Yale-New Haven Hospital
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 55 Trials 
144 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Miller, Edward
CHASM-CS-RCT, NCT03593759: Cardiac Sarcoidosis Randomized Trial

Recruiting
3
194
Europe, Canada, Japan, US
Prednisone or Prednisolone, Methotrexate
Ottawa Heart Institute Research Corporation, Canadian Institutes of Health Research (CIHR)
Cardiac Sarcoidosis, Sarcoidosis
12/25
12/25
NCT05374564: Parametric Cardiac 18F-flutemetamol PET Imaging in ATTR Cardiomyopathy

Recruiting
1
12
US
(18F)Flutemetamol, Vizamyl
Yale University, Pfizer
Cardiomyopathies, Primary
06/25
06/25
PATH, NCT03725332: The Home Trial: a Comparative Effectiveness Study of Peripartum Opioid Use Disorder in Rural Kentucky

Active, not recruiting
N/A
268
US
Telemedicine, Group Care
Wendy F Hansen, Patient-Centered Outcomes Research Institute
Neonatal Abstinence Syndrome
12/24
12/24
NCT04569903: Evaluation of a Claims-based Algorithm for the Identification of Transthyretin-mediated Amyloidosis (ATTR) Amyloidosis in Medical Records

Recruiting
N/A
100
US
Computer algorithm for ATTR
Yale University, Alnylam Pharmaceuticals Inc
Transthyretin Amyloidosis
02/26
02/26
Bravata, Dawn M
ASAP, NCT04322162: Addressing Sleep Apnea Post-Stroke/TIA

Active, not recruiting
N/A
6
US
ASAP Intervention Quality Improvement Protocol
VA Office of Research and Development
Ischemic Stroke, Transient Ischemic Attack (TIA), Obstructive Sleep Apnea
09/23
07/24
NCT06568601: Pharmacogenomic Informed Statin Prescribing

Not yet recruiting
N/A
410
US
Pharmacogenetic and polygenic risk testing, Active control, Control
VA Office of Research and Development
Hypercholesterolemia
05/27
07/28
Sinusas, Albert J
NCT02327455: Integrated RF and B-mode Deformation Analysis for 4D Stress Echocardiography

Withdrawn
N/A
20
NA
Stress Dobutamine Echocardiographic using 4DE System
Yale University, National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
09/23
09/23
NCT02791204: SPECT/CT Imaging of Skeletal Muscle Perfusion

Recruiting
N/A
140
US
SPECT/CT imaging following revascularization procedures, SPECT/CT imaging
Yale University, University of Illinois at Urbana-Champaign
Peripheral Arterial Disease, Diabetes Mellitus
12/25
12/26
Nowak, Richard M
NCT02093624: A Phase II Trial of Rituximab In Myasthenia Gravis

Not yet recruiting
2
50
US
Rituximab, Placebo
Yale University
Myasthenia Gravis
05/17
12/17
ADAPT-teleMG, NCT05917184: The Adapting Disease Specific Outcome Measures Pilot Trial for Telehealth in Myasthenia Gravis

Completed
N/A
52
US
Telehealth
Yale University, National Institute of Neurological Disorders and Stroke (NINDS), National Center for Advancing Translational Sciences (NCATS)
Myasthenia Gravis
01/23
01/23
NCT03792659: The EXPLORE MG Registry for Myasthenia Gravis

Recruiting
N/A
800
US
Blood Sample Draw
Yale University
Myasthenia Gravis
09/26
10/26
EXPLORE-MG2, NCT06002945: Exploring Outcomes and Characteristics of Myasthenia Gravis 2

Active, not recruiting
N/A
400
US
Blood sample
Yale University, National Center for Advancing Translational Sciences (NCATS), National Institute of Neurological Disorders and Stroke (NINDS)
Myasthenia Gravis
12/26
12/26
Lustberg, Maryam
NCT06377852: The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study

Recruiting
3
500
US
Palbociclib 125mg, Ribociclib 600mg, Ribociclib, Palbociclib
American Society of Clinical Oncology, Patient-Centered Outcomes Research Institute
Metastatic Breast Cancer
08/28
09/28
NCI-2022-02754, NCT05379153: Testing Laser Therapy for Treatment of Vaginal Dryness in Survivors of Breast Cancer, The Revitalize Trial

Not yet recruiting
3
250
NA
Laser Therapy, Sham Intervention, Questionnaire Administration, Quality of Life Assessment
Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI)
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8, Anatomic Stage IIB Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Anatomic Stage IIIC Breast Cancer AJCC v8, Vaginal Atrophy
09/25
05/27
EMBER-4, NCT05514054: A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer

Recruiting
3
6000
Europe, Canada, Japan, US, RoW
Imlunestrant, LY3484356, Tamoxifen, Anastrozole, Letrozole, Exemestane
Eli Lilly and Company
Breast Neoplasms
10/27
03/32
OFSET, NCT05879926: Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

