| Brochard, Laurent |
OWED, NCT02539732: Prediction of Outcome of Weaning From Mechanical Ventilation Using the Electrical Activity of the Diaphragm |
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| Recruiting | N/A | 110 | Europe, Canada | | Unity Health Toronto | Respiratory Insufficiency | 12/21 | 12/21 | | |
NCT03902639: Examining the Effects of Nasal High Flow Oxygen Therapy Compared to Non-invasive Ventilation in Health Volunteers |
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| Recruiting | N/A | 10 | Canada | | Unity Health Toronto | Healthy Volunteers | 12/24 | 12/24 | | |
| Recruiting | N/A | 171 | Europe, Canada, RoW | Specific lung recruitment maneuvers | Unity Health Toronto | Acute Respiratory Distress Syndrome (ARDS) | 12/21 | 06/22 | | |
HiFOLD, NCT03033251: High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease |
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| Recruiting | N/A | 30 | Canada | Non Invasive Ventilation, Standard of Care, High Flow Oxygen Cannula 50, HFNO 50, High Flow Oxygen Cannula 30, HFNO 30 | Unity Health Toronto | Exacerbation Copd, Acute Respiratory Distress, Acute Hypercapnic Respiratory Failure | 07/24 | 07/24 | | |
| Recruiting | N/A | 300 | Europe, Canada, RoW | | Unity Health Toronto | ARDS, Acute Hypoxemic Respiratory Failure | 08/22 | 08/22 | | |
| Not yet recruiting | N/A | 72 | Canada, US | Venovenous ECMO | University of Toronto, University Health Network, Toronto | ARDS | 06/23 | 12/23 | | |
| Recruiting | N/A | 30 | Canada | Mechanical Ventilation | Unity Health Toronto | Respiratory Support | 06/23 | 06/23 | | |
PROMIZING, NCT02447692: Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The Study |
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| Completed | N/A | 575 | Europe, Canada, RoW | PSV ventilation strategy, PAV+ ventilation strategy | Lawson Health Research Institute, Canadian Institutes of Health Research (CIHR), Medtronic, Canadian Critical Care Trials Group | Critically Ill, Acute Respiratory Failure | 07/24 | 07/24 | | |
VICTORY, NCT06196125: Ventilation dIstribution and effeCt of posTural Lateralization On Traumatic Lung injuRY: a Physiological Study |
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| Active, not recruiting | N/A | 24 | Canada | Four body positions | Unity Health Toronto | Trauma Chest, Mechanical Ventilation | 11/24 | 11/24 | | |
RENOVATE, NCT03643939: High-Flow Nasal Oxygen Cannula Compared to Non-Invasive Ventilation in Adult Patients With AcuTE Respiratory Failure |
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| Completed | N/A | 1801 | RoW | High Flow Nasal Catheter, Optiflow, Airvo, trans-nasal insufflation, Nasal High Flow, High Flow Nasal Cannula, nasal cannula with high-flow oxygen, Noninvasive ventilation, BiPAP, Non-invasive ventilation, Noninvasive positive pressure ventilation | Hospital do Coracao, Ministry of Health, Brazil, Berry Consultants | Respiratory Insufficiency, Respiratory Failure | 11/23 | 02/24 | | |
HONOUR, NCT05078034: HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT |
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| Recruiting | N/A | 200 | Canada | Helmet Non-Invasive Ventilation (HNIV), HNIV, High Flow Nasal Oxygen, HFNO | Sunnybrook Health Sciences Centre | Acute Hypoxemic Respiratory Failure | 02/25 | 02/25 | | |
| Recruiting | N/A | 40 | US | Stimit Activator 1 | Stimit AG | Diaphragm Issues | 12/24 | 03/25 | | |
| Recruiting | N/A | 299 | Canada | Acute hypoxemic respiratory failure patients on VV-ECMO | Lorenzo delSorbo, Unity Health Toronto | Acute Hypoxemic Respiratory Failure | 04/25 | 04/26 | | |
| Recruiting | N/A | 30 | Europe | EIT monitoring | Centre Hospitalier Universitaire, Amiens, Unity Health Toronto | Acute Respiratory Distress Syndrome, Acute Lung Injury | 05/24 | 05/24 | | |
SEVERE, NCT06293976: Susceptibility for Entrainment: Role of Ventilator Settings on the Occurrence of Reverse Triggering and Its Physiological Consequences - the SEVeRe Study |
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| Recruiting | N/A | 30 | Canada | Changes in the ventilator respiratory rate and tidal volume | Unity Health Toronto | Respiration, Artificial, Reverse Triggering | 03/26 | 03/26 | | |
