| Wang, Yongjun NA |
FAITH, NCT05169021: Folic Acid and Intensive Antihypertensive Therapy for Hypertension With CSVD |
|
|
| Not yet recruiting | 4 | 15000 | RoW | Amlodipine folic acid 5.8mg+intensive antihypertensive therapy, Amlodipine folic acid 5.8mg+standard antihypertensive therapy, Amlodipine+intensive antihypertensive therapy, Amlodipine+standard antihypertensive therapy, Standard antihypertensive therapy | Beijing Tiantan Hospital | Cerebral Small Vessel Diseases, Stroke | 12/24 | 12/28 | | |
| Completed | 3 | 1362 | RoW | Edaravone Dexborneol Concentrated Solution for injection, Xian Bi Xin, CFDA Approval Number H20200007, Edaravone Dexborneol placebo, Xian Bi Xin placebo | Beijing Tiantan Hospital | Acute Ischemic Stroke, Mechanical Thrombectomy, Edaravone Dexborneol, Phase III | 02/23 | 05/23 | | |
| Completed | 3 | 1412 | RoW | Injection of recombinant human tissue plasminogen kinase derivatives, Reteplase, brand name: Ruitongli, r-PA, Recombinant human tissue plasminogen activator, Alteplase, brand name: Actilyse, rt-PA | Angde Biotech Pharmaceutical Co., Ltd., Beijing Tiantan Hospital | Acute Ischemic Stroke | 06/23 | 06/23 | | |
| Completed | 3 | 516 | RoW | tenecteplase (0.25 mg/kg, Max 25 mg), standard medical treatment, Aspirin, Clopidogrel | Beijing Tiantan Hospital | Ischemic Stroke, Acute | 01/24 | 02/24 | | |
NCT05745259: Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients （3T Stroke-Ⅲ） |
|
|
| Recruiting | 3 | 1630 | RoW | Alteplase, rt-PA, Tenecteplase, TNK-tPA | Beijing Tiantan Hospital, Jiangsu FENG HUA Biotech Pharmaceutical Co., Ltd, The Place Pharmaceutical(Jiangsu) Co., Ltd | Acute Ischemic Stroke | 11/23 | 03/24 | | |
| Completed | 3 | 1446 | NA | Recombinant Human Prourokinase for Injection (rhPro-UK), Puyouke, standard medical treatment, Aspirin, clopidogrel, anticoagulant | Beijing Tiantan Hospital | Ischemic Stroke, Mild, Thrombosis | 03/24 | 06/24 | | |
| Recruiting | 3 | 452 | RoW | Tenecteplase, rhTNK-tPA, TNK-tPA, Best Practice (which may include intravenous Alteplase), rt-PA | Beijing Tiantan Hospital | Ischemic Stroke, Acute | 02/26 | 05/26 | | |
NCT06299579: GD-11 for Injection in the Treatment of Acute Ischemic Stroke |
|
|
| Recruiting | 3 | 980 | RoW | GD-11 for injection test group, Placebo control group | Beijing Tiantan Hospital, Jiangsu Wangao Pharmaceutical Co. ltd | Acute Ischemic Stroke | 02/25 | 12/25 | | |
| Completed | 3 | 1552 | RoW | rhPro-UK, rt-PA | Tasly Biopharmaceuticals Co., Ltd. | Acute Ischemic Stroke | 03/24 | 03/24 | | |
| Recruiting | 3 | 998 | RoW | Y-3 for injection, Placebo control group | Beijing Tiantan Hospital, NeuroDawn Pharmaceutical Co., Ltd. | Acute Ischemic Stroke | 12/24 | 07/25 | | |
NCT06522269: Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-C ) |
|
|
| Recruiting | 3 | 1622 | RoW | Emergency Stroke Unit based on 0.23-T MRI, Standard stroke unit adherent to guidelines | Beijing Tiantan Hospital | Ischemic Stroke, Acute | 12/24 | 07/25 | | |
NCT06522282: Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-D ) |
|
|
| Recruiting | 3 | 600 | RoW | Emergency Stroke Unit based on 0.23-T MRI, Standard stroke unit | Beijing Tiantan Hospital | Ischemic Stroke, Acute | 12/25 | 03/26 | | |
