University of North Carolina Hospital
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 41 Trials 
91 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Shea, Thomas C
NCT04223765: Study of Kappa Chimeric Antigen Receptor (CAR) T Lymphocytes Co-Expressing the Kappa and CD28 CARs for Relapsed/Refractory Kappa+ Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.

Recruiting
1
20
US
CAR.k.28, Kappa Chimeric Antigen Receptor and CD28 Endodomain, Fludarabine, FLUDARA, Cyclophosphamide, Cytoxan, Bendamustine, Bendeka, Treanda
UNC Lineberger Comprehensive Cancer Center, National Cancer Institute (NCI)
Mantle Cell Lymphoma, Follicular Lymphoma, Splenic Marginal Zone Lymphoma, Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue, Nodal Marginal Zone Lymphoma, Indolent Non-hodgkin Lymphoma
03/28
03/43
Condos, Rany
NCT04482595: BIO 300 Oral Suspension in Previously Hospitalized Long COVID Patients

Active, not recruiting
2
50
US
BIO 300 Oral Suspension, Placebo
Humanetics Corporation, NYU Langone Health, National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19, Long COVID, Pulmonary Fibrosis, Post-acute Respiratory Complications of COVID-19
07/24
04/25
PHINDER, NCT05776225: Pulmonary Hypertension Screening in Patients with Interstitial Lung Disease for Earlier Detection

Recruiting
N/A
200
US
Right heart catheterization (RHC)
United Therapeutics
Interstitial Lung Disease, Pulmonary Hypertension
05/25
06/25
NCT06404047: RECOVER-ENERGIZE Platform Protocol

Recruiting
N/A
660
US
Personalized Cardiopulmonary Rehabilitation, Structured Pacing, Education, Usual Care
Duke University, National Heart, Lung, and Blood Institute (NHLBI)
Long COVID, Long Covid19, Long Covid-19
10/25
01/26
NCT02777879: Lung Microbiome and Inflammation in Early COPD

Recruiting
N/A
230
US
Bronchoscopy
NYU Langone Health
Chronic Obstuctive Pulmonary Disease
08/26
08/26
NCT04527315: COVID-19 Survivorship Registry

Recruiting
N/A
1200
US
Questionnaires
NYU Langone Health
Covid19
12/27
12/27
IPF-PRO, NCT01915511: Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry

Checkmark
Oct 2015 - Oct 2015: 
Recruiting
N/A
3000
US
Duke University, Boehringer Ingelheim
Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
01/28
01/28
Whang, Young
PSMAddition, NCT04720157 / 2020-003968-56: An International Prospective Open-label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With SoC, Versus SoC Alone, in Adult Male Patients With mHSPC

Jan 2024 - Dec 2024: Primary data from PSMAddition trial for metastatic hormone sensitive prostate cancer
Active, not recruiting
3
1145
Europe, Canada, Japan, US, RoW
177Lu-PSMA-617, 68Ga-PSMA-11, ARDT, ADT
Novartis Pharmaceuticals, Alliance Foundation Trials, LLC., RTOG Foundation, Inc.
Prostatic Neoplasms
07/25
02/26
DORA, NCT03574571 / 2018-002944-10: A Study to Test Radium-223 With Docetaxel in Patients With Prostate Cancer

Recruiting
3
738
Europe, US, RoW
Docetaxel 75 mg/m2, Docetaxel 60 mg/m2, Radium-223
Memorial Sloan Kettering Cancer Center, Bayer
Prostate Cancer
06/26
06/26
BRCAAway, NCT03012321: Abiraterone/Prednisone, Olaparib, or Abiraterone/Prednisone + Olaparib in Patients With Metastatic Castration-Resistant Prostate Cancer With DNA Repair Defects

Active, not recruiting
2
70
US
Olaparib, Lynparza, Abiraterone Acetate, Prednisone
Northwestern University, AstraZeneca, National Cancer Institute (NCI)
Prostate Cancer Metastatic Castration-Resistant, Abnormal DNA Repair, Metastatic Prostate Carcinoma, Stage IV Prostate Cancer
12/26
01/27
PRESERVE-006, NCT05682443: ONC-392 Plus Lutetium Lu 177 Vipivotide Tetraxetan in Patients With mCRPC