Recruiting
3
3960
Canada, US
Ovarian Function Suppression + Aromatase Inhibitor, Adjuvant Chemotherapy + Ovarian Function Suppression
NRG Oncology, National Cancer Institute (NCI)
Breast Cancer
01/32
07/34
OSU-13165, NCT02203552: Minocycline Hydrochloride in Reducing Chemotherapy Induced Depression and Anxiety in Patients With Stage I-III Breast Cancer

Completed
2
56
US
minocycline hydrochloride, Dynacin, Minocin, Minomax, Minomycin, placebo, PLCB, laboratory biomarker analysis, special studies, Correlative studies, Questionnaire administration, Ancillary studies
Ohio State University Comprehensive Cancer Center
Anxiety Disorder, Depression, Recurrent Breast Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer
06/20
06/20
MARGOT, NCT04425018: MARGetuximab Or Trastuzumab

Active, not recruiting
2
174
US
Paclitaxel, Taxol, Onxal, Pertuzumab, Perjeta, Margetuximab, Margenza, Trastuzumab, Herceptin, Kanjinti, Ogivri, Herzuma
Dana-Farber Cancer Institute, MacroGenics, Translational Breast Cancer Research Consortium
Breast Cancer, Stage II Breast Cancer, Stage III Breast Cancer, HER2-positive Breast Cancer
09/24
07/27
NCT06750484: Trial of Trastuzumab Deruxtecan in Previously Treated HER2

Not yet recruiting
2
50
US
Trastuzumab Deruxtecan
Yale University, Daiichi Sankyo, AstraZeneca
Breast Cancer Metastatic
12/28
12/28
DAANCE, NCT06749210: FOR CHEMOTHERAPY-INDUCED NEUROPATHY

Not yet recruiting
2
140
US
Tango
Ohio State University Comprehensive Cancer Center, National Institute on Aging (NIA), Yale University, Emory University
Cancer of the Breast, Chemotherapy-induced Neuropathy
09/30
09/30
NCT02204098: Safety and Immune Response to a Mammaglobin-A DNA Vaccine In Breast Cancer Patients Undergoing Neoadjuvant Endocrine Therapy

Active, not recruiting
1
27
US
Mammaglobin-A DNA Vaccine, Optional biopsy
Washington University School of Medicine, Rising Tide Foundation, United States Department of Defense
Breast Cancer, Breast Carcinoma, Malignant Neoplasm of Breast
04/22
08/28
NCT04205903: Nilotinib in Preventing Paclitaxel-Induced Peripheral Neuropathy in Patients With Stage I-III Breast Cancer

Recruiting
1
20
US
Nilotinib, AMN 107 Base Form, Nilotinib Hydrochloride Monohydrate, AMN107, Nilotinib Monohydrochloride Monohydrate, Tasigna, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Placebo, placebo therapy, PLCB, sham therapy, Questionnaire Administration
Ohio State University Comprehensive Cancer Center, National Cancer Institute (NCI)
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8, Anatomic Stage IIB Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Anatomic Stage IIIC Breast Cancer AJCC v8, Prognostic Stage I Breast Cancer AJCC v8, Prognostic Stage IA Breast Cancer AJCC v8, Prognostic Stage IB Breast Cancer AJCC v8, Prognostic Stage II Breast Cancer AJCC v8, Prognostic Stage IIA Breast Cancer AJCC v8, Prognostic Stage IIB Breast Cancer AJCC v8, Prognostic Stage III Breast Cancer AJCC v8, Prognostic Stage IIIA Breast Cancer AJCC v8, Prognostic Stage IIIB Breast Cancer AJCC v8, Prognostic Stage IIIC Breast Cancer AJCC v8
01/24
01/24
NCT05989347: Study to Evaluate Biomarkers and Safety of Dapagliflozin Concomitant With Neoadjuvant Therapy

Recruiting
1
20
US
Dapagliflozin 10mg
Yale University, AstraZeneca
Breast Cancer, Hyperinsulinism, HER2-negative Breast Cancer
12/25
12/25
NCT02831582: Omega-3 Supplementation in Prevention of Aromatase Inhibitor-Induced Toxicity in Patients With Stage I-III Breast Cancer

Completed
N/A
75
US
Omega-3 Fatty Acid, n-3 Fatty Acid, Omega 3 Fatty Acid, OMEGA-3 FATTY ACIDS, Omega-3 Polyunsaturated Fatty Acid, Omega-3 PUFA, omega-3-Fatty Acids, Placebo, placebo therapy, sham therapy
Ohio State University Comprehensive Cancer Center, National Cancer Institute (NCI)
Arthralgia, Breast Neoplasms
12/21
12/21
EPIPHANY, NCT03997981: Chemotherapy Induced Peripheral Neuropathy Natural History Study

Recruiting
N/A
200
US
Disarm Therapeutics, Eli Lilly and Company
Chemotherapy-induced Peripheral Neuropathy
03/24
04/24
ICAVS, NCT04633655: International CIPN Assessment and Validation Study

Recruiting
N/A
1000
Europe, Canada, US, RoW
outcome measures for CIPN testing
University of Milano Bicocca
Chemotherapy-induced Peripheral Neuropathy, Quality of Life
05/24
10/25
MIND-TNBC, NCT06582615: Food for Thought - a Nutrition Intervention for Women Undergoing Active Treatment for Triple Negative Breast Cancer