NCT06414499: Teneteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-Ⅳ(TRACE Ⅳ) |
|
|
| Recruiting | 3 | 1394 | RoW | rhTNK-tPA, Control group | Beijing Tiantan Hospital | Tenecteplase, Minor Ischemic Stroke | 07/25 | 12/25 | | |
CN-CATCH, NCT06255977: A Study Evaluating the Safety and Efficacy of Neuroprotective Peptide CN-105 Peptide in Patients With Acute Supratentorial Intracerebral Hemorrhage |
|
|
| Recruiting | 2 | 240 | RoW | CN-105, CN-105peptide | Beijing Tiantan Hospital, SDM Bio Service Inc. | Intracerebral Hemorrhage | 05/24 | 08/24 | | |
NCT04984577: Study of Compound Edaravone Injection for Treatment of Acute Ischemic Stroke |
|
|
| Suspended | 2 | 240 | RoW | Compound Edaravone Injection-Low dose, Compound Edaravone Injection-High dose, Edaravone Injection, Placebo injection | Nanjing Yoko Biomedical Co., Ltd. | Acute Ischemic Stroke | 12/26 | 12/26 | | |
NCT05700097: Dengzhanxixin Injection for Acute Ischemic Stroke Receiving Reperfusion Therapy |
|
|
| Active, not recruiting | 2 | 240 | RoW | Dengzhanxixin Injection, Dengzhanxixin Zhusheye, Placebo injection, Placebo | Beijing Tiantan Hospital | Acute Ischemic Stroke | 09/23 | 12/23 | | |
NCT06202378: Safety and Efficacy of SHPL-49 Injection in Participants With Acute Ischemic Stroke |
|
|
| Active, not recruiting | 2 | 270 | RoW | 3 ampoules of SHPL-49 Injection, 6 ampoules of SHPL-49 Injection, 0.9% Sodium Chloride Injection | Shanghai Hutchison Pharmaceuticals Limited, Beijing Tiantan Hospital | Acute Ischemic Stroke | 12/24 | 12/25 | | |
NCT06322394: BXOS110 Injection in the Treatment of Acute Ischaemic Stroke |
|
|
| Recruiting | 2 | 300 | RoW | high-dose BXOS110, BXOS110, low-dose BXOS110, Placebo | Biocells (Beijing) Biotech Co.,Ltd | Acute Ischemic Stroke | 03/25 | 09/25 | | |
NCT05745311: Study of the KPCXM18 Injection for Treatment of Acute Ischemic Stroke |
|
|
| Not yet recruiting | 2 | 240 | NA | The KPCXM18 injection, Placebo | Kunming Pharmaceuticals, Inc. | Acute Ischemic Stroke | 05/24 | 07/24 | | |
NCT06492239: Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-A ) |
|
|
| Recruiting | 2 | 200 | RoW | Emergency Stroke Unit based on 0.23-T MRI, Standard stroke unit adherent to guidelines | Beijing Tiantan Hospital | Ischemic Stroke, Acute | 02/25 | 08/25 | | |
NCT06492265: Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-B ) |
|
|
| Recruiting | 2 | 100 | RoW | Emergency Stroke Unit based on 0.23-T MRI, Standard stroke unit adherent to guidelines | Yongjun Wang | Ischemic Stroke, Acute | 02/25 | 04/25 | | |
NCT06601127: Study of Tiprogrel in the Treatment of High-risk Patients with Acute Ischemic Cerebrovascular Events (THRIVE). |
|
|
| Not yet recruiting | 2 | 600 | RoW | Tiprogrel+Aspirin, Clopidogrel+Aspirin | Tianjin Institute of Pharmaceutical Research Co., Ltd | Ischemic Stroke | 04/26 | 06/26 | | |
NCT05686642: Efficacy and Safety of LT3001 on Treating the Acute Ischemic Stroke |
|
|
| Recruiting | 2 | 300 | RoW | LT3001 Drug:high dose, Placebo, LT3001 Drug:low dose | Shanghai Pharmaceuticals Holding Co., Ltd | Acute Ischemic Stroke | 04/25 | 07/25 | | |
NCT04590118: Allogeneic Mesenchymal Stem Cells for the Survivors of Ischemic Stroke Trial (ASSIST) |
