| Thompson, James |
NCT03610971: Treatment Free Remission After Combination Therapy With Ruxolitinib Plus Tyrosine Kinase Inhibitors |
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| Recruiting | 2 | 41 | US | Ruxolitinib, Jakafi®, BCR-ABL Tyrosine Kinase Inhibitor (TKI), TKI | H. Lee Moffitt Cancer Center and Research Institute, H. Jean Khoury Cure CML Consortium, Incyte Corporation | Chronic Phase Chronic Myeloid Leukemia, Chronic Myeloid Leukemia, Chronic Phase | 12/25 | 12/26 | | |
NCT04439396: Toradol (Ketorolac) in Breast Surgery to Reduce Pain & Opioid Use |
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| Completed | 1 | 183 | US | Ketorolac Tromethamine, Toradol, Saline | Carilion Clinic | Breast Reduction, Breast Reconstruction | 01/23 | 01/23 | | |
| Enrolling by invitation | N/A | 250 | US | PFO Closure Rate, Published PFO Device Closure | HeartStitch.Com | Foramen Ovale, Patent, Septal Defect, Atrial, Septal Defect, Heart | 11/19 | 11/22 | | |
| Active, not recruiting | N/A | 3500 | US, RoW | Therapeutic | National Heart, Lung, and Blood Institute (NHLBI), National Cancer Institute (NCI) | Myelodysplastic Syndromes (MDS) | 03/25 | 06/25 | | |
| Suspended | N/A | 640 | Europe, US | NobleStitch™EL Suture Mediated Closure System, Amplatzer PFO Occluder | Nobles Medical Technologies II Inc | Foramen Ovale, Patent, Stroke, Ischemic | 12/26 | 06/27 | | |
| Macdonald, David R |
| Active, not recruiting | 3 | 240 | Europe, Canada, US, RoW | Brentuximab vedotin, Rituximab, Lenalidomide, Placebo | Seagen Inc. | Diffuse Large B-cell Lymphoma | 05/25 | 04/27 | | |
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EVOLVE CLL/SLL, NCT04269902: Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), Study |
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| Recruiting | 3 | 247 | Canada, US | Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy, Biopsy of Bone Marrow, Biopsy, Bone Marrow, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Obinutuzumab, Anti-CD20 Monoclonal Antibody R7159, GA 101, GA-101, GA101, Gazyva, huMAB(CD20), R 7159, R-7159, R7159, RO 5072759, RO-5072759, RO5072759, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Venetoclax, ABT 199, ABT-0199, ABT-199, ABT199, GDC 0199, GDC-0199, GDC0199, RG7601, Venclexta, Venclyxto | National Cancer Institute (NCI) | Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | 10/28 | 10/28 | | |
CLC3E, NCT05371808: Economic Analysis of Early vs Delayed Therapy in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: |
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| Recruiting | 3 | 247 | Canada | EQ-5D-5L Instrument, Work Productivity and Daily Activity Impairment (WPAI) survey, Resource Utilization Form (SMRC) | Canadian Cancer Trials Group, Canadian Institutes of Health Research (CIHR) | Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | 10/28 | 10/28 | | |
NCT05998642: Ibrutinib Combination Therapy in Transplant Ineligible Individuals With Newly Diagnosed Primary CNS Lymphoma |
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| Recruiting | 2 | 30 | Canada | Methotrexate, Rituximab (where available), Ibrutinib | Canadian Cancer Trials Group, Janssen Inc. | Non-hodgkin Lymphoma | 05/28 | 12/28 | | |
CHARM COPD, NCT05290831: Changes in Heart Rate Variability And Heart Rate/Activity Slope After Hospitalization for Acute Exacerbations of COPD |
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| Not yet recruiting | N/A | 45 | NA | VitalPatch | Minneapolis Veterans Affairs Medical Center | Pulmonary Disease, Chronic Obstructive | 01/24 | 04/24 | | |
| Alda, Martin |
NCT05625555: Predictors of Intravenous Ketamine Response in TRD |
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| Recruiting | 3 | 40 | Canada | Ketamine, Ketamine Hydrochloride, Kevlar, Midazolam, Midazolam Hydrochloride | Abraham Nunes, Nova Scotia Health Authority | Treatment Resistant Depression, Major Depressive Disorder, Bipolar Disorder | 01/25 | 02/25 | | |
| Recruiting | 3 | 360 | Canada | Cannabidiol, CBD, Placebo | University of British Columbia | Bipolar Disorder | 12/29 | 12/30 | | |
| Chauhan, Balwantray C |
NCT02785029: Optical Coherence Tomography (OCT) Reference Data Collection Study (S-2015-1) |