| Recruiting | N/A | 740 | Europe, Canada, US, RoW | Respiratory Mechanics, Standard Ventilation Strategy | Unity Health Toronto, Canadian Institutes of Health Research (CIHR), University of Toronto, Applied Health Research Centre | ARDS | 11/25 | 03/26 | | |
INTRINSIC, NCT06445049: Intrinsic Respiratory Rate Assessment During Mechanical Ventilation to Accelerate Spontaneous Breathing and Extubation |
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| Not yet recruiting | N/A | 70 | NA | brief test | Unity Health Toronto | Reverse Triggering, Patient Ventilator Dyssynchrony | 06/27 | 06/27 | | |
PUMA, NCT06494085: Pressure Muscle Index and Threshold of Over-assistance During Pressure Support Ventilation |
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| Not yet recruiting | N/A | 20 | NA | Measuring Respiratory Mechanics, Randomized Pressure Support | Unity Health Toronto | Acute Hypoxemic Respiratory Failure | 02/25 | 02/25 | | |
| Recruiting | N/A | 40 | Canada | CNAP | The Hospital for Sick Children, Unity Health Toronto | Acute Respiratory Distress Syndrome | 12/24 | 12/24 | | |
| Not yet recruiting | N/A | 50 | NA | High-flow nasal cannula therapy | Unity Health Toronto | Acute Hypercapnic Respiratory Failure | 07/24 | 07/24 | | |
| Tullis, Elizabeth |
| Completed | 3 | 76 | Canada | Prednisone, Placebos | The Hospital for Sick Children, Canadian Cystic Fibrosis Foundation | Cystic Fibrosis Pulmonary Exacerbation | 10/23 | 10/23 | | |
| Seely, Andrew |
POISE, NCT04871412: The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage III |
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| Recruiting | 3 | 20 | Canada | Vitamin D3 Drops, Vitamin D, Coriolus Versicolor, Trident SAP 66:33 Lemon, Fish Oil, Probiotic Pro12, Probiotics, Provitalix Pure Whey Protein, Protein Powder, Theracurmin 2X, Curcumin, Green Tea Extract, EGCG, Nutrition Recommendations, Physical Activity Recommendations, Psychological Recommendations | Ottawa Hospital Research Institute, The Canadian College of Naturopathic Medicine, Lotte & John Hecht Memorial Foundation, The Centre for Health Innovation, University of Ottawa | Lung Cancer, Gastric Cancer, Esophageal Cancer | 12/29 | 12/31 | | |
NCT04708509: Extubation Advisor: Initial Implementation and Evaluation of a Novel Extubation Clinical Decision Support Tool |
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| Recruiting | 1 | 72 | Canada | Extubation Advisor | Ottawa Hospital Research Institute | Airway Extubation | 01/23 | 02/23 | | |
| Not yet recruiting | N/A | 72 | Canada, US | Venovenous ECMO | University of Toronto, University Health Network, Toronto | ARDS | 06/23 | 12/23 | | |
NCT04661787: Donation Advisor Clinical Decision Support Tool Study |
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| Recruiting | N/A | 70 | Canada | | Ottawa Hospital Research Institute, Gift of Life, Canadian Blood Services, Health Canada, Canadian National Transplant Research Program, The Physicians' Services Incorporated Foundation, The Ottawa Hospital, Unity Health Toronto, Queen's University, London Health Sciences Centre, Sunnybrook Health Sciences Centre, Hamilton Health Sciences Corporation, University Health Network, Toronto | Organ Donation | 11/23 | 12/23 | | |
LEADS, NCT05506904: Liberation From Mechanical Ventilation Using Extubation Advisor Decision Support |
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| Recruiting | N/A | 100 | Canada | Extubation Advisor | Ottawa Hospital Research Institute | Airway Extubation | 03/25 | 06/25 | | |
VSI, NCT05108376: Feasibility and Initial Clinical Impressions of Predictive Monitoring Integrated With the RACE Team |
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| Not yet recruiting | N/A | 140 | Canada | Visensia Safety Index (VSI) | Ottawa Hospital Research Institute | Deterioration, Clinical | 01/24 | 01/24 | | |
HONOUR, NCT05078034: HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT |
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| Recruiting | N/A | 200 | Canada | Helmet Non-Invasive Ventilation (HNIV), HNIV, High Flow Nasal Oxygen, HFNO | Sunnybrook Health Sciences Centre | Acute Hypoxemic Respiratory Failure | 02/25 | 02/25 | | |
| Recruiting | N/A | 80 | Canada | Amiodarone, Placebo | Ottawa Hospital Research Institute | Atrial Fibrillation | 03/24 | 04/24 | | |
REVIVe, NCT05246098: Frailty, Rehabilitation, and Outcomes in Critically Ill Adult and Pediatric Survivors of COVID-19 or ARI |
