| Scheinert, Dierk |
NCT02701543: Compare I Pilot Study for the Treatment of Subjects With Symptomatic Femoropopliteal Artery Disease |
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| Completed | N/A | 414 | Europe | Ranger Drug Eluting Balloon, In Pact Drug Eluting Balloon | University of Leipzig | Peripheral Artery Disease | 10/18 | 12/23 | | |
| Active, not recruiting | N/A | 3638 | Europe, Canada, Japan, US, RoW | CEA, CAS | University of Oxford, NHS Health Technology Assessment Programme, BUPA Foundation, British Heart Foundation | Carotid Stenosis | 12/20 | 12/25 | | |
NCT03776799: BEST SFA Pilot Study - Best Endovascular STrategy for Complex Lesions of the Superficial Femoral Artery |
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| Active, not recruiting | N/A | 120 | Europe | Stent-avoiding, Stent-based | University of Leipzig | Peripheral Arterial Disease | 08/22 | 07/26 | | |
NCT03751527: ZENFlex-Registry to Evaluate the Outcome of Bare Metal Stent-assisted Angioplasty |
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| Recruiting | N/A | 200 | Europe | ZENFLEX peripheral stent system | Zhejiang Zylox Medical Device Co., Ltd. | Atherosclerosis of Femoral Artery | 12/22 | 12/23 | | |
| Active, not recruiting | N/A | 70 | Europe | Solaris Vascular Stent Graft | Dr. Sabrina Overhagen, FCRE (Foundation for Cardiovascular Research and Education), Scitech Produtos Medicos Ltda | Peripheral Arterial Disease, Iliac Artery Stenosis, Common Femoral Artery Stenosis | 11/24 | 12/24 | | |
| Recruiting | N/A | 300 | Europe, US, RoW | SELUTION SLR™ 018 DEB, Plain (Uncoated) Balloon Angioplasty (PTA) | MedAlliance, LLC, NAMSA, Cordis Corporation | Peripheral Arterial Disease, Superficial Femoral Artery Stenosis | 08/25 | 12/29 | | |
STRIDE II, NCT06747117: A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo™ Aspiration System |
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| Not yet recruiting | N/A | 300 | NA | Indigo Aspiration System | Penumbra Inc. | Lower Extremity Acute Limb Ischemia, LE ALI | 06/28 | 01/29 | | |
| Recruiting | N/A | 204 | Europe | ESAR treatment: Endograft + Heli-FX Endoanchor, FEVAR treatment : Fenestrated endograft | FCRE (Foundation for Cardiovascular Research and Education), Medtronic | Aortic Aneurysm, Abdominal | 06/26 | 06/28 | | |
CRACK-IT, NCT06112171: Comparison of a Lithotripsy vs Standard Preparation Followed by Stenting With Supera Stent in Femoropopliteal Lesions |
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| Recruiting | N/A | 120 | Europe | Intravascular lithotripsy, Standard lesion preparation | University of Leipzig | Peripheral Arterial Disease | 11/26 | 12/30 | | |
LIMES, NCT04772300: Trial to Assess the Safety and Efficacy of Sirolimus-Coated Balloon vs. Uncoated Standard Angioplasty for the Treatment of Below-the-knee Peripheral Arterial Disease |
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| Recruiting | N/A | 230 | Europe | Percutaneous Transluminal Angioplasty (PTA) MagicTouch Sirolimus Coated PTA Balloon Catheter, Percutaneous Transluminal Angioplasty (PTA) with non-coated balloon catheter (POBA) | Jena University Hospital, Concept Medical Inc., Vascuscience, CoreLab Black Forest, Center for Clinical Studies, University Hospital Jena | Peripheral Artery Disease | 12/27 | 09/28 | | |
| Laufs, Ulrich |
| Active, not recruiting | 3 | 75 | Europe, Canada, Japan, US, RoW | Plozasiran, ARO-APOC3, Placebo | Arrowhead Pharmaceuticals | Familial Chylomicronemia | 04/24 | 04/26 | | |
PERI-DYS, NCT03110432: Prospective German Very High Cardiovascular Risk Patients Dyslipidemia Treatment Indication Registry |