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| Terminated | N/A | 234 | US | OCT | Heidelberg Engineering GmbH | Glaucoma | 05/23 | 07/23 | | |
NCT02785042: Optical Coherence Tomography (OCT) Reference Data Collection Study (S-2015-3) |
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| Terminated | N/A | 224 | US | Heidelberg Spectralis OCT | Heidelberg Engineering GmbH | Glaucoma | 06/23 | 07/23 | | |
| Completed | N/A | 165 | Canada | iCare ST500, GAT, iCare IC200 | Icare Finland Oy | Intraocular Pressure | 11/23 | 11/23 | | |
NCT03108443: Novel Markers for Detecting Early Progression of Glaucoma |
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| Active, not recruiting | N/A | 250 | Canada | Optical Coherence tomography angiography | Balwantray Chauhan | Glaucoma | 05/25 | 05/25 | | |
| Corkum, Penny |
| Active, not recruiting | N/A | 218 | Canada | BNBD-NDD Intervention | IWK Health Centre | Nonorganic Insomnia, Neurodevelopmental Disorders, Primary Insomnia | 05/22 | 05/22 | | |
| Recruiting | N/A | 60 | Canada | The ABCs of SLEEPING | IWK Health Centre | Sleep Problems, Behavioural Insomnia of Childhood | 10/22 | 01/23 | | |
| Girkin, Christopher A |
NCT04328207: Providing Financial Incentives to Improve Adherence to Referral Eye Care Visits |
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| Active, not recruiting | N/A | 1000 | US | No Financial Incentive, Standard of Care, Financial Incentive | University of Alabama at Birmingham, Centers for Disease Control and Prevention | Glaucoma, Diabetic Retinopathy, Refractive Errors, Cataract, Behavior, Health | 12/23 | 09/24 | | |
| Walmsley, Sharon L |
DeLiTE, NCT04665375: Can INSTI-associated Weight Gain be Halted or Reversed With a Switch to Doravirine/Lamivudine/Tenofovir DF? |
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| Terminated | 4 | 4 | Canada | DOR/3TC/TDF, Delstrigo | University Health Network, Toronto, Merck Canada Inc. | Hiv, Weight Gain | 03/24 | 03/24 | | |
| Recruiting | 3 | 120 | Canada | Tecovirimat, TPOXX, Placebo | Marina Klein, McGill University Health Centre/Research Institute of the McGill University Health Centre, University Health Network, Toronto, Unity Health Toronto, University of British Columbia, CIHR Canadian HIV Trials Network | Monkeypox | 06/24 | 03/25 | | |
| Recruiting | 3 | 450 | Canada | Nonavalent HPV vaccine, Gardasil9 | University of British Columbia | HPV, Human Papilloma Virus, Human Immunodeficiency Virus | 08/24 | 08/26 | | |
CINNAMON, NCT06039579: Proof of Concept Treatment Study of Orally Administered VH4004280 or VH4011499 in HIV-1 Infected Adults |
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| Completed | 2 | 44 | Europe, Canada, US, RoW | VH4004280, VH4011499, VH4004280 Matching Placebo, VH4011499 Matching Placebo | ViiV Healthcare | HIV Infections | 06/24 | 06/24 | | |
| Recruiting | N/A | 500 | Canada | COVID-19 Vaccine | CIHR Canadian HIV Trials Network, McGill University Health Centre/Research Institute of the McGill University Health Centre, The Ottawa Hospital (TOH) | HIV Infections | 03/22 | 07/23 | | |
| Recruiting | N/A | 250 | Canada | | Unity Health Toronto | Monkeypox | 09/24 | 09/24 | | |
| Active, not recruiting | N/A | 1286 | Canada | mRNA Vaccines or Viral vector-based vaccines for COVID, Moderna Spikevax COVID-19 vaccine, Pfizer-BioNTech Comirnaty COVID-19 vaccine, AstraZeneca Vaxzevria COVID-19 vaccine, Janssen (Johnson & Johnson) COVID-19 vaccine | University Health Network, Toronto, Canadian Institutes of Health Research (CIHR), Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Public Health Agency of Canada (PHAC) | COVID-19 Virus Infection, Vaccine Response | 03/24 | 04/24 | | |
| MacKay-Lyons, Marilyn |
CAMAROS, NCT04789616: The Canadian Maraviroc Randomized Controlled Trial To Augment Rehabilitation Outcomes After Stroke |
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| Recruiting | 2 | 120 | Canada | Maraviroc, Celsentri, Exercise Program, Placebo, "Sugar" Pill, Activity Sensor, Motor Learning | University of Calgary, University Health Network, Toronto, University of California, Los Angeles, Sunnybrook Health Sciences Centre, University of British Columbia, Memorial University of Newfoundland, Dalhousie University, Parkwood Hospital, London, Ontario, Riverview Health Centre Foundation, The Dr. Miriam and Sheldon G. Adelson Medical Research Foundation | Stroke | 12/25 | 12/25 | | |
