| Søgaard, Ole |
| Recruiting | 2a | 580 | Europe | Camostat Mesilate, Foipan, Placebo oral tablet, Placebo | University of Aarhus | Corona Virus Infection | 01/22 | 05/22 | | |
| Completed | 2a | 47 | Europe, US, RoW | Saline, Lefitolimod, MGN1703, 3BNC117 and 10-1074, RUhumab-001 and RUhumab-002 | University of Aarhus, Aalborg University Hospital, Odense University Hospital, Rigshospitalet, Denmark, Hvidovre University Hospital, The Peter Doherty Institute for Infection and Immunity, University of Utah, Oslo University Hospital | HIV-1-infection | 07/22 | 05/23 | | |
| Active, not recruiting | 2 | 60 | Europe | Romidepsin, Istodax, 3BNC117, Broadly neutralizing antibody, Antiretrovirals, ART | Aarhus University Hospital, Rigshospitalet, Denmark, Hvidovre University Hospital, Odense University Hospital, Aalborg University Hospital, Herning Hospital, Hammersmith Hospitals NHS Trust, St Mary's Hospital, London | Hiv | 08/21 | 12/21 | | |
| Recruiting | 2 | 72 | Europe | Investigational Medicinal Product, 10-1074-LS and 3BNC117-LS | Imperial College London, Bill and Melinda Gates Foundation, University of Oxford, Rockefeller University | HIV/AIDS and Infections | 07/27 | 07/27 | | |
SAMBA, NCT06668727: Safety and Antiviral Activity of a Monoclonal Hepatitis B Antibody (The Study) |
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| Recruiting | 1 | 30 | Europe | HepB mAb19 | Aarhus University Hospital, Charite University, Berlin, Germany | Hepatitis B | 08/27 | 08/27 | | |
| Trivedi, Uday |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| Hildick-Smith, David |
Omega, NCT04829929: Evaluation od Safety and Performance of the ™ LAA (Left Atrial Appendage) Occluder and ™ Delivery System in Patients With Non-Valvular Atrial Fibrillation and High Bleeding Risk |
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| Recruiting | N/A | 150 | Europe | Omega™LAA Occluder implantation | Eclipse Medical Ltd., KCRI | Non-Valvular Atrial Fibrillation | 05/23 | 11/23 | | |
NCT04029844: Colibri Transcatheter Aortic Heart Valve System Study |
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| Recruiting | N/A | 30 | Europe | Colibri TAVI System | Colibri Heart Valve LLC | Severe Aortic Stenosis | 07/23 | 07/28 | | |
| Recruiting | N/A | 200 | Europe, Canada, US | AVP III | Abbott Medical Devices | Paravalvular Aortic Regurgitation | 07/25 | 06/26 | | |
HighFLO, NCT04888247: Study - HighLife Trans-septal Mitral Valve Replacement (TSMVR) Feasibility Study of the Open Cell CLARITY Valve |
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| Recruiting | N/A | 30 | Europe, RoW | CLARITY | HighLife SAS | Mitral Regurgitation | 12/25 | 02/31 | | |
NCT04029363: Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk |
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| Recruiting | N/A | 120 | Europe, RoW | HighLife Transcatheter Mitral Valve Replacement | HighLife SAS, ICON plc | Mitral Regurgitation | 03/25 | 06/30 | | |
| Recruiting | N/A | 2650 | Europe, Canada, Japan, US, RoW | Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC | Abbott Medical Devices | Atrial Fibrillation, Stroke, Bleeding | 08/27 | 08/30 | | |
| Active, not recruiting | N/A | 3326 | Europe, RoW | SELUTION SLR, DES | M.A. Med Alliance S.A. | Coronary Artery Disease | 08/25 | 07/30 | | |
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion |
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| Active, not recruiting | N/A | 450 | Europe, Canada, US | Investigational PFO Closure Device, Standard of Care PFO Closure Device | Occlutech International AB | Stroke, Patent Foramen Ovale, PFO | 11/25 | 10/26 | | |
| Recruiting | N/A | 3000 | Europe | Ultimaster Nagomi™ | Terumo Europe N.V. | Cardiovascular Disease, Coronary Artery Occlusion, Ischemic Heart Disease | 09/26 | 09/27 | | |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| Recruiting | N/A | 2844 | Europe, RoW | Aortic valve replacement | University of Leicester, University of Auckland, New Zealand, University Hospitals, Leicester, The University of Western Australia | Aortic Stenosis | 04/31 | 04/31 | | |