|
|
| Recruiting | 1/2 | 60 | RoW | it-hMSC, Placebo | Jiuzhitang Maker (Beijing) Cell Technology Co.,Ltd., Beijing Tiantan Hospital | Ischemic Stroke | 04/23 | 08/23 | | |
NCT05200728: The Tolerability, Safety, and PK Characteristics of SIM1910-09 in Healthy Chinese Volunteers |
|
|
| Completed | 1 | 68 | RoW | SIM1910-09, AER-271, Placebo | Jiangsu Simcere Pharmaceutical Co., Ltd. | Acute Ischemic Stroke, Cerebral Edema | 03/23 | 03/23 | | |
NCT04951440: Study on the Effectiveness and Safety of Nitrone for Injection in Patients With Acute Ischemic Stroke |
|
|
| Active, not recruiting | N/A | 200 | RoW | Nitrate ketone oxazine | Peking University Third Hospital, Capital Medical University | Acute Ischemic Stroke | 12/20 | 12/21 | | |
NCT04524624: An AI-Based CDSS for Integrated Management of Patients With Acute Ischemic Stroke(GOLDEN BRIDGE II) |
|
|
| Not yet recruiting | N/A | 21689 | RoW | AI-based CDSS | Beijing Tiantan Hospital | Stroke | 09/22 | 06/23 | | |
NCT02147782: Clinical Observation on Bone Metabolism Induced by Chronic Renal Insufficiency |
|
|
| Recruiting | N/A | 300 | RoW | | Shanghai University of Traditional Chinese Medicine, Anhui Provincial Hospital, Huadong Hospital, Longhua Hospital | Chronic Renal Insufficiency, Renal Osteodystrophy | 12/22 | 12/22 | | |
| Recruiting | N/A | 600 | RoW | | Shanghai University of Traditional Chinese Medicine | Family Genetic Characteristics of Osteoporosis | 09/23 | 10/23 | | |
RETRACE-II, NCT06064747: Low-Frequency REpetitive TRanscranial Magnetic Stimulation Combined With Endovascular Treatment in ACute Ischemic StrokE |
|
|
| Not yet recruiting | N/A | 60 | RoW | LF-rTMS, Sham stimulation | Beijing Tiantan Hospital | Stroke, Acute Ischemic | 10/24 | 10/24 | | |
RETRACE-I, NCT06064734: Low-Frequency REpetitive TRanscranial Magnetic Stimulation in ACute Ischemic StrokE Within 48 Hours |
|
|
| Not yet recruiting | N/A | 60 | RoW | LF-rTMS | Beijing Tiantan Hospital | Stroke, Acute, Stroke, Ischemic | 10/24 | 10/24 | | |
NCT04503941: Ultrasound Examination of Inguinal Lymph Node Used to Evaluate the Effect of Acupuncture on Knee Osteoarthritis |
|
|
| Enrolling by invitation | N/A | 122 | RoW | Acupuncture treatment, False Needle treatment | Shanghai University of Traditional Chinese Medicine | Knee Osteoarthritis | 01/25 | 05/25 | | |
BTH-DREAM-PRIDE, NCT04948749: Drug Eluting Stenting and Aggressive Medical Treatment for Preventing Recurrent Stroke in Intracranial Atherosclerotic Disease Trial |
|
|
| Recruiting | N/A | 792 | RoW | Drug Eluting Stent implantation, Maurora ® Sirolimus Eluting Stent implantation, Aggressive medical treatment, Dual antiplatelet therapy for 6 months, Risk factor management, Risk factor and life style management, Standard medical treatment, Dual antiplatelet therapy for 3 months | Beijing Tiantan Hospital | ICAD - Intracranial Atherosclerotic Disease, ICAS - Intracranial Atherosclerosis, Drug-eluting Stent, Stroke, Drug Eluting Stents (DES), Medical Treatment | 12/26 | 12/26 | | |
