The Lindner Research Center
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 29 Trials 
64 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Sapp, John L
VANISH2, NCT02830360: Antiarrhythmics or Ablation for Ventricular Tachycardia 2

Completed
4
416
Europe, Canada, US
Antiarrythmic Drug Therapy, Amiodarone (Cordarone) or Sotalol (Sotacor), Catheter ablation, VT ablation
John Sapp, Heart and Stroke Foundation of Canada, Abbott Medical Devices, Biosense Webster, Inc., Ottawa Heart Institute Research Corporation, Canadian Institutes of Health Research (CIHR), Cardiac Arrhythmia Network of Canada, Abbott, Nova Scotia Health Authority
Ventricular Tachycardia (VT)
06/24
06/24
REFINE-ICD, NCT00673842: Efficacy of Implantable Defibrillator Therapy After a Myocardial Infarction

Active, not recruiting
3
700
Europe, Canada, US, RoW
Implantable Cardioverter Defibrillator + Usual Care, Implantable Cardioverter Defibrillator, ICD, Usual care, Standard medical therapy alone
University of Calgary, Canadian Institutes of Health Research (CIHR), Alberta Innovation and Science, Medtronic, GE Healthcare, Cardiac Arrhythmia Network of Canada, Accelerating Clinical Trials Consortium
Myocardial Infarction, Sudden Death
12/24
12/24
COAST-AF RCT, NCT03347227: Characterization of Arrhythmia Substrate to Ablate Persistent Atrial Fibrillation

Recruiting
N/A
502
Canada
Catheter ablation, Atrial Fibrillation Ablation
Ottawa Heart Institute Research Corporation, Heart and Stroke Foundation of Canada
Atrial Fibrillation
12/24
12/24
ECGI-VT, NCT03713866: Peri-Procedural Transmural Electrophysiological (EP) Imaging of Scar-Related Ventricular Tachycardia

Recruiting
N/A
20
Canada
EP Imaging and Testing
John Sapp, Nova Scotia Health Authority, Rochester Institute of Technology
Ventricular Tachycardia, Myocardial Infarction
12/26
03/27
RASTA AF, NCT03682991: Reversal of Atrial Substrate to Prevent Atrial

Recruiting
N/A
670
Canada
Aggressive Risk Factor Control, Standard of Care
Nova Scotia Health Authority, Canadian Institutes of Health Research (CIHR), Abbott, Phillips, Cardiac Arrhythmia Network of Canada
Atrial Fibrillation
06/25
06/27
NCT04162171: Cohort Study - SBRT for VT Radioablation

Recruiting
N/A
12
Canada
Stereotactic Body Radiotherapy (SBRT) ablation of VT, VT Radioablation
John Sapp
Ventricular Tachycardia, Myocardial Infarction, Heart Disease Structural Disorder
06/26
09/26
END VT, NCT05835791: END - VT Cohort Study

Recruiting
N/A
2454
Canada
Nova Scotia Health Authority, Maritime Heart Centre
Ventricular Tachycardia, Implantable Defibrillator User, ICD
04/28
04/29
Kereiakes, Dean
NCT02806570: The CorCinch - Functional Mitral Valve Regurgitation (FMR) Study

Completed
N/A
35
US
Mitral valve repair
Ancora Heart, Inc.
Heart Failure, Mitral Valve Insufficiency, Cardiomyopathies
01/20
08/24
NCT03168776: PIONEER III Trial to Assess Safety and Efficacy of the BuMA Supreme™ Drug Coated Coronary Stent in Patients With Coronary Disease

Active, not recruiting
N/A
1632
Europe, Canada, Japan, US
BuMA Supreme DES, Xience or Promus DES
Sino Medical Sciences Technology Inc., Nova Vascular LLC
Coronary Artery Disease
10/20
09/24
NCT02799823: Transfemoral Replacement of Aortic Valve With HLT MeriDIAN Valve Early Feasibility Trial

Terminated
N/A
11
US
HLT Transcatheter Aortic Valve System
HLT Inc.
Aortic Valve Stenosis
01/23
01/23
RIVAL - AR EFS, NCT05409378: HLT® Meridian® TAVR Valve System Early Feasibility Study for Aortic Regurgitation

Withdrawn
N/A
10
US
The HLT® Meridian® TAVR Valve (Meridian® with TriVentTM Anticalcification Treatment Valve and Pathfinder® Delivery System)
HLT Inc.
Aortic Regurgitation
01/23
01/23
CRYSTAL, NCT03423511: Trial to Demonstrate the Safety and Effectiveness of the MiStent II for the Revascularization of Coronary Arteries.

