceutici S.p.A | Infectious Pneumonia, Severe COVID-19 | 09/24 | 09/24 | | |
| Withdrawn | 2 | 40 | US | Ocular Surface Immune Globulin (OSIG), Placebo | University of Illinois at Chicago | Dry Eye | 11/23 | 01/24 | | |
| Recruiting | 2 | 140 | Canada, US | brentuximab vedotin, ADCETRIS, pembrolizumab, KEYTRUDA® | Seagen Inc., Merck Sharp & Dohme LLC | Melanoma, Non-small Cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck | 10/25 | 09/26 | | |
NCT04657068: A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors |
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| Recruiting | 1/2 | 547 | Europe, US | ART0380, Gemcitabine, Gemzar, Irinotecan, Camptosar, Camptothecin-11 | Artios Pharma Ltd | Advanced Cancer, Metastatic Cancer, Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancer | 06/25 | 06/25 | | |
| Recruiting | N/A | 300 | US | OPTIMIZER® Integra CCM-D System (Treatment Arm) | Impulse Dynamics | Heart Failure, Heart Failure with Reduced Ejection Fraction, Implantable Defibrillator User, CCM Therapy, Non-ischemic Cardiomyopathy, Ischemic Cardiomyopathy, Sudden Cardiac Arrest, Arrhythmias, Cardiac, Ventricular Tachycardia, Ventricular Fibrillation | 06/25 | 12/25 | | |
NCT03970343: Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy |
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| Recruiting | N/A | 620 | US | OPTIMIZER Smart System | Impulse Dynamics | Heart Failure | 03/26 | 03/26 | | |
NCT06048731: Enlighten Study: The EV-ICD Post Approval Registry |
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| Recruiting | N/A | 1000 | Europe, Canada, US, RoW | Defibrillation using EV-ICD | Medtronic | Ventricular Arrhythmia, Tachycardia | 05/30 | 10/37 | | |
| Chelly, Jacques E |
NCT04208516: Continuous Nerve Block Block vs Combination of Single Block Plus Intravenous Lidocaine for Postoperative Pain. |
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| Terminated | 4 | 17 | US | Continuous Erector Spinae Plane Nerve Block, Continuous Quadratus Lumborum Nerve Block, Single Erector Spinae Plane Nerve Block, Single Quadratus Lumborum Nerve Block, Lidocaine IV, Ropivacaine 0.5% Injectable Solution, Dexamethasone, Dexmedetomidine, Lidocaine | Jeremy Kearns | Postoperative Pain | 08/22 | 08/22 | | |
NCT04220489: Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine Surgery |
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| Terminated | 2 | 1 | US | Ketamine, Ketalar, Placebo Comparator, Placebo Group | Jacques E. Chelly | Opioid Dependence, Chronic Pain | 11/22 | 11/22 | | |
NCT05252858: A Pilot Study Investigating the nCAP Signal Relief Patch in Subjects Undergoing Primary Hip or Knee Replacement Surgery |
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| Completed | N/A | 79 | US | nCAP Signal Relief Patch, nCAP, treatment patch, Standard of Care, Enhanced Recovery After Surgery (ERAS) | Jacques E. Chelly, nCap Medical | Opioid Use, Pain, Post Operative | 10/22 | 10/22 | | |
NCT04800744: Aromatherapy for Improving Post-Surgical Quality of Life |
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| Completed | N/A | 70 | US | Lavender peppermint elequil aromatab, treatment aromatab, Sweet almond oil elequil aromatab, active comparator aromatab | University of Pittsburgh, Beekley Medical | Quality of Life, Anxiety Postoperative | 04/23 | 05/23 | | |
NCT04836936: Auriculotherapy in the Treatment of Pre-Operative Anxiety |
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| Recruiting | N/A | 60 | US | Auriculotherapy cryopuncture device without nitrogen gas, Auriculotherapy cryopuncture device with nitrogen gas | Jacques E. Chelly | Anxiety Preoperative | 06/25 | 06/25 | | |
NCT05263635: Music Therapy in the Treatment of Perioperative Anxiety and Pain |
