UPMC Pinnacle Health Trials

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52 Trials

Active Trials

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Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

Link, Michael P

NCT03755804: Pediatric Classical Hodgkin Lymphoma Consortium Study: cHOD17

Recruiting

250

bendamustine, TREANDA (R), Etoposide, VP-16, Vepeside, Doxorubicin, Adriamycin (R), Bleomycin, Blenoxane (R), Vincristine, Oncovin (R), Vinblastine, Velban (R), Prednisone, Prednisolone, Filgrastim, Neupogen (R), Brentuximab Vedotin, Adcetris, Cyclophosphamide, Cytoxan (R), DTIC, DACARBAZINE (R), Dimethyl Triazeno Imidazole Carboximide, Quality of Life Measurements, Quality of Life Measurements (QOL), Radiotherapy, radiation therapy, irradiation

St. Jude Children's Research Hospital, Teva Pharmaceuticals USA, Seagen Inc.

Hodgkin Lymphoma

01/27

07/28

EFFORTS, NCT05116878: Enhancing Facial Nerve Function With Omega-3 After Resection of Vestibular Schwannoma

Terminated

N/A

Omega-3, Placebo

Mayo Clinic

Vestibular Schwannoma

08/23

Patel, Chinmay

NCT05809596: HEAL-LAA Clinical Trial

Active, not recruiting

N/A

949

WATCHMAN FLX Pro LAAC Device, Left Atrial Appendage Closure

Boston Scientific Corporation

Atrial Fibrillation, Bleeding, Stroke

07/24

08/25

ADVENT PAS, NCT06431815: ADVENT Post Approval Study

Recruiting

N/A

220

Canada, US, RoW

FARAPULSE™ Pulsed Field Ablation System, FARAWAVE™ Pulsed Field Ablation Catheter

Boston Scientific Corporation

Paroxysmal Atrial Fibrillation

10/28

10/29

SIMPLAAFY, NCT06521463: Clinical Trial

Recruiting

N/A

1857

WATCHMAN FLX Pro LAAC Device, WATCHMAN FLX Pro Left Atrial Appendage Closure Device

Boston Scientific Corporation

Atrial Fibrillation, Stroke, Bleeding

07/26

01/27

ADVENT LTO, NCT06526546: ADVENT Trial Long Term Outcomes Evaluating Atrial Fibrillation Progression Study

Enrolling by invitation

N/A

583

Boston Scientific Corporation

Paroxysmal Atrial Fibrillation

07/25

10/25

ADVANTAGE AF, NCT05443594: A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects with Persistent Atrial Fibrillation

Active, not recruiting

N/A

669

Europe, Canada, US

Phase 1: FARAPULSE Ablation System, Phase 2: FARAPULSE Ablation System

Boston Scientific Corporation

Persistent Atrial Fibrillation

03/25

Alaswad, Khaldoon

AGENT IDE, NCT06492174: A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis (ISR) - Long Lesion Cohort

Active, not recruiting

AGENT DCB 40 mm

Boston Scientific Corporation

In-Stent Restenosis

12/25

12/27

ECP EFS, NCT04477603: Impella ECP Early Feasibility Study

Active, not recruiting

N/A

100

Impella ECP

Abiomed Inc.

High-risk Percutaneous Coronary Intervention

10/25

PROGRESS CTO, NCT02061436: Prospective Global Registry for the Study of Chronic Total Occlusion Intervention

Recruiting

N/A

2000

Europe, Canada, US, RoW

Minneapolis Heart Institute Foundation

Coronary Artery Disease

01/24

ECLIPSE, NCT03108456: Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The Trial

Active, not recruiting

N/A

2005

Orbital Atherectomy, Balloon

Abbott Medical Devices, Cardiovascular Research Foundation, New York

Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction

06/24

06/25

Short-Cut, NCT06089135: Shockwave Lithoplasty Compared to Cutting Balloon Treatment in Calcified Coronary Disease - A Randomized Controlled Trial

Recruiting

N/A

410

Intravascular Lithotripsy, Cutting Balloon

Baim Institute for Clinical Research, Robert W. Yeh, MD, Ajay Kirtane, MD, C. Michael Gibson, MS, MD, Kathleen Kearney, MD, Akiko Maehara, MD, Suzanne Baron, MD

