| Thille, Arnaud |
INASED, NCT04341350: Comparison of an Inhaled Sedation Strategy to an Intravenous Sedation Strategy in Intensive Care Unit Patients Treated with Invasive Mechanical Ventilation |
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| Recruiting | 3 | 250 | Europe | Propofol + analgesic drug, Isoflurane + analgesic drug | University Hospital, Brest | Prevention of Delirium | 08/25 | 08/26 | | |
| Completed | 3 | 700 | Europe | Inhaled sedation with sevoflurane, intravenous sedation with propofol | University Hospital, Clermont-Ferrand | Acute Respiratory Distress Syndrome | 10/23 | 10/24 | | |
Corticop, NCT04163536: Comparison of Corticosteroids vs Placebo on Duration of Ventilatory Support During Severe Acute Exacerbations of COPD Patients in the ICU |
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| Recruiting | 3 | 440 | Europe | Methylprednisolone, Placebos | Versailles Hospital | Chronic Obstructive Pulmonary Disease | 10/25 | 03/26 | | |
EXSUPEEP, NCT05147636: EXtubation With SUctioning or With Positive End-Expiratory Pressure in Intensive Care Unit |
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| Recruiting | N/A | 424 | Europe | Extubation with PEEP, Endotracheal Aspiration | Centre Hospitalier de Bourg en Bresse, Direction Générale de l'Offre de Soins, Hospices Civils de Lyon | Extubation in Intensive Care Unit | 06/25 | 07/25 | | |
| Active, not recruiting | N/A | 17 | Europe | ECCO2R | Assistance Publique - Hôpitaux de Paris, Ministry of Health, France, Xenios AG | COPD Acute Exacerbation | 05/24 | 03/25 | | |
| Recruiting | N/A | 670 | Europe | High-Flow Oxygen, Non invasive ventilation | Poitiers University Hospital | Post Extubation Respiratory Failure | 03/26 | 08/26 | | |
PROBIty, NCT05686577: How to Reduce Unnecessary Blood Cultures: Construction and Validation of a Predictive Score for Blood Culture Positivity in Intensive Care |
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| Completed | N/A | 2411 | Europe | no intervention | University Hospital, Tours | Infection, Bacterial, Infection, Fungal, Bacteremia | 09/23 | 10/23 | | |
| Frat, Jean-Pierre |
SOHO, NCT04468126: Standard Oxygen Versus High Flow Nasal Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure |
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| Recruiting | N/A | 1110 | Europe | Standard oxygen, High-flow nasal oxygen therapy | Poitiers University Hospital | Acute Respiratory Failure, Hypoxemic Respiratory Failure | 10/24 | 12/24 | | |
| MIMOZ, OLIVIER |
InSaKa, NCT04012138: Insulin Dextrose Infusion vs Nebulized Salbutamol vs Combination of Salbutamol and Insulin Dextrose in Acute Hyperkalemia |
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| Recruiting | 4 | 525 | Europe | Salbutamol, Salbutamol and Hyperkaliemia, Insulin Aspart, Insulin and Hyperkaliemia | Nantes University Hospital | Hyperkalemia | 12/25 | 06/26 | | |
ProP, NCT05741866: Novel Antimicrobial Dressing in Peripheral Intravenous Catheters (PIVCs) |
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| Recruiting | N/A | 300 | Europe, RoW | Chlorhexidine gluconate impregnated bordered polyurethane dressing, Tegaderm™ Antimicrobial I.V. Advanced Securement (9132), Standard bordered polyurethane dressing, Tegaderm™ IV Advanced (1682 or 1683) | The University of Queensland, Queensland Children's Hospital, Royal Brisbane and Women's Hospital, University Hospital of Poitiers, Griffith University | Vascular Access Complication, Device Related Infection, Device Related Sepsis, Device Site Reactions, Catheter Infection, Catheter Complications, Catheter-Related Infections, Catheter Related Complication, Occlusive Dressings, Wound Infection, Wound of Skin, Wound | 11/23 | 12/23 | | |
