University Hospital RWTH Aachen
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 55 Trials 
79 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
ROSSAINT, Rolf
NCT05388071: Feasibility of Telemedicine Under Ambulance Station Conditions

Completed
N/A
404
Europe
Usage of telemedicine and tele-consultation for treatment
RWTH Aachen University
Telemedicine, Disaster Medicine, Emergency Medicine
07/22
06/23
Bruix, Jordi
ABC-HCC, NCT04803994 / 2020-004210-35: The Trial: Atezolizumab Plus Bevacizumab vs. Transarterial Chemoembolization (TACE) in Intermediate-stage HepatoCellular Carcinoma

Recruiting
3
434
Europe, Japan
Atezolizumab, Tecentriq, Bevacizumab, Avastin, TACE, transarterial chemoembolization
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest, F. Hoffmann-La Roche Ltd
Hepatocellular Carcinoma
07/27
07/27
SIRCCA, NCT02807181: SIRT Followed by CIS-GEM Chemotherapy Versus CIS-GEM Chemotherapy Alone as 1st Line Treatment of Patients With Unresectable Intrahepatic Cholangiocarcinoma

Completed
2/3
89
Europe, US, RoW
Cisplatin-gemcitabine, CIS-GEM, Radiation: SIRT + chemotherapy (cisplatin-gemcitabine)
Sirtex Medical
Intrahepatic Cholangiocarcinoma
10/22
10/22
LT for iCCA, NCT02878473: Liver Transplantation for Early Intrahepatic Cholangiocarcinoma

Terminated
2
2
Canada
Deceased donor Liver Transplantation
University Health Network, Toronto
Intrahepatic Cholangiocarcinoma
12/24
12/24
Coburn, Mark
LIBERAL, NCT03369210: Liberal Transfusion Strategy in Elderly Patients

Recruiting
3
2470
Europe
red blood cell transfusion trigger
Johann Wolfgang Goethe University Hospital, Wuerzburg University Hospital
Transfusion-dependent Anemia, Surgery, Anemia
12/24
12/25
PrepTAB, NCT04160234: Preoperative Risk Assessment in the Elderly

Recruiting
N/A
100
Europe
web-based questionnaires
RWTH Aachen University
Preoperative Risk Assessment
12/21
01/22
POPIMAGE, NCT05368896: Peri-operative Inflammaging in the Elderly After Surgery

Recruiting
N/A
150
Europe
University of Bonn
Aging, Immunology, Postoperative Complications, Surgery
12/24
03/25
Trautwein, Christian
NCT03866187 / 2017-001452-55: Safety, Efficacy, Immunogenicity Study of GSK Biologicals' HBV Viral Vector and Adjuvanted Proteins Vaccine (GSK3528869A) in Adult Patients With Chronic Hepatitis B Infection

Terminated
1/2
135
Europe, RoW
ChAd155-hIi-HBV low dose formulation, ChAd155-hIi-HBV high dose formulation, HBc-HBs/AS01B-4 low dose formulation, HBc-HBs/AS01B-4 high dose formulation, MVA-HBV low dose formulation, MVA-HBV high dose formulation, Placebo
GlaxoSmithKline, GlaxoSmithKline Biologicals
Hepatitis B, Chronic
10/24
10/24
ADLH, NCT03897218: Dietary Modulation of Intestinal Microbiota as Trigger of Liver Health: Role of Bile Acids - "A Diet for Liver Health"

Completed
N/A
84
Europe
oatmeal flakes with prebiotic food supplements, millet flakes
RWTH Aachen University
NASH - Nonalcoholic Steatohepatitis
04/22
04/22
PBC-Cohort, NCT04076527 / 2016-004141-90: Prospective, Multicenter Cohort Study on Primary Biliary Cholangitis

Recruiting
N/A
1200
Europe
UDCA, ursodeoxycholic acid, Ocaliva, obeticholic acid
University of Leipzig, RWTH Aachen University, Zentrum für Klinische Studien Leipzig, Intercept Pharma Europe Limited (IPEL), Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), University Hospital Erlangen, Medical care center for Gastroenterology, Berlin, Institute for Interdisciplinary Medicine, Hamburg, Leberhilfe Projekt gUG, Cologne, Hannover Medical School
PBC, Primary Biliary Cholangitis
03/24
03/24
NCT04442334: The European NAFLD Registry