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| Active, not recruiting | N/A | 1713 | Europe | PCSK9 Inhibitor [EPC], Repatha, Praluent, Standard lipid lowering therapy, Statins, ezetimibe, nicotinic acid, fibrates, cholestagel, omega-3 fatty acids | GWT-TUD GmbH | Dyslipoproteinemias | 03/24 | 06/24 | | |
| Recruiting | N/A | 200 | Europe | Cholesterol self-measurement | University of Leipzig | Acute Coronary Syndrome, Prevention, LDL Hyperlipoproteinemia, Therapeutic Adherence | 06/25 | 09/25 | | |
JaZ, NCT05587621: Intensive Lipid-lowering in Patients With STEMI and NSTEMI (Germany on Target) |
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| Not yet recruiting | N/A | 300 | Europe | statins, ezetimibe, bempedoic acid, evolocumab, alirocumab, inclisiran, dietary advice | Jena University Hospital | ST Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infarction, LDL-cholesterol | 04/26 | 12/26 | | |
| Recruiting | N/A | 1054 | Europe | measurement of FFR, measurement of Pd/Pa | Helios Health Institute GmbH, Heart Center Leipzig - University Hospital | Coronary Artery Disease, Coronary Artery Stenoses | 05/26 | 11/26 | | |
| Active, not recruiting | N/A | 1000 | Europe | | University of Leipzig, University of Jena, University Hospital Dresden, Charite University, Berlin, Germany | Dyslipidemias | 08/26 | 08/26 | | |
| Kuhnt, Thomas |
| Terminated | 3 | 166 | Europe, Canada, Japan, US, RoW | Xevinapant (Debio 1143), IMRT, Placebo | EMD Serono Research & Development Institute, Inc., Merck KGaA, Darmstadt, Germany | Head and Neck Cancer | 08/24 | 08/24 | | |
NCT04246684: Short RT Versus RCT,Followed by Chemo.and Organ Preservation for Interm and High-risk Rectal Cancer Patients |
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| Active, not recruiting | 3 | 702 | Europe | Oxaliplatin, 85 mg/m2, Control arm, 5FU; 2400 mg/m2, 5-FU, control arm, 5FU, 250 mg/m2, Experimental arm: 5-FU, 5FU, 2400 mg/m2, experimental arm, Oxaliplatin 50 mg/m2, Experimental arm, Folinic Acid, 400 mg/m2, Folinic Acid, Radiotherapy control, 5x5 Gy: 25 Gy, Capecitabine, 1000 mg/m2, Capecitabine, Oxaliplatin 85 mg/m2, radiotherapy experimental, 30 x 1,8 Gy: 54 Gy, Capecitabine, 825 mg/m2, Oxaliplatin, 130 mg/m2, Oxaliplatin | Prof. Dr. med. Claus Rödel | Rectal Cancer Stage III | 09/23 | 09/28 | | |
| Active, not recruiting | 2 | 180 | Europe | Chemotherapy, all brands of 5-fluorouracil (5-FU) are allowed, all brands of Mitomycin C (MMC) are allowed, Radiation, Durvalumab, PD-L1 inhibitor | Goethe University, German Cancer Aid, AstraZeneca | Anal Cancer, Anal Carcinoma, Anal Cancer Stage III, Anal Cancer Stage II | 12/26 | 03/27 | | |
ACO/ARO/AIO-22, NCT06729645: External Beam Radiotherapy Combined with Endorectal High-dose-rate Brachytherapy in Elderly and Frail Patients with Rectal Cancer |
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| Not yet recruiting | N/A | 80 | Europe | radiotherapy | University Hospital of Cologne | Rectal Cancer | 12/27 | 12/30 | | |
| Wolf, Joachim |
| Recruiting | N/A | 392 | Europe | Ultra-high-caloric fatty diet, Placebo | University of Ulm | Amyotrophic Lateral Sclerosis | 06/27 | 06/27 | | |
| Schmidt, Andrej |
NCT04799769: Safety and Performance Study of Large Hole Vascular Closure Device - FRONTIER V Study |
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| Recruiting | N/A | 90 | Europe | Percutaneous arterial closure device | Vivasure Medical Limited | Percutaneous Arteriotomy Closure | 01/23 | 03/23 | | |
HEAL, NCT04110327: An All-Comers Observational Study of the MicroStent™ Peripheral Vascular Stent System in Subjects with Peripheral Arterial Disease |