Recruiting
N/A
60
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Cognitive Assessment, Dietary Intervention, Dietary Modification, intervention, dietary, Nutrition Intervention, Nutrition Interventions, Nutritional Interventions, Medical Device Usage and Evaluation, Questionnaire Administration
Ohio State University Comprehensive Cancer Center, American Institute for Cancer Research
Anatomic Stage II Breast Cancer AJCC V8, Anatomic Stage III Breast Cancer AJCC V8, Triple-Negative Breast Carcinoma
12/26
12/26
Garralda, Elena
SERPENTINE, NCT06680739: Single cEll pRofiling PErsistaNce To ImmuNothErapy

Recruiting
2
60
Europe
Durvalumab, Tremelimumab
Vall d'Hebron Institute of Oncology
Colorectal Cancer, Endometrial Cancer
09/25
12/25
PragmaTIL, NCT06630611: Evaluation of a Pragmatic Approach to Adoptive Cell Therapy (ACT) Using an IL2 Analog (ANV419) vs High Dose IL2 After Tumor Infiltrating Lymphocytes (TIL) Therapy in Patients With Melanoma, NSCLC and Cervical Cancer

Recruiting
2
40
Europe
NMA-LD regimen, Cyclophosphamide and Fludarabine, Tumor infiltrating lymphocytes adoptive cell therapy (TIL-ACT) infusion, High dose IL-2, IL-2 analog
Vall d'Hebron Institute of Oncology, Banc de Sang i Teixits
Melanoma, Non Small Cell Lung Cancer, Cervical Cancer
09/29
09/29
NCT04259450 / 2019-003296-19: Study to Assess AFM24 in Advanced Solid Cancers

Completed
1/2
85
Europe, US, RoW
14 mg AFM24, 40 mg AFM24, 80 mg AFM24, 160 mg AFM24, 320 mg AFM24, 480 mg AFM24, 720 mg AFM24
Affimed GmbH
Advanced Solid Tumor
07/23
06/24
IMC-C103C-101, NCT03973333: Safety and Efficacy of IMC-C103C as Monotherapy and in Combination With Atezolizumab

Withdrawn
1/2
75
Europe, US
IMC-C103C, Atezolizumab, TECENTRIQ
Immunocore Ltd
Select Advanced Solid Tumors
09/23
09/23
EVICTION, NCT04243499 / 2019-003847-31: First-in-Human Study of ICT01 in Patients With Advanced Cancer

Checkmark Data from EVICTION study in combination with Keytruda for solid tumor at ESMO 2022
Sep 2022 - Sep 2022: Data from EVICTION study in combination with Keytruda for solid tumor at ESMO 2022
Recruiting
1/2
150
Europe, US
IV ICT01
ImCheck Therapeutics, ImCheck Therapeutics, Inc.
Solid Tumor, Adult, Hematopoietic/Lymphoid Cancer
06/25
12/25
GCT1055-01, NCT06391775: Trial to Assess the Safety and Preliminary Efficacy of GEN1055 on Malignant Solid Tumors as Monotherapy and as Combination Therapy

Recruiting
1/2
270
Europe, US
GEN1055, Pembrolizumab, Standard Chemotherapy
Genmab, BioNTech SE
Malignant Solid Tumor
05/28
05/28
IMAG1NE, NCT05430555: A Phase 1/ 2, First-in-Human, Open-Label, Accelerated-Titration, Two-Part Clinical Trial of TK-8001 in Patients With HLA-A*02:01 Genotype and Advanced-Stage/ Metastatic MAGE-A1+ Solid Tumors

Terminated
1/2
23
Europe
Autologous CD8+ T-cells, transduced with MAGE-A1 directed TCR
T-knife GmbH
Advanced Solid Tumors
01/24
01/24
MYCure, NCT04808362 / 2020-003802-30: Phase 1/2 Study to Evaluate Safety, PK and Efficacy of the MYC-Inhibitor OMO-103 in Solid Tumours

Terminated
1/2
22
Europe
OMO-103
Peptomyc S.L., Peptomyc S.L.
Advanced Solid Tumors, Pancreatic Cancer, CRC
12/22
01/23
NCT05435339 / 2021-006692-42: A Study to Evaluate Safety, Tolerability, and Preliminary Effect of the GEN1053 Antibody on Malignant Solid Tumors as Monotherapy

Terminated
1/2
31
Europe, US
GEN1053
Genmab, BioNTech SE
Solid Tumor, Adult
05/24
05/24
NCT05620134 / 2022-000339-21: Study of JK08 in Patients with Unresectable Locally Advanced or Metastatic Cancer