Recruiting
N/A
10000
Europe
Newcastle University, Newcastle-upon-Tyne Hospitals NHS Trust, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Institute of Cardiometabolism and Nutrition, France, University of Cambridge, Örebro University, Sweden, University of Bern, University of Oxford, University of Turin, Italy, University of Angers, University Hospital, Antwerp, Linkoeping University, University of Helsinki, UMC Utrecht, National and Kapodistrian University of Athens, University of Lisbon, University of Milan, University of Palermo, Catholic University of the Sacred Heart, Wuerzburg University Hospital, RWTH Aachen University, University of Nottingham, Medical University of Vienna, University of Birmingham, University of Florence, Assistance Publique - Hôpitaux de Paris, University Medical Center Mainz
NAFLD, NASH, NASH - Nonalcoholic Steatohepatitis, Fibrosis, Liver, Steatosis of Liver, Hepatocellular Carcinoma, Cardiovascular Diseases, Type 2 Diabetes, Dyslipidaemia, Hypertension, Obesity, Other Associated Comorbidities
12/30
12/30
Brokmann, Jörg C
Optimal@NRW, NCT04873973: Optimized Acute Care for Geriatric Patients Using an Intersectoral Telemedical Cooperation Network - Around the Clock - Technical Performance

Recruiting
N/A
3073
Europe
Telemedical support
RWTH Aachen University, Optimal@NRW Research Group
Emergencies
03/23
03/23
Optimal@NRW, NCT04879537: Optimized Acute Care for Geriatric Patients Using an Intersectoral Telemedical Cooperation Network - Around the Clock

Completed
N/A
1600
Europe
Telemedical support
RWTH Aachen University, Optimal@NRW Research Group
Emergencies
03/23
04/23
Stoppe, Christian
SUSTAINCSX, NCT02002247: SodiUm SeleniTe Adminstration IN Cardiac Surgery (SUSTAIN CSX®-Trial).

Active, not recruiting
3
1400
Europe, Canada
sodium selenite, selenium, Placebo, NaCl 0.9%
Daren K. Heyland, biosyn Arzneimittel GmbH, Queen's University, RWTH Aachen University
Heart Disease
02/21
07/21
PROPER-LVAD, NCT04205760: Preoperative Nutritional Optimization and Physical Exercise for Patients Scheduled for Elective Implantation for a Left-Ventricular Assist Device

Recruiting
3
40
Europe
Nutrition + exercise, bed cycling, ONS
RWTH Aachen University
Left Ventricular Assist Device, End-stage Heart Failure, Cardiac Surgery
07/23
12/23
LIBERAL, NCT03369210: Liberal Transfusion Strategy in Elderly Patients

Recruiting
3
2470
Europe
red blood cell transfusion trigger
Johann Wolfgang Goethe University Hospital, Wuerzburg University Hospital
Transfusion-dependent Anemia, Surgery, Anemia
12/24
12/25
VICToRY, NCT04138394: VItamin C in Thermal injuRY: The Trial

Recruiting
3
666
Europe, Canada, US, RoW
Ascorbic Acid, vitamin C, placebo, saline, D5W
Clinical Evaluation Research Unit at Kingston General Hospital, Dr. Christian Stoppe, MD, Co-Principal Investigator, Wurzburg University, Wurzburg, Germany
Shock, Thermal Burn
12/26
06/27
MODIFYCSX, NCT06279793: Intravenous Fish Oil Based Lipid Emulsion to Enhance Recovery in High-Risk Cardiac Surgery Patients

Recruiting
2
120
Europe
Long-chain n-3 fatty acids, Omegaven®, Intravenous 0.9% Sodium Chloride, Saline Infusion
GCP-Service International West GmbH, University Hospital, Bonn, University Hospital Muenster, University Hospital Goettingen, University Hospital Schleswig-Holstein, Charite University, Berlin, Germany, Wuerzburg University Hospital
Cardiac Surgery, High Risk Patients, Intensive Care Unit, Cardiopulmonary Bypass, Valve Surgeries
12/24
12/25
Biobank OIM, NCT03014427: Development of a Biological Database in the Field of Operative Intensive Care

Recruiting
N/A
99999999
Europe
Biological Database
RWTH Aachen University
Intensive Care in General
02/50
02/50
Marx, Gernot
PEPPER, NCT03334006 / 2016-001788-34: Prospective, Randomized Trial of Personalized Medicine with Pentaglobin® After Surgical Infectious Source Control in Patients with Peritonitis

Recruiting
2
200
Europe
Pentaglobin®/Standard of Care
RWTH Aachen University, Biotest
Peritonitis, Sepsis, Septic Shock
09/27
03/28
Schulz, Jörg B
NICOFA, NCT03761511 / 2017-002163-17: Study of the Efficacy and Safety of Nicotinamide in Patients With Friedreich Ataxia