Recruiting
1/2
144
US
ONC-392, A humanized anti-CTLA4 IgG1 monoclonal antibody, Gotistobart, lutetium Lu 177 vipivotide tetraxetan, IV infusion, Q6W for up to 6 doses., Pluvicto
OncoC4, Inc., Prostate Cancer Clinical Trials Consortium
Metastatic Castration-resistant Prostate Cancer
06/26
06/27
ACR-368-201, NCT05548296: A Study of ACR-368 in Ovarian Carcinoma, Endometrial Adenocarcinoma, and Urothelial Carcinoma

Recruiting
1/2
390
US
ACR-368, prexasertib, Gemcitabine, OncoSignature
Acrivon Therapeutics, GOG Foundation
Platinum-resistant Ovarian Cancer, Endometrial Adenocarcinoma, Urothelial Carcinoma
07/26
12/27
IRONMAN, NCT03151629: International Registry for Men With Advanced Prostate Cancer

Recruiting
N/A
5000
Europe, Canada, US, RoW
Standard of Care
Prostate Cancer Clinical Trials Consortium
Prostate Cancer
01/31
01/32
NCT05612880: Physical Function During ARSI Treatment

Completed
N/A
24
US
androgen receptor signaling inhibitors, abiraterone, enzalutamide, darolutamide, apalutamide
UNC Lineberger Comprehensive Cancer Center
Advanced Prostate Carcinoma
11/24
11/24
Abboud, Camille
AIM4CML, NCT04666259: Asciminib in Monotherapy for Chronic Myeloid Leukemia in Chronic Phase (CML-CP) With and Without T315I Mutation

Completed
3
56
US
ABL001
Novartis Pharmaceuticals
Chronic Myelogenous Leukemia - Chronic Phase
06/23
06/24
NCT04543279: Fostamatinib as a Single Agent or in Combination With Ruxolitinib for Treatment of Patients With Myelofibrosis With Severe Thrombocytopenia

Terminated
2
3
US
Fostamatinib, Tavalisse, Ruxolitinib, Jakafi
Washington University School of Medicine, Rigel Pharmaceuticals
Myelofibrosis, Thrombocytopenia
07/22
07/22
ASC2ESCALATE, NCT05384587: Asciminib Monotherapy, With Dose Escalation, for 2nd and 1st Line Chronic Myelogenous Leukemia

Active, not recruiting
2
196
US
asciminib, ABL001
Novartis Pharmaceuticals
Chronic Myelogenous Leukemia - Chronic Phase
09/25
10/27
NCT02782546: Cytokine Induced Memory-like NK Cell Adoptive Therapy After Haploidentical Donor Hematopoietic Cell Transplantation

Recruiting
2
60
US
Graft cell infusion, HCT, Tacrolimus, Prograf, Mycophenolate mofetil, CellCept, Myfortic, G-CSF, Granulocyte-colony stimulating factor, CIML NK cell infusion, ALT-803, Leukapheresis
Washington University School of Medicine, National Institutes of Health (NIH), The V Foundation for Cancer Research, National Cancer Institute (NCI), ImmunityBio, Inc.
Acute Myeloid Leukemia
07/26
07/26
NCT04354025: Cytokine-induced Memory-like NK Cells in Combination With Chemotherapy in Pediatric Patents With Refractory or Relapsed AML

Withdrawn
2
48
NA
Cytokine induced memory-like NK cells, CIML NK cells, Fludarabine, Ara-C, Cytarabine, G-CSF, Filgrastim, Interleukin-2, IL-2, Leukapheresis
Washington University School of Medicine
Refractory Acute Myeloid Leukemia, Relapsed Acute Myeloid Leukemia
09/26
07/28
NCT05820763: Selinexor and Lenalidomide for Consolidation and Maintenance Treatment in Multiple Myeloma Post-transplant

Withdrawn
2
35
NA
Selinexor, EXPOVIO, KPT-330, Lenalidomide, Revlimid, Dexamethasone, Decadron
Washington University School of Medicine, Karyopharm Therapeutics Inc
Multiple Myeloma, Myeloma-Associated Amyloidosis
01/27
01/27
NCT04331119: Duvelisib Maintenance After Autologous Stem Cell Transplant in T-Cell Lymphomas

Active, not recruiting
2
17
US
Duvelisib, Copiktra, Peripheral blood draw
Washington University School of Medicine, SecuraBio
T-Cell Lymphoma
07/26
07/26
NCT02756962: Improving Risk Assessment of AML With a Precision Genomic Strategy to Assess Mutation Clearance

