Completed

2

257

US

Moderna mRNA-1273, mRNA-1273 vaccine (Moderna), Moderna COVID-19 Vaccine, SARS-CoV-2 RNA vaccine, COVID-19 vaccine, BNT162b2, mRNA-1273 vaccine (Pfizer/BioNTech), Pfizer-BioNTech COVID-19 vaccine, Ad26.COV2.S, Janssen COVID-19 Vaccine, JNJ-78436735, Continue IS (MMF or MPA), immunosuppressive medication, mycophenolate mofetil, MMF, CellCept®, mycophenolic acid, MPA, Continue IS (MTX), methotrexate, MTX, Continue IS (B cell depletion therapy), mAbs targeting CD19 or CD20, anti-BAFF mAb, Monovalent [B.1.351] CoV2 preS dTM-AS03, Sanofi-GSK COVID-19 Vaccine, Withhold IS (MMF or MPA), Withhold IS (MTX), Withhold IS (B cell depletion therapy), Moderna mRNA-1273, Bivalent, mRNA-1273 vaccine (Moderna), Bivalent, Moderna COVID-19 Vaccine, Bivalent, SARS-CoV-2 RNA vaccine, Bivalent, COVID-19 vaccine, Bivalent, BNT162b2, Bivalent, mRNA-1273 vaccine (Pfizer/BioNTech), Bivalent, Pfizer-BioNTech COVID-19 vaccine, Bivalent

National Institute of Allergy and Infectious Diseases (NIAID), Autoimmunity Centers of Excellence, Rho Federal Systems Division, Inc.

Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), Pemphigus Vulgaris, Multiple Sclerosis (MS), Systemic Sclerosis (SSc), Pediatric SLE, Juvenile Idiopathic Arthritis (JIA), Juvenile Dermatomyositis (JDM), Pediatric-Onset Multiple Sclerosis (POMS)

06/23

03/24

Terminated

2

301

Europe, RoW

HZN-825 BID, Placebo, HZN-825 QD

Amgen, Horizon Therapeutics USA, Inc

Diffuse Cutaneous Systemic Sclerosis, Sclerosis, Systemic

02/25

02/25

Completed

1/2

17

US

Brentuximab Vedotin, Adcetris®, Placebo, Placebo for brentuximab vedotin

National Institute of Allergy and Infectious Diseases (NIAID), Immune Tolerance Network (ITN), Seagen Inc., PPD, Rho Federal Systems Division, Inc.

Diffuse Cutaneous Systemic Sclerosis, Scleroderma, dcSSc

04/23

04/23

Terminated

2

174

Europe, Japan, US, RoW

HZN-825

Amgen, Horizon Therapeutics USA, Inc, Horizon Therapeuthics USA, Inc

Diffuse Cutaneous Systemic Sclerosis, Sclerosis, Systemic

02/25

02/25

Recruiting

2

400

US

Amlitelimab, BI 1015550, Placebo

Scleroderma Research Foundation, Inc., Sanofi, Boehringer Ingelheim

Interstitial Lung Disease Due to Systemic Disease, Scleroderma

11/26

11/26