ATLANREA, NCT02714387: Non Traumatic Neuro-Vascular Diseases Critical Complications : a Prospective Cohort Study |
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| Recruiting | N/A | 5000 | Europe | Collection of medical data | Nantes University Hospital | Non Traumatic Acute Brain Injury | 01/50 | 01/50 | | |
NCT02426255: Post Traumatic Critical Complications: a Prospective Cohort Study (ATLANREA) |
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| Recruiting | N/A | 5000 | Europe | Collection of medical data from ICU patients | Nantes University Hospital | Severe Trauma (With or Without Traumatic Brain Injury) | 01/50 | 01/50 | | |
| Rousselot, Philippe |
| Active, not recruiting | 3 | 245 | Europe, Canada, Japan, US, RoW | Ponatinib, Iclusig, Imatinib, Gleevec, Vincristine, Dexamethasone, Cytarabine, Methotrexate, Prednisone | Takeda | Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ALL) | 08/22 | 07/27 | | |
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| Recruiting | 3 | 550 | Europe, Canada, US, RoW | Tamibarotene, SY-1425, Placebo, Azacitidine | Syros Pharmaceuticals | Myelodysplastic Syndromes | 11/24 | 02/29 | | |
| Recruiting | 3 | 322 | Europe, Canada, US | Crenolanib, Crenolanib besylate, Cytarabine, Mitoxantrone, Placebo Oral Tablet, Fludarabine, Idarubicin, G-CSF | Arog Pharmaceuticals, Inc. | Relapsed/Refractory Acute Myeloid Leukemia With FLT3 Activating Mutations | 10/24 | 10/24 | | |
NCT05753384: Discontinuation of TyrosIne Kinase Inhibitors (TKI) in Chronic Myeloid Leukemia (CML) and Impact on the Immune System |
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| Recruiting | 3 | 140 | Europe | treatment of TKI in CML | Poitiers University Hospital | Tyrosine Kinase Inhibitors, Chronic Myeloid Leukemia | 12/28 | 12/29 | | |
BIG-1, NCT02416388: Study to Improve OS in 18 to 60 Year-old Patients, Comparing Daunorubicin Versus High Dose Idarubicin Induction Regimens, High Dose Versus Intermediate Dose Cytarabine Consolidation Regimens, and Standard Versus MMF Prophylaxis of GvHD in Allografted Patients in First CR |
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| Recruiting | 2/3 | 3100 | Europe | Idarubicin, Daunorubicin, HD Cytarabine, Cyclosporine, Methotrexate, Mycophenolic acid (MPA), vosaroxin, ID cytarabine, Dexamethasone, Venetoclax | University Hospital, Angers | Acute Myeloid Leukemia (AML) | 07/25 | 01/32 | | |
| Not yet recruiting | 2 | 99 | Europe | Experimental drug | Versailles Hospital | SARS Virus | 12/20 | 12/21 | | |
PONAZA, NCT03895671: : A COMBINATION OF PONATINIB AND 5-AZACITIDINE IN CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE OR IN MYELOID BLAST CRISIS |
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| Recruiting | 2 | 40 | Europe | Ponatinib, Azacitidine | Versailles Hospital | CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE, CHRONIC MYELOGENOUS LEUKAEMIA IN MYELOID BLAST CRISIS | 12/23 | 12/24 | | |
| Active, not recruiting | 2 | 95 | Europe, US | Tamibarotene, Venetoclax, Venclexta, Azacitidine, Vidaza | Syros Pharmaceuticals, Syros Pharmaceuticals, Inc. | Acute Myeloid Leukemia | 04/28 | 04/28 | | |
ACTIW, NCT02767063: Therapies in Combination or Sequentially With Tyrosine Kinase Inhibitors (TKIs) in Chronic Phase Chronic Myelogenous Leukemia Patients in CCR |