Active, not recruiting
2
107
US
Cytarabine, Ara-C, Cytosar-U, Tarabine-PFS, AraC, Allogeneic stem cell transplant, AlloSCT, Bone marrow aspiration, Punch skin biopsy, ClinSeq
Washington University School of Medicine, The Leukemia and Lymphoma Society, American Society of Hematology
Acute Myeloid Leukemia
07/29
07/29
NCT03068819: Cytokine Induced Memory-like NK Cell Adoptive Therapy for Relapsed AML After Allogeneic Hematopoietic Cell Transplant

Recruiting
1/2
110
US
CIML NK Cell Infusion, CD3+ T Cell Product Infusion
Washington University School of Medicine, National Cancer Institute (NCI), Wugen, Inc., Children's Discovery Institute
Acute Myeloid Leukemia
10/28
10/28
NCT04912427: Isatuximab, Velcade, and Dexamethasone in Patients With Multiple Myeloma and Severe KIDNEY Disease

Terminated
1
1
US
Isatuximab, Sarclisa, Bortezomib, Velcade, Dexamethasone
Washington University School of Medicine, Sanofi
Multiple Myeloma
12/22
01/24
NCT04006652: ApoGraft for the Prevention of Acute Graft Versus Host Disease in Haploidentical Hematopoietic Cell Transplant Recipients

Terminated
1
4
US
ApoGraft
Washington University School of Medicine, Cellect Biotechnology
Acute Graft Versus Host Disease, Haploidentical Hematopoietic Stem Cell Transplant
12/22
12/22
NCT04083898: Isatuximab, Bendamustine, and Prednisone in Refractory Multiple Myeloma

Hourglass Apr 2020 - Jun 2020 : From trial in combination with bendamustine for penta-refractory multiple myeloma
Terminated
1
15
US
Isatuximab, Bendamustine, Bendeka, Treanda, Prednisone, Deltasone, Rayos, Prednisone Intensol
Washington University School of Medicine, Sanofi
Multiple Myeloma
03/23
03/24
RIVER-51, NCT04021368: RVU120 in Patients With Acute Myeloid Leukemia or High-risk Myelodysplastic Syndrome

Active, not recruiting
1
112
Europe, US
RVU120(SEL120)
Ryvu Therapeutics SA
Acute Myeloid Leukemia, High-risk Myelodysplastic Syndrome
12/24
12/24
haplo-HCT, NCT03755414: Study of Itacitinib for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation

Completed
1
55
US
Stem cell transplantation, Itacitinib, Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT), Human Activity Profile
Washington University School of Medicine, Incyte Corporation, American Society of Hematology, National Cancer Institute (NCI)
Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia, Myelodysplastic Syndromes, Non-Hodgkin Lymphoma, Hodgkin Disease
04/24
05/24
NCT05412290: Mosunetuzumab Consolidation Therapy After autoSCT in r/r Aggressive B Cell Lymphoma

Recruiting
1
15
US
Mosunetuzumab, RO7030816, BTCT4465A
Washington University School of Medicine, Genentech, Inc.
B Cell Lymphoma, Aggressive Lymphoma, Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Transformed Lymphoma, Follicular Lymphoma Grade 3
07/27
06/29
NCT06008808: Ruxolitinib for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation

Recruiting
1
49
US
Ruxolitinib, Jakafi
Washington University School of Medicine, Incyte Corporation
Graft Vs Host Disease, Graft-versus-host-disease, Graft Versus Host Disease
09/26
12/26
NCT02611180: Dendritic Cells in Patients With Acute or Chronic Skin Graft Versus Host Disease

Recruiting
N/A
50
US
Skin punch biopsy, Peripheral blood draw
Washington University School of Medicine
Acute Graft-versus-host Disease, Acute GVHD, Chronic Graft-versus-host Disease, Chronic GVHD
04/25
04/25
NCT04263181: AML/MDS Drug Sensitization by in Vivo Chemotherapy Administration

Recruiting
N/A
165
US
Peripheral blood draw, Bone marrow aspirate, Buccal swab
Washington University School of Medicine, Notable Labs
Acute Myeloid Leukemia, Myelodysplastic Syndromes
01/25
01/25
Peterson, Linda
iNIX-HF, NCT05562167: The Inorganic Nitrate and eXercise Performance in Heart Failure