| Folliguet, Thierry |
| Completed | N/A | 3902 | Europe, RoW | Surgery on the ascending aorta with or without repair of the aortic root and/or aortic arch | Helsinki University Central Hospital, University Hospitals, Leicester, University Hospital Southampton NHS Foundation Trust, Azienda Ospedaliera Universitaria Integrata Verona, Centre Hospitalier Universitaire de Besancon, Assistance Publique - Hôpitaux de Paris, Ziekenhuis Oost-Limburg, University Hospital Muenster, University of Hamburg-Eppendorf, Institute for Clinical and Experimental Medicine, Northern General Hospital, Herries Road, Sheffield, Liverpool Heart and Chest Hospital NHS Foundation Trust, University Hospital, Udine, Italy, Heart Center Leipzig - University Hospital, Cliniques universitaires Saint-Luc- Université Catholique de Louvain, AZ Sint-Jan AV, University Hospital, Antwerp, Universitaire Ziekenhuizen KU Leuven, University of Turin, Italy, University of Barcelona | Type A Aortic Dissection | 12/24 | 12/24 | | |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| Branagan, Graham |
| Recruiting | N/A | 236 | Europe | Biological mesh reconstruction, Myocutaneous flap reconstruction, Primary closure reconstruction | University Hospital Southampton NHS Foundation Trust, Salisbury NHS Foundation Trust, University of Southampton, Dorset County Hospital NHS Foundation Trust, The Leeds Teaching Hospitals NHS Trust, Mid Yorkshire Teaching NHS Trust, Newcastle-upon-Tyne Hospitals NHS Trust, University Hospitals Dorset NHS Foundation Trust, Somerset NHS Foundation Trust, Swansea Bay University Health Board, Portsmouth Hospitals NHS Trust, Hampshire Hospitals NHS Foundation Trust, Royal Devon and Exeter NHS Foundation Trust, Sussex Partnership NHS Foundation Trust, London North West Healthcare NHS Trust, Manchester University NHS Foundation Trust, NHS Greater Glasgow and Clyde, The Christie NHS Foundation Trust | Surgery--Complications, Pelvic Cancer, Abdominal Cancer, Quality of Life | 09/26 | 01/28 | | |
TRACC, NCT04050345: Tracking Mutations in Cell Free Tumour DNA to Predict Relapse in Early Colorectal Cancer |
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| Recruiting | N/A | 1000 | Europe | | Royal Marsden NHS Foundation Trust | Colorectal Cancer | 07/29 | 07/31 | | |
| Recruiting | N/A | 282 | Europe | Diffusion Weighted MRI scan | Imperial College London, Pelican Cancer Foundation | Colorectal Neoplasms, Neoplasm Metastases, Hepatic Neoplasms | 12/26 | 12/31 | | |
| Recruiting | N/A | 244 | Europe | Preoperative MRI scan | Imperial College London, Pelican Cancer Foundation | Cancer, Colorectal Neoplasms, Colon, Sigmoid, Magnetic Resonance Imaging, General Surgery | 12/26 | 12/31 | | |
| Recruiting | N/A | 441 | Europe | High resolution MRI scan, mrTRG assessment | Imperial College London | Rectal Cancer | 12/26 | 12/36 | | |
| TEIGER, Emmanuel |
MESAMI2, NCT02462330: Administration of Mesenchymal Stem Cells in Patients With Chronic Ischemic Cardiomyopathy |
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| Completed | 2 | 39 | Europe | Autologous MSC from bone marrow, mesenchymal stem cells, Placebo comparator, Human Albumin | University Hospital, Toulouse | Chronic Myocardial Ischemia | 12/22 | 12/22 | | |
SWISS-APERO, NCT03399851: Comparison of Amplatzer Amulet and Watchman Device in Patients Undergoing Left Atrial Appendage Closure. |
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| Active, not recruiting | N/A | 200 | Europe | Amplatzer Amulet for left atrial appendage closure, Watchman/FLX for left atrial appendage closure | Insel Gruppe AG, University Hospital Bern | Left Atrial Appendage Closure | 07/21 | 05/26 | | |