| Recruiting | N/A | 96 | Canada | TRAIL, EDUCATION | University of British Columbia, McMaster University | Stroke, Stroke, Ischemic, Stroke Hemorrhagic, Cerebral Injury, Cerebral Infarction, Brain Diseases, Central Nervous System Diseases, Cerebral Vascular Accident, Cerebral Vascular Disorder, Brain Ischemia, Brain Infarction, Cardiovascular Diseases, Infarction | 08/24 | 08/24 | | |
ORDER-P, NCT06576089: Optimizing Recruitment to Drive Equitable Research Opportunity in Stroke Rehabilitation Trials in Canada |
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| Not yet recruiting | N/A | 120 | Canada | Supported, women-centred and aphasia-friendly recruitment and enrollment process (ORDER), Traditional recruitment and enrollment processes (TRAD) | McMaster University | Stroke | 06/27 | 06/27 | | |
| Hernandez, Paul |
TETON, NCT04708782: Study of Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis |
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| Recruiting | 3 | 576 | Canada, US | Placebo, Inhaled Treprostinil, Tyvaso, Treprostinil Ultrasonic Nebulizer | United Therapeutics | Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease | 06/25 | 06/25 | | |
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SPARTA, NCT01983241 / 2013-001870-38: Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD) |
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| Active, not recruiting | 3 | 345 | Europe, Canada, US, RoW | Alpha-1 MP, Prolastin-C, 0.9% Sodium Chloride for Injection, USP, Saline | Grifols Therapeutics LLC | Pulmonary Emphysema in Alpha-1 PI Deficiency | 08/26 | 01/27 | | |
| Active, not recruiting | N/A | 1500 | Canada | | McGill University Health Centre/Research Institute of the McGill University Health Centre, Canadian Institutes of Health Research (CIHR), GlaxoSmithKline, AstraZeneca, Pfizer, Boehringer Ingelheim, Novartis, Takeda, Merck Sharp & Dohme LLC, Almirall, SAS | COPD, Chronic Obstructive Pulmonary Disease | 12/22 | 12/22 | | |
NCT05181670: The Canadian Respiratory Research Network Long COVID-19 Study |
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| Enrolling by invitation | N/A | 650 | Canada | | Sunnybrook Health Sciences Centre, Canadian Institutes of Health Research (CIHR) | SARS-CoV-2 Infection, Post-acute Sequelae of SARS-CoV-2 | 08/24 | 12/24 | | |
| Weir, Matthew R |
NCT06474273: TACKLE-IT Trial - Treat Acute T Cell Rejection With Evidence and Confidence in Kidney Transplant Recipients |
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| Not yet recruiting | 4 | 540 | Canada, RoW | Methylprednisolone, IV MP, Prednisone | University of Sydney, University of Manitoba | Rejection; Transplant, Kidney, Rejection; Transplant, Pancreas | 12/29 | 12/29 | | |
| Active, not recruiting | 4 | 60 | Canada | Denosumab 60 mg/ml, Prolia, Calcium and vitamin D prophylaxis, Monitoring of post-injection calcium and phosphate | Western University, Canada, ICES, Academic Medical Organization of Southwestern Ontario, Western University, The Kidney Foundation of Canada | Kidney Diseases, Dialysis; Complications, Fragility Fracture, Chronic Kidney Disease-Mineral and Bone Disorder | 12/25 | 12/25 | | |
| Active, not recruiting | 3 | 404 | Europe, Canada, Japan, US, RoW | Atrasentan, CHK-01, Atrasentan Hydrochloride, ABT-627, Placebo | Chinook Therapeutics, Inc. | IgA Nephropathy, Immunoglobulin A Nephropathy | 12/26 | 12/26 | | |
| Recruiting | 3 | 2750 | Europe, Canada, RoW | Spironolactone 25Mg Tablet, Placebo Oral Tablet | Population Health Research Institute, Canadian Institutes of Health Research (CIHR) | Endstage Renal Disease | 07/25 | 04/26 | | |
NCT04658017: GARNETâ„¢ Filter (GARNET Device) IDE Used in Chronic Hemodialysis Patients With a Bloodstream Infection |
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| Recruiting | N/A | 15 | US | GARNET device | Boa Biomedical, Inc., Avania | Bloodstream Infection | 10/21 | 12/21 | | |
PHOSPHATE, NCT03573089: Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease |
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| Recruiting | N/A | 3600 | Europe, Canada, RoW | Liberal phosphate target, Intensive phosphate target | The University of Queensland, National Health and Medical Research Council, Australia, Applied Health Research Centre, Cambridge University Hospitals NHS Foundation Trust, University of Otago | Kidney Failure, Chronic, Hyperphosphatemia | 12/27 | 12/28 | | |
| Recruiting | N/A | 5000 | US | | Wake Forest University Health Sciences, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Minority Health and Health Disparities (NIMHD), National Institute of Allergy and Infectious Diseases (NIAID) | Kidney Diseases, Kidney Failure, Kidney Disease, Chronic | 09/24 | 09/24 | | |
COPE-AKI, NCT05805709: A Patient-centered Trial of a Process-of-care Intervention in Hospitalized AKI Patients: the Trial |
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| Recruiting | N/A | 2145 | US | Study Physician/Advance Practice Provider, Nurse Navigator, Pharmacist, Patient Education | University of Pittsburgh, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Acute Kidney Injury | 06/26 | 03/27 | | |
| Nathan, Cherie-Ann O |
NCT05237960: Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia |
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| Recruiting | 2 | 86 | Canada, US | Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Extended Release Metformin Hydrochloride, ER Metformin Hydrochloride, Extended-release Metformin Hydrochloride, Glucophage XR, Glumetza, Metformin Hydrochloride Extended Release, Placebo Administration | University of Arizona, National Cancer Institute (NCI) | Erythroplakia, Oral Leukoplakia | 08/26 | 08/28 | | |
| Weiss, Shelly |
| Active, not recruiting | N/A | 218 | Canada | BNBD-NDD Intervention | IWK Health Centre | Nonorganic Insomnia, Neurodevelopmental Disorders, Primary Insomnia | 05/22 | 05/22 | | |
| Clarke, James |
| Recruiting | N/A | 12 | Canada | Stereotactic Body Radiotherapy (SBRT) ablation of VT, VT Radioablation | John Sapp | Ventricular Tachycardia, Myocardial Infarction, Heart Disease Structural Disorder | 06/26 | 09/26 | | |
| Eskes, Gail A |
PDWM, NCT01647698: Pilot Study to Determine if Working Memory Training Aids Cognitive Functioning in Patients With Parkinson's Disease |
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| Active, not recruiting | N/A | 30 | Canada | Adaptive working memory training task, Non-adaptive working memory training task (i.e. an active control task), No training | Gail Eskes, Nova Scotia Health Authority | Parkinson Disease | 12/24 | 12/24 | | |
| Klein, Raymond |
PDWM, NCT01647698: Pilot Study to Determine if Working Memory Training Aids Cognitive Functioning in Patients With Parkinson's Disease |
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| Active, not recruiting | N/A | 30 | Canada | Adaptive working memory training task, Non-adaptive working memory training task (i.e. an active control task), No training | Gail Eskes, Nova Scotia Health Authority | Parkinson Disease | 12/24 | 12/24 | | |
| Westwood, David |
PDWM, NCT01647698: Pilot Study to Determine if Working Memory Training Aids Cognitive Functioning in Patients With Parkinson's Disease |
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| Active, not recruiting | N/A | 30 | Canada | Adaptive working memory training task, Non-adaptive working memory training task (i.e. an active control task), No training | Gail Eskes, Nova Scotia Health Authority | Parkinson Disease | 12/24 | 12/24 | | |
| Jones, Stephanie |
NCT06378528: Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP) |
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| Not yet recruiting | 1 | 5 | US | Ketamine, Ketamine Assisted Psychotherapy, SmartSleep EEG recording headband | University of Wisconsin, Madison | Posttraumatic Stress Disorder | 01/26 | 01/26 | | |
| Recruiting | N/A | 25 | US | Online active TMS | Brown University, National Institute of General Medical Sciences (NIGMS) | Beta Rhythm, Tactile Perception | 01/22 | 01/22 | | |
NCT05956548: Lead Migration During the Spinal Cord Stimulation Trial Period and Therapeutic Response |