Withdrawn
2
225
Europe
Nicotinamide, Placebo
RWTH Aachen University, Assistance Publique - Hôpitaux de Paris
Friedreich Ataxia
06/25
12/25
EvalMZEB, NCT04781452: Evaluating the Treatment in the MZEB Aachen

Recruiting
N/A
2000
Europe
standard treatment
RWTH Aachen University
Intellectual Disability, Disability Physical
07/29
07/29
EFACTS, NCT02069509: Patient Registry of the European Friedreich's Ataxia Consortium for Translational Studies

Recruiting
N/A
1200
Europe, RoW
European Friedreich's Ataxia Consortium for Translational Studies
Friedreich's Ataxia
12/24
12/24
TRACK-FA, NCT04349514: A Natural History Study to TRACK Brain and Spinal Cord Changes in Individuals with Friedreich Ataxia

Active, not recruiting
N/A
300
Europe, Canada, US, RoW
Natural history
Monash University, University of Minnesota, RWTH Aachen University, University of Campinas, Brazil, Children's Hospital of Philadelphia, University of Florida, Friedreich's Ataxia Research Alliance, McGill University
Friedreich Ataxia
10/25
10/25
UNIFAI, NCT06016946: Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study

Recruiting
N/A
3000
Europe, Canada, US, RoW
Friedreich's Ataxia Research Alliance
Friedreich Ataxia
01/48
01/48
Dreher, Michael
NCT04144296: Mathematical Arterialisation of Capillary Blood for Blood Gas Analysis in Critical Ill Patients

Recruiting
N/A
70
Europe
Study procedure
RWTH Aachen University, OBI Medical
Lung Diseases
10/21
11/21
HOmeVent, NCT02811588: HomeVent ( Connect) Registry: EU COPD Home NIV Registry

Active, not recruiting
N/A
169
Europe
Non-invasive ventilation
ResMed, CRI-The Clinical Research Institute GmbH
Chronic Obstructive Pulmonary Disease
12/24
06/25
NCT05582642: Respiratory Muscles After Inspiratory Muscle Training After COVID-19

Completed
N/A
18
Europe
Inspiratory Muscle Training (IMT)
RWTH Aachen University, Philipps University Marburg Medical Center
COVID-19, Diaphragm Injury
04/23
04/23
REMAP-COVID-19, NCT04854863: Respiratory Muscles After Hospitalisation for COVID-19

Completed
N/A
50
Europe
Comprehensive assessment of respiratory muscle function.
RWTH Aachen University
Covid19, Diaphragm Injury
07/23
11/23
SNA in COPD, NCT04849806: Sympathetic Nerve Activity Predictors in Patients With Chronic Obstructive Pulmonary Disease

Recruiting
N/A
80
Europe
Assessments of the sympathetic nerve activity axis, OSA severity, Determination of PH and right HF severity, Comprehensive lung function and inspiratory muscle function testing., Assessment of systemic inflammation
RWTH Aachen University
COPD, Sympathetic Nervous System Diseases, Catecholamine; Overproduction
04/24
08/24
DAM, NCT05211661: Diaphragm Atrophy and Dysfunction in Mechanical Ventilation

Recruiting
N/A
15
Europe
Respiratory Muscle Testing
RWTH Aachen University
Diaphragm Issues, Mechanical Ventilation Complication, Respiratory Failure, Intensive Care (ICU) Myopathy
12/23
12/23
RMA-COVID-19, NCT06105450: Respiratory Muscle Assesment in COVID-patients Without Hospitalization

Not yet recruiting
N/A
25
Europe
Comprehensive assessment of respiratory muscle function.
RWTH Aachen University
Covid19, Diaphragm Injury
12/24
12/24
DFUNBIO, NCT05903001: Diaphragmatic Function as a Biomarker

Recruiting
N/A
800
Europe
Diaphragm Ultrasound, Intercostal Muscle Ultrasound, Borg scale, MRC Breathlessness Scale, Respiratory Questionaire, GINA classification of Asthma, Measurement of respiratory mouth pressure, SNIP, 6-minute walking distance, 60 seconds sit-to-stand test, Electromyography, Lung Function, CAT-Questionnaire, European Society of Cardiology (ESC)/ European Respiratory Society (ERS) risk group
RWTH Aachen University
Dyspnea; Asthmatic, COPD, Fibrosis, Pulmonary Hypertension, Asthma, Dyspnea
06/25
06/25
MSNA in Asthma, NCT05704101: NHFT Effects on Symptatheic Drive of Asthma Patients