| Recruiting | N/A | 50000 | RoW | | Shanghai University of Traditional Chinese Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Dongzhimen Hospital, Beijing, The First Affiliated Hospital of Guangzhou University of TCM, Guangdong Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Changchun University of Chinese Medicine, Gansu Provincial Hospital, Guangzhou Kingmed Diagnostics Co., Ltd., Shandong Provincial Hospital of Traditional Chinese Medicine, Yunnan Provincial Hospital of Traditional Chinese Medicine, Shenzhen Pingle Orthopedic Hospital, First People's Hospital of Nankang District, Ganzhou City | Osteoporosis | 10/26 | 10/28 | | |
| Peng, Yuming |
CANVAS-II, NCT03317535: Choice of Anesthesia for Endovascular Treatment of Acute Ischemic Stroke in Posterior Circulation |
|
|
| Completed | N/A | 93 | RoW | General anesthesia, Local anesthesia/concious sedation, Spontaneous breath, Controlled ventilation | Beijing Tiantan Hospital | Posterior Circulation Brain Infarction | 06/21 | 06/21 | | |
NCT04036812: Superficial Cervical Plexus Block for Postoperative Analgesia |
|
|
| Recruiting | N/A | 106 | RoW | Superficial cervical plexus block, Control group | Beijing Tiantan Hospital | Plexus Block;Analgesia;Neurosurgery | 03/22 | 03/22 | | |
STAMP, NCT04595786: The Safety of Intravenous Tranexamic Acid in Patients Undergoing Supratentorial Meningiomas Resection |
|
|
| Active, not recruiting | N/A | 600 | RoW | Tranexamic acid, 0.9% saline | Beijing Tiantan Hospital | Seizures, Meningioma | 08/22 | 02/23 | | |
NCT03323580: Effects of Intraoperative GDFT on the Postoperative Brain Edema |
|
|
| Completed | N/A | 480 | RoW | GDFT, traditional fluid therapy | Beijing Tiantan Hospital | Fluid Therapy, Brain Edema, Brain Tumor | 09/22 | 10/22 | | |
NCT04362709: Study of Post-anesthesia Management in Patients Undergoing Neurosurgery |
|
|
| Recruiting | N/A | 10000 | RoW | | Beijing Tiantan Hospital | Anesthesia, Neurosurgery, Complication | 11/24 | 11/24 | | |
NCT02756312: The Impact of Anesthesia on High- Grade Glioma Patients |
|
|
| Not yet recruiting | N/A | 196 | RoW | IV Anesthesia, IH anesthesia | Beijing Tiantan Hospital | Anesthesia, Outcome, High-grade Glioma | 12/22 | 12/22 | | |
NCT05108337: Superficial Cervical Plexus Block for Postoperative Chronic Pain |
|
|
| Completed | N/A | 292 | RoW | Superficial cervical plexus block, Control group | Beijing Tiantan Hospital | Neurosurgery | 11/23 | 11/23 | | |
NCT06138340: The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma |
|
|
| Recruiting | N/A | 120 | RoW | Dexmedetomidine, Propofol | Beijing Tiantan Hospital | Brain Network Connectivity, Postoperative Delirium, Dexmedetomidine, Propofol | 11/25 | 12/25 | | |
NCT05177159: Postoperative Delirium and Its Biomarkers in Elderly Patients Undergoing Non-cardiac and Non-neurosurgery. |
|
|
| Recruiting | N/A | 417 | RoW | The regional cerebral oxygen saturation (rSO2), The glial fibrillary acidic protein (GFAP), The brain-derived-neurotrophic factor (BDNF) | Beijing Tiantan Hospital | Anesthesia, Postoperative Delirium | 12/23 | 12/23 | | |
NCT05198635: Association Between Local Cerebral Oxygenation Monitoring and Postoperative Delirium in Carotid Endarterectomy |
|
|
| Recruiting | N/A | 140 | RoW | local cerebral oxygen saturation | Beijing Tiantan Hospital | Cerebral Oxygen Saturation, Postoperative Delirium, Carotid Endarterectomy | 12/23 | 12/23 | | |
