| Nair, Devi |
| Recruiting | 4 | 360 | Europe, US | Catheter ablation, Ablation, Rate or Rhythm control antiarrhythmic drugs for atrial fibrillation, Antiarrhythmic Drug, Insertion of CardioMems Hemodynamic monitor, IPM, Empiric heart failure drug therapy, HFDrug | Electrophysiology Research Foundation | Atrial Fibrillation, Heart Failure, Diastolic Heart Failure | 12/24 | 06/25 | | |
NCT03505801: Confirm Rx Insertable Cardiac Monitor SMART Registry |
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| Active, not recruiting | N/A | 1826 | Europe, Canada, Japan, US, RoW | Confirm Rx ICM insertion procedure | Abbott Medical Devices | Cardiac Arrhythmias, Symptoms and Signs, Atrial Fibrillation | 09/19 | 03/26 | | |
| Completed | N/A | 117 | US | Patient Preference Survey | Abbott Medical Devices | Cardiac Rhythm Disorder, Bradycardia, Cardiac Pacemaker Artificial | 06/23 | 06/23 | | |
AVANT GUARD, NCT06096337: Pulsed Field Ablation (PFA) Versus Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation |
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| Recruiting | N/A | 387 | Europe, Canada, US, RoW | FARAPULSE™ Pulsed Field Ablation (PFA) System, Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, and Dofetilide | Boston Scientific Corporation | Persistent Atrial Fibrillation | 12/25 | 12/27 | | |
| Active, not recruiting | N/A | 200 | Europe, Canada, US | Adagio AF Cryoablation System (iCLAS™) | Adagio Medical | Persistent Atrial Fibrillation | 08/23 | 08/24 | | |
| Enrolling by invitation | N/A | 1500 | US | Experimental: Laminar Left Atrial Appendage Closure System, Active Comparator: WATCHMAN / Amulet | Laminar, Inc., Cardiovascular Research Foundation, New York | Non-valvular Atrial Fibrillation, Stroke | 08/28 | 02/32 | | |
ULTRA-HFIB, NCT04182620: Ultrasound-Based Renal Sympathetic Denervation as Adjunctive Upstream Therapy During Atrial Fibrillation Ablation |
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| Active, not recruiting | N/A | 160 | US | renal denervation, Catheter ablation | Vivek Reddy | Atrial Fibrillation | 06/24 | 06/24 | | |
NCT05565599: An Early Feasibility Study Evaluating the Safety and Efficacy of the Laminar Left Atrial Appendage Closure System in Subjects With Non-Valvular Atrial Fibrillation |
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| Active, not recruiting | N/A | 45 | US | Left Atrial Appendage Closure | Laminar, Inc. | Non-valvular Atrial Fibrillation | 08/24 | 09/29 | | |
| Recruiting | N/A | 1000 | US | WATCHMAN FLX Pro LAAC Device, Left Atrial Appendage Closure | Boston Scientific Corporation | Atrial Fibrillation, Bleeding, Stroke | 08/24 | 06/25 | | |
| Recruiting | N/A | 900 | US | Reveal LINQ™ Insertable Cardiac Monitor with investigational ALLEVIATE-HF RAMware download, Medication intervention | Medtronic Cardiac Rhythm and Heart Failure | Heart Failure NYHA Class II, Heart Failure NYHA Class III | 04/25 | 04/25 | | |
| Recruiting | N/A | 2650 | Europe, Canada, Japan, US, RoW | Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC | Abbott Medical Devices | Atrial Fibrillation, Stroke, Bleeding | 08/27 | 08/30 | | |
ADVANTAGE AF, NCT05443594: A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects With Persistent Atrial Fibrillation |
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| Active, not recruiting | N/A | 669 | Europe, Canada, US | Phase 1: FARAPULSE Ablation System, Phase 2: FARAPULSE Ablation System | Boston Scientific Corporation | Persistent Atrial Fibrillation | 03/25 | 03/25 | | |
NCT05826665: Observational Study to Examine the Procedural and Outcomes of AF Ablation Assisted by STAR Apollo™ Mapping System |
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| Recruiting | N/A | 200 | US | Persistent AF ablation assisted with the STAR Apollo Mapping System | Kansas City Heart Rhythm Research Foundation, Kansas City Heart Rhythm Institute, St. Bernards Medical Center, Sarasota Medical Center | Persistent Atrial Fibrillation | 07/25 | 07/25 | | |
LUX-Dx TRENDS, NCT04790344: Evaluates Diagnostics Sensors in Heart Failure Patients Receiving Boston Scientific's Investigational ICM System. |
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| Active, not recruiting | N/A | 525 | US | Investigational LUX-Dx ICM Implant | Boston Scientific Corporation | Heart Failure | 05/26 | 06/26 | | |
| Recruiting | N/A | 1000 | US | Left atrial appendage occlusion (LAAO) | Abbott Medical Devices | Atrial Fibrillation, Stroke, Bleeding | 06/27 | 06/27 | | |
NCT04088071: Real-world Experience of Catheter Ablation for the Treatment of Paroxysmal and Persistent Atrial Fibrillation |
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| Recruiting | N/A | 15000 | US | Catheter ablation | Heart Rhythm Clinical and Research Solutions, LLC, Biosense Webster, Inc. | Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation | 12/27 | 12/27 | | |
| Recruiting | N/A | 4000 | Canada, US | WATCHMAN device | Hamilton Health Sciences Corporation, McMaster University, Population Health Research Institute, Boston Scientific Corporation | Atrial Fibrillation, Stroke, Ischemic, Systemic Embolism | 09/29 | 12/29 | | |
| Quin, E Matthew |
LUX-Dx TRENDS, NCT04790344: Evaluates Diagnostics Sensors in Heart Failure Patients Receiving Boston Scientific's Investigational ICM System. |
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| Active, not recruiting | N/A | 525 | US | Investigational LUX-Dx ICM Implant | Boston Scientific Corporation | Heart Failure | 05/26 | 06/26 | | |