Recruiting
N/A
30
Europe
RWTH Aachen University, ResMed
Asthma
 
 
Gründer, Gerhard
EPIsoDE, NCT04670081 / 2019-003984-24: Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression

Active, not recruiting
2
144
Europe
Psilocybin, Nicotinamide
Central Institute of Mental Health, Mannheim, Charite University, Berlin, Germany, MIND Foundation gGmbH, German Federal Ministry of Education and Research, Usona Institute
Treatment-resistant Depression
02/24
12/24
NCT03911726: Do Antipsychotic Agents Induce Supersensitivity in Humans: A Combined PET/MRI Study in Patients With Schizophrenia

Recruiting
N/A
140
Europe
Single PET/MR-measurement
Central Institute of Mental Health, Mannheim
Schizophrenia
12/24
12/24
Kersten, Alexander
EuroECMO-COVID, NCT04366921: European/Euro-ELSO Survey on Adult and Neonatal/ Pediatric COVID-19 Patients in ECMO

Recruiting
N/A
150
Europe, RoW
Maastricht University Medical Center, European chapter of the Extracorporeal Life Support Organization, Erasmus Medical Center, Leiden University Medical Center, UMC Utrecht, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Papa Giovanni XXIII Hospital, Niguarda Hospital, Ospedale San Donato, Ospedale S. Giovanni Bosco, IRCCS Policlinico S. Matteo, The Mediterranean Institute for Transplantation and Advanced Specialized Therapies, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Ospedale dell'Angelo, Venezia-Mestre, University Hospital, Udine, Italy, San Gerardo Hospital, Ospedali Riuniti Ancona, San Camillo Hospital, Rome, San Giorgio Clinic, GVM Care & Research, San Raffaele University Hospital, Italy, Ospedale San Bortolo di Vicenza, Klinik Hirslanden, Zurich, University of Zurich, Cardiocentro Ticino, Vilnius University Hospital Santaros Klinikos, Universitätsklinikum Düsseldorf, Klinikum Nürnberg, Hannover Medical School, Heart Center Leipzig - University Hospital, University Hospital Regensburg, University Hospital, Essen, German Heart Center, University Hospital, Aachen, University Heart Center Freiburg - Bad Krozingen, Klinikum Kassel, General University Hospital, Prague, Universitaire Ziekenhuizen Leuven, Onze Lieve Vrouwziekenhuis Aalst, Erasme University Hospital, University Hospital, Antwerp, Hôpital Civil Marie Curie de Charleroi, University Hospital, Ghent, Centre Hospitalier Universitaire Saint Pierre, Hospital Vall d'Hebron, Hospital Universitario Ramon y Cajal, Hospital Miguel Servet, Henri Mondor University Hospital, Hospices Civils de Lyon, Pitié-Salpêtrière Hospital, Rennes University Hospital, Guy's and St Thomas' NHS Foundation Trust, Karolinska University Hospital, Hospital Sao Joao, Medical University of Warsaw, Universitätskliniken Innsbruck, Medical University of Vienna, University Hospital, Alexandroupolis, Novosibirsk City Hospital #2, City Clinical Hospital No. 67, Moscow, Russia, City Hospital No 40, Saint Petersburg, Russia, Krasnodar Regional Hospital no 1, Kemerovo Regional Clinical Cardiological Center named after academician L.S. Barbarash, City Hospital No 41, Ekaterinburg, Russia, G. Pasquinucci Heart Hospital, Massa, Charles University, Czech Republic, University Hospital, Bordeaux, Bambino Gesù Hospital and Research Institute, Policlinico Hospital Milan, Gaslini Children's Hospital, Children's Medical Hospital, University of Essen, Essen, Germany, University Hospital, Geneva, Newcastle-upon-Tyne Hospitals NHS Trust, Paediatric Intensive Care Glasgow, Paris South University Hospitals, University of Groningen, Great Ormond Street Hospital for Children NHS Foundation Trust, Hospital Sant Joan de Deu, Heim Pal Children's Hospital, University Hospital, Montpellier, Royal Brompton & Harefield NHS Foundation Trust, Lund University Hospital, Landesklinikum Sankt Polten, Chelyabinsk Regional Clinical Hospital, ECMO Centers Israel, Copenhagen University Hospital at Herlev, Ospedale M. Bufalini Cesena, A.O.U. Città della Salute e della Scienza - Molinette Hospital, Mauriziano Umberto I Hospital, University of Bern, University Hospital, Basel, Switzerland, University of Lausanne Hospitals, University Hospital Tuebingen, Universitätsklinikum Köln, Chirec, Universitair Ziekenhuis Brussel, Centre Hospitalier Universitaire de Liège, La Louvière Hopital, Leicester Royal Infirmary NHS Trust
COVID, SARS-CoV-2, ARDS, Human, Refractory Hypoxemia, Cardiogenic Shock, Septic Shock, Extracorporeal Membrane Oxygenation
04/22
04/22
OuTCASt, NCT04306419: Observational Trial on Cytokine Adsorption in Sepsis