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| Recruiting | 1/2 | 100 | Europe | Pioglitazone, Avelumab | Versailles Hospital | Leukemia, Myeloid, Chronic-Phase | 11/22 | 06/23 | | |
IMGN632-0802, NCT04086264: IMGN632 as Monotherapy or With Venetoclax and/or Azacitidine for Participants With CD123-Positive Acute Myeloid Leukemia |
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| Active, not recruiting | 1/2 | 218 | Europe, US | Azacitidine, Vidaza, Decitabine, IMGN632, CD123-targeted ADC, Venetoclax, Venclexta, Venclyxto | AbbVie, Jazz Pharmaceuticals | Acute Myeloid Leukemia | 04/26 | 04/26 | | |
| Recruiting | 1 | 180 | Europe, Canada, US, RoW | ELVN-001 | Enliven Therapeutics | Chronic Myeloid Leukemia, Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Cml | 12/26 | 12/26 | | |
EPIK, NCT03481868: EPIgenetics and in Vivo Resistance of Chronic Myeloid Leukemia Stem Cells to Tyrosine Kinase Inhibitors |
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| Recruiting | N/A | 160 | Europe | Collection of blood and bone marrow | University Hospital, Clermont-Ferrand, Institut Paoli-Calmettes, CHRU Lille, hematology department, CH Annecy Genevois, Institut Bergonié Bordeaux, hematology department, CHU Nancy, hematology department, CHU Saint-Etienne, hematology department, Institut Universitaire du Cancer de Toulouse - Oncopole, hematology department, CHU Caen, hematology department, CHU Nice, hematology department, CHU Lyon, hematology department, AP-HP, hematology department, AP-HP Hôpital Henri-Mondor, hematology department, Versailles Hospital, Centre Leon Berard, University Hospital, Grenoble | Chronic Myeloid Leukemia (CML), Chronic Phase | 05/25 | 02/26 | | |
BIO-TIMER, NCT06130787: Value of Biological Age, in Addition to Individual Frailty, for Personalising the Management of Cancer Treated with Targeted Therapy |
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| Recruiting | N/A | 321 | Europe | Blood and bone marrow sample | University Hospital, Clermont-Ferrand | Leukemia,Myeloid, Chronic | 11/25 | 11/28 | | |
NCT05963061: Chronic Myeloid Leukemia (CML) Real-Life Database |
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| Recruiting | N/A | 3500 | Europe | | University Hospital, Clermont-Ferrand, Centre Hospitalier Universitaire de Saint Etienne, Bicetre Hospital, University Hospital, Caen, Central Hospital, Nancy, France, University Hospital, Toulouse, CH Annecy Genevois, Rennes University Hospital, Hopital Paul Brousse, Versailles Hospital, Centre Hospitalier Emile Roux, University Hospital, Limoges, Institut Paoli-Calmettes, Centre Hospitalier de Rochefort | Chronic Myeloid Leukemia (CML) | 04/34 | 04/34 | | |
| Disse, Emmanuel |
NCT06484868: Open-label Study to Evaluate Metreleptin in Patients With Partial Lipodystrophy |
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| Recruiting | 4 | 12 | Europe | Metreleptin | Amryt Pharma | Partial Lipodystrophy | 09/27 | 09/27 | | |
| Recruiting | 3 | 126 | Europe | Metformin, Standard Care, Standardized meal | Assistance Publique - Hôpitaux de Paris, Ministry of Health, France | Diabetes, Bariatric Surgery, Metformin | 07/26 | 11/26 | | |
| Active, not recruiting | 3 | 15374 | Europe, Canada, Japan, US, RoW | Tirzepatide, LY3298176, Placebo | Eli Lilly and Company | Obesity, Overweight | 10/27 | 10/27 | | |
| Completed | 2 | 39 | Europe, US, RoW | RGH-706, Placebo | Gedeon Richter Plc., Gedeon Richter Plc, Chemical Works of Gedeon Richter Plc | Prader-Willi Syndrome | 04/24 | 04/24 | | |