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| Recruiting | N/A | 36 | US | external securement of scs leads during the scs trial period | Augusta University | Spinal Cord Stimulator Trial Period, Neuromodulation Trial Period, SCS Trial Period | 05/24 | 07/24 | | |
NCT06341413: Sleep and Emotion Processing in Adolescent Post-traumatic Stress Disorder |
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| Recruiting | N/A | 180 | NA | SmartSleep device | University of Wisconsin, Madison, National Institute of Mental Health (NIMH) | Post Traumatic Stress Disorder | 10/24 | 10/24 | | |
PDWM, NCT01647698: Pilot Study to Determine if Working Memory Training Aids Cognitive Functioning in Patients With Parkinson's Disease |
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| Active, not recruiting | N/A | 30 | Canada | Adaptive working memory training task, Non-adaptive working memory training task (i.e. an active control task), No training | Gail Eskes, Nova Scotia Health Authority | Parkinson Disease | 12/24 | 12/24 | | |
| Green, Janet |
| Completed | N/A | 53 | US | Mediterranean Diet -- Mushrooms, Mediterranean Diet -- Control | Purdue University, Mushroom Council | Diet, Healthy | 11/22 | 11/22 | | |
| Williams, Jason G |
NCT05544240: Phase 1 Trial of SYNC-T - Immunotherapy for Patients With Advanced/Metastatic Solid Tumors |
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| Recruiting | 1 | 20 | RoW | SV-101 | Williams Cancer Foundation, Syncromune, Inc. | Metastatic Cancer, Metastatic Breast Cancer, Metastatic Lung Cancer, Solid Tumor, Cancer | 12/24 | 12/24 | | |
NCT05544227: Phase 1 Trial of SYNC-T - Immunotherapy for Advanced/Metastatic Castration-Resistant Prostate Cancer |
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| Active, not recruiting | 1 | 15 | RoW | SV-102 | Williams Cancer Foundation, Syncromune, Inc. | Metastatic Castration-resistant Prostate Cancer | 01/24 | 03/25 | | |
NCT04506255: Silicone Taping for the Improvement of Abdominal Donor Site Scars |
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| Recruiting | N/A | 32 | Canada | Silicone tape | Nova Scotia Health Authority | Hypertrophic Scar, Scar | 09/24 | 12/24 | | |
| Mulvagh, Sharon L |
| Recruiting | N/A | 1500 | Canada | Carotid Contrast Enhanced Ultrasound, Contrast injection, DEFINITY®, Perflutren Lipid Microsphere | Dr. Amer Johri, Lantheus Medical Imaging | Atherosclerosis, Cardiovascular Diseases, Acute Coronary Syndrome, Ischemic Heart Disease, Myocardial Infarction, Carotid Artery Diseases | 08/26 | 08/26 | | |
| Phillips, Stephen |
| Recruiting | 4 | 1200 | Europe, Canada, US, RoW | Edoxaban, Lixiana, Savaysa, Non-anticoagulant medical therapy | Population Health Research Institute | Intracranial Hemorrhages, Atrial Fibrillation | 04/26 | 10/26 | | |
| Mountain, Anita |
CAMAROS, NCT04789616: The Canadian Maraviroc Randomized Controlled Trial To Augment Rehabilitation Outcomes After Stroke |
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| Recruiting | 2 | 120 | Canada | Maraviroc, Celsentri, Exercise Program, Placebo, "Sugar" Pill, Activity Sensor, Motor Learning | University of Calgary, University Health Network, Toronto, University of California, Los Angeles, Sunnybrook Health Sciences Centre, University of British Columbia, Memorial University of Newfoundland, Dalhousie University, Parkwood Hospital, London, Ontario, Riverview Health Centre Foundation, The Dr. Miriam and Sheldon G. Adelson Medical Research Foundation | Stroke | 12/25 | 12/25 | | |
| Wong, Ivan |
NCT01957722: NOVOCART®3D for Treatment of Articular Cartilage of the Knee |
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| Active, not recruiting | 3 | 233 | Canada, US | Microfracture, NOVOCART 3D | Aesculap Biologics, LLC | Articular Cartilage of the Femoral Condyle Between 2-6cm2 | 12/25 | 12/27 | | |
| Recruiting | N/A | 68 | Canada | Coracoid Transfer, Distal Tibia Allograft with Bankart repair | Nova Scotia Health Authority | Shoulder Dislocation, Bone Loss, Arthroscopy | 01/26 | 12/26 | | |
| Active, not recruiting | N/A | 13 | Europe, Canada, US | Episealer Knee System, Microfracture | Episurf Medical Inc., MCRA | Degenerative Lesion of Articular Cartilage of Knee | 06/26 | 06/28 | | |