Treatment in Calcified Coronary Disease

08/25

12/25

NCT06358508: Sapphire 3 CTO Study

Recruiting

N/A

170

Sapphire 3 Coronary Dilatation Catheter

OrbusNeich, Avania

Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Heart Diseases, Arteriosclerosis, Cardiovascular Diseases, Chronic Total Occlusion, Chronic Total Occlusion of Coronary Artery

12/25

NCT05187351: Native Coronary Artery Instead of SAphenous Vein Graft Intervention for Treatment of Significant Saphenous Vein Graft Lesions

Active, not recruiting

N/A

Percutaneous coronary intervention of the native coronary artery with Synergy

Minneapolis Heart Institute Foundation

Target Vessel Failure in Saphenous Vein Grafts, Percutaneous Coronary Intervention

01/30

Bachinsky, William

AGENT IDE, NCT06492174: A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis (ISR) - Long Lesion Cohort

Active, not recruiting

AGENT DCB 40 mm

Boston Scientific Corporation

In-Stent Restenosis

12/25

12/27

C-Guardians, NCT04900844: Safety and Efficacy of the CGuard™ Carotid Stent System in Carotid Artery Stenting

Active, not recruiting

N/A

317

Europe, US

CGuard Carotid Stent implantation, Carotid stenting

InspireMD

Carotid Artery Stenosis

07/22

10/25

PERFORMANCE II, NCT04201132: Protection Against Emboli During Carotid Artery Stenting Using the Neuroguard IEP System

Active, not recruiting

N/A

305

Europe, US, RoW

Carotid artery stenting with Neuroguard IEP System

Contego Medical, Inc., Yale Cardiovascular Research Group, Advance Research Associates, CardioMed Device Consultants, LLC, Iqvia Pty Ltd, Medidata Solutions

Carotid Artery Stenosis, Carotid Artery Diseases, Carotid Stenosis

10/23

12/25

NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Recruiting

N/A

1400

Europe, US, RoW

Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation

Medtronic Vascular

Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus

11/26

11/29

TARGET-IV_NA, NCT04562532: Firehawk Rapamycin Target Eluting Coronary Stent North American Trial

Active, not recruiting

N/A

1720

Europe, Canada, US

Microport Firehawk stent, MicroPort Firehawk rapamycin target eluting stent, 2nd generation DES (XIENCE family, Promus family, Resolute/Onyx family/Endeavor, and Orsiro stent)

Shanghai MicroPort Medical (Group) Co., Ltd.

Coronary Artery Disease

12/23

06/27

Short-Cut, NCT06089135: Shockwave Lithoplasty Compared to Cutting Balloon Treatment in Calcified Coronary Disease - A Randomized Controlled Trial

Recruiting

N/A

410

Intravascular Lithotripsy, Cutting Balloon

Baim Institute for Clinical Research, Robert W. Yeh, MD, Ajay Kirtane, MD, C. Michael Gibson, MS, MD, Kathleen Kearney, MD, Akiko Maehara, MD, Suzanne Baron, MD

Treatment in Calcified Coronary Disease

08/25

12/25

SPIRIT XLV PAS, NCT05423379: XIENCE Skypoint Large Vessel Post Approval Study

Active, not recruiting

N/A

102

Europe, US

XIENCE Skypoint Large Vessel Everolimus Eluting Coronary Stent System (EECSS)

Abbott Medical Devices

Coronary Artery Disease

08/25

08/27

CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting

N/A

2486

Europe, Canada, US, RoW

Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS

Mayo Clinic, National Institute of Neurological Disorders and Stroke (NINDS)

Carotid Stenosis

02/26

RECIPE, NCT04636021: Restoring Non-Emergent Cardiovascular Care in the Peri- COVID-19 Era

Recruiting

N/A

1000

COVID-19 testing

Pinnacle Health Cardiovascular Institute

Corona Virus Infection

12/21

06/22

Meise, Gretchen

C-Guardians, NCT04900844: Safety and Efficacy of the CGuard™ Carotid Stent System in Carotid Artery Stenting

Active, not recruiting

N/A

317

Europe, US

CGuard Carotid Stent implantation, Carotid stenting

InspireMD

Carotid Artery Stenosis

07/22

10/25

PERFORMANCE II, NCT04201132: Protection Against Emboli During Carotid Artery Stenting Using the Neuroguard IEP System