NCT03847701: Cardio-metabolic and Inflammatory Impact of Starch Digestibility in Type 2 Diabetic Patients |
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| Recruiting | N/A | 80 | Europe | Balanced diet high in Slowly Digestible Starch, Diet A, H-SDS, Balanced diet low in Slowly Digestible Starch, Diet B, L-SDS | Mondelēz International, Inc., Centre de Recherche en Nutrition Humaine Rhone-Alpe, Biofortis Mérieux NutriSciences | Type2 Diabetes | 07/22 | 12/22 | | |
| Recruiting | N/A | 1610 | Europe | Online survey - questionnaire | Hospices Civils de Lyon | Food Addiction, Obesity | 10/22 | 06/23 | | |
| Recruiting | N/A | 238 | Europe | Bariatric surgery | Assistance Publique - Hôpitaux de Paris | Bariatric Surgery, Obesity, Reproductive Health, Fertility | 06/25 | 03/28 | | |
GLUCOGEN, NCT06570278: Role of High-Throughput Whole Genome Sequencing for the Diagnosis and Care of Atypical Diabetes |
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| Recruiting | N/A | 1020 | Europe | WGS coupled with MCM | Institut National de la Santé Et de la Recherche Médicale, France, Commissariat A L'energie Atomique, Rennes University Hospital, Central Hospital, Nancy, France, Nantes University Hospital, Imagine Institute, APHP, Hospices Civils de Lyon, Université Lumière Lyon 2, Toulouse University Hospital | Diabetes Mellitus | 11/31 | 11/34 | | |
| Not yet recruiting | N/A | 1000 | Europe | Data collection, Blood sampling, Questionnaires | Hospices Civils de Lyon | Obesity, Bariatric Surgery, Binge Eating Disorder, Syndromic Obesity, Sarcopenic Obesity, Iatrogenic Obesity, Psychotropic Drugs | 04/26 | 04/26 | | |
| Recruiting | N/A | 75 | Europe | Low-fat dairy products, Whole-fat dairy products, Milk polar lipid enriched whole-fat dairy products | Hospices Civils de Lyon, Laboratoire de Recherche en Cardiovasculaire, Métabolisme, Diabétologie et Nutrition, Centre de Recherche en Nutrition Humaine Rhone-Alpe, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement | Morbid Obesity | 09/25 | 09/25 | | |
| DELETAGE, Céline |
NCT03656081: Chronic Pulmonary Aspergillosis and Ambisome Aerosol With Itraconazole |
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| Recruiting | 3 | 224 | Europe | inhaled Ambisome®, inhaled placebo, placebo (for Ambisome®), Itraconazole, Sporanox® | Poitiers University Hospital | Chronic Pulmonary Aspergillosis | 06/27 | 12/29 | | |
| Not yet recruiting | N/A | 23 | Europe | Intermittent hypoxia | Poitiers University Hospital | Intermittent Hypoxia, Respiratory Endurance | 11/26 | 11/26 | | |
| LELEU |
XPORT-MM-031, NCT05028348 / 2021-001691-41: A Study of Combination of Selinexor, Pomalidomide, and Dexamethasone (SPd) Versus Elotuzumab, Pomalidomide, and Dexamethasone (EloPd) in Subject With Previously Treated Multiple Myeloma |
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| Recruiting | 3 | 222 | Europe, US | Selinexor, KPT-330, Elotuzumab, Pomalidomide, Dexamethasone Oral | Stichting European Myeloma Network, Karyopharm Therapeutics Inc | Multiple Myeloma | 03/26 | 03/29 | | |
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MajesTEC-4, NCT05243797 / 2021-002531-27: Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation |
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| Recruiting | 3 | 1594 | Europe, Canada, US, RoW | Teclistamab, JNJ-64007957, Lenalidomide | Stichting European Myeloma Network, Janssen Pharmaceutica | Multiple Myeloma | 04/28 | 04/32 | | |