| Recruiting | N/A | 200 | Canada | Anatomic Glenoid Reconstruction, Cannulated Bristow-Latarjet Instability Shoulder System (Depuy-Mitek, MA, USA)., Arthroscopic bankart Repair | Nova Scotia Health Authority | Shoulder Dislocation | 07/24 | 01/25 | | |
NCT04505020: The Innovation of 3D Printing for Preoperative Planning in Hip Preservation Surgery |
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| Enrolling by invitation | N/A | 80 | Canada | 3D Print + Conventional imaging, Conventional imaging | Nova Scotia Health Authority | Femoro Acetabular Impingement | 08/24 | 12/24 | | |
| Recruiting | N/A | 234 | Europe, Canada, US | Microfracture, Microfracture plus placement of Chondro-Gide® ACC | Geistlich Pharma AG, Telos Partners | Knee Injuries, Cartilage Injury, Cartilage Disease, Knee Discomfort | 11/24 | 11/26 | | |
NCT04248751: Evaluating the Use of a Bioinductive Graft in Treating Massive Rotator Cuff Tears |
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| Recruiting | N/A | 76 | Canada | Regeneten, Debridement | Ivan Wong, Smith & Nephew, Inc. | Rotator Cuff Tear, Rotator Cuff Injury | 03/25 | 08/25 | | |
| Active, not recruiting | N/A | 60 | Canada | Bridging Rotator Cuff Reconstruction, Superior Capsular Reconstruction, GRAFTJACKET™ allograft, Acellular human dermal allograft | Nova Scotia Health Authority | Rotator Cuff Tear Arthropathy | 07/25 | 08/25 | | |
NCT05564494: Surgical Treatment of Recurrent Shoulder Dislocations |
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| Recruiting | N/A | 200 | Canada | Bankart Repair, Arthroscopic bankart repair, Anatomic Glenoid Reconstruction, Arthroscopic distal tibia bone graft | Nova Scotia Health Authority, Canadian Institutes of Health Research (CIHR) | Shoulder Instability | 12/26 | 12/27 | | |
NCT02540200: Efficacy of BST-CarGel in Treating Chondral Lesions of the Hip |
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| Withdrawn | N/A | 50 | NA | BST-CarGel, Microfracture | Nova Scotia Health Authority | Disorder of Hip Region | 12/23 | 12/23 | | |
NCT05925881: Lower Trapezius Transfer vs Bridging Reconstruction |
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| Recruiting | N/A | 60 | Canada | Surgical Repair of Large to Massive Rotator Cuff Tears | Nova Scotia Health Authority | Rotator Cuff Tears | 09/26 | 09/27 | | |
NCT05959733: Maximal Repair Versus Bridging Reconstruction With BioBrace® |
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| Recruiting | N/A | 60 | Canada | Bridging Reconstruction using BioBrace, Repair | Nova Scotia Health Authority, CONMED Corporation | Rotator Cuff Tears, Bioinductive Implant | 07/27 | 07/27 | | |
| Henderson, Joanna |
IAMSAFE, NCT06225661: Focused Suicide Prevention Strategy for Youth Presenting to the Emergency Department With Suicide Related Behaviour |
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| Recruiting | N/A | 330 | Canada | SAFE Intervention, NAV (Telephone Navigation) | The Hospital for Sick Children, Canadian Institutes of Health Research (CIHR), SickKids Foundation | Suicide, Suicide Prevention, Suicidal Ideation, Self-Injurious Behavior, Behavioral Symptoms, Suicide, Attempted, Suicide and Self-harm | 03/25 | 09/25 | | |
NCT02836080: Integrated Collaborative Care Teams for Youth With Mental Health and/or Addiction Challenges (YouthCan IMPACT) |
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| Active, not recruiting | N/A | 247 | Canada | Integrated Collaborative Care Team (ICCT), Treatment as Usual (TAU) | Centre for Addiction and Mental Health, East Metro Youth Services, Delisle Youth Services, LOFT Community Services, The Sashbear Foundation, The Anne Johnston Health Station, South East Toronto Family Health Team, Institute for Clinical Evaluative Sciences, Medical Psychiatry Alliance, Graham Boeckh Foundation, The Ontario Spor Support Unit | Mental Disorders, Addiction | 04/21 | 04/25 | | |
| Olthuis, Janine |
NCT06154369: JoyPop Mobile Mental Health App With Post-Secondary Students |
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| Recruiting | N/A | 120 | Canada | JoyPop | Lakehead University | Emotion Regulation, Depression, Anxiety, Stress, Well-Being, Psychological | 12/25 | 12/25 | | |
NCT06239545: JoyPop Mobile Mental Health App With Transitional-Aged Youth |