Active, not recruiting
1/2
263
Europe
JK08, Pembrolizumab, Lenvatinib Pill
Salubris Biotherapeutics Inc, Salubris Biotherapeutics, Inc.
Cancer, Tumor, Solid, Advanced Solid Tumor, Metastatic Cancer, Melanoma, Colorectal Cancer, Non-small Cell Lung Cancer, Small-cell Lung Cancer, Urothelial Carcinoma, Squamous Cell Carcinoma of Head and Neck, Luminal Breast Cancer, Triple Negative Breast Cancer, Clear Cell Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Gastric Adenocarcinoma, GastroEsophageal Cancer, Squamous Cell Carcinoma Skin, Pancreatic Adenocarcinoma, Hepatocellular Carcinoma, Colorectal Adenocarcinoma, Epithelial Ovarian Cancer, Thyroid Cancer
10/25
02/26
GDFATHER, NCT04725474 / 2020-002103-19: First-in-Human Study of the GDF-15 Neutralizing Antibody Visugromab (CTL-002) in Patients With Advanced Cancer

Active, not recruiting
1/2
274
Europe
visugromab (CTL-002)
CatalYm GmbH, CatalYm GmbH
Solid Tumor, Adult
10/25
10/27
PYNNACLE, NCT04585750: The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation

Recruiting
1/2
230
Europe, US, RoW
PC14586, rezatapopt, pembrolizumab, KEYTRUDA®, MK-3475, KEYNOTE-D79, MK-3475-D79
PMV Pharmaceuticals, Inc, Merck Sharp & Dohme LLC
Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor, Lung Cancer, Ovarian Cancer, Endometrial Cancer, Prostate Cancer, Colorectal Cancer, Breast Cancer, Other Cancer, Locally Advanced, Head and Neck Cancer
03/26
07/26
TNG462-C101, NCT05732831: Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors

Recruiting
1/2
225
Europe, US
TNG462, Pembrolizumab, Keytruda
Tango Therapeutics, Inc.
Locally Advanced Solid Tumor
05/26
09/26
START-001, NCT05592626: A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants with Advanced Solid Tumors

Recruiting
1/2
365
Europe, Canada, US
STAR0602
Marengo Therapeutics, Inc.
Advanced Solid Tumors, Genital Neoplasm, Female, Urogenital Neoplasms, Lung Neoplasm, Neoplasms by Site, Papillomavirus Infection, Epstein-Barr Virus Infections, Carcinoma, Neoplasms, Vulvar Neoplasms, Vulvar Diseases, Abdominal Neoplasm
10/26
10/26
EP0031-101, NCT05443126: A Study of EP0031 in Patients With Advanced RET-altered Malignancies

Recruiting
1/2
265
Europe, US, RoW
EP0031
Ellipses Pharma
Advanced Solid Tumor
12/26
06/27
CFT1946-1101, NCT05668585: A Study to Characterize the Safety, Tolerability, and Preliminary Efficacy of CFT1946 as Monotherapy and Combination Therapy in Subjects With BRAF V600 Mutant Solid Tumors

Recruiting
1/2
206
Europe, US
CFT1946, Trametinib, Cetuximab
C4 Therapeutics, Inc.
Solid Tumors, Melanoma, NSCLC, CRC, ATC
03/27
04/27
NCT05584670 / 2022-001239-95: A First-in-human, Dose Escalation and Dose Expansion Study of SAR445877 in Adult Participants With Advanced Solid Tumors

Recruiting
1/2
285
Europe, US, RoW
SAR445877, Cetuximab, Erbitux
Sanofi, Sanofi Aventis Recherche & Développement
Solid Tumor
01/27
09/28
NCT05076396: PM14 Administered Intravenously to Patients with Advanced Solid Tumors

Recruiting
1
150
Europe, US
PM14
PharmaMar
Advanced Solid Tumor
08/25
08/25
NCT04053673: Phase 1 Study of RBN-2397, an Oral PARP7 Inhibitor, in Patients With Solid Tumors

Recruiting
1
130
Europe, US
RBN-2397
Ribon Therapeutics, Inc.
Solid Tumor, Adult
06/23
07/23
TT-CSP-001, NCT06403436: A Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of TT125-802 in Subjects With Advanced Solid Tumors

Recruiting
1
50
Europe
TT125-802
TOLREMO therapeutics AG
Advanced Solid Tumor, Adult Solid Tumor, Adult Disease, Cancer, NSCLC
07/25
12/25
VICTORIA-01, NCT06163391: A Study to Assess Safety and Efficacy of SOT201 in Patients With Advanced/Metastatic Cancer

Recruiting
1
40
Europe, US, RoW
SOT201
SOTIO Biotech AG
Advanced Solid Tumor, Metastatic Solid Tumor
10/26
10/26
NCT04901806 / 2021-001029-32: Study of PBI-200 in Subjects With NTRK-Fusion-Positive Solid Tumors

Terminated
1
29
Europe, US, RoW
PBI-200
Pyramid Biosciences, Pyramid Biosciences, Inc., Pyramid Biosciences
Solid Tumor, Adult, Brain Tumor, Primary, Desmoplastic Small Round Cell Tumor
07/23
07/23
NCT05385705: A Study of Allogenic Natural Killer Cells in Combination With Trastuzumab and Pertuzumab in Adult Patients With Refractory Metastatic Her2 Positive Breast Cancer. NK-ACT-BC_2020