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| Recruiting | N/A | 300 | Europe | MicroStent | Micro Medical Solution, Inc. | Peripheral Arterial Disease, Critical Lower Limb Ischemia | 12/26 | 12/28 | | |
| Recruiting | N/A | 292 | Europe, US | MOTIV Sirolimus-Eluting Bioresorbable Scaffold, Percutaneous Transluminal Angioplasty (PTA) Device | REVA Medical, Inc. | Critical Limb Ischemia | 09/25 | 03/29 | | |
| Recruiting | N/A | 50 | Europe | | Nurea, Universitätsklinikum Leipzig | Abdominal Aortic Aneurysm | 11/23 | 12/23 | | |
| Active, not recruiting | N/A | 149 | Europe, US | PerQseal® Closure Device System | Vivasure Medical Limited | Percutaneous Large Hole Vascular Closure | 12/24 | 06/25 | | |
| Active, not recruiting | N/A | 118 | Europe | BGP+ Stent Graft System as bridging stent | Dr. Sabrina Overhagen, Bentley InnoMed GmbH | Thoracoabdominal Aortic Aneurysm, Without Mention of Rupture | 05/24 | 07/25 | | |
| Recruiting | N/A | 550 | Europe, Japan, US, RoW | Medtronic Endurant II or Endurant IIs Stent Graft System, Gore Excluder or Gore/ Excluder Conformable AAA Endoprosthesis | Medtronic Cardiovascular | Abdominal Aortic Aneurysm, Abdominal Aortic Aneurysm >= 5.5 Centimeters in Male (Disorder), Abdominal Aortic Aneurysm >= 5.0 Centimeters in Female (Disorder) | 05/27 | 05/31 | | |
| Recruiting | N/A | 300 | Europe, US | ClotTriever System, Commercially available/market approved anticoagulation medication including but not limited to: Heparin Sodium, Coumadin, Rivaroxaban, Apixaban, etc. | Inari Medical | Venous Thromboembolism, Deep Venous Thrombosis, Post-Thrombotic Syndrome | 06/25 | 10/25 | | |
| Recruiting | N/A | 3000 | Europe | AcoArt Orchid (0.035"), AcoArt Tulip (0.018") and AcoArt Litos (0.014") percutaneous transluminal angioplasty (PTA) paclitaxel drug coated balloon catheter manufactured by Acotec Scientific Co., Ltd. | Acotec Scientific Co., Ltd | Peripheral Artery Disease | 12/25 | 03/27 | | |
CRACK-IT, NCT06112171: Comparison of a Lithotripsy vs Standard Preparation Followed by Stenting With Supera Stent in Femoropopliteal Lesions |
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| Recruiting | N/A | 120 | Europe | Intravascular lithotripsy, Standard lesion preparation | University of Leipzig | Peripheral Arterial Disease | 11/26 | 12/30 | | |
ILICO, NCT05192616: Safety and Effectiveness Evaluation of iCover Covered Stent for the Treatment of the Aorto-iliac Occlusive Disease |
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| Not yet recruiting | N/A | 214 | Europe | Covered stent implantation | iVascular S.L.U. | Angioplasty, Peripheral Arterial Disease, Iliac Artery Disease, Covered Stent, Aorto-Iliac Atherosclerosis | 05/24 | 05/25 | | |
| Steiner, Sabine |
PeriPREVENT, NCT06656988: A Contrast Medium Sparing Strategy Using Automated CO2 Injection During PVI for Prevention of Major Adverse Kidney Events (MAKE) |
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| Not yet recruiting | 3 | 1960 | Europe | CO2, carbon dioxide, Iodinated Contrast Media (ICM) | University of Leipzig | Peripheral Vascular Diseases, Kidney Diseases | 02/28 | 02/29 | | |
CRACK-IT, NCT06112171: Comparison of a Lithotripsy vs Standard Preparation Followed by Stenting With Supera Stent in Femoropopliteal Lesions |
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| Recruiting | N/A | 120 | Europe | Intravascular lithotripsy, Standard lesion preparation | University of Leipzig | Peripheral Arterial Disease | 11/26 | 12/30 | | |
| Lenzer, Janin |
| Recruiting | N/A | 50 | Europe | | Nurea, Universitätsklinikum Leipzig | Abdominal Aortic Aneurysm | 11/23 | 12/23 | | |
| Active, not recruiting | N/A | 149 | Europe, US | PerQseal® Closure Device System | Vivasure Medical Limited | Percutaneous Large Hole Vascular Closure | 12/24 | 06/25 | | |