Recruiting
2
75
US
KNO3, Potassium nitrate, Placebo
Washington University School of Medicine
Heart Failure
01/28
01/28
NCT02797184: Inorganic NItrate and EXercise Performance in Heart Failure (iNIX-HF): Dose Response

Active, not recruiting
1/2
42
US
KNO3, potassium nitrate, saltpeter
Washington University School of Medicine
Heart Failure
10/21
12/25
NCT01682356: Dietary Nitrate for Heart Failure

Completed
1/2
17
US
Beetroot juice, Beet It
Washington University School of Medicine, The Foundation for Barnes-Jewish Hospital
Heart Failure, Hypertension, Pulmonary
07/23
07/23
NCT05521984: Targeting Pediatric Brain Tumors and Relapsed/Refractory Solid Tumors With Sodium Glucose Cotransporter 2 Inhibitors (SGLT2i)

Recruiting
1
20
US
Dapagliflozin, Carmustine, Topotecan, Cyclophosphamide
Washington University School of Medicine, Children's Discovery Institute
Pediatric Brain Tumor, Pediatric Solid Tumor
08/26
11/26
NCT04887935: Neoadjuvant SGLT2 Inhibition in High-Risk Localized Prostate Cancer

Recruiting
1
24
US
Dapagliflozin, Farxiga
Washington University School of Medicine, The Foundation for Barnes-Jewish Hospital
Prostate Cancer, Cancer of Prostate
08/26
08/26
DRTC, NCT01067209: Reversal of Obese/Diabetic Cardiomyopathy After Gastric Bypass Surgery

Completed
N/A
18
US
Washington University School of Medicine
Cardiomyopathy
02/13
02/13
NCT02987049: Intensive Cardiac Rehabilitation (ICR): Tolerability and Effectiveness

Enrolling by invitation
N/A
500
NA
Washington University School of Medicine
Cardiac Disease
12/24
12/24
NCT04072393: Cardiac Rehabilitation for Patients Receiving Radiation Therapy for Thoracic Cancers

Terminated
N/A
24
US
Home-based cardiac rehabilitation
Washington University School of Medicine, The Foundation for Barnes-Jewish Hospital
Lung Cancer, Esophageal Cancer, Thoracic Cancer, Hodgkin Lymphoma, Hodgkin Disease, Non-hodgkin Lymphoma, Sarcoma, Thymoma, Breast Cancer
05/24
05/24
NCT00776035: Sex and Obesity: Effects on Heart Failure Study

Completed
N/A
19
US
PET (Positron Emission Tomography), PET scan, Echocardiogram, Echo, ^15O-water, 1-^11C-palmitate, 1-^11C-glucose
Washington University School of Medicine, The Foundation for Barnes-Jewish Hospital
Obesity, Heart Failure
04/11
04/11
NCT01372397: Reversal of Obesity Cardiomyopathy

Completed
N/A
27
US
Washington University School of Medicine
Cardiomyopathy
04/12
04/12
NCT06404047: RECOVER-ENERGIZE Platform Protocol

Recruiting
N/A
660
US
Personalized Cardiopulmonary Rehabilitation, Structured Pacing, Education, Usual Care
Duke University, National Heart, Lung, and Blood Institute (NHLBI)
Long COVID, Long Covid19, Long Covid-19
10/25
01/26
Chung, Eugene
DETECT-HF, NCT06378632: AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

Recruiting
N/A
500
Europe, US, RoW
Hearo App
Cordio Medical
Heart Failure
01/25
03/25
NCT05206422: DORAYA-HF Early Feasibility Study

Recruiting
N/A
30
US
Doraya Catheter
Revamp Medical Inc.
Acute Decompensated Heart Failure
10/25
12/25
NCT05425459: RESPONDER-HF Trial

Recruiting
N/A
750
Europe, Canada, US, RoW
Corvia Atrial Shunt System / IASD System II, Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE)
Corvia Medical
Heart Failure, Heart Failure, Diastolic
05/25
03/31
Laughon, Matthew M
SIL02, NCT03142568: Safety of Sildenafil in Premature Infants

Recruiting
2
120
Canada, US
Sildenafil, Revatio, Placebo, sugar water
University of North Carolina, Chapel Hill, Duke University, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), The Emmes Company, LLC
Bronchopulmonary Dysplasia
02/25
04/25
POPS or POP02, NCT04278404: Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