Recruiting
1
20
Europe
Cyclophosphamide, Trastuzumab, Pertuzumab, NK cells, Interleukin-2
Vall d'Hebron Institute of Oncology, Clinica Universidad de Navarra, Universidad de Navarra, Puerta de Hierro University Hospital, Hospital del Mar, Banc de Sang i Teixits
Breast Neoplasms
09/26
04/27
NCT06607185: A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors

Recruiting
1
750
Europe, Japan, US, RoW
LY4066434., Cetuximab, Nab paclitaxel, Gemcitabine, Oxaliplatin, Leucovorin, Irinotecan, 5Fluorouracil, Carboplatin, Cisplatin, Pemetrexed, Pembrolizumab
Eli Lilly and Company
Pancreatic Ductal Adenocarcinoma, Non-small Cell Lung Cancer, Colorectal Cancer, Advanced Solid Tumor, Metastatic Solid Tumor
01/30
01/30
NCT06458712: Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants with Advanced Malignancies

Recruiting
1
90
Europe
DSB2455
Duke Street Bio Ltd
Advanced Malignancies with Homologous Recombination Deficiency (HRD) (Breast, Ovarian, MCRPC, Brain Metastases)
08/27
08/28
RP2-001-18, NCT04336241: Study of RP2 Monotherapy and RP2 in Combination With Nivolumab in Patients With Solid Tumors

Hourglass Oct 2021 - Dec 2021 : Updated data from trial in combination with RP2 for solid tumors
Checkmark From trial in combination with RP2 for solid tumors at ASCO 2021
Jun 2021 - Jun 2021: From trial in combination with RP2 for solid tumors at ASCO 2021
Recruiting
1
36
Europe
RP2, nivolumab, Opdivo
Replimune Inc.
Cancer
10/26
04/28
NEXTGENTIL-ACT, NCT05141474: Assessment of the Safety and Tolerability of ex Vivo Next-generation Neoantigen-selected Tumor-infiltrating Lymphocyte (TIL) Therapy in Advanced Epithelial Tumors and Immune Checkpoint Blockade (ICB) Resistant Solid Tumors

Recruiting
1
10
Europe
NEXTGEN-TIL, Tumor-infiltrating Lymphocyte Adoptive Cell Therapy, Non-myeloablative Lymphodepletion (NMA-LD) Regimen, Cyclophosphamide, Fludarabine, Interleukin-2, IL-2, Aldesleukin
Vall d'Hebron Institute of Oncology, Banc de Sang i Teixits
Epithelial Tumors, Malignant, Malignant Solid Tumor
01/27
01/27
King, Brett
BRAVE-AA1, NCT03570749: A Study of Baricitinib (LY3009104) in Participants With Severe or Very Severe Alopecia Areata

Checkmark Efficacy and safety data from BRAVE-AA1 trial in adults with severe alopecia areata
Apr 2021 - Apr 2021: Efficacy and safety data from BRAVE-AA1 trial in adults with severe alopecia areata
Checkmark From BRAVE-AA1 trial for alopecia areata
Oct 2020 - Oct 2020: From BRAVE-AA1 trial for alopecia areata
Active, not recruiting
2/3
824
Japan, US, RoW
Baricitinib, LY3009104, Placebo
Eli Lilly and Company, Incyte Corporation
Alopecia Areata
02/21
01/25
REVEAL, NCT04338581: Evaluation of AMG 714 for Vitiligo

Active, not recruiting
2
57
US
AMG 714, Placebo, nbUVB phototherapy, narrow band ultraviolet B phototherapy
National Institute of Allergy and Infectious Diseases (NIAID), Immune Tolerance Network (ITN), PPD DEVELOPMENT, LP, Rho Federal Systems Division, Inc., Amgen
Vitiligo
10/24
04/25
NCT05866562: Dupilumab in the Treatment of Pediatric Alopecia Areata

Recruiting
2
76
US
Dupilumab, Dupixent, Placebo
Icahn School of Medicine at Mount Sinai
Alopecia Areata
05/28
05/29
Davis, J Clay
HCD CoP, NCT05640648: Human-centered Design and Communities of Practice to Improve Delivery of Home-based Tuberculosis Contact Investigation in Uganda

Completed
N/A
10477
RoW
User-Centered Implementation Strategy, Enhanced Contact Investigation Implementation Strategy, Standard Implementation Strategy, Usual Implementation Strategy
Yale University, National Institute of Allergy and Infectious Diseases (NIAID), National Heart, Lung, and Blood Institute (NHLBI)
Tuberculosis, Tuberculosis, Pulmonary
10/23
10/23
CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting
N/A
1247
Europe, Canada, US
Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System
Edwards Lifesciences
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
01/25
04/30
NCT06338462: Cali Sin Tos Aim 2

Recruiting
N/A
120
RoW
Chatbot, Oral testing
Yale University, National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis
12/24
05/25
TEACH, NCT05917210: Peer-led Implementation of TB-HIV Education and Adherence Counseling in Uganda

Not yet recruiting
N/A
1920
RoW
Standard TB-EC, Peer navigation strategy for TB-EC
Yale University, National Institutes of Health (NIH)
Tuberculosis, HIV
09/27
09/27
Herzog, Raimund
NCT02471040: Brain Ketone Metabolism in Type 1 Diabetes