Active, not recruiting

N/A

305

Europe, US, RoW

Carotid artery stenting with Neuroguard IEP System

Contego Medical, Inc., Yale Cardiovascular Research Group, Advance Research Associates, CardioMed Device Consultants, LLC, Iqvia Pty Ltd, Medidata Solutions

Carotid Artery Stenosis, Carotid Artery Diseases, Carotid Stenosis

10/23

12/25

NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Recruiting

N/A

1400

Europe, US, RoW

Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation

Medtronic Vascular

Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus

11/26

11/29

TARGET-IV_NA, NCT04562532: Firehawk Rapamycin Target Eluting Coronary Stent North American Trial

Active, not recruiting

N/A

1720

Europe, Canada, US

Microport Firehawk stent, MicroPort Firehawk rapamycin target eluting stent, 2nd generation DES (XIENCE family, Promus family, Resolute/Onyx family/Endeavor, and Orsiro stent)

Shanghai MicroPort Medical (Group) Co., Ltd.

Coronary Artery Disease

12/23

06/27

ADVENT PAS, NCT06431815: ADVENT Post Approval Study

Recruiting

N/A

220

Canada, US, RoW

FARAPULSE™ Pulsed Field Ablation System, FARAWAVE™ Pulsed Field Ablation Catheter

Boston Scientific Corporation

Paroxysmal Atrial Fibrillation

10/28

10/29

NCT05966662: Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO)

Active, not recruiting

N/A

145

IVL with Shockwave C2+ 2Hz Coronary IVL Catheter

Shockwave Medical, Inc.

Coronary Artery Disease, Myocardial Infarction

01/25

12/25

ADVENT LTO, NCT06526546: ADVENT Trial Long Term Outcomes Evaluating Atrial Fibrillation Progression Study

Enrolling by invitation

N/A

583

Boston Scientific Corporation

Paroxysmal Atrial Fibrillation

07/25

10/25

AIM HIGHer, NCT05064709: Assessment of CCM in HF With Higher Ejection Fraction

Recruiting

N/A

1500

Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System, CCM Group (CCM ON), OPTIMIZER™ Smart Mini System, Sham Group (CCM OFF)

Impulse Dynamics

Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mid Range Ejection Fraction, Heart Failure With Moderately Reduced Ejection Fraction, Diastolic Heart Failure

02/26

ROADSTER 3, NCT05365490: Post-approval Study of Transcarotid Artery Revascularization in Standard Risk Patients With Significant Carotid Artery Disease

Active, not recruiting

N/A

344

Transcarotid Artery Revascularization (TCAR), Carotid Revascularization, Carotid Artery Stenting

Silk Road Medical

Carotid Artery Diseases

09/25

CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting

N/A

2486

Europe, Canada, US, RoW

Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS

Mayo Clinic, National Institute of Neurological Disorders and Stroke (NINDS)

Carotid Stenosis

02/26

NCT03970343: Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy

Recruiting

N/A

620

OPTIMIZER Smart System

Impulse Dynamics

Heart Failure

03/26

LeAAPS, NCT05478304: Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial

Recruiting

N/A

6500

Europe, Canada, US, RoW

AtriClip LAA Exclusion System

AtriCure, Inc., Population Health Research Institute

Ischemic Stroke, Systemic Embolism

12/31

04/32

Yeh, Robert

AGENT IDE, NCT04647253: A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis (ISR)

Active, not recruiting

600

AGENT DCB, PTCA balloon catheter

Boston Scientific Corporation

In-Stent Restenosis

10/23

09/27

AGENT IDE, NCT06492174: A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis (ISR) - Long Lesion Cohort

Active, not recruiting

AGENT DCB 40 mm

Boston Scientific Corporation

In-Stent Restenosis

12/25

12/27

PROGRESS CTO, NCT02061436: Prospective Global Registry for the Study of Chronic Total Occlusion Intervention

Recruiting

N/A

2000

Europe, Canada, US, RoW

Minneapolis Heart Institute Foundation

Coronary Artery Disease

01/24

VITALYST EFS, NCT06132568: VITALYST Early Feasibility Study in High-Risk PCI Patients

Completed

N/A

Europe, US

VITALYST System, Percutaneous Mechanical Circulatory Support

Boston Scientific Corporation

High-risk Percutaneous Coronary Intervention, Heart Disease, Coronary

10/24

01/25

SAFE-PAD, NCT04496544: Safety Assessment of Femoropopliteal Endovascular Treatment With PAclitaxel-coated Devices ( Study)