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| Completed | N/A | 80 | US | Music therapy, Standard of Care Enhanced Recovery After Surgery (ERAS) | University of Pittsburgh, Shadyside Hospital Foundation | Pain, Post Operative, Anxiety, Opioid Use | 08/23 | 08/23 | | |
| Active, not recruiting | N/A | 150 | US | +RxWell, -RxWell | University of Pittsburgh, National Institutes of Health (NIH), National Institute on Drug Abuse (NIDA) | Mood Disorders, Anxiety, Depressive Symptoms, Depression, Anxiety Disorders, Anxiety Depression | 07/25 | 07/25 | | |
NCT06460350: NEUROCUPLE™ in TKA Patients to Enhance Pain Management |
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| Recruiting | N/A | 140 | US | NEUROCUPLE™ Patch, Placebo Patch | nCap Medical, University of Pittsburgh | Total Knee Arthroplasty | 09/25 | 09/26 | | |
NCT06648759: Vagal Stimulator to Reduce Nasogastric Tube Use |
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| Recruiting | N/A | 60 | US | Vagal Nerve Stimulator, Placebo Vagal Nerve Stimulator | Jacques E. Chelly | Nasogastric Tube Intubation | 09/26 | 09/26 | | |
NCT05506878: Auriculo-Nerve Stimulation on Post-Operative Opioid Requirement |
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| Recruiting | N/A | 286 | US | NSS-2 BRIDGE, Bridge, Sham NSS-2 BRIDGE, Placebo | Jacques E. Chelly, Masimo Corporation, National Institute on Drug Abuse (NIDA) | Opioid Use, Auriculotherapy, Pain, Abdominal, Cancer Pain | 06/26 | 09/26 | | |
| Engh, Johnathan |
NCT02054689: Fractionated Stereotactic Radiosurgery for Large Brain Metastases |
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| Active, not recruiting | 1 | 20 | US | Fractionated Stereotactic Radiosurgery, SRS, SBRT, CyberKnife, Trilogy, True Beam, Radiosurgery | Steven Burton | Large Brain Mets | 11/17 | 04/24 | | |
| Monroe, Amy L |
NCT04208516: Continuous Nerve Block Block vs Combination of Single Block Plus Intravenous Lidocaine for Postoperative Pain. |
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| Terminated | 4 | 17 | US | Continuous Erector Spinae Plane Nerve Block, Continuous Quadratus Lumborum Nerve Block, Single Erector Spinae Plane Nerve Block, Single Quadratus Lumborum Nerve Block, Lidocaine IV, Ropivacaine 0.5% Injectable Solution, Dexamethasone, Dexmedetomidine, Lidocaine | Jeremy Kearns | Postoperative Pain | 08/22 | 08/22 | | |
NCT03261193: ITM + Bupivacaine QLB vs. ITM + Sham Saline QLB for Cesarean Delivery Pain |
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| Terminated | 3 | 21 | US | ITM + Sham QLB, Saline, ITM + Bupivacaine QLB, Bupivacaine | Nicholas Schott | Pain, Postoperative | 06/18 | 11/22 | | |
OPSTAHT, NCT03341156: Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart Transplantation |
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| Recruiting | 3 | 60 | US | Kcentra, prothrombin complex concentrate, Frozen Plasma Product, Human, Fresh Frozen Plasma | Kathirvel Subramaniam, University of Maryland, Baltimore, CSL Behring | Heart Disease End Stage, Heart Failure，Congestive | 10/24 | 12/24 | | |
NCT06626503: Evaluation of Analgesia for Spine Fusion Elective Surgery in Children |
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| Not yet recruiting | 2 | 500 | US | Methadone based ERAS, Methadone Based, SOC non-methadone based group, Standard Care | Senthil Sadhasivam, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Idiopathic Scoliosis | 09/25 | 09/25 | | |
NCT06626035: Prospective Randomized Evaluation of Analgesia for Cardiac Elective Surgery in Children |
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| Not yet recruiting | 2 | 500 | US | Methadone based ERAS, Methadone-Based, SOC non-methadone based group, Standard Care | Senthil Sadhasivam, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Pediatric Cardiac Surgery | 09/25 | 09/25 | | |
PREPARE-2, NCT06767566: Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery |
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| Not yet recruiting | 1 | 50 | US | Ketamine (Ketalar), 0.18 mg/kg/1hr loading dose Ketamine | Grace Lim, MD, MS, National Institute of Mental Health (NIMH) | Pain, Postpartum Depression | 12/27 | 03/28 | | |
| Completed | 1 | 12 | US | Ketamine (Ketalar) Dose Level 1, 0.05 mg/kg/1hr loading dose Ketamine, Ketamine (Ketalar) Dose Level 2, 0.08 mg/kg/1hr loading dose Ketamine, Ketamine (Ketalar) Dose Level 3, 0.12 mg/kg/1hr loading dose Ketamine, Ketamine (Ketalar) Dose Level 4, 0.18 mg/kg/1hr loading dose Ketamine | Grace Lim, MD, MS, National Institute of Mental Health (NIMH) | Pain, Postoperative, Depression, Postpartum | 06/24 | 09/24 | | |
NCT06275308: Effect of Raised End-Tidal PCo2 on Choroidal Volume |
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| Recruiting | N/A | 20 | US | Ventilation manipulation | University of Pittsburgh | Intraocular Pressure | 04/25 | 04/25 | | |
NCT03633604: Expanded Access IND Administration of HBOC-201 in Patients With Severe Acute Anemia |
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| Available | N/A | | US | HBOC-201, Hemopure, hemoglobin glutamer - 250 (bovine) | Jonathan H. Waters, HbO2 Therapeutics LLC | Anemia Severe | | | | |
NCT02887820: Evaluating the Use of Thromboelastography (TEG) in Patient's Requiring Extracorporeal Membrane Oxygenation (ECMO) |
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| Completed | N/A | 15 | US | Thromboelastograph, TEG 5000 | Stephen Esper, American Heart Association | Heart Disease, Lung Disease | 12/23 | 12/23 | | |
NCT04836936: Auriculotherapy in the Treatment of Pre-Operative Anxiety |
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| Recruiting | N/A | 60 | US | Auriculotherapy cryopuncture device without nitrogen gas, Auriculotherapy cryopuncture device with nitrogen gas | Jacques E. Chelly | Anxiety Preoperative | 06/25 | 06/25 | | |
NCT06071884: Bridge Device for Surgical Pain for Rotator Cuff Surgery |
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| Recruiting | N/A | 15 | US | Bridge Percutaneous Nerve Field Stimulator, NSS-2 BRIDGE | Steven Orebaugh, Masimo Corporation | Pain, Rotator Cuff Injuries | 02/25 | 12/25 | | |
NCT05104307: Echocardiogram and Cardiac Performance System (CPS) Ejection Fraction Validation Study |
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| Completed | N/A | 79 | US | Cardiac Performance System (CPS) Device | Stephen Esper, Sensydia Corporation | Heart Diseases | 01/24 | 01/24 | | |
NCT06460350: NEUROCUPLE™ in TKA Patients to Enhance Pain Management |
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| Recruiting | N/A | 140 | US | NEUROCUPLE™ Patch, Placebo Patch | nCap Medical, University of Pittsburgh | Total Knee Arthroplasty | 09/25 | 09/26 | | |
NCT05452694: OpalGenix- Personalized Postoperative Pain Management Following Lumbar Spinal Fusion and Decompression Surgery in Adults |
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| Recruiting | N/A | 200 | US | | OpalGenix, Inc | Lumbar Spine Stenosis, Lumbar Spine Degeneration | 09/24 | 09/24 | | |
NCT05906368: Hypotension Prediction Index to Predict Epidural-labor Analgesia Induced Hypotension |
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| Recruiting | N/A | 30 | US | ClearSight HPI Monitoring system, Standard of Care Blood Pressure Monitoring | Grace Lim, MD, MS, Edwards Lifesciences | Anesthesia, Epidural, Hypotension | 10/24 | 04/25 | | |
NCT06648759: Vagal Stimulator to Reduce Nasogastric Tube Use |
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| Recruiting | N/A | 60 | US | Vagal Nerve Stimulator, Placebo Vagal Nerve Stimulator | Jacques E. Chelly | Nasogastric Tube Intubation | 09/26 | 09/26 | | |
| Not yet recruiting | N/A | 70 | US | BioButton Device, Providing Clinical Care with BioButton Device | Charles Lin, Jewish Healthcare Foundation | Gait, Medication Induced Gait Disturbances | 12/25 | 02/26 | | |