Completed
1
44
US
Beta-hydroxybutyrate, BHB, Normal Saline, NaCl 0.9%
Yale University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes, Hypoglycemia
04/22
04/22
NCT05317455: Regulation of Brain Glucose Metabolism in Type 1 Diabetes

Not yet recruiting
1
16
NA
Dichloroacetate, DCA
Yale University
Diabetes Mellitus, Type 1, Hypoglycemia Unawareness
10/25
12/25
U/S_in_T2DM, NCT05354947: Ultrasound Effects on Glycemic Control in T2DM

Recruiting
N/A
30
US
Ultrasound Delivery
Yale University, GE Healthcare
Type 2 Diabetes
05/25
05/25
NCT04622683: Effects of Hepatic Ultrasound on Metabolic Homeostasis

Completed
N/A
37
US
Ultrasound
Yale University, GE Healthcare
Healthy, Insulin Resistance
09/23
09/23
NCT06042517: Mechanisms of Ultrasound Neuromodulation Effects in Diabetes

Recruiting
N/A
77
US
Ultrasound, OGTT with unlabeled glucose and liver NMR, OGTT with carbon-13 labeled glucose and liver NMR, CGM glucose reading, HEC - Hyperinsulinemic-Euglycemic-Clamp
Yale University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Insulin Sensitivity
09/27
09/27
Baldassarri, Stephen R
NCT05664763: Understanding Effects of Cannabis Use and Abstinence on Neural Glutamate Homeostasis

Terminated
1
6
US
[18F]FPEB with PET, Cannabis abstinence
Yale University, National Institute on Drug Abuse (NIDA)
Cannabis Use Disorder
07/24
07/24
NCT04258852: Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors

Withdrawn
N/A
20
US
Low strength nicotine e-liquid, High strength nicotine e-liquid
Yale University, National Institute on Drug Abuse (NIDA)
Electronic Cigarette Use
02/24
02/25
NCT05706701: Nicotine Flux, a Potentially Powerful Tool for Regulating Nicotine Delivery From Electronic Cigarettes

Active, not recruiting
N/A
15
US
Nicotine vaping visit 1 (free-base nicotine), Nicotine vaping visit 1 (protonated nicotine), Nicotine vaping visit 2 (free-base nicotine), Nicotine vaping visit 2 (protonated nicotine)
Yale University, American University of Beirut Medical Center
Nicotine Vaping
01/25
01/25
Ash, Garrett I
ASPA, NCT05662826: Avatar-based Social Physical Activity

Suspended
N/A
24
US
Avatar-based Social Physical Activity
Yale University, American Heart Association
Type 1 Diabetes
12/25
12/25
NCT06098729: Digital Exercise for Middle-Aged Adults With Type 1 Diabetes and Other Absolute Insulin Deficiency Diabetes

Completed
N/A
24
US
Digital Exercise
Yale University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Exerscrip LLC
Type 1 Diabetes, Latent Autoimmune Diabetes in Adults, Pancreatitis
10/24
10/24
Havenon, Adam de
NCT05365880: Sphenopalatine Ganglion Block for the Treatment of Post-Stroke Headache

Withdrawn
2
20
US
Liquid Lidocaine, Placebo
University of Utah
Headache, Stroke, Ischemic Stroke
03/25
06/25
NCT03084523: Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRI

Active, not recruiting
1
80
US
Ferumoxytol Injectable Product, Feraheme
Yale University
Stroke, Intracranial Atherosclerosis
12/24
12/24
RESCUE-ICAS, NCT05403593: Registry of Emergent Large VeSsel OCclUsion DuE to IntraCranial AtherosclerosiS

Completed
N/A
600
Europe, US, RoW
No Intervention
Medical University of South Carolina, University of Göttingen, Thomas Jefferson University, University of Miami, University of Basel, University of Tennessee, Wake Forest University Health Sciences, Emory University, The University of Texas Health Science Center at San Antonio, University of Iowa, Indiana University, University of Chicago, Careggi Hospital, Massachusetts General Hospital, Imam Abdulrahman Bin Faisal University, Brown University, Yale University, Sutter Health, Centro Hospitalar de Lisboa Central, HCA Houston Healthcare Kingwood, advocate christ medical center
Intracranial Stenosis, Large Vessel Occlusion, Mechanical Thrombectomy
03/24
06/24
MR SCREEN, NCT06533631: Measuring Brain Health Using Low-Field Portable MRI

Not yet recruiting
N/A
100
US
Portable low-field MRI (pMRI), 3T MRI
Yale University, National Institute of Neurological Disorders and Stroke (NINDS)
White Matter Hyperintensity
11/26
11/26
BP-VISO, NCT05756257: Blood Pressure Variability and Ischemic Stroke Outcome

Recruiting
N/A
150
US
Yale University, University of Chicago, Massachusetts General Hospital, National Institute of Neurological Disorders and Stroke (NINDS)
Acute Ischemic Stroke, Blood Pressure Variability
03/26
03/26
Garcia-Tsao, Guadalupe
NCT04615091: Non-invasive Methods and Surgical Risk Stratification in Cirrhotics Undergoing Elective Extrahepatic Surgery