Recruiting
N/A
100
Europe
RWTH Aachen University
Sepsis, Septic Shock, Multiple Organ Failure
06/23
05/24
NCT05759377: V-A ECMO AUTO Mode Registry

Recruiting
N/A
30
Europe
V-A ECMO AUTO Mode algorithm
Abiomed Inc.
Heart Failure
03/25
06/25
NCT06308055: Abiomed Impella RT-DAQ - Observational Study

Recruiting
N/A
125
Europe
Data Acquisition
Abiomed Inc.
Cardiogenic Shock
12/25
03/26
Strnad, Pavel
NCT05899673: An Extension Study to Learn About the Long-Term Safety of Fazirsiran and if Fazirsiran Can Help People With Alpha-1 Antitrypsin Liver Disease

Active, not recruiting
3
37
Europe, US
Fazirsiran Injection, TAK-999, ARO-AAT
Takeda
Alpha1-Antitrypsin Deficiency
05/26
05/26
NCT05677971: Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein

Recruiting
3
160
Europe, Canada, US, RoW
Fazirsiran Injection, TAK-999, ARO-AAT, ADS-001, Placebo, Sodium chloride
Takeda, Takeda Development Center Americas, Inc.
Alpha1-Antitrypsin Deficiency
03/27
03/29
NCT06512454: A Study in Adults to Learn About Inherited Alpha-1 Antitrypsin Deficiency (AATD) and AATD Related Liver Problems

Recruiting
N/A
1000
Europe, US
No Intervention
Takeda
Alpha1-Antitrypsin Deficiency
04/32
04/32
GOmbert, Alexander
TAAA-Cytosorb, NCT04765748: Cytokine Filter Usage During Open Thoracoabdominal Aortic Aneurysm Repair- a Single-center Randomized Prospective Trial

Completed
N/A
20
Europe
Cytosorb
RWTH Aachen University
Postoperative Complications, Inflammatory Response
11/22
12/22
PROMOTE-ALI, NCT05138679: Evaluation of Acute Lower Limb Ischemia

Completed
N/A
700
Europe, RoW
Revascularization, Surgical embolectomy, Peripheral bypass, Catheter directed thrombolysis, Catheter guided aspiration, Catheter guided atherectomy, Percutaneous transluminal angioplasty, Primary major amputation, Best medical treatment
Medical University Innsbruck
Acute Limb Ischemia
05/23
08/23
NCT03982940: BGP+ Stent as Bridging Stent in BEVAR

Active, not recruiting
N/A
118
Europe
BGP+ Stent Graft System as bridging stent
Dr. Sabrina Overhagen, Bentley InnoMed GmbH
Thoracoabdominal Aortic Aneurysm, Without Mention of Rupture
05/24
07/25
Müller, Tobias
NCT04144296: Mathematical Arterialisation of Capillary Blood for Blood Gas Analysis in Critical Ill Patients

Recruiting
N/A
70
Europe
Study procedure
RWTH Aachen University, OBI Medical
Lung Diseases
10/21
11/21
PBC-Cohort, NCT04076527 / 2016-004141-90: Prospective, Multicenter Cohort Study on Primary Biliary Cholangitis

Recruiting
N/A
1200
Europe
UDCA, ursodeoxycholic acid, Ocaliva, obeticholic acid
University of Leipzig, RWTH Aachen University, Zentrum für Klinische Studien Leipzig, Intercept Pharma Europe Limited (IPEL), Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), University Hospital Erlangen, Medical care center for Gastroenterology, Berlin, Institute for Interdisciplinary Medicine, Hamburg, Leberhilfe Projekt gUG, Cologne, Hannover Medical School
PBC, Primary Biliary Cholangitis
03/24
03/24
Stevanovic, Ana
Impact, NCT04103723: of Premedication on Anxiety

Recruiting
N/A
4000
Europe
Preoperative premedication
RWTH Aachen University
Preoperative Anxiety
08/21
09/21
Jost, Edgar
DaunoDouble, NCT02140242 / 2013-003191-12: Comparison Between Two Dose Levels of Daunorubicin and Between One vs. Two Induction Cycles for Adult Patients With AML