RESTO, NCT04268875: Morphological Parameters of In-stent RESTenosis Assessed and Identified by OCT |
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| Completed | N/A | 307 | Europe | Optical Coherence Tomography (OCT) | University Hospital, Clermont-Ferrand, Abbott, Corelab ISIT | In-stent Restenosis | 12/22 | 12/22 | | |
| Recruiting | N/A | 20 | Europe | Topaz TTVR System | TRiCares | Tricuspid Regurgitation | 12/24 | 05/29 | | |
| Recruiting | N/A | 768 | Europe, RoW | Myval THV Series, Myval/Myval Inception THVs or any subsequent advanced version commercially available at the study site., Contemporary Valves (Sapien THV Series and Evolut THV Series), Sapien THV Series (Sapien 3/Sapien 3 Ultra THVs) and Evolut THV Series (Evolut R/Evolut PRO THVs ) or any subsequent advanced version commercially available at the study site. | Meril Life Sciences Pvt. Ltd. | Aortic Valve Stenosis | 03/24 | 12/33 | | |
| Recruiting | N/A | 2650 | Europe, Canada, Japan, US, RoW | Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC | Abbott Medical Devices | Atrial Fibrillation, Stroke, Bleeding | 08/27 | 08/30 | | |
BEST, NCT05454150: Balloon-Expandable Versus Self-expanding Transcatheter Heart Valve for Treatment of Symptomatic Native Aortic Valve Stenosis |
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| Recruiting | N/A | 1862 | Europe | balloon-expandable valve, self-expanding valve | University Hospital, Lille, Ministry of Health, France | Aortic Valve Stenosis | 07/25 | 07/25 | | |
MITRA-HR, NCT03271762: Multicentre Study of MITRACLIP® Transcatheter Mitral Valve Repair in Patients With Severe Primary Mitral Regurgitation Eligible for High-risk Surgery |
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| Recruiting | N/A | 330 | Europe, RoW | percutaneous mitral valve repair with MITRACLIP NT, MITRACLIP NTR/XTR, MITRACLIP G4NT/XT, MITRACLIP G4NTW/XTW, MITRACLIP, cardiac surgery | Nantes University Hospital, Ministère de la Santé, Abbott | Mitral Regurgitation | 03/27 | 05/28 | | |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| Recruiting | N/A | 400 | Europe, RoW | percutaneous paravalvular leak closure, transcatheter paravalvular leak closure | Centre Chirurgical Marie Lannelongue, Easy-CRF | Cardiac Valve Disease, Paravalvular Aortic Regurgitation, Paravalvular Mitral Regurgitation, Paravalvular Leak, Quality of Life, Outcomes | 12/24 | 07/26 | | |
| Mitra, Sandip |
PHOSPHATE, NCT03573089: Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease |
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| Recruiting | N/A | 3600 | Europe, Canada, RoW | Liberal phosphate target, Intensive phosphate target | The University of Queensland, National Health and Medical Research Council, Australia, Applied Health Research Centre, Cambridge University Hospitals NHS Foundation Trust, University of Otago | Kidney Failure, Chronic, Hyperphosphatemia | 12/27 | 12/28 | | |
| ETIENNE, Christophe SAINT |
BENCHMARK, NCT04579445: Setting a Benchmark for Resource Utilization and Quality of Care in Patients Undergoing TAVI in Europe |
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| Completed | N/A | 2408 | Europe, RoW | Education on tailored Quality Improvement measures, Education on Quality of Care Improvement measures | Institut für Pharmakologie und Präventive Medizin, Edwards Lifesciences | Transcatheter Aortic Valve Implantation (TAVI) | 04/23 | 08/24 | | |
| Active, not recruiting | N/A | 251 | Europe | Amplatzer™ Trevisio™ Intravascular Delivery System using Amplatzer PFO Occluder, ASO or Amplatzer Cribriform Occluder, Amplatzer™ Trevisio™ Intravascular Delivery System using Amplatzer Muscular VSD Occluder or Amplatzer Post-Infarct Muscular VSD Occluder | Abbott Medical Devices | PFO - Patent Foramen Ovale, ASD - Atrial Septal Defect, VSD - Muscular Ventricular Septal Defect, PIVSD - Post Infarct Muscular Ventricular Septal Defect | 09/25 | 10/25 | | |