Recruiting
N/A
250
Europe, Canada, US, RoW
Azienda Ospedaliera Universitaria Integrata Verona
Advanced Chronic Liver Disease, Surgery--Complications
10/21
08/22
Johnston, Lindsay
OPTION SAFE, NCT05838690: Optimizing Tracheal Intubation Outcomes and Neonatal Safety

Recruiting
N/A
3000
Canada, US
Personalized Intubation Safety (PINS) Bundle, PINS Bundle
Children's Hospital of Philadelphia, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infant, Intubation Complication
04/27
06/27
NEAR4KIDs, NCT02493478: Improving Safety and Quality of Tracheal Intubation Practice in Pediatric ICUs

Recruiting
N/A
150000
Europe, Canada, Japan, US, RoW
Children's Hospital of Philadelphia, Agency for Healthcare Research and Quality (AHRQ)
Failed or Difficult Intubation, Sequela, Intubation; Difficult, Intubation Complication
01/30
01/30
Champagne, Alison
NCT03084523: Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRI

Active, not recruiting
1
80
US
Ferumoxytol Injectable Product, Feraheme
Yale University
Stroke, Intracranial Atherosclerosis
12/24
12/24
TRIOMPHE, NCT04471909: NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Recruiting
N/A
110
US, RoW
NEXUS Aortic Stent Graft System
Endospan Ltd.
Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
11/24
10/29
TOBA PMS, NCT05361967: Tack Optimized Balloon Angioplasty Post-Market Study

Terminated
N/A
6
US
The Tack Endovascular System
Spectranetics Corporation
PAD - Peripheral Arterial Disease, PAD, Dissection, Arterial Dissection, Peripheral Arterial Disease, Peripheral Vascular Diseases
06/24
06/24
PERSEVERE, NCT05174767: - a Trial to Evaluate AMDS in Acute DeBakey Type I Dissection

Active, not recruiting
N/A
115
US
AMDS
Artivion Inc., Syneos Health
Acute Aortic Dissection
12/23
12/29
BP-VISO, NCT05756257: Blood Pressure Variability and Ischemic Stroke Outcome

Recruiting
N/A
150
US
Yale University, University of Chicago, Massachusetts General Hospital, National Institute of Neurological Disorders and Stroke (NINDS)
Acute Ischemic Stroke, Blood Pressure Variability
03/26
03/26
Attaran, Robert
C-TRACT, NCT03250247: Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy (The Trial)

Recruiting
N/A
250
US
Stents
Washington University School of Medicine, Ontario Clinical Oncology Group (OCOG), Massachusetts General Hospital, Saint Luke's Mid America Heart Institute
Deep Vein Thrombosis, Venous Stasis, Venous Insufficiency, Venous Leg Ulcer, Venous Reflux, Post Thrombotic Syndrome
01/26
04/26
NCT03820947: VenaSeal Spectrum: Global Post-Market Randomized Controlled Trial

Active, not recruiting
N/A
506
Europe, Canada, US, RoW
VenaSeal™ Closure System, Endothermal Ablation (ETA), Endovenous laser ablation(EVLA), Radiofrequency ablation (RFA), Surgical Stripping
Medtronic Endovascular
Venous Reflux
06/24
04/28
Alian, Aymen
LBPN, NCT03592290: Hemodynamics Monitoring During Lower Body Negative Pressure (LBNP) Induced Controlled Hypovolemia

Recruiting
N/A
120
US
Lower body negative pressure
Yale University
Hypovolemia, Hemodynamic Instability
06/26
06/26
NCT05185037: NIBP (Non-invasive Blood Pressure) Algorithm Enhancements (Characterize the Robustness of Motion Artifact Suppression)

Terminated
N/A
17
US
Philips IntelliVue X3 patient monitor with investigational NIBP measurement algorithm (measured once per 3 minutes)
Philips Clinical & Medical Affairs Global
Movement, Involuntary
11/23
11/23
Nally, Laura M
NCT05325294: Evaluation of the Advanced Hybrid Closed Loop (AHCL) System in Type 1 Adults and Pediatrics Utilizing Lyumjev®

Completed
N/A
244
US
MiniMed 780G System
Medtronic Diabetes, Eli Lilly and Company
Type 1 Diabetes
01/24
01/24
NCT04955691: Metabolic Changes Induced by a Very Low Carbohydrate Diet in Youth With Type 1 Diabetes

Completed
N/A
20
US
low carbohydrate diet, standard carbohydrate diet
Yale University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type1diabetes, Low Carbohydrate Diet
08/24
08/24
Laine, Loren
TREET, NCT06188585: Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Bleeding Ulcers

Recruiting
N/A
278
Europe, Canada, US, RoW
UI-EWD, Nexpowder™, Conventional therapy, Bipolar electrocoagulation or Bipolar electrocoagulation endoscopic hemostasis, Epinephrine (1:10,000 dilution) injection or Endoscopic hemostatic injection of epinephrine (1:10,000 dilution), Endoscopic hemostatic clip
Medtronic - MITG, North American Science Associates Ltd.
Acute Gastrointestinal Bleeding
07/26
08/26
NCT03325855: Fecal Microbiota Transplant National Registry

