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Trial + Data / Events	Status	Ph	N	Region	Interventions	Sponsor	Conditions	Primary compl	Study compl
Griffin, Kurt
NCT03929601: Rituximab-pvvr and Abatacept Vs Rituximab-pvvr Alone in New Onset Type 1 Diabetes	Recruiting	2	74	US, RoW	Rituximab-pvvr, Ruxience, Abatacept, Orencia, Sterile Sodium Chloride, 0.9% Sodium Chloride Water for Injection	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH)	Type 1 Diabetes Mellitus	10/27	10/29
DESIGNATE, NCT05574335: Siplizumab in T1DM	Active, not recruiting	1/2	120	US	Siplizumab, TCD 601	National Institute of Allergy and Infectious Diseases (NIAID)	Type 1 Diabetes Mellitus	12/26	12/27
T1DES, NCT02734277: Type 1 Diabetes Extension Study	Recruiting	N/A	111	US		National Institute of Allergy and Infectious Diseases (NIAID), Immune Tolerance Network (ITN)	Type 1 Diabetes Mellitus, T1DM, T1D	03/25	03/25
PLEDGE, NCT04477928: General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery	Recruiting	N/A	33000	US	Sera and whole blood sampling, Differential Gene Expression (DGE)	Sanford Health, The Leona M. and Harry B. Helmsley Charitable Trust, Pacific Northwest Research Institute, University of Exeter	Type 1 Diabetes, Celiac Disease	03/31	03/31
Mays, Ann
PLEDGE, NCT04477928: General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery	Recruiting	N/A	33000	US	Sera and whole blood sampling, Differential Gene Expression (DGE)	Sanford Health, The Leona M. and Harry B. Helmsley Charitable Trust, Pacific Northwest Research Institute, University of Exeter	Type 1 Diabetes, Celiac Disease	03/31	03/31

Trial + Data / Events	Status	Ph	N	Region	Interventions	Sponsor	Conditions	Primary compl	Study compl
Griffin, Kurt
NCT03929601: Rituximab-pvvr and Abatacept Vs Rituximab-pvvr Alone in New Onset Type 1 Diabetes	Recruiting	2	74	US, RoW	Rituximab-pvvr, Ruxience, Abatacept, Orencia, Sterile Sodium Chloride, 0.9% Sodium Chloride Water for Injection	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH)	Type 1 Diabetes Mellitus	10/27	10/29
DESIGNATE, NCT05574335: Siplizumab in T1DM	Active, not recruiting	1/2	120	US	Siplizumab, TCD 601	National Institute of Allergy and Infectious Diseases (NIAID)	Type 1 Diabetes Mellitus	12/26	12/27
T1DES, NCT02734277: Type 1 Diabetes Extension Study	Recruiting	N/A	111	US		National Institute of Allergy and Infectious Diseases (NIAID), Immune Tolerance Network (ITN)	Type 1 Diabetes Mellitus, T1DM, T1D	03/25	03/25
PLEDGE, NCT04477928: General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery	Recruiting	N/A	33000	US	Sera and whole blood sampling, Differential Gene Expression (DGE)	Sanford Health, The Leona M. and Harry B. Helmsley Charitable Trust, Pacific Northwest Research Institute, University of Exeter	Type 1 Diabetes, Celiac Disease	03/31	03/31
Mays, Ann
PLEDGE, NCT04477928: General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery	Recruiting	N/A	33000	US	Sera and whole blood sampling, Differential Gene Expression (DGE)	Sanford Health, The Leona M. and Harry B. Helmsley Charitable Trust, Pacific Northwest Research Institute, University of Exeter	Type 1 Diabetes, Celiac Disease	03/31	03/31