MITRA-HR, NCT03271762: Multicentre Study of MITRACLIP® Transcatheter Mitral Valve Repair in Patients With Severe Primary Mitral Regurgitation Eligible for High-risk Surgery |
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| Recruiting | N/A | 330 | Europe, RoW | percutaneous mitral valve repair with MITRACLIP NT, MITRACLIP NTR/XTR, MITRACLIP G4NT/XT, MITRACLIP G4NTW/XTW, MITRACLIP, cardiac surgery | Nantes University Hospital, Ministère de la Santé, Abbott | Mitral Regurgitation | 03/27 | 05/28 | | |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| Carrier, François |
CINERGY, NCT05148715: Calcineurin Inhibitor in NEuRoloGically Deceased Donors to Decrease Kidney delaYed Graft Function |
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| Recruiting | 2 | 414 | Canada | Tacrolimus, Prograf, Placebo | Université de Sherbrooke, McMaster University | Organ Transplant Failure or Rejection, Brain Death, Ischemic Reperfusion Injury | 01/25 | 01/26 | | |
PRICE2, NCT03651154: Hypovolemic Phlebotomy to Reduce Blood Transfusions in Major Hepatic Resections |
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| Active, not recruiting | N/A | 440 | Canada | Hypovolemic Phlebotomy | Ottawa Hospital Research Institute | Liver Neoplasms, Hepatectomy, Blood Transfusion, Blood Loss, Surgical | 07/23 | 03/24 | | |
| Recruiting | N/A | 1440 | Europe, Canada, US, RoW | Restrictive Transfusion Strategy, Liberal transfusion strategy | Unity Health Toronto | Disorder, Heart, Postoperative, Cardiac Surgery | 12/25 | 06/26 | | |
POCAS, NCT05197465: Persistent Opioid Consumption After Major Abdominal Surgery and Its Determinants |
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| Active, not recruiting | N/A | 700 | Canada | Questionnaires | Centre hospitalier de l'Université de Montréal (CHUM), Maisonneuve-Rosemont Hospital | Major Abdominal Surgery, Chronic Pain, Opioid Use | 03/24 | 09/24 | | |
| Recruiting | N/A | 270 | Canada | Protective "open-lung" extubation, Conventional extubation | Centre hospitalier de l'Université de Montréal (CHUM), CHU de Quebec-Universite Laval, The Ottawa Hospital, University Health Network, Toronto, Canadian Institutes of Health Research (CIHR) | Intra-abdominal Surgery, Anesthesia, Lung Injury, Ventilator-Induced Lung Injury, Atelectasis | 12/25 | 04/26 | | |
ERASCs, NCT05225272: Effectiveness of an Enhanced Recovery After Surgery Protocol in Patients Undergoing On-pump Cardiac Surgery |
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| Not yet recruiting | N/A | 92 | Canada | Enhanced Recovery Program for on-pump cardiac surgery | Centre hospitalier de l'Université de Montréal (CHUM) | Disorder; Heart, Functional, Postoperative, Cardiac Surgery | 01/25 | 01/26 | | |
| Bourguignon, Thierry |
| Recruiting | N/A | 92 | Europe | HeartMate 3 TM Left Ventricular Assist System, Guideline Directed Medical Therapy | Hospices Civils de Lyon | End-stage Heart Failure | 02/29 | 02/29 | | |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| NEJJARI, Mohammed P |
| Recruiting | N/A | 20 | Europe | Topaz TTVR System | TRiCares | Tricuspid Regurgitation | 12/24 | 05/29 | | |
NCT04029363: Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk |
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| Recruiting | N/A | 120 | Europe, RoW | HighLife Transcatheter Mitral Valve Replacement | HighLife SAS, ICON plc | Mitral Regurgitation | 03/25 | 06/30 | | |
PROVE, NCT05539573: ACURATE neo2™ - Post Market Safety and Performance Surveillance in Aortic Stenosis |
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| Active, not recruiting | N/A | 1043 | Europe | Planned TAVI with the ACURATE neo2™ aortic bioprosthesis and ACURATE neo2™ transfemoral delivery system. | University of Leipzig, National University of Ireland, Galway | Aortic Stenosis | 04/25 | 04/25 | | |