CRACK-IT, NCT06112171: Comparison of a Lithotripsy vs Standard Preparation Followed by Stenting With Supera Stent in Femoropopliteal Lesions |
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| Recruiting | N/A | 120 | Europe | Intravascular lithotripsy, Standard lesion preparation | University of Leipzig | Peripheral Arterial Disease | 11/26 | 12/30 | | |
| Branzan, Daniela |
NCT04799769: Safety and Performance Study of Large Hole Vascular Closure Device - FRONTIER V Study |
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| Recruiting | N/A | 90 | Europe | Percutaneous arterial closure device | Vivasure Medical Limited | Percutaneous Arteriotomy Closure | 01/23 | 03/23 | | |
| Recruiting | N/A | 125 | Europe | IMPEDE, IMPEDE-FX or IMPEDE-FX RapidFill | Shape Memory Medical, Inc. | Peripheral Vascular Embolization | | | | |
| Recruiting | N/A | 50 | Europe | | Nurea, Universitätsklinikum Leipzig | Abdominal Aortic Aneurysm | 11/23 | 12/23 | | |
| Active, not recruiting | N/A | 149 | Europe, US | PerQseal® Closure Device System | Vivasure Medical Limited | Percutaneous Large Hole Vascular Closure | 12/24 | 06/25 | | |
| Recruiting | N/A | 550 | Europe, Japan, US, RoW | Medtronic Endurant II or Endurant IIs Stent Graft System, Gore Excluder or Gore/ Excluder Conformable AAA Endoprosthesis | Medtronic Cardiovascular | Abdominal Aortic Aneurysm, Abdominal Aortic Aneurysm >= 5.5 Centimeters in Male (Disorder), Abdominal Aortic Aneurysm >= 5.0 Centimeters in Female (Disorder) | 05/27 | 05/31 | | |
| Popescu, Corneliu |
| Active, not recruiting | 3 | 871 | Europe, Canada, Japan, US, RoW | Bepirovirsen, Placebo | GlaxoSmithKline, GlaxoSmithKline Research & Development Limited | Chronic Hepatitis B, Hepatitis B, Chronic | 11/25 | 05/26 | | |
| Lenk, Karsten |
EXAMINE-CAD, NCT05294887: Randomized Trial to Examine a Differential Therapeutic Response in Symptomatic Patients With Non-obstructive Coronary Artery Disease |
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| Recruiting | 4 | 132 | Europe | Bisoprolol, beta blocker, Diltiazem, Placebo | Charite University, Berlin, Germany, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) | Coronary Microvascular Dysfunction, Microvascular Angina, Vasospasm, Coronary, Vasospastic Angina, Prinzmetal Angina, Coronary Artery Disease | 06/24 | 06/24 | | |
| Active, not recruiting | N/A | 2001 | Europe | QFR-based diagnostic strategy, FFR-based diagnostic strategy | Aarhus University Hospital Skejby, Medis Medical Imaging Systems | Coronary Artery Disease | 07/23 | 12/25 | | |
CLEARANCE, NCT04298723: Comparison of LAA-Closure vs Oral Anticoagulation in Patients With NVAF and Status Post Intracranial Bleeding. |
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| Recruiting | N/A | 530 | Europe | Percutaneous closure of the LAA (Watchman / Watchman FLX) | Jena University Hospital | Atrial Fibrillation (AF), Intracranial Bleed | 06/27 | 06/27 | | |
| Metelmann, Moritz |
| Recruiting | N/A | 54 | Europe | case focus groups | University of Leipzig, Leipzig University Medical Center | Amyotrophic Lateral Sclerosis | 08/24 | 12/24 | | |
| Recruiting | N/A | 392 | Europe | Ultra-high-caloric fatty diet, Placebo | University of Ulm | Amyotrophic Lateral Sclerosis | 06/27 | 06/27 | | |
| Struck, Manuel F |
NCT05751395: Siting Central Venous Catheters Precisely While Performing the Access Procedure |
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| Not yet recruiting | N/A | 120 | Europe | Central Venous Access | Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin | Central Venous Catheter | 12/24 | 12/24 | | |