Recruiting
N/A
5000
Canada, US
The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:, Aminocaproic acid, Amiodarone, Bosentan, Budesonide, Cefdinir, Cefepime, Ceftazidime, Clindamycin, Clobazam, Dexamethasone, Dexmedetomidine, Dextroamphetamine/Amphetamine, Fosfomycin, Furosemide, Gabapentin, Guanfacine, Hydrocortisone, Labetalol, Meropenem, Metformin, Milrinone, Nalbuphine, Nicardipine, Nifedipine, Oseltamivir, Oxycodone, Risperidone, Sertraline, Sevelamer Carbonate / Sevelamer Hydrochloride, Spironolactone, Terbutaline, Tranexamic acid, Voriconazole, Zolpidem, Azithromycin, Lopinavir/Ritonavir, Ribavirin, Tocilizumab, Anakinra, Aspirin, Canakinumab, Colchicine, Interferon, Remdesivir, Ruxolitinib, Sarilumab, Abatacept, Infliximab
Duke University, The Emmes Company, LLC, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension, Pain, Hyperphosphatemia, Primary Hyperaldosteronism, Edema, Hypokalemia, Heart Failure, Hemophilia, Menorrhagia, Insomnia, Pneumonia, Skin Infection, Arrythmia, Asthma in Children, Bronchopulmonary Dysplasia, Adrenal Insufficiency, Fibrinolysis; Hemorrhage, Attention Deficit Hyperactivity Disorder, Multisystem Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease, Coagulation Disorder, Down Syndrome
09/26
09/27
NCT01286519: Pharmacokinetics of Off Label Pediatric Medications

Recruiting
N/A
400
US
University of North Carolina, Chapel Hill
Off Label Use of Medications in Pediatric Patients
12/35
12/35
Stuebe, Alison
NCT03593473: Inhaled Oxytocin and HPA Axis Reactivity

Completed
2
109
US
Intranasal Oxytocin, Syntocinon, Placebo, Inactive
University of North Carolina, Chapel Hill, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Depression, Postpartum, Anxiety Disorders, Stress, Psychological
07/23
07/23
BELIEVE, NCT06483022: Building Equitable Linkages with Interprofessional Education Valuing Everyone

Enrolling by invitation
N/A
32000
US
BELIEVE IPE Training, Usual Care
University of North Carolina, Chapel Hill, American Heart Association
Pregnancy Related, Postpartum, Pain
06/26
09/26
NCT06744231: Thriving Hearts: Healing-Centered, Integrated, Community Maternity Care

Not yet recruiting
N/A
17500
US
Usual Care, Thriving Hearts
University of North Carolina, Chapel Hill, Orange County Health Department, Duke University, Wake Forest University Health Sciences, The North Carolina Alliance of Public Health Agencies, Inc., Jacaranda Health, Piedmont Health Services, Inc., Patient-Centered Outcomes Research Institute
Hypertensive Disorder of Pregnancy
12/29
12/29
Buchman, Craig A
PINIHL-AET, NCT04768569: Noise-Induced Hearing Loss-Acute Exposure Treatment

Terminated
2
24
US
Zonisamide 100Mg Cap, Zonegran, ZNS, Placebo, microcrystalline cellulose
Washington University School of Medicine, University of Texas, Gateway Biotechnology, Inc., United States Department of Defense
Hearing Loss, Noise-Induced
09/23
09/23
Hurt, Ryan
RECOVER-VITAL, NCT05595369: Platform Protocol to Measure the Effects of Antiviral Therapies on Long COVID Symptoms

Active, not recruiting
2
964
US
Experimental: Paxlovid 25 day dosing, Experimental: Paxlovid 15 day dosing, Placebo Comparator: Control
Kanecia Obie Zimmerman
Long COVID, Long Covid19
08/24
03/25
NCT06404086: RECOVER-SLEEP: Platform Protocol

Recruiting
2
1074
US
Modafinil, Modafinil Placebo, Solriamfetol, Solriamfetol Placebo, Melatonin, Melantonin Placebo, Tailored lighting (TL) Active, Tailored lighting (TL) Placebo
Duke University
Long COVID, Long COVID-19, Hypersomnia, Sleep Disturbance
07/25
07/25
LLLT, NCT05083442: Low-level Laser and Lifestyle Modifications

Active, not recruiting
N/A
60
US
Low Level Laser Therapy, Sham (placebo)
Mayo Clinic, Erchonia Corporation
Overweight and Obesity, Weight Loss
04/24
12/24
NCT05199233: Mindfulness Intervention for Post-Covid Symptoms