Not yet recruiting
N/A
1300
NA
MiStent II coronary artery stent, Xience or Promus coronary artery stents
Micell Technologies, Baim Institute for Clinical Research, North American Science Associates Inc., Yale Cardiovascular Research Group
Coronary Artery Disease
06/23
06/27
JVTF EFS, NCT06034028: J-Valve TF Early Feasibility Study

Active, not recruiting
N/A
25
US
J-Valve TF System
JC Medical, Inc.
Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Regurgitation
07/24
08/29
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF): the CORCINCH-HF Study

Recruiting
N/A
400
Europe, US, RoW
AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy
Ancora Heart, Inc.
Heart Failure with Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy
12/26
12/30
NCT05966662: Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO)

Active, not recruiting
N/A
145
US
IVL with Shockwave C2+ 2Hz Coronary IVL Catheter
Shockwave Medical, Inc.
Coronary Artery Disease, Myocardial Infarction
01/25
12/25
JOURNEY, NCT06455787: J-Valve Transfemoral Pivotal Study

Recruiting
N/A
194
US
J-Valve Transfemoral (TF) System
JC Medical, Inc., Bright Research Partners, Minneapolis Heart Institute Foundation, Cardiovascular Research Foundation, New York
Aortic Valve Regurgitation, Aortic Valve Disease Mixed
09/27
09/31
NCT04496518: Personalized Therapy Study - Intrinsic Antitachycardia Pacing Post-Approval Study (iATP PAS)

Active, not recruiting
N/A
2200
Europe, US
Intrinsic Antitachycardia Pacing (iATP) Therapy
Medtronic
Ventricular Tachycardia
01/25
01/27
NCT04489225: Personalized Therapy Study - HFRS (TriageHF) Post Approval Study

Active, not recruiting
N/A
2200
Europe, US
Observational
Medtronic
Heart Failure
01/25
01/27
NCT03142152: The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR

Recruiting
N/A
300
Europe, US
Carillon Mitral Contour System, Carillon, Percutaneous mitral valve repair, Guideline Directed Heart Failure Medication
Cardiac Dimensions, Inc.
Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases
12/26
12/30
ASQ, NCT04024943: Personalized Therapy Study - Attain Stability Quad Post-Approval Study

Active, not recruiting
N/A
1092
Europe, US
Quadripolar LV Lead, Medtronic CRT-P, Medtronic CRT-D
Medtronic
Heart Failure
01/27
04/27
NCT06048731: Enlighten Study: The EV-ICD Post Approval Registry

Recruiting
N/A
1000
Europe, Canada, US, RoW
Defibrillation using EV-ICD
Medtronic
Ventricular Arrhythmia, Tachycardia
05/30
10/37
Chung, Eugene
DETECT-HF, NCT06378632: AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

Recruiting
N/A
500
Europe, US, RoW
Hearo App
Cordio Medical
Heart Failure
01/25
03/25
NCT05206422: DORAYA-HF Early Feasibility Study

Recruiting
N/A
30
US
Doraya Catheter
Revamp Medical Inc.
Acute Decompensated Heart Failure
10/25
12/25
NCT05425459: RESPONDER-HF Trial

Recruiting
N/A
750
Europe, Canada, US, RoW
Corvia Atrial Shunt System / IASD System II, Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE)
Corvia Medical
Heart Failure, Heart Failure, Diastolic
05/25
03/31
McGrew, Frank
REBIRTH, NCT05180773: Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy

Recruiting
4
250
US
Bromocriptine, Parlodel, Cycloset, Placebo, Guideline Directed Medical Therapy for Heart Failure (GDMT), Rivaroxaban, Xarelto, Second Placebo
Dennis M. McNamara, MD, MS, National Heart, Lung, and Blood Institute (NHLBI)
Peripartum Cardiomyopathy, Postpartum
06/26
12/28
NCT06267560: Lp(a) Lowering Study of Pelacarsen (TQJ230) in US Black/African American and Hispanic Participants With Elevated Lp(a) and Established ASCVD