Completed

N/A

168553

Retrospective data collection

Beth Israel Deaconess Medical Center, Medtronic, Philips Healthcare, Bard Peripheral Vascular, Inc., Boston Scientific Corporation, Cook Medical

Peripheral Arterial Disease, Paclitaxel Adverse Reaction, Safety Issues

03/24

06/24

TARGET-IV_NA, NCT04562532: Firehawk Rapamycin Target Eluting Coronary Stent North American Trial

Active, not recruiting

N/A

1720

Europe, Canada, US

Microport Firehawk stent, MicroPort Firehawk rapamycin target eluting stent, 2nd generation DES (XIENCE family, Promus family, Resolute/Onyx family/Endeavor, and Orsiro stent)

Shanghai MicroPort Medical (Group) Co., Ltd.

Coronary Artery Disease

12/23

06/27

Short-Cut, NCT06089135: Shockwave Lithoplasty Compared to Cutting Balloon Treatment in Calcified Coronary Disease - A Randomized Controlled Trial

Recruiting

N/A

410

Intravascular Lithotripsy, Cutting Balloon

Baim Institute for Clinical Research, Robert W. Yeh, MD, Ajay Kirtane, MD, C. Michael Gibson, MS, MD, Kathleen Kearney, MD, Akiko Maehara, MD, Suzanne Baron, MD

Treatment in Calcified Coronary Disease

08/25

12/25

NCT06662500: FORWARD CAD IDE Study

Recruiting

N/A

158

Intravascular Lithotripsy

Shockwave Medical, Inc.

Coronary Arterial Disease (CAD)

08/26

07/28

MAGICAL ISR, NCT05908331: MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions

Recruiting

N/A

492

Sirolimus Drug Coated Balloon, Plan balloon Angioplasty (POBA)

Concept Medical Inc., Cardiovascular Research Foundation, New York

In-Stent Restenosis, Cardiovascular Diseases, Coronary Artery Disease

09/25

07/28

PROTECT IV, NCT04763200: Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function

Recruiting

N/A

1252

Europe, Canada, US

Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®, IABP Intra-aortic balloon pump

Abiomed Inc.

Left Ventricular Dysfunction, Coronary Artery Disease

03/26

10/27

Reitman, Arthur

AGENT IDE, NCT06492174: A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis (ISR) - Long Lesion Cohort

Active, not recruiting

AGENT DCB 40 mm

Boston Scientific Corporation

In-Stent Restenosis

12/25

12/27

Levisay, Justin

AGENT IDE, NCT06492174: A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis (ISR) - Long Lesion Cohort

Active, not recruiting

AGENT DCB 40 mm

Boston Scientific Corporation

In-Stent Restenosis

12/25

12/27

NCT02661451: Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

Active, not recruiting

N/A

178

Europe, Canada, US

SAPIEN 3 THV, Optimal Heart Failure Therapy

Cardiovascular Research Foundation, New York, Cardialysis BV, Avania

Aortic Valve Stenosis

02/23

02/25

NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

Active, not recruiting

N/A

1948

Canada, US

ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL

Boston Scientific Corporation

Aortic Stenosis

06/24

09/34

DTU-STEMI, NCT03947619: Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction: the STEMI-DTU Trial

Active, not recruiting

N/A

527

Europe, Canada, US

Impella CP® placement prior to reperfusion with Primary PCI

Abiomed Inc.

ST Elevation (STEMI) Myocardial Infarction of Anterior Wall

09/24

10/30

MITRAL-II, NCT04408430: The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter VaLves).

Active, not recruiting

N/A

185

US, RoW

Transseptal ViMAC, ViMAC

Mayra Guerrero

Mitral Annular Calcification, Mitral Stenosis, Mitral Regurgitation, Mitral Valve Disease

12/26

12/30

NCT03142152: The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR

Recruiting

N/A

300

Europe, Canada, US

Carillon Mitral Contour System, Carillon, Percutaneous mitral valve repair, Guideline Directed Heart Failure Medication

Cardiac Dimensions, Inc.

Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases

12/26

12/30

Witherow, Megan

No trials found

Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

Link, Michael P

NCT03755804: Pediatric Classical Hodgkin Lymphoma Consortium Study: cHOD17

Recruiting

250

St. Jude Children's Research Hospital, Teva Pharmaceuticals USA, Seagen Inc.