Active, not recruiting
N/A
60
US
Muse S™ Headband system
Mayo Clinic
COVID-19, Post Acute Sequelae of SARS-CoV-2
01/25
01/25
NCT05445427: Vagal Nerve Stimulation for Post COVID Fatigue

Completed
N/A
19
US
vagal nerve stimulator
Mayo Clinic
Post COVID Syndrome, Fatigue, Headache
03/24
03/24
NCT06404047: RECOVER-ENERGIZE Platform Protocol

Recruiting
N/A
660
US
Personalized Cardiopulmonary Rehabilitation, Structured Pacing, Education, Usual Care
Duke University, National Heart, Lung, and Blood Institute (NHLBI)
Long COVID, Long Covid19, Long Covid-19
10/25
01/26
NRM, NCT06345443: on Vascular Perfusion in Healthy Adults

Enrolling by invitation
N/A
200
US
Nicotinamide Riboside Malate, NRM, Placebo
Mayo Clinic
Vascular Stiffness
02/26
09/26
NCT06007976: LLLT to Reduce Low Back Pain

Recruiting
N/A
60
US
Erchonia® Trident
Mayo Clinic, Erchonia Corporation
Low Back Pain
06/25
12/25
Marston, William
C-TRACT, NCT03250247: Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy (The Trial)

Recruiting
N/A
250
US
Stents
Washington University School of Medicine, Ontario Clinical Oncology Group (OCOG), Massachusetts General Hospital, Saint Luke's Mid America Heart Institute
Deep Vein Thrombosis, Venous Stasis, Venous Insufficiency, Venous Leg Ulcer, Venous Reflux, Post Thrombotic Syndrome
01/26
04/26
NCT04927702: Assessment of Wound Closure Comparing Synthetic Hybrid-Scale Fiber Matrix With Standard of Care in Treating Diabetic Foot Ulcers (DFU) and With Living Cellular Skin Substitute in Treating Venous Leg Ulcers (VLU)

Terminated
N/A
47
US
Synthetic Hybrid-Scale Fiber Matrix, Restrata, Standard of Care, Living Cellular Skin Substitute, Apligraf
Acera Surgical, Inc.
Diabetic Foot Ulcer, Venous Leg Ulcer
07/24
08/24
NCT05489588: The GORE® VIAFORT Vascular Stent Iliofemoral Study

Active, not recruiting
N/A
165
US
GORE® VIAFORT Vascular Stent
W.L.Gore & Associates
Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease
04/25
04/29
Park, Eliza
FACT, NCT05377749: The Families Addressing Cancer Together Intervention for Parents With Cancer

Completed
N/A
47
US
FACT
UNC Lineberger Comprehensive Cancer Center, National Institute of Allergy and Infectious Diseases (NIAID), National Cancer Institute (NCI)
Neoplasms, Cancer, Parenting, Communication, Parents, Parent-Child Relations
02/23
02/23
Fearn, Laura
TANGOKIDS, NCT02687906 / 2016-000656-99: Dose-finding, Pharmacokinetics, and Safety of VABOMERE in Pediatric Subjects With Bacterial Infections

Recruiting
1
67
US
Vabomere, Combination meropenem and vaborbactam, carbapenem and beta-lactamase inhibitor
Rempex (a wholly owned subsidiary of Melinta Therapeutics, LLC), Department of Health and Human Services
Bacterial Infections
12/24
06/25
POPS or POP02, NCT04278404: Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

Recruiting
N/A
5000
Canada, US
The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:, Aminocaproic acid, Amiodarone, Bosentan, Budesonide, Cefdinir, Cefepime, Ceftazidime, Clindamycin, Clobazam, Dexamethasone, Dexmedetomidine, Dextroamphetamine/Amphetamine, Fosfomycin, Furosemide, Gabapentin, Guanfacine, Hydrocortisone, Labetalol, Meropenem, Metformin, Milrinone, Nalbuphine, Nicardipine, Nifedipine, Oseltamivir, Oxycodone, Risperidone, Sertraline, Sevelamer Carbonate / Sevelamer Hydrochloride, Spironolactone, Terbutaline, Tranexamic acid, Voriconazole, Zolpidem, Azithromycin, Lopinavir/Ritonavir, Ribavirin, Tocilizumab, Anakinra, Aspirin, Canakinumab, Colchicine, Interferon, Remdesivir, Ruxolitinib, Sarilumab, Abatacept, Infliximab
Duke University, The Emmes Company, LLC, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension, Pain, Hyperphosphatemia, Primary Hyperaldosteronism, Edema, Hypokalemia, Heart Failure, Hemophilia, Menorrhagia, Insomnia, Pneumonia, Skin Infection, Arrythmia, Asthma in Children, Bronchopulmonary Dysplasia, Adrenal Insufficiency, Fibrinolysis; Hemorrhage, Attention Deficit Hyperactivity Disorder, Multisystem Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease, Coagulation Disorder, Down Syndrome
09/26
09/27
NCT03511118: Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