Completed
3
721
Europe, RoW
study part 1 - dose daunorubicin, induction cycles
Technische Universität Dresden, University Hospital Dresden, Masaryk University
Leukemia, Myelocytic, Acute
04/22
04/22
GRAPPA, NCT05153226: GvHD Prophylaxis in Unrelated Donor HCT: Randomized Trial Comparing PTCY Versus ATG

Active, not recruiting
3
640
Europe
Cyclophosphamide, all brands, ATG, ATG Grafalon
DKMS gemeinnützige GmbH
Graft Vs Host Disease, Peripheral Blood Stem Cell Transplantation, AML, MDS, MDS/MPN, CMML
06/25
12/26
AlloRelapseMM, NCT05675319: Allogeneic Stem Cell Transplantation vs. Conventional Therapy as Salvage Therapy for Relapsed / Progressive Patients With Multiple Myeloma After First-line Therapy

Recruiting
3
482
Europe
Allogeneic Stem Cells, carfilzomib/lenalidomide/dexamethasone (KRD), elotuzumab/lenalidomide/dexamethasone (ERD), daratumumab/bortezomib/dexamethasone (DVD), daratumumab/lenalidomide/dexamethasone (DRD), ixazomib/lenalidomide/dexamethasone (IRD), pomalidomide/bortezomib/dexamethasone (PVD), carfilzomib/daratumumab/dexamethasone (KDD), Autologous Stem Cells, daratumumab/pomalidomide/dexamethasone (DPD), isatuximab/carfilzomib/dexamethasone (Isa-KD), selinexor/bortezomib/dexamethasone (SVD)
Universitätsklinikum Hamburg-Eppendorf, Gemeinsamer Bundesausschuss (G-BA), Staburo GmbH
Multiple Myeloma
03/28
03/33
VINCENT, NCT05904106 / 2021-003248-26: Venetoclax Plus Azacitidine Versus Intensive Chemotherapy for Fit Patients With Newly Diagnosed NPM1 Mutated AML

Recruiting
2
146
Europe
Venetoclax plus Azacitidine, standard of care chemotherapy plus gemtuzumab ozogamicin
Technische Universität Dresden, University Hospital Heidelberg, AbbVie
Acute Myeloid Leukemia
09/28
09/28
NCT05807932: Venetoclax in Addition to Sequential Conditioning With Fludarabine / Amsacrine / Ara-C (FLAMSA) + Treosulfan for Allogeneic Blood Stem Cell Transplantation in Patients With MDS, CMML or sAML

Recruiting
1/2
38
Europe
Venetoclax, Amsacrine, Ara-C, Tacrolimus, Mycophenolate Mofetil
Heinrich-Heine University, Duesseldorf, Koordinierungszentrum für Klinische Studien - Duesseldorf
Myelodysplastic Syndromes, Secondary Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia
01/26
01/28
MOSAIC, NCT04385290 / 2019-003863-23: Combination of Midostaurin and Gemtuzumab Ozogamicin in First-line Standard Therapy for Acute Myeloid Leukemia

Recruiting
1/2
214
Europe
MODULE: conventional chemotherapy (Cytarabine+Daunorubicin) in combination with midostaurin+GO, Rydapt, Mylotarg, MAGNOLIA-trial: Midostaurin associated with conventional chemotherapy (AraC+DNR)+GO, MAGNOLIA-trial: conventional chemotherapy (AraC+DNR)+GO, MAGMA-trial:GO associated with conventional chemotherapy (AraC+DNR)+Midostaurin, MAGMA-trial: conventional chemotherapy (AraC+DNR)+Midostaurin
Technische Universität Dresden, Novartis Pharmaceuticals, Pfizer
Acute Myeloid Leukemia
04/27
04/28
NCT04230265: Dose-escalating Trial With UniCAR02-T Cells and CD123 Target Module (TM123) in Patients With Hematologic and Lymphatic Malignancies

Recruiting
1
90
Europe
Cyclophosphamide (Non-IMP), Fludarabine (Non-IMP), TM123 (IMP), UniCAR02-T (IMP)
AvenCell Europe GmbH, PHARMALOG Institut für klinische Forschung GmbH
Acute Myeloid Leukemia (AML)
05/25
09/25
Kotelis, sos
SOCRATES, NCT04503395: ShOrt neCK AAA RAndomized Trial - ESAR and FEVAR:

Recruiting
N/A
204
Europe
ESAR treatment: Endograft + Heli-FX Endoanchor, FEVAR treatment : Fenestrated endograft
FCRE (Foundation for Cardiovascular Research and Education), Medtronic
Aortic Aneurysm, Abdominal
06/26
06/28
Gezer, Deniz
AlloRelapseMM, NCT05675319: Allogeneic Stem Cell Transplantation vs. Conventional Therapy as Salvage Therapy for Relapsed / Progressive Patients With Multiple Myeloma After First-line Therapy

Recruiting
3
482
Europe
Allogeneic Stem Cells, carfilzomib/lenalidomide/dexamethasone (KRD), elotuzumab/lenalidomide/dexamethasone (ERD), daratumumab/bortezomib/dexamethasone (DVD), daratumumab/lenalidomide/dexamethasone (DRD), ixazomib/lenalidomide/dexamethasone (IRD), pomalidomide/bortezomib/dexamethasone (PVD), carfilzomib/daratumumab/dexamethasone (KDD), Autologous Stem Cells, daratumumab/pomalidomide/dexamethasone (DPD), isatuximab/carfilzomib/dexamethasone (Isa-KD), selinexor/bortezomib/dexamethasone (SVD)
Universitätsklinikum Hamburg-Eppendorf, Gemeinsamer Bundesausschuss (G-BA), Staburo GmbH
Multiple Myeloma
03/28
03/33
Kowark, Ana
Impact, NCT04103723: of Premedication on Anxiety

Recruiting
N/A
4000
Europe
Preoperative premedication
RWTH Aachen University
Preoperative Anxiety
08/21
09/21
PrepTAB, NCT04160234: Preoperative Risk Assessment in the Elderly

Recruiting
N/A
100
Europe
web-based questionnaires
RWTH Aachen University
Preoperative Risk Assessment
12/21
01/22
NCT04894045: Perioperative Personalized Blood Pressure Management

Completed
N/A
105
Europe
Personalized management
Universitätsklinikum Hamburg-Eppendorf, RWTH Aachen University
Blood Pressure, Intraoperative Hypotension, Postoperative Complications
11/22
11/22
Modabber, Ali
NCT04098146: Registry to Collect Data on Patients Undergoing Segmental Mandibular Defect Reconstruction Following Oral Squamous Cell Carcinoma Resection

Recruiting
N/A
300
Europe, US
Surgical Resection and Reconstruction
AO Innovation Translation Center
Mandibular Reconstruction, Segmental Mandibular Defects
06/30
12/30
Bruns, Tony
COMBAT, NCT05895136: A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome ( Trial).

Recruiting
2
90
Europe
Human albumin, Enoxaparin, Standard medical treatment
European Foundation for Study of Chronic Liver Failure
Liver Cirrhosis
03/25
03/25
GLOBAL-AKI, NCT05387811: International Registry of Acute Kidney Injury in Cirrhosis: The GLOBAL AKI Project

Completed
N/A
1456
Europe, US, RoW
Crystalloids, albumin, vasoconstrictors, diuretics, renal replacement therapy
Azienda Ospedaliera di Padova
Liver Cirrhosis, Acute Kidney Injury, Hepatorenal Syndrome
09/23
11/23
PIONEER, NCT05810480: PredIcting SterOid DepeNdEnt LivEr InjuRy with Polyreactive Immunoglobulin G

Recruiting
N/A
200
Europe
polyreactive immunoglobulin G, Conventional diagnostic autoantibodies
Hannover Medical School
Autoimmune Hepatitis, Autoimmune Liver Disease
07/26
01/27
Liver-HERO, NCT05346393: HRS-AKI Treatment With TIPS in Patients With Cirrhosis

Recruiting
N/A
124
Europe
TIPS, Standard of Care, Terlipressin + Albumin
Jena University Hospital, German Research Foundation, University Hospital Halle (Saale)
Cirrhosis, Liver, Hepatorenal Syndrome, Acute Kidney Injury, Ascites Hepatic
06/25
06/26
Follmann, Andreas
NCT04518514: Telemedical Risk Assessment and Preoperative Evaluation (TAPE)

Recruiting
N/A
100
Europe
TAPE-Software
RWTH Aachen University, Docs in Clouds Telecare GmbH
Patients Undergoing Elective Surgery With Anesthesia
10/20
11/20
NCT05388071: Feasibility of Telemedicine Under Ambulance Station Conditions

Completed
N/A
404
Europe
Usage of telemedicine and tele-consultation for treatment
RWTH Aachen University
Telemedicine, Disaster Medicine, Emergency Medicine
07/22
06/23
Kappel, Ben A
BIO-2-HEART, NCT03323216: Identification of Biomarkers in T2DM and Heart Failure