Recruiting
3
400
US
TQJ230, pelacarsen, Placebo
Novartis Pharmaceuticals
Elevated Lp(a) and Established Atherosclerotic Cardiovascular Disease
03/27
03/27
PREVAIL, NCT05202509 / 2021-005092-39: Cardiovascular Outcome Study to Evaluate the Effect of Obicetrapib in Patients With Cardiovascular Disease

Active, not recruiting
3
9541
Europe, Canada, Japan, US, RoW
Obicetrapib, Placebo
NewAmsterdam Pharma, Monash University
Atherosclerotic Cardiovascular Disease
11/26
11/26
GenePHIT, NCT05598333: Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects with Non-Ischemic NYHA Class III Heart Failure

Recruiting
2
150
US
AB-1002, Gene Therapy, NAN-101
Asklepios Biopharmaceutical, Inc.
Congestive Heart Failure
10/26
12/30
INTEGRA-D, NCT05855135: Assessment of Combined CCM and ICD Device in HFrEF

Recruiting
N/A
300
US
OPTIMIZER® Integra CCM-D System (Treatment Arm)
Impulse Dynamics
Heart Failure, Heart Failure with Reduced Ejection Fraction, Implantable Defibrillator User, CCM Therapy, Non-ischemic Cardiomyopathy, Ischemic Cardiomyopathy, Sudden Cardiac Arrest, Arrhythmias, Cardiac, Ventricular Tachycardia, Ventricular Fibrillation
06/25
12/25
ALLEVIATE-HF, NCT04452149: Algorithm Using LINQ Sensors for Evaluation And Treatment of Heart Failure

Active, not recruiting
N/A
826
US
Reveal LINQ™ Insertable Cardiac Monitor with investigational ALLEVIATE-HF RAMware download, Medication intervention
Medtronic Cardiac Rhythm and Heart Failure
Heart Failure NYHA Class II, Heart Failure NYHA Class III
05/25
05/25
NCT04502316: Real-World Experience - Barostim™ Advancing the Level of Clinical Evidence (REBALANCE Registry)

Recruiting
N/A
5000
US
Barostim™ System
CVRx, Inc.
Heart Failure
06/28
06/28
Malik, Amir
COSIRA-II, NCT05102019: Efficacy of the COronary SInus Reducer in Patients with Refractory Angina II

Recruiting
N/A
380
Canada, US
Arm 1: treatment with Neovasc Reducer, Arm 2 (control): Implantation procedure with no device implanted, Arm 3 (unblinded, non-randomized): Single arm registry
Neovasc Inc., Shockwave Medical, Inc.
Refractory Angina
06/25
12/28
ALLEVIATE-HF, NCT04452149: Algorithm Using LINQ Sensors for Evaluation And Treatment of Heart Failure

Active, not recruiting
N/A
826
US
Reveal LINQ™ Insertable Cardiac Monitor with investigational ALLEVIATE-HF RAMware download, Medication intervention
Medtronic Cardiac Rhythm and Heart Failure
Heart Failure NYHA Class II, Heart Failure NYHA Class III
05/25
05/25
PROTECT IV, NCT04763200: Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function

Recruiting
N/A
1252
Europe, Canada, US
Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®, IABP Intra-aortic balloon pump
Abiomed Inc.
Left Ventricular Dysfunction, Coronary Artery Disease
03/26
10/27
NCT05412927: AngelMed Guardian® System PMA Post Approval Study

Recruiting
N/A
500
US
PMA P150009 AngelMed Guardian® System
Angel Medical Systems
Acute Coronary Syndrome
12/26
12/26
White, David P
NCT05425459: RESPONDER-HF Trial

Recruiting
N/A
750
Europe, Canada, US, RoW
Corvia Atrial Shunt System / IASD System II, Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE)
Corvia Medical
Heart Failure, Heart Failure, Diastolic
05/25
03/31
ALT-FLOW II, NCT05686317: Trial of the Edwards APTURE Transcatheter Shunt System