Recruiting
N/A
1600
Canada, US
Tranexamic acid (TXA), labetalol, metformin, nifedipine, clindamycin, oxycodone, azithromycin, escitalopram, sertraline, ondansetron, Ciprofloxacin, Doxycycline, Levofloxacin, Methylphenidate, Sumatriptan, Citalopram, Cyclobenzaprine, Furosemide, Gabapentin, Hydrochlorothiazide, Hydroxyurea, Rosuvastatin, Topiramate, Trazodone, Valganciclovir, Venlafaxine, Verapamil, Remdesivir, Anakinra, Tocilizumab, Fluvoxamine, Amoxicillin, Bupropion, Duloxetine, Hydrocodone, Levetiracetam, Paroxetine, Buprenorphine
Duke University, The Emmes Company, LLC, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Lactating Women on Select DOI, Breastfed Infants of Mothers on Select DOI
07/26
07/27
Gehi, Anil
REACT-AF, NCT05836987: The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

Recruiting
3
5350
US
AFSW Guided DOAC, Apple Watch, Continuous DOAC therapy, Oral Anticoagulation therapy
Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI)
Atrial Fibrillation
07/29
07/29
NCT05818592: Screening for Atrial Fibrillation With Self Pulse Monitoring

Completed
N/A
526
US
Self-Pulse Monitoring
University of North Carolina, Chapel Hill, Bristol-Myers Squibb Foundation
Atrial Fibrillation New Onset
05/22
05/22
NCT05890274: Atrial Fibrillation (AF) and Electrocardiogram (EKG) Interpretation Project ECHO

Enrolling by invitation
N/A
120
US
AF and EKG Interpretation Project ECHO
University of North Carolina, Chapel Hill, Duke University, Wake Forest University, Bristol-Myers Squibb
Atrial Fibrillation
04/25
04/25
NCT05810896: AF at Home: A Virtual Education Program for Patients With Atrial Fibrillation (AF)

Enrolling by invitation
N/A
300
US
AF at Home
University of North Carolina, Chapel Hill, Duke University, Wake Forest University, Bristol-Myers Squibb
Atrial Fibrillation
04/25
04/25
Drummond, Bradley
RELIANCE, NCT04069312: Roflumilast or Azithromycin to Prevent COPD Exacerbations

Recruiting
4
1250
US
Roflumilast, Daliresp, Azithromycin, Zithromax
Johns Hopkins University, Patient-Centered Outcomes Research Institute, University of Illinois at Chicago
Chronic Obstructive Pulmonary Disease Severe, Chronic Bronchitis
03/26
05/26
NCT04543461: American Lung Association (ALA) Lung Health Cohort

Recruiting
N/A
4000
US
Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI), American Lung Association, Stanford University
Lung Diseases
09/26
09/26
Rohr, Aaron
INDIGO, NCT04297787: Safety and Efficacy of Thrombolysis in Combination With Endhole Aspiration in the Treatment of Acute DVT

Completed
N/A
3
US
Thrombolysis in combination with endhole aspiration
University of Kansas Medical Center, Penumbra Inc.
Acute Deep Vein Thrombosis
06/23
06/23
OCCLUDE, NCT06170619: Obsidio™ Conformable Embolic Registry

Recruiting
N/A
125
US
Obsidio™ Conformable Embolic
Boston Scientific Corporation
Hypervascular Tumors, Bleeding, Hemorrhage
06/25
06/25
Syed, Faisal
AIM-POWER, NCT04191330: Artificial Intelligence Mobile Health Trial Of A Digital Platform To Optimize GDMT Using Wearable Sensors

Active, not recruiting
N/A
122
US
BiovitalsHF
Biofourmis Inc.
Heart Failure
06/24
08/24
INTEGRA-D, NCT05855135: Assessment of Combined CCM and ICD Device in HFrEF