MITRA-HR, NCT03271762: Multicentre Study of MITRACLIP® Transcatheter Mitral Valve Repair in Patients With Severe Primary Mitral Regurgitation Eligible for High-risk Surgery |
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| Recruiting | N/A | 330 | Europe, RoW | percutaneous mitral valve repair with MITRACLIP NT, MITRACLIP NTR/XTR, MITRACLIP G4NT/XT, MITRACLIP G4NTW/XTW, MITRACLIP, cardiac surgery | Nantes University Hospital, Ministère de la Santé, Abbott | Mitral Regurgitation | 03/27 | 05/28 | | |
| Recruiting | N/A | 500 | Europe, RoW | Robotic-assisted PCI | Robocath, European Cardiovascular Research Center | Coronary Disease | 05/26 | 06/26 | | |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| Recruiting | N/A | 400 | Europe, RoW | percutaneous paravalvular leak closure, transcatheter paravalvular leak closure | Centre Chirurgical Marie Lannelongue, Easy-CRF | Cardiac Valve Disease, Paravalvular Aortic Regurgitation, Paravalvular Mitral Regurgitation, Paravalvular Leak, Quality of Life, Outcomes | 12/24 | 07/26 | | |
| Parker, Jessica |
NCT04781673: Ketamine vs Lidocaine in Traumatic Rib Fractures |
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| Recruiting | 4 | 74 | US | Ketamine, Ketalar, Lidocaine, Xylocaine | Brittany Hoyte | Rib Fractures, Rib Fracture Multiple, Rib Trauma | 07/25 | 01/26 | | |
OnPrime, NCT05281471: Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (, GOG-3076) |
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| Recruiting | 3 | 186 | US | olvimulogene nanivacirepvec, GL-ONC1 and GLV-1h68, Platinum chemotherapy: carboplatin (preferred) or cisplatin, Non-platinum chemotherapy: Physician's Choice of gemcitabine, taxane (paclitaxel, docetaxel or nab-paclitaxel) or pegylated liposomal doxorubicin, Bevacizumab (or biosimilar) | Genelux Corporation, GOG Foundation | Platinum-resistant Ovarian Cancer, Platinum-refractory Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer, High-grade Serous Ovarian Cancer, Endometrioid Ovarian Cancer, Ovarian Clear Cell Carcinoma | 08/25 | 10/26 | | |
GLORIOSA, NCT05445778: Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Ovarian, Fallopian Tube, or Peritoneal Cancer |
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| Recruiting | 3 | 418 | Europe, Canada, US, RoW | Mirvetuximab soravtansine plus Bevacizumab, MIRV, Bevacizumab | AbbVie, GOG Foundation | Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer | 03/27 | 04/29 | | |
NRG-GY026, NCT05256225: Testing the Addition of Trastuzumab or Trastuzumab/Pertuzumab to the Usual Chemotherapy for HER2 Positive Endometrial Cancer |
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| Recruiting | 2/3 | 525 | US | Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, JM8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Echocardiography, EC, High-Dose-Rate Vaginal Cuff Brachytherapy, HDR-VCB, Hyaluronidase-zzxf/Pertuzumab/Trastuzumab, Pertuzumab and Trastuzumab hyaluronidase, Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf, Pertuzumab/Trastuzumab/Hyaluronidase-zzxf, Phesgo, Multigated Acquisition Scan, Blood Pool Scan, Equilibrium Radionuclide Angiography, Gated Blood Pool Imaging, MUGA, Radionuclide Ventriculography, RNVG, SYMA Scanning, Synchronized Multigated Acquisition Scanning, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Quality-of-Life Assessment, Quality of Life Assessment, Trastuzumab/Hyaluronidase-oysk, Herceptin Hylecta, Trastuzumab and Hyaluronidase, Trastuzumab and Hyaluronidase-oysk, Trastuzumab and Recombinant Human Hyaluronidase PH20, Trastuzumab and rHuPH20, Trastuzumab-Hyaluronidase-oysk | National Cancer Institute (NCI), NRG Oncology | Endometrial Carcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Dedifferentiated Carcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Mixed Cell Adenocarcinoma, Endometrial Serous Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Uterine Corpus Carcinosarcoma | 10/27 | 10/27 | | |