Recruiting
N/A
4000
Canada, US
None - Observational, Observational
American Gastroenterological Association, OpenBiome, University of California, San Diego, Commure, University of Pennsylvania, University of Minnesota, Loyola University Chicago
Fecal Microbiota Transplantation, Clostridium Difficile Infection, Gut Microbiome
08/27
08/27
Hwang, Janice
NCT04328337: Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism

Recruiting
1/2
40
US
Intralipid, 20% Intravenous Emulsion, Placebos
University of North Carolina, Chapel Hill, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity
06/25
06/25
NCT03738852: Mechanisms for Restoration of Hypoglycemia Awareness

Completed
1
40
US
Continuous Glucose Monitor (CGM), Dexcom G6, Insulin
Yale University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type1 Diabetes Mellitus
08/23
08/23
NCT04622683: Effects of Hepatic Ultrasound on Metabolic Homeostasis

Completed
N/A
37
US
Ultrasound
Yale University, GE Healthcare
Healthy, Insulin Resistance
09/23
09/23
Arora, Mili
LIBRETTO-531, NCT04211337 / 2019-001978-28: A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer

Active, not recruiting
3
291
Europe, Canada, Japan, US, RoW
Selpercatinib, LY3527723, LOXO-292, Cabozantinib, Vandetanib
Loxo Oncology, Inc., Eli Lilly and Company
Medullary Thyroid Cancer
05/23
02/26
EMBER-3, NCT04975308 / 2021-000079-35: A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer

Active, not recruiting
3
866
Europe, Japan, US, RoW
Imlunestrant, LY3484356, Exemestane, Fulvestrant, Abemaciclib, LY2835219
Eli Lilly and Company, Eli Lilly and Company
Breast Neoplasms, Neoplasm Metastasis
06/24
08/27
EMBER-4, NCT05514054: A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer

Recruiting
3
6000
Europe, Canada, Japan, US, RoW
Imlunestrant, LY3484356, Tamoxifen, Anastrozole, Letrozole, Exemestane
Eli Lilly and Company
Breast Neoplasms
10/27
03/32
CompassHER2 RD, NCT04457596: T-DM1 and Tucatinib Compared with T-DM1 Alone in Preventing Relapses in People with High Risk HER2-Positive Breast Cancer, the Trial

Calendar Jan 2028 - Dec 2028: From CompassHER2 RD trial in combination with Kadcyla for HER2+ breast cancer
Recruiting
3
1031
Canada, US
Trastuzumab Emtansine, Placebo Administration, Tucatinib, Questionnaire Administration, Quality-of-Life Assessment
Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI), Seagen Inc.
Anatomic Stage IA Breast Cancer AJCC V8, Anatomic Stage II Breast Cancer AJCC V8, Anatomic Stage IIA Breast Cancer AJCC V8, Anatomic Stage IIB Breast Cancer AJCC V8, Anatomic Stage III Breast Cancer AJCC V8, Anatomic Stage IIIA Breast Cancer AJCC V8, Anatomic Stage IIIB Breast Cancer AJCC V8, Anatomic Stage IIIC Breast Cancer AJCC V8, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Multifocal Breast Carcinoma, Prognostic Stage I Breast Cancer AJCC V8, Prognostic Stage IA Breast Cancer AJCC V8, Prognostic Stage IB Breast Cancer AJCC V8, Prognostic Stage II Breast Cancer AJCC V8, Prognostic Stage IIA Breast Cancer AJCC V8, Prognostic Stage IIB Breast Cancer AJCC V8, Prognostic Stage III Breast Cancer AJCC V8, Prognostic Stage IIIA Breast Cancer AJCC V8, Prognostic Stage IIIB Breast Cancer AJCC V8, Prognostic Stage IIIC Breast Cancer AJCC V8, Synchronous Bilateral Breast Carcinoma
01/28
05/35
NCT04090398: Testing the Addition of Radium Therapy (Radium-223 Dichloride) to the Usual Chemotherapy Treatment (Paclitaxel) for Advanced Breast Cancer That Has Spread to the Bones

Active, not recruiting
2
70
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Scan, Bone Scintigraphy, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Electronic Health Record Review, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Radium Ra 223 Dichloride, Alpharadin, BAY 88-8223, BAY88-8223, Radium 223 Dichloride, RADIUM RA-223 DICHLORIDE, Radium-223 Chloride, Radium-223 Dichloride, Xofigo, Single Photon Emission Computed Tomography, Medical Imaging, Single Photon Emission Computed Tomography, Single Photon Emission Tomography, Single-Photon Emission Computed, single-photon emission computed tomography, SPECT, SPECT imaging, SPECT SCAN, SPET, ST, tomography, emission computed, single photon, Tomography, Emission-Computed, Single-Photon
National Cancer Institute (NCI)
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic HER2-Negative Breast Carcinoma, Metastatic Malignant Neoplasm in the Bone
06/26
06/26
 

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