CARTITUDE-6, NCT05257083 / 2021-003284-10: A Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Ciltacabtagene Autoleucel Versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Autologous Stem Cell Transplant (ASCT) in Participants With Newly Diagnosed Multiple Myeloma |
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| Recruiting | 3 | 750 | Europe, Canada, Japan, US, RoW | Daratumumab, Bortezomib, Lenalidomide, Dexamethasone, Cilta-cel, JNJ-68284528, Cyclophosphamide, Fludarabine | Stichting European Myeloma Network, Janssen Research & Development, LLC | Multiple Myeloma | 06/33 | 08/40 | | |
| Recruiting | 2 | 50 | Europe | Elranatamab | Stichting European Myeloma Network, Pfizer | Smoldering Multiple Myeloma | 07/27 | 07/31 | | |
I2D IFM2021_03, NCT04998786: A Multi-center Open-label Phase 2 Study of Ixazomib, Iberdomide and Dexamethasone in Elderly Patients With Multiple Myeloma at First Relapse." |
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| Active, not recruiting | 2 | 80 | Europe | Ixazomib, Iberdomide, Dexamethasone Oral | Nantes University Hospital | Multiple Myeloma at First Relapse | 01/25 | 01/27 | | |
| DAHYOT-FIZELIER, Claire |
BICCS, NCT05681442: Beta-lactam Intermittent Versus Continuous Infusion and Combination Antibiotic Therapy in Sepsis |
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| Recruiting | 4 | 600 | Europe | continuous pivotal βL-AB, CID group, intermittent pivotal βL-AB, IID control group, AG infusion most 1 dose, AMT group, AG infusion for 5 days, ACT Group | Assistance Publique - Hôpitaux de Paris | Sepsis | 12/25 | 12/25 | | |
| Recruiting | 3 | 272 | Europe | 56 days of weight-adjusted L-Carnitine treatment, 10 days of intravenous placebo (isotonic saline) | Centre Hospitalier Universitaire de Nīmes | Severe Sepsis, Shock, Septic, Acute Kidney Injury | 05/25 | 05/26 | | |
| Completed | 3 | 700 | Europe | Inhaled sedation with sevoflurane, intravenous sedation with propofol | University Hospital, Clermont-Ferrand | Acute Respiratory Distress Syndrome | 10/23 | 10/24 | | |
NCT03481569: Population Pharmacokinetic-pharmacodynamic (PK-PD) Study of 9 Broad-Spectrum Anti-infective Agents in the Cerebro Spinal Fluid (CSF) of Brain Injured Patients With an External Ventricular Drainage (EVD). |
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| Completed | 1 | 176 | Europe | Blood and cerebrospinal fluid pharmacocinetic samples on one of the nine antibiotics prescribed in routine use | Poitiers University Hospital | Infection | 07/23 | 07/23 | | |
| Recruiting | N/A | 660 | Europe | Extubation readiness clinical score, Standard of care | University Hospital, Clermont-Ferrand, AZUREA Network (www.azurea.org), ANARLF Network, Direction Générale de l'Offre de Soin (DGOS) | Mechanical Ventilator Weaning, Acute Brain Injury, Altered Level of Consciousness, Mechanical Ventilation, Airway Control | 02/27 | 10/27 | | |
| DARMON, Patrice |
| Completed | 4 | 282 | Europe, US, RoW | Tirzepatide, LY3298176, Dulaglutide, LY2189265 | Eli Lilly and Company | Type 2 Diabetes | 07/24 | 08/24 | | |
REGENDER, NCT02866565: Assessment of the Efficacy and Tolerance of Sub-cutaneous Re-injection of Autologous Adipose-derived REGEnerative Cells in the Local Treatment of Neuropathic Diabetic Foot ulcERs |
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| Not yet recruiting | 2 | 45 | Europe | adipose-derived regenerative cells (ADRCs) | Assistance Publique Hopitaux De Marseille | Diabetic Foot Ulcer | 09/26 | 12/26 | | |