| Recruiting | N/A | 2650 | Europe, Canada, Japan, US, RoW | Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC | Abbott Medical Devices | Atrial Fibrillation, Stroke, Bleeding | 08/27 | 08/30 | | |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
SOROCk, NCT04251052: A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer |
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| Recruiting | N/A | 2262 | Canada, US, RoW | Bilateral Salpingectomy, Bilateral Salpingectomy with Oophorectomy, bilateral salpingo-oophorectomy, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Transvaginal Ultrasound, transvaginal sonography, TVS, TVU, Ultrasound Imaging, 2-Dimensional Grayscale Ultrasound Imaging, 2-Dimensional Ultrasound Imaging, 2D-US, Ultrasonography, Ultrasound, Ultrasound Test, Ultrasound, Medical, US | NRG Oncology, National Cancer Institute (NCI) | Ovarian Carcinoma | 06/36 | 06/37 | | |
| Clarke, Amanda |
| Recruiting | 2 | 72 | Europe | Investigational Medicinal Product, 10-1074-LS and 3BNC117-LS | Imperial College London, Bill and Melinda Gates Foundation, University of Oxford, Rockefeller University | HIV/AIDS and Infections | 07/27 | 07/27 | | |
| Recruiting | 2 | 150 | Canada | Cannabis, Tetrahydrocannabinol, Cannabidiol | Pippa Hawley | Pain, Nausea, Anxiety, Sleep Disturbance | 03/25 | 03/25 | | |
NCT05298254 / 2021-003586-35: A Study on the Reactogenicity, Safety, Immune Response, and Efficacy of a Targeted Immunotherapy Against HSV in Healthy Participants Aged 18-40 Years or in Participants Aged 18-60 Years With Recurrent Genital Herpes |
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| Active, not recruiting | 1/2 | 505 | Europe, Canada, US, RoW | Non-adjuvanted HSV formulation 1, Non-adjuvanted HSV formulation 2, Non-adjuvanted HSV formulation 3, HSV formulation 1 with adjuvant 1, HSV formulation 2 with adjuvant 1, HSV formulation 3 with adjuvant 1, HSV formulation 1 with adjuvant 2, HSV formulation 2 with adjuvant 2, HSV formulation 3 with adjuvant 2, Placebo, HSVTI_F1, HSVTI_F2 | GlaxoSmithKline, GlaxoSmithKline Biologicals | Herpes Simplex | 07/25 | 07/25 | | |
| Completed | N/A | 114 | Europe | The Feasibility of Intervention Measure (FIM) and Acceptability of Intervention Measure (AIM) | Queen Mary University of London, Chelsea and Westminster NHS Foundation Trust, Barts & The London NHS Trust, Guy's and St Thomas' NHS Foundation Trust, Royal Free Hospital NHS Foundation Trust, Liverpool University Hospitals NHS Foundation Trust, Brighton and Sussex University Hospitals NHS Trust | Human Immunodeficiency Viruses | 12/23 | 12/23 | | |
| Active, not recruiting | N/A | 1000 | Europe, RoW | | Rigshospitalet, Denmark, IrsiCaixa, Horizon 2020 - European Commission | HIV-1-infection, Inflammation, AIDS | 12/25 | 12/25 | | |
| Cross, Elizabeth LA |
| Completed | N/A | 230 | Europe | | University of Sussex | Cellulitis, Cellulitis of Leg, Antibiotic Duration | 06/23 | 09/23 | | |
| Bidaud, Brigitte |
| Completed | N/A | 1127 | Europe, Canada, US, RoW | Evolut™ PRO and Evolut™ PRO+ System (Evolut™ FX System for the addendum) | Medtronic Cardiovascular | Symptomatic Aortic Stenosis | 12/23 | 11/24 | | |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| Linforth, Richard |
ATNEC, NCT04109079: Axillary Management in Breast Cancer Patients with Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy |
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| Recruiting | N/A | 1900 | Europe | Axillary lymph node dissection, Axillary radiotherapy, Breast or chest wall radiotherapy | University Hospitals of Derby and Burton NHS Foundation Trust | Breast Cancer, Sentinel Lymph Node, Neoplasm, Breast | 02/30 | 02/30 | | |
| Ghalli, Farid |