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| Recruiting | N/A | 110 | Canada | Usual Practice + JoyPop | Lakehead University | Emotion Regulation, Depression, Anxiety, Stress | 12/25 | 12/25 | | |
| Recruiting | N/A | 110 | Canada | Usual Practice + JoyPop | Lakehead University | Emotion Regulation, Depression, Anxiety, Stress | 12/25 | 12/25 | | |
NCT05898516: JoyPop Mobile Mental Health App With Indigenous Youth |
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| Recruiting | N/A | 110 | Canada | Usual Practice + JoyPop | Lakehead University, Dilico Anishinabek Family Care | Emotion Regulation, Depression, Anxiety, Stress | 12/24 | 12/24 | | |
NCT05991154: JoyPop Mobile Mental Health App With Indigenous Transitional-Aged Youth |
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| Recruiting | N/A | 110 | Canada | Usual Practice + JoyPop | Lakehead University, Dilico Anishinabek Family Care | Emotion Regulation, Depression, Anxiety, Stress | 12/24 | 12/24 | | |
| Tennankore, Karthik K |
| Recruiting | 3 | 2750 | Europe, Canada, RoW | Spironolactone 25Mg Tablet, Placebo Oral Tablet | Population Health Research Institute, Canadian Institutes of Health Research (CIHR) | Endstage Renal Disease | 07/25 | 04/26 | | |
PHOSPHATE, NCT03573089: Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease |
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| Recruiting | N/A | 3600 | Europe, Canada, RoW | Liberal phosphate target, Intensive phosphate target | The University of Queensland, National Health and Medical Research Council, Australia, Applied Health Research Centre, Cambridge University Hospitals NHS Foundation Trust, University of Otago | Kidney Failure, Chronic, Hyperphosphatemia | 12/27 | 12/28 | | |
| Recruiting | N/A | 160 | Canada, RoW | Intradialytic Cycling | University of Manitoba, Canadian Institutes of Health Research (CIHR) | End-stage Kidney Disease, Hemodialysis | 03/25 | 09/25 | | |
ReDACKD, NCT05113641: Reducing Dietary Acid with Food Versus Oral Alkali in People with Chronic Kidney Disease |
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| Recruiting | N/A | 40 | Canada | Alkalizing Fruit and Vegetables, Sodium bicarbonate | Dylan MacKay, Dalhousie University, Mount Saint Vincent University | Chronic Kidney Diseases, Metabolic Acidosis | 07/25 | 12/25 | | |
QuitWIT, NCT05166460: Novel Cooling Device for the Elimination of Warm Ischemia During Renal Transplantation |
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| Not yet recruiting | N/A | 45 | Canada | Kidney cooling device, Kidney Skinn | Thomas Skinner, Nova Scotia Health Authority | Kidney Transplant; Complications, Delayed Graft Function | 01/26 | 01/26 | | |
| Loubani, Osama |
| Completed | 3 | 4800 | Europe, Canada, US, RoW | Placebo (0.9% saline), normal saline; NaCl 0.9%, Pantoprazole, Protonix | McMaster University, Canadian Institutes of Health Research (CIHR), Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group, National Health and Medical Research Council, Australia | Gastrointestinal Hemorrhage (Clinically Important, Upper) | 10/23 | 01/24 | | |
| Terminated | 2/3 | 40 | Canada | Nebulized Furosemide, Nebulized Saline | Dr. John Muscedere, University Health Network, Toronto | Covid19, Respiratory Failure | 02/23 | 04/23 | | |
| Recruiting | 2/3 | 1096 | Canada, RoW | higher chloride crystalloid, lower chloride crystalloid | McMaster University, The Physicians' Services Incorporated Foundation, Canadian Institutes of Health Research (CIHR) | Sepsis, Septic Shock | 11/25 | 03/26 | | |
| Completed | N/A | 3622 | Europe, Canada, US, RoW | 7 days of adequate antibiotic treatment, 14 days of adequate antibiotic treatment. | Sunnybrook Health Sciences Centre | Bacteremia, Intensive Care, Critically Ill, Sepsis, Mortality, Antimicrobial | 05/23 | 08/23 | | |
| Sills, Laura |
CARSK, NCT03674307: Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates |
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| Recruiting | N/A | 3306 | Europe, Canada, US | No screening, Regular Screening | University of British Columbia, University of Sydney | Cardiovascular Diseases, End Stage Renal Disease, Kidney Transplantation, Dialysis Related Complication | 12/25 | 12/25 | | |