Recruiting
N/A
300
US
OPTIMIZER® Integra CCM-D System (Treatment Arm)
Impulse Dynamics
Heart Failure, Heart Failure with Reduced Ejection Fraction, Implantable Defibrillator User, CCM Therapy, Non-ischemic Cardiomyopathy, Ischemic Cardiomyopathy, Sudden Cardiac Arrest, Arrhythmias, Cardiac, Ventricular Tachycardia, Ventricular Fibrillation
06/25
12/25
Hemphill, Caleb
HALT-IPF, NCT04262167: Human Autologous Lung Stem Cell Transplant for Idiopathic Pulmonary Fibrosis

Recruiting
1
24
US
Lung Spheroid Stem Cells 100 million, LSCs, Lung Spheroid Stem Cells 200 million
University of North Carolina, Chapel Hill
Idiopathic Pulmonary Fibrosis and Progressive Fibrotic Interstitial Lung Disease
03/26
03/27
NCT04543461: American Lung Association (ALA) Lung Health Cohort

Recruiting
N/A
4000
US
Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI), American Lung Association, Stanford University
Lung Diseases
09/26
09/26
A1BC, NCT05297812: Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of Disease

Active, not recruiting
N/A
286
US
Columbia University, Alpha-1 Foundation, National Heart, Lung, and Blood Institute (NHLBI)
Alpha 1-Antitrypsin Deficiency, Genetic Disease
01/27
01/27
IPF-PRO, NCT01915511: Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry

Checkmark
Oct 2015 - Oct 2015: 
Recruiting
N/A
3000
US
Duke University, Boehringer Ingelheim
Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
01/28
01/28
Garcia, Eric
RISE 2, NCT06132893: A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy

Recruiting
2/3
390
Europe, US, RoW
BHV-7000, Placebo
Biohaven Therapeutics Ltd.
Focal Epilepsy
08/25
09/25
NCT04543461: American Lung Association (ALA) Lung Health Cohort

Recruiting
N/A
4000
US
Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI), American Lung Association, Stanford University
Lung Diseases
09/26
09/26
EspritBTKPAS, NCT06656364: Esprit BTK Post-Approval Study

Recruiting
N/A
200
US, RoW
Esprit BTK System
Abbott Medical Devices
Chronic Limb-Threatening Ischemia
04/27
05/29
XeLHC, NCT05766384: Hyperpolarized 129Xe MRI Lung Health Cohort

Recruiting
N/A
260
US
Hyperpolarized Xe129, Xenon, 129Xe, HP Xenon
University of Kansas Medical Center, Johns Hopkins University, University of Iowa, Duke University, University of Illinois at Chicago, Baylor College of Medicine, Temple University, University of Pennsylvania
Healthy
03/27
03/27
Mclean, John
DLP-LHC, NCT06177717: Deep Functional Phenotyping of the ALA Lung Health Cohort

Recruiting
N/A
1000
US
Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI), American Lung Association, University of Vermont
Lung Diseases
07/26
07/26
NCT04543461: American Lung Association (ALA) Lung Health Cohort

Recruiting
N/A
4000
US
Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI), American Lung Association, Stanford University
Lung Diseases
09/26
09/26
Gerhard, Hildebrandt
ASC2ESCALATE, NCT05384587: Asciminib Monotherapy, With Dose Escalation, for 2nd and 1st Line Chronic Myelogenous Leukemia

Active, not recruiting
2
196
US
asciminib, ABL001
Novartis Pharmaceuticals
Chronic Myelogenous Leukemia - Chronic Phase
09/25
10/27
Grimshaw, Crystal
NCT06404047: RECOVER-ENERGIZE Platform Protocol

Recruiting
N/A
660
US
Personalized Cardiopulmonary Rehabilitation, Structured Pacing, Education, Usual Care
Duke University, National Heart, Lung, and Blood Institute (NHLBI)
Long COVID, Long Covid19, Long Covid-19
10/25
01/26
Sheehan, Elyce
NCT06404047: RECOVER-ENERGIZE Platform Protocol

Recruiting
N/A
660
US
Personalized Cardiopulmonary Rehabilitation, Structured Pacing, Education, Usual Care
Duke University, National Heart, Lung, and Blood Institute (NHLBI)
Long COVID, Long Covid19, Long Covid-19
10/25
01/26

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