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| Recruiting | N/A | 900 | Canada | | McMaster University, Canadian Institutes of Health Research (CIHR), Canadian Critical Care Trials Group | Respiratory Disease, COVID-19, Viral Infection | 03/25 | 10/25 | | |
| Recruiting | N/A | 200 | Canada | | Ottawa Hospital Research Institute | Achalasia, Paraesophageal Hernia, GERD, Epiphrenic Diverticula, Zenker's Diverticulum | 11/27 | 11/27 | | |
| Burns, Karen EA |
| Recruiting | 2/3 | 1096 | Canada, RoW | higher chloride crystalloid, lower chloride crystalloid | McMaster University, The Physicians' Services Incorporated Foundation, Canadian Institutes of Health Research (CIHR) | Sepsis, Septic Shock | 11/25 | 03/26 | | |
CINERGY, NCT05148715: Calcineurin Inhibitor in NEuRoloGically Deceased Donors to Decrease Kidney delaYed Graft Function |
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| Recruiting | 2 | 414 | Canada | Tacrolimus, Prograf, Placebo | Université de Sherbrooke, McMaster University | Organ Transplant Failure or Rejection, Brain Death, Ischemic Reperfusion Injury | 01/25 | 01/26 | | |
NCT04708509: Extubation Advisor: Initial Implementation and Evaluation of a Novel Extubation Clinical Decision Support Tool |
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| Recruiting | 1 | 72 | Canada | Extubation Advisor | Ottawa Hospital Research Institute | Airway Extubation | 01/23 | 02/23 | | |
| Terminated | N/A | 8 | Canada | Phenobarbital Sodium, Symptom-triggered benzodiazepines (e.g., Valium), Inactive placebo, Symptom triggered benzodiazepines (e.g., Valium) | Unity Health Toronto | Alcohol Withdrawal Delirium, Alcohol Withdrawal, Alcohol Withdrawal Seizures | 07/23 | 07/23 | | |
PROMIZING, NCT02447692: Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The Study |
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| Completed | N/A | 575 | Europe, Canada, RoW | PSV ventilation strategy, PAV+ ventilation strategy | Lawson Health Research Institute, Canadian Institutes of Health Research (CIHR), Medtronic, Canadian Critical Care Trials Group | Critically Ill, Acute Respiratory Failure | 07/24 | 07/24 | | |
LEADS, NCT05506904: Liberation From Mechanical Ventilation Using Extubation Advisor Decision Support |
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| Recruiting | N/A | 100 | Canada | Extubation Advisor | Ottawa Hospital Research Institute | Airway Extubation | 03/25 | 06/25 | | |
| Active, not recruiting | N/A | 200 | Europe, Canada, US | Adagio AF Cryoablation System (iCLAS™) | Adagio Medical | Persistent Atrial Fibrillation | 08/23 | 08/24 | | |
| Recruiting | N/A | 198 | Canada | | Lady Davis Institute, Jewish General Hospital, Canadian Institutes of Health Research (CIHR) | Family Engagement, Patient-centered Care, Critical Care | 12/25 | 12/25 | | |
REVIVe, NCT05246098: Frailty, Rehabilitation, and Outcomes in Critically Ill Adult and Pediatric Survivors of COVID-19 or ARI |
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| Recruiting | N/A | 900 | Canada | | McMaster University, Canadian Institutes of Health Research (CIHR), Canadian Critical Care Trials Group | Respiratory Disease, COVID-19, Viral Infection | 03/25 | 10/25 | | |
| Chokar, Kamalprit |
| Completed | 3 | 76 | Canada | Prednisone, Placebos | The Hospital for Sick Children, Canadian Cystic Fibrosis Foundation | Cystic Fibrosis Pulmonary Exacerbation | 10/23 | 10/23 | | |
| Kim, Audery |
SEVERE, NCT06293976: Susceptibility for Entrainment: Role of Ventilator Settings on the Occurrence of Reverse Triggering and Its Physiological Consequences - the SEVeRe Study |
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| Recruiting | N/A | 30 | Canada | Changes in the ventilator respiratory rate and tidal volume | Unity Health Toronto | Respiration, Artificial, Reverse Triggering | 03/26 | 03/26 | | |
| Recruiting | N/A | 40 | Canada | CNAP | The Hospital for Sick Children, Unity Health Toronto | Acute Respiratory Distress Syndrome | 12/24 | 12/24 | | |
| Tran, Alexander |
LEADS, NCT05506904: Liberation From Mechanical Ventilation Using Extubation Advisor Decision Support |
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| Recruiting | N/A | 100 | Canada | Extubation Advisor | Ottawa Hospital Research Institute | Airway Extubation | 03/25 | 06/25 | | |