Recruiting
N/A
100
Europe, Canada, US
Edwards APTURE transcatheter shunt system, Sham procedure
Edwards Lifesciences
Heart Failure
01/26
07/30
NCT03523416: Early Feasibility Study - Edwards APTURE Transcatheter Shunt System

Active, not recruiting
N/A
71
US
Transcatheter Atrial Shunt System
Edwards Lifesciences
Heart Failure
12/23
11/28
Remote-CaRe, NCT06015191: Remote Cardiac Rehab for Adolescents With Congenital Heart Disease

Recruiting
N/A
74
US
Remote Cardiac Rehabilitation, RCR, Active Control
Children's Mercy Hospital Kansas City, University of Kansas, Children's Hospital of Philadelphia, University of North Carolina, Chapel Hill, National Heart, Lung, and Blood Institute (NHLBI)
Congenital Heart Disease in Children
06/27
12/27
Tschopp, David
NCT05280093: HEAL-IST IDE Trial

Recruiting
N/A
142
Europe, US
AtriCure ISOLATOR Synergy Surgical Ablation System
AtriCure, Inc.
Inappropriate Sinus Tachycardia
06/26
06/27
NCT05005949: STOP Persistent AF PAS

Recruiting
N/A
400
Europe, US
Arctic Front™ Cardiac Cryoablation Catheter System
Medtronic Cardiac Rhythm and Heart Failure
Persistent Atrial Fibrillation
08/27
08/27
Answini, Geoffrey
NCT03111459: Repair of Thoracoabdominal Aortic Aneurysms

Recruiting
N/A
15
US
Medtronic Valiant Thoracoabdominal Stent Graft System
The Christ Hospital, Medtronic
Thoracoabdominal Aneurysm
05/24
05/29
TRIOMPHE, NCT04471909: NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Recruiting
N/A
110
US, RoW
NEXUS Aortic Stent Graft System
Endospan Ltd.
Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
11/24
10/29
ASPIRE PH, NCT04555161: Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System

Recruiting
N/A
30
US
Aria CV Pulmonary Hypertension System, Aria CV PH System
Aria CV, Inc
Pulmonary Arterial Hypertension, Pulmonary Hypertension, Right Heart Dysfunction
10/25
10/26
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
10/26
09/36
Beyerbach, Daniel
NCT05005949: STOP Persistent AF PAS

Recruiting
N/A
400
Europe, US
Arctic Front™ Cardiac Cryoablation Catheter System
Medtronic Cardiac Rhythm and Heart Failure
Persistent Atrial Fibrillation
08/27
08/27
Pelchovitz, Daniel
REACT-AF, NCT05836987: The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

Recruiting
3
5350
US
AFSW Guided DOAC, Apple Watch, Continuous DOAC therapy, Oral Anticoagulation therapy
Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI)
Atrial Fibrillation
07/29
07/29
NCT05280093: HEAL-IST IDE Trial

Recruiting
N/A
142
Europe, US
AtriCure ISOLATOR Synergy Surgical Ablation System
AtriCure, Inc.
Inappropriate Sinus Tachycardia
06/26
06/27
NCT05227053: STOP AF First Post-Approval Study

Recruiting
N/A
200
US
Arctic Front™ Cardiac Cryoablation Catheter
Medtronic Cardiac Rhythm and Heart Failure
Paroxysmal Atrial Fibrillation
01/28
01/28
Harding, Mark
TRIOMPHE, NCT04471909: NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Recruiting
N/A
110
US, RoW
NEXUS Aortic Stent Graft System
Endospan Ltd.
Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
11/24
10/29
Mazzei, W Robert
ALLEVIATE-HF, NCT04452149: Algorithm Using LINQ Sensors for Evaluation And Treatment of Heart Failure

Active, not recruiting
N/A
826
US
Reveal LINQ™ Insertable Cardiac Monitor with investigational ALLEVIATE-HF RAMware download, Medication intervention
Medtronic Cardiac Rhythm and Heart Failure
Heart Failure NYHA Class II, Heart Failure NYHA Class III
05/25
05/25
Walt, Janet
NCT04325789: Rotator Cuff Healing Using a Nanofiber Scaffold in Patients Greater Than 55 Years