NCT06164314: Perioperative Dexmedetomidine on Postoperative Delirium in Patients With Brain Tumors |
|
|
| Not yet recruiting | N/A | 222 | RoW | Dexmedetomidine | Beijing Tiantan Hospital | Postoperative Delirium | 09/26 | 09/26 | | |
NCT05274789: Effect of Intraoperative Dexmedetomidine on Postoperative Delirium in Elderly Patients Undergoing Robot-assisted Pancreaticoduodenectomy: a Randomized Controlled Study |
|
|
| Recruiting | N/A | 300 | RoW | Dexmedetomidine, Saline | Chinese PLA General Hospital, Beijing Tiantan Hospital | Delirium in Old Age | 04/24 | 04/24 | | |
NCT05168280: Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium in Elderly Patients |
|
|
| Recruiting | N/A | 420 | RoW | Dexmedetomidine, 0.9% saline | Beijing Tiantan Hospital | Dexmedetomidine, Postoperative Delirium | 05/24 | 05/24 | | |
NCT06406829: Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy |
|
|
| Not yet recruiting | N/A | 2000 | NA | Dexmedetomidine, DEX, Normal saline, NS, Local analgesic techniques, LAT, no Local analgesic techniques, NLAT | Beijing Tiantan Hospital | Postoperative Pain, Analgesia, Supratentorial Brain Tumor | 12/26 | 12/26 | | |
NCT05436964: Effect of Intraoperative Dexmedetomidine on Postoperative Delirium in Elderly Patients Undergoing Major Abdominal Surgery |
|
|
| Recruiting | N/A | 300 | RoW | saline, Dexmedetomidine | Chinese PLA General Hospital, Beijing Tiantan Hospital | Delirium in Old Age | 06/24 | 06/24 | | |
NCT06406842: Association Between Local Cerebral Oxygenation Monitoring and Postoperative Stroke in Carotid Endarterectomy |
|
|
| Recruiting | N/A | 560 | RoW | Cerebral oxygenation index guided hemodynamics management | Beijing Tiantan Hospital | Carotid Endarterectomy, Cerebral Autoregulation | 11/26 | 12/26 | | |
NCT06587906: Postoperative Complications Following Skull Base Tumor Resection |
|
|
| Not yet recruiting | N/A | 122 | NA | Pulmonary ultrasound examination | Beijing Tiantan Hospital | Skull Base Tumor, Postoperative Complications | 09/27 | 09/27 | | |
NCT05197439: Dexmedetomidine Prevents Postoperative Delirium After Deep Brain Stimulation in Patients With Parkinson's Disease |
|
|
| Not yet recruiting | N/A | 192 | RoW | Dexmedetomidine, 0.9% saline | Beijing Tiantan Hospital | Dexmedetomidine, Postoperative Delirium, Deep Brain Stimulation | 11/24 | 12/24 | | |
NCT05198648: Trigeminal Nerve Cardiac Reflex During Resection of Cerebellopontine Angle Tumors and Postoperative Myocardial Injury |
|
|
| Recruiting | N/A | 591 | RoW | Trigeminal cardiac reflex, Non-trigeminal cardiac reflex | Beijing Tiantan Hospital | Myocardial Injury, Trigeminal Cardiac Reflex | 12/24 | 12/24 | | |
NCT05888389: Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for CSDH |
|
|
| Recruiting | N/A | 190 | RoW | Cranial Nerve Block Anesthesia Combined With Sedative Anesthesia, General Anesthesia | Beijing Tiantan Hospital | Chronic Subdural Hematoma, Anesthesia | 06/25 | 12/25 | | |
NCT05195034: Effect of Dexmedetomidine on Postoperative Delirium After Awake Craniotomies |
|
|
| Recruiting | N/A | 210 | RoW | Dexmedetomidine, 0.9% saline | Beijing Tiantan Hospital | Dexmedetomidine, Delirium, Awake Craniotomy | 11/25 | 12/25 | | |