| Terminated | N/A | 129 | Europe | Psycho-emotional and semiological measures, Cognitive measures, Physiological measurements, Qualitative measures | Assistance Publique Hopitaux De Marseille | Epilepsy | 06/23 | 06/23 | | |
GLUCOGEN, NCT06570278: Role of High-Throughput Whole Genome Sequencing for the Diagnosis and Care of Atypical Diabetes |
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| Recruiting | N/A | 1020 | Europe | WGS coupled with MCM | Institut National de la Santé Et de la Recherche Médicale, France, Commissariat A L'energie Atomique, Rennes University Hospital, Central Hospital, Nancy, France, Nantes University Hospital, Imagine Institute, APHP, Hospices Civils de Lyon, Université Lumière Lyon 2, Toulouse University Hospital | Diabetes Mellitus | 11/31 | 11/34 | | |
| GARCIA, Rodrigue |
NCT04619888: HeartLogic France Study: Heart Failure Patients Managed With the HeartLogic Algorithm |
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| Recruiting | N/A | 310 | Europe | HeartLogic | Poitiers University Hospital | Heart Failure | 07/23 | 07/23 | | |
RESOUDRE, NCT06642168: Sudden Cardiac Arrest Related to Sport in Young and Value of the Genetic Assessment: a French Prospective Register |
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| Recruiting | N/A | 80 | Europe | Whole exome sequencing to detect myocardial genetic mutations (SCA group only) | Rennes University Hospital | Sudden Cardiac Arrest, Sudden Cardiac Death | 01/28 | 01/28 | | |
FALCON, NCT05790707: EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive Impairment |
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| Recruiting | N/A | 120 | Europe | Atrial fibrillation ablation + antiarrhythmic drugs, Antiarrhythmic drug | Poitiers University Hospital | Mild Cognitive Impairment, Persistent Atrial Fibrillation | 02/25 | 02/25 | | |
DILEMMA, NCT05373940: Cardioverter DefIbriIlator PlacEMent for priMary Prevention of Sudden cArdiac Death in Patients Older Than 70 Years |
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| Recruiting | N/A | 730 | Europe | ICD implantation, No ICD implantation | Assistance Publique - Hôpitaux de Paris, Ministry of Health, France | Heart Failure, Primary Prevention of Sudden Cardiac Death, Implantable Cardioverter Defibrillator | 05/30 | 05/30 | | |
| CAZENAVE-ROBLOT, France |
ONCOVIR, NCT03389997: Assessement of Viral Shedding Duration After a Respiratory Tract Infection in Oncology and Hematology Patients |
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| Completed | N/A | 44 | Europe | nasal swabs | Poitiers University Hospital | Respiratory Tract Viral Infection | 02/24 | 02/24 | | |
| JOSSART, Anne |
| Recruiting | N/A | 60 | Europe | Rehabilitation program 1, Rehabilitation program 2 | University Hospital, Limoges | Stroke Rehabilitation | 05/26 | 05/26 | | |
| Genis, Quentin Saint |
CoC, NCT06194058: Rapid Sequence Intubation and Hemodynamic Disorders in the Operating Room: a Prospective Multicenter Observational Study |
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| Recruiting | N/A | 1150 | Europe | rapid sequence anesthetic induction | Nantes University Hospital, Société Française d'Anesthésie et de Réanimation | Rapid Sequence Intubation | 11/24 | 05/25 | | |
| MUSUMECI, Alfredo |
| Recruiting | N/A | 60 | Europe | Rehabilitation program 1, Rehabilitation program 2 | University Hospital, Limoges | Stroke Rehabilitation | 05/26 | 05/26 | | |