| Herman, Christine |
| Recruiting | N/A | 282 | Canada, US | Hypothermic circulatory arrest | Ottawa Heart Institute Research Corporation | Thoracic Aortic Disease | 02/25 | 09/25 | | |
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial |
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| Active, not recruiting | N/A | 2486 | Europe, Canada, US, RoW | Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS | Thomas G. Brott, M.D., National Institute of Neurological Disorders and Stroke (NINDS) | Carotid Stenosis | 02/26 | 02/26 | | |
| Walji, Nazlin |
| Not yet recruiting | 4 | 2726 | Canada, US | Cariprazine, Vraylar, Aripiprazole/Escitalopram combination, Abilify/ Lexapro, Quetiapine, Seroquel, Lurasidone, Latuda | Massachusetts General Hospital, Patient-Centered Outcomes Research Institute | Bipolar I Disorder, Depression | 02/30 | 02/30 | | |
| Recruiting | 3 | 150 | Europe, Canada, Japan, US | lurasidone, Latuda, Placebo | Nazlin Walji | Bipolar Disorder | 12/24 | 03/25 | | |
| Recruiting | 3 | 360 | Canada | Cannabidiol, CBD, Placebo | University of British Columbia | Bipolar Disorder | 12/29 | 12/30 | | |
| Stewart, Sherry H |
NCT03614884: Effectiveness of an Online Integrated Treatment for Problem Gambling and Tobacco Smoking |
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| Recruiting | N/A | 300 | Canada | Gambling and Smoking Treatment, Online CBT and MI, Gambling only treatment | University of Manitoba | Gambling Disorder | 08/21 | 12/21 | | |
NCT04546178: Psychotherapy for Psychosis, Adverse Events, and Substance Misuse |
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| Completed | N/A | 19 | Canada | Prolonged exposure (PE)+ therapy, PE+ therapy, Treatment as usual (TAU), Antipsychotics and program access | Nova Scotia Health Authority, Queen Elizabeth II Health Sciences Centre Foundation, Research Nova Scotia, Killam Laureates | Psychotic Disorders, Stress Disorders, Traumatic, Substance Use | 09/23 | 09/23 | | |
NCT06154369: JoyPop Mobile Mental Health App With Post-Secondary Students |
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| Recruiting | N/A | 120 | Canada | JoyPop | Lakehead University | Emotion Regulation, Depression, Anxiety, Stress, Well-Being, Psychological | 12/25 | 12/25 | | |
NCT06239545: JoyPop Mobile Mental Health App With Transitional-Aged Youth |
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| Recruiting | N/A | 110 | Canada | Usual Practice + JoyPop | Lakehead University | Emotion Regulation, Depression, Anxiety, Stress | 12/25 | 12/25 | | |
| Recruiting | N/A | 110 | Canada | Usual Practice + JoyPop | Lakehead University | Emotion Regulation, Depression, Anxiety, Stress | 12/25 | 12/25 | | |
| Recruiting | N/A | 1000 | Canada | UniVenture Hopelessness manual, UniVenture Anxiety Sensitivity manual, UniVenture Sensation Seeking manual, UniVenture Impulsivity manual, Service as usual provided by the University | Sherry Stewart, Dalhousie University, St. Francis Xavier University, Université de Montréal, York University, University of British Columbia, University of Victoria, Canadian Centre on Substance Use and Addiction (CCSA), Canadian Research Initiative in Substance Misuse, Injury Free Nova Scotia (IFNS), Mental Health Commission of Canada (MHCC), Postsecondary Education Partnership - Alcohol Harms (PEP-AH), Strategy for Patient Orientated Research, SHARP- Students for Healthy Alternatives & Risk Prevention, Nova Scotia Health Authority | Anxiety Sensitivity, Hopelessness, Sensation Seeking, Impulsivity | 02/24 | 07/24 | | |
NCT06211972: The Feasibility of the OpiVenture Program for Clients Undergoing Opioid Agonist Therapy |
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| Not yet recruiting | N/A | 96 | NA | OpiVenture | Dalhousie University, Canadian Institutes of Health Research (CIHR), Direction 180 | Nova Scotia Mental Health and Addictions, Centre for Research, Education, and Clinical Care of At-Risk Populations (RECAP), River Stone Recovery Centre, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Université de Montréal, University of New Brunswick | Opioid Use Disorder, Polysubstance Addiction, Substance Use | 02/25 | 02/26 | | |