NCT06661291: Pip Care to Improve Surgical Patient Outcomes - Phase II |
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| Not yet recruiting | N/A | 1300 | US | Pip Care Digital Health Platform, Standard of Care Protocol | University of Pittsburgh, National Heart, Lung, and Blood Institute (NHLBI) | Abdominal Surgery | 09/28 | 09/28 | | |
| Recruiting | N/A | 300 | US | Preoperative Genotyping | Senthil Sadhasivam, National Institute on Drug Abuse (NIDA) | PPAP, Spine Fusion | 08/25 | 09/25 | | |
NCT06042413: Prediction and Prevention of Postoperative Mortality and Morbidity |
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| Not yet recruiting | N/A | 1200 | US | Personalized CPC Prehabilitation, Cognitive Training, Meditation, Daily Exercise, Enhanced Social Support, Proactive Bundle Interventions, Pre-operative Standard of Care, Intra-operative Standard of Care | University of Pittsburgh, National Institute on Aging (NIA) | Alzheimer Disease, Alzheimer Disease Related Dementias | 09/25 | 09/25 | | |
| Recruiting | N/A | 600 | US | Preoperative Genotyping | Senthil Sadhasivam, National Center for Advancing Translational Sciences (NCATS) | Cesarean Section Complications, Opioid Use | 04/26 | 10/26 | | |
| Not yet recruiting | N/A | 400 | US | | Kathirvel Subramaniam | Analgesia, Cardiac Surgery | 12/26 | 12/26 | | |
| Uskova, Anna |
NCT04259645: Volume Versus Concentration: Clinical Effectiveness of Single Shot Quadrates Lumborum Block Using Either a High Volume/Low Concentration or Low Volume/High Concentration Injectate for Total Hip Arthroplasty. |
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| Completed | 4 | 60 | US | Drug: Bupivacaine 0.375% 20 mL, Low Volume, Drug: Bupivacaine 0.375% diluted to 0.1875%, High Volume | Anna Uskova | Acute Pain | 01/23 | 01/23 | | |
| Davenport, Michael |
NCT04259645: Volume Versus Concentration: Clinical Effectiveness of Single Shot Quadrates Lumborum Block Using Either a High Volume/Low Concentration or Low Volume/High Concentration Injectate for Total Hip Arthroplasty. |
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| Completed | 4 | 60 | US | Drug: Bupivacaine 0.375% 20 mL, Low Volume, Drug: Bupivacaine 0.375% diluted to 0.1875%, High Volume | Anna Uskova | Acute Pain | 01/23 | 01/23 | | |
| Newhide, Danny Rifaat |
NCT04259645: Volume Versus Concentration: Clinical Effectiveness of Single Shot Quadrates Lumborum Block Using Either a High Volume/Low Concentration or Low Volume/High Concentration Injectate for Total Hip Arthroplasty. |
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| Completed | 4 | 60 | US | Drug: Bupivacaine 0.375% 20 mL, Low Volume, Drug: Bupivacaine 0.375% diluted to 0.1875%, High Volume | Anna Uskova | Acute Pain | 01/23 | 01/23 | | |
| Chelly, Jacque E |
NCT04836936: Auriculotherapy in the Treatment of Pre-Operative Anxiety |
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| Recruiting | N/A | 60 | US | Auriculotherapy cryopuncture device without nitrogen gas, Auriculotherapy cryopuncture device with nitrogen gas | Jacques E. Chelly | Anxiety Preoperative | 06/25 | 06/25 | | |
| Goel, Shiv K |
NCT05263635: Music Therapy in the Treatment of Perioperative Anxiety and Pain |
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| Completed | N/A | 80 | US | Music therapy, Standard of Care Enhanced Recovery After Surgery (ERAS) | University of Pittsburgh, Shadyside Hospital Foundation | Pain, Post Operative, Anxiety, Opioid Use | 08/23 | 08/23 | | |
| Finger, Logan E |
NCT06489626: The Effect of a Methylprednisolone Taper on Outcomes Following Total Knee Arthroplasty |
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| Not yet recruiting | 4 | 100 | US | Methylprednisolone 4 milligram Tab, Dexamethasone injection | F. Johannes Plate | Arthritis Knee, Knee Osteoarthritis, Pain, Postoperative | 10/25 | 12/25 | | |