Recruiting
N/A
400
Europe
6-minute walk test, Study specific questionnaire, Blood collection
RWTH Aachen University
Heart Failure, Diabetes Mellitus, Type 2
12/25
12/26
Kouz, Karim
NCT04894045: Perioperative Personalized Blood Pressure Management

Completed
N/A
105
Europe
Personalized management
Universitätsklinikum Hamburg-Eppendorf, RWTH Aachen University
Blood Pressure, Intraoperative Hypotension, Postoperative Complications
11/22
11/22
NCT06314074: 2.5 Versus 5 Minutes Trial

Completed
N/A
264
Europe
Oscillometric blood pressure monitoring at 2.5-minute intervals, Oscillometric blood pressure monitoring at 5-minute intervals
Universitätsklinikum Hamburg-Eppendorf
Hypotension
10/24
10/24
IMPROVE, NCT05416944: Perioperative Personalized Blood Pressure Management: -multi

Completed
N/A
1272
Europe
Personalized blood pressure management
Universitätsklinikum Hamburg-Eppendorf, Jena University Hospital, The Cleveland Clinic
Blood Pressure, Intraoperative Hypotension, Postoperative Complications, Surgery, Anesthesia
05/24
07/24
DETECT II, NCT06753097: Continuous Finger-cuff Arterial Pressure Monitoring and Intraoperative Hypotension During Non-cardiac Surgery: the Randomized Trial

Recruiting
N/A
930
Europe
Continuous finger-cuff arterial pressure monitoring
Universitätsklinikum Hamburg-Eppendorf
Intraoperative Hypotension
01/26
02/26
Daher, Ayham
NCT04993612: Postcapillary Blood Gas Analysis in Wedge Position (Wedge-BGA)

Recruiting
N/A
100
Europe
Blood gas analysis
Ayham Daher
Pulmonary Hypertension
02/25
06/26
NCT05042219: Effects of Pulmonary Diseases and Their Treatment on Cardiac Function

Recruiting
N/A
120
Europe
Cardiac MRI, Echocardiography
Ayham Daher
COPD, Bronchial Asthma, Idiopathic Pulmonary Fibrosis
09/26
12/26
Berres, Marie-Luise
ABC-HCC, NCT04803994 / 2020-004210-35: The Trial: Atezolizumab Plus Bevacizumab vs. Transarterial Chemoembolization (TACE) in Intermediate-stage HepatoCellular Carcinoma

Recruiting
3
434
Europe, Japan
Atezolizumab, Tecentriq, Bevacizumab, Avastin, TACE, transarterial chemoembolization
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest, F. Hoffmann-La Roche Ltd
Hepatocellular Carcinoma
07/27
07/27
Arimond, Robert
NCT05388071: Feasibility of Telemedicine Under Ambulance Station Conditions

Completed
N/A
404
Europe
Usage of telemedicine and tele-consultation for treatment
RWTH Aachen University
Telemedicine, Disaster Medicine, Emergency Medicine
07/22
06/23
Knull, Miriam
AlloRelapseMM, NCT05675319: Allogeneic Stem Cell Transplantation vs. Conventional Therapy as Salvage Therapy for Relapsed / Progressive Patients With Multiple Myeloma After First-line Therapy

Recruiting
3
482
Europe
Allogeneic Stem Cells, carfilzomib/lenalidomide/dexamethasone (KRD), elotuzumab/lenalidomide/dexamethasone (ERD), daratumumab/bortezomib/dexamethasone (DVD), daratumumab/lenalidomide/dexamethasone (DRD), ixazomib/lenalidomide/dexamethasone (IRD), pomalidomide/bortezomib/dexamethasone (PVD), carfilzomib/daratumumab/dexamethasone (KDD), Autologous Stem Cells, daratumumab/pomalidomide/dexamethasone (DPD), isatuximab/carfilzomib/dexamethasone (Isa-KD), selinexor/bortezomib/dexamethasone (SVD)
Universitätsklinikum Hamburg-Eppendorf, Gemeinsamer Bundesausschuss (G-BA), Staburo GmbH
Multiple Myeloma
03/28
03/33
Naros, Andreas
NCT04098146: Registry to Collect Data on Patients Undergoing Segmental Mandibular Defect Reconstruction Following Oral Squamous Cell Carcinoma Resection

Recruiting
N/A
300
Europe, US
Surgical Resection and Reconstruction
AO Innovation Translation Center
Mandibular Reconstruction, Segmental Mandibular Defects
06/30
12/30

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