| Liu, Weiming |
| Recruiting | N/A | 420 | RoW | Dietary and nutritional questionnaire, Neurological function, cognitive function, and life quality assessment, Peripheral blood test, Metabonomic test, Hematoma test | Beijing Tiantan Hospital | Chronic Subdural Hematoma | 12/24 | 03/25 | | |
ECHO, NCT04573387: Exhaustive Drainage Versus Fixed-time Drainage for Chronic Subdural Hematoma After One-burr Hole Craniostomy |
|
|
| Completed | N/A | 309 | RoW | Operation, Fixed-time drainage, Exhaustive drainage, Postoperative computed tomography | Beijing Tiantan Hospital | Hematoma, Subdural, Chronic | 07/24 | 12/24 | | |
NCT06429774: Comparative Effectiveness of Intervention in Multi-level Hospitals for Acute Traumatic Brain Injury(Metric-TBI) |
|
|
| Recruiting | N/A | 2000 | RoW | Neurological function, Mental State, cognitive function, and life quality assessment, Peripheral blood test, Hematoma test | Beijing Tiantan Hospital | Traumatic Brain Injury | 12/26 | 12/26 | | |
| Recruiting | N/A | 460 | RoW | Burr Hole Craniostomy and Postoperative Exhaustive Drainage Strategy, YL-1 puncture needle and Postoperative Exhaustive Drainage Strategy | Beijing Tiantan Hospital | Chronic Subdural Hematoma | 01/25 | 05/25 | | |
CHARM, NCT06427980: Efficacy and Safety of Chinese Herbal HuoXue LiShui Formula for Chronic Subdural Hematoma |
|
|
| Not yet recruiting | N/A | 160 | RoW | Chinese Herbal formula HuoXue LiShui, HuoXue LiShui, Chinese Herbal formula Placebo, Placebo | Beijing Tiantan Hospital | Chronic Subdural Hematoma | 12/25 | 03/26 | | |
NCT05888389: Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for CSDH |
|
|
| Recruiting | N/A | 190 | RoW | Cranial Nerve Block Anesthesia Combined With Sedative Anesthesia, General Anesthesia | Beijing Tiantan Hospital | Chronic Subdural Hematoma, Anesthesia | 06/25 | 12/25 | | |
| Wu, Liang |
| Recruiting | N/A | 420 | RoW | Dietary and nutritional questionnaire, Neurological function, cognitive function, and life quality assessment, Peripheral blood test, Metabonomic test, Hematoma test | Beijing Tiantan Hospital | Chronic Subdural Hematoma | 12/24 | 03/25 | | |
ECHO, NCT04573387: Exhaustive Drainage Versus Fixed-time Drainage for Chronic Subdural Hematoma After One-burr Hole Craniostomy |
|
|
| Completed | N/A | 309 | RoW | Operation, Fixed-time drainage, Exhaustive drainage, Postoperative computed tomography | Beijing Tiantan Hospital | Hematoma, Subdural, Chronic | 07/24 | 12/24 | | |
| Recruiting | N/A | 150 | RoW | Brain temperature-pressure monitoring | Beijing Tiantan Hospital | Intracranial Pressure, Brain Injuries, Traumatic, Subarachnoid Hemorrhage, Cerebral Hemorrhage | 10/24 | 12/24 | | |
| Recruiting | N/A | 460 | RoW | Burr Hole Craniostomy and Postoperative Exhaustive Drainage Strategy, YL-1 puncture needle and Postoperative Exhaustive Drainage Strategy | Beijing Tiantan Hospital | Chronic Subdural Hematoma | 01/25 | 05/25 | | |
NCT05888389: Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for CSDH |
|
|
| Recruiting | N/A | 190 | RoW | Cranial Nerve Block Anesthesia Combined With Sedative Anesthesia, General Anesthesia | Beijing Tiantan Hospital | Chronic Subdural Hematoma, Anesthesia | 06/25 | 12/25 | | |