PHOSPHATE, NCT03573089: Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease |
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| Recruiting | N/A | 3600 | Europe, Canada, RoW | Liberal phosphate target, Intensive phosphate target | The University of Queensland, National Health and Medical Research Council, Australia, Applied Health Research Centre, Cambridge University Hospitals NHS Foundation Trust, University of Otago | Kidney Failure, Chronic, Hyperphosphatemia | 12/27 | 12/28 | | |
| Brooks, Catriona |
| Completed | N/A | 30 | Europe | Bolus Pouch Feed | Nutricia UK Ltd | Cancer, Neurological Disorder, Gastrointestinal Dysfunction, Oral Complication, Stroke | 01/24 | 01/24 | | |
| Bonnet, Nicolas |
DASSOH, NCT06020495: Systematic Use of DDAVP to Prevent Serum Sodium Overcorrection in Severe Hyponatremia |
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| Recruiting | 3 | 260 | Europe | DDAVP, Standard hyponatremia treatment | Assistance Publique - Hôpitaux de Paris | Hyponatremia | 09/26 | 11/26 | | |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| Bonnet, Alexandra |
NCT04619888: HeartLogic France Study: Heart Failure Patients Managed With the HeartLogic Algorithm |
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| Recruiting | N/A | 310 | Europe | HeartLogic | Poitiers University Hospital | Heart Failure | 07/23 | 07/23 | | |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| Doherty, Teresa |
| Active, not recruiting | 4 | 43 | Europe | Hydroxychloroquine, Plaquenil, Placebo, Control | Guy's and St Thomas' NHS Foundation Trust, Medical Research Council | ANCA Associated Vasculitis, Microscopic Polyangiitis, Churg-Strauss Syndrome, Wegener Granulomatosis | 05/25 | 05/25 | | |
| Verne, Céleste |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| Matthews, Violet |
| Recruiting | N/A | 64 | Europe | Temperature controlled DiamondTemp (DT) ablation catheter, Tacticath/Tactiflex (TF) ablation catheter | University Hospitals Coventry and Warwickshire NHS Trust, Medtronic, Coventry University | Ventricular Tachycardia | 11/25 | 03/26 | | |
| Recruiting | N/A | 10 | Europe | PROLIMB Prosthesis | University Hospitals Coventry and Warwickshire NHS Trust, University of Warwick, University College, London | Prosthesis Durability, Prosthesis User, Amputation, Amputation; Traumatic, Hand | 08/25 | 08/25 | | |
CREED AF, NCT06042231: Impact of Cardiac Prehabilitation, REhabilitation and Patient EDucation on Outcomes in Patients Undergoing First-time AF Ablation |
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| Recruiting | N/A | 106 | Europe | Exercise Intervention, Education Intervention | University Hospitals Coventry and Warwickshire NHS Trust | Atrial Fibrillation | 02/25 | 09/25 | | |
| Morera, Pierre |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| Blondelon, Aurélie |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| Barritt, Andrew |
| Recruiting | 2/3 | 800 | Europe | Memantine Hydrochloride Oral Solution, Trazodone Hydrochloride oral solution, Placebo oral solution, Amantadine Hydrochloride Oral Solution | University of Edinburgh, University College, London, University of Warwick, NHS Lothian | Motor Neuron Disease, Amyotrophic Lateral Sclerosis | 09/26 | 12/26 | | |
| Tobehn, Anke |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| Bagnall, Mark |
EXTEND, NCT05148702: ed Antibiotic Durations Compared to Standard Durations for Patients With Complicated Intra-abdominal Infection. |
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| Recruiting | 3 | 1166 | Europe | Antibiotic - standard duration, Antibiotic - fixed-extended-duration | Sarah Cockayne, University of York, University of Birmingham, Chesterfield Royal Hospital NHS Foundation Trust, University of Leeds, The Leeds Teaching Hospitals NHS Trust | Complicated Intra-abdominal Infection | 12/25 | 12/25 | | |