Active, not recruiting
N/A
91
US
nanofiber scaffold, ROTIUM™ Bioresorbable Wick (Atreon Orthopedics)
Atreon Orthopedics
Rotator Cuff Tears
03/25
03/25
SPINE, NCT04176562: Prospective Registry

Recruiting
N/A
5000
Europe, US
RTI Spine products
Xtant Medical, RTI Surgical
Sacroiliac; Fusion, Sacroiliac, Joint Diseases, Musculoskeletal Diseases, Spinal Disease, Spinal Stenosis, Spinal Instability, Fusion of Joint, Fusion of Spine, Spinal Fusion, Spine
03/25
06/25
Bhatia, Ankit
NCT05206422: DORAYA-HF Early Feasibility Study

Recruiting
N/A
30
US
Doraya Catheter
Revamp Medical Inc.
Acute Decompensated Heart Failure
10/25
12/25
ALLEVIATE-HF, NCT04452149: Algorithm Using LINQ Sensors for Evaluation And Treatment of Heart Failure

Active, not recruiting
N/A
826
US
Reveal LINQ™ Insertable Cardiac Monitor with investigational ALLEVIATE-HF RAMware download, Medication intervention
Medtronic Cardiac Rhythm and Heart Failure
Heart Failure NYHA Class II, Heart Failure NYHA Class III
05/25
05/25
Douglas, Shaneka
TRIOMPHE, NCT04471909: NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Recruiting
N/A
110
US, RoW
NEXUS Aortic Stent Graft System
Endospan Ltd.
Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
11/24
10/29
PERSEVERE, NCT05174767: - a Trial to Evaluate AMDS in Acute DeBakey Type I Dissection

Active, not recruiting
N/A
115
US
AMDS
Artivion Inc., Syneos Health
Acute Aortic Dissection
12/23
12/29
NCT06029660: AAA-SHAPE Pivotal Trial: Abdominal Aortic Aneurysm Sac Healing and Prevention of Expansion

Recruiting
N/A
180
Europe, US, RoW
IMPEDE-FX RapidFill Implants, EndoVascular Aneurysm Repair, EVAR
Shape Memory Medical, Inc., NAMSA
Aortic Aneurysm, Abdominal
06/27
06/31
Hoyle, Mark
TRIOMPHE, NCT04471909: NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Recruiting
N/A
110
US, RoW
NEXUS Aortic Stent Graft System
Endospan Ltd.
Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
11/24
10/29
Maskoun, Waddah
NCT05936294: Adaptive Cardiac Resynchronization Therapy in Patients With RBBB

Terminated
N/A
5
US
Optimization of CRT Device
Henry Ford Health System, Central Arkansas Veterans Healthcare System
Right Bundle-Branch Block
03/21
03/21
NCT05005949: STOP Persistent AF PAS

Recruiting
N/A
400
Europe, US
Arctic Front™ Cardiac Cryoablation Catheter System
Medtronic Cardiac Rhythm and Heart Failure
Persistent Atrial Fibrillation
08/27
08/27
NCT05227053: STOP AF First Post-Approval Study

Recruiting
N/A
200
US
Arctic Front™ Cardiac Cryoablation Catheter
Medtronic Cardiac Rhythm and Heart Failure
Paroxysmal Atrial Fibrillation
01/28
01/28
LAAOS-4, NCT05963698: The Fourth Left Atrial Appendage Occlusion Study

Recruiting
N/A
4000
Europe, Canada, US
WATCHMAN device
Hamilton Health Sciences Corporation, McMaster University, Population Health Research Institute, Boston Scientific Corporation
Atrial Fibrillation, Stroke, Ischemic, Systemic Embolism
09/29
12/29
Rhea, Isaac
ALLEVIATE-HF, NCT04452149: Algorithm Using LINQ Sensors for Evaluation And Treatment of Heart Failure

Active, not recruiting
N/A
826
US
Reveal LINQ™ Insertable Cardiac Monitor with investigational ALLEVIATE-HF RAMware download, Medication intervention
Medtronic Cardiac Rhythm and Heart Failure
Heart Failure NYHA Class II, Heart Failure NYHA Class III
05/25
05/25

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