Hodgkin Lymphoma

01/27

07/28

EFFORTS, NCT05116878: Enhancing Facial Nerve Function With Omega-3 After Resection of Vestibular Schwannoma

Terminated

N/A

Omega-3, Placebo

Mayo Clinic

Vestibular Schwannoma

08/23

Patel, Chinmay

NCT05809596: HEAL-LAA Clinical Trial

Active, not recruiting

N/A

949

WATCHMAN FLX Pro LAAC Device, Left Atrial Appendage Closure

Boston Scientific Corporation

Atrial Fibrillation, Bleeding, Stroke

07/24

08/25

ADVENT PAS, NCT06431815: ADVENT Post Approval Study

Recruiting

N/A

220

Canada, US, RoW

FARAPULSE™ Pulsed Field Ablation System, FARAWAVE™ Pulsed Field Ablation Catheter

Boston Scientific Corporation

Paroxysmal Atrial Fibrillation

10/28

10/29

SIMPLAAFY, NCT06521463: Clinical Trial

Recruiting

N/A

1857

WATCHMAN FLX Pro LAAC Device, WATCHMAN FLX Pro Left Atrial Appendage Closure Device

Boston Scientific Corporation

Atrial Fibrillation, Stroke, Bleeding

07/26

01/27

ADVENT LTO, NCT06526546: ADVENT Trial Long Term Outcomes Evaluating Atrial Fibrillation Progression Study

Enrolling by invitation

N/A

583

Boston Scientific Corporation

Paroxysmal Atrial Fibrillation

07/25

10/25

ADVANTAGE AF, NCT05443594: A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects with Persistent Atrial Fibrillation

Active, not recruiting

N/A

669

Europe, Canada, US

Phase 1: FARAPULSE Ablation System, Phase 2: FARAPULSE Ablation System

Boston Scientific Corporation

Persistent Atrial Fibrillation

03/25

Alaswad, Khaldoon

AGENT IDE, NCT06492174: A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis (ISR) - Long Lesion Cohort

Active, not recruiting

AGENT DCB 40 mm

Boston Scientific Corporation

In-Stent Restenosis

12/25

12/27

ECP EFS, NCT04477603: Impella ECP Early Feasibility Study

Active, not recruiting

N/A

100

Impella ECP

Abiomed Inc.

High-risk Percutaneous Coronary Intervention

10/25

PROGRESS CTO, NCT02061436: Prospective Global Registry for the Study of Chronic Total Occlusion Intervention

Recruiting

N/A

2000

Europe, Canada, US, RoW

Minneapolis Heart Institute Foundation

Coronary Artery Disease

01/24

Active, not recruiting

N/A

2005

Orbital Atherectomy, Balloon

Abbott Medical Devices, Cardiovascular Research Foundation, New York

Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction

06/24

06/25

Short-Cut, NCT06089135: Shockwave Lithoplasty Compared to Cutting Balloon Treatment in Calcified Coronary Disease - A Randomized Controlled Trial

Recruiting

N/A

410

Intravascular Lithotripsy, Cutting Balloon

Baim Institute for Clinical Research, Robert W. Yeh, MD, Ajay Kirtane, MD, C. Michael Gibson, MS, MD, Kathleen Kearney, MD, Akiko Maehara, MD, Suzanne Baron, MD

Treatment in Calcified Coronary Disease

08/25

12/25

NCT06358508: Sapphire 3 CTO Study

Recruiting

N/A

170

Sapphire 3 Coronary Dilatation Catheter

OrbusNeich, Avania

Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Heart Diseases, Arteriosclerosis, Cardiovascular Diseases, Chronic Total Occlusion, Chronic Total Occlusion of Coronary Artery

12/25

NCT05187351: Native Coronary Artery Instead of SAphenous Vein Graft Intervention for Treatment of Significant Saphenous Vein Graft Lesions

Active, not recruiting

N/A

Percutaneous coronary intervention of the native coronary artery with Synergy

Minneapolis Heart Institute Foundation

Target Vessel Failure in Saphenous Vein Grafts, Percutaneous Coronary Intervention

01/30

Bachinsky, William

AGENT IDE, NCT06492174: A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis (ISR) - Long Lesion Cohort

Active, not recruiting

AGENT DCB 40 mm

Boston Scientific Corporation

In-Stent Restenosis

12/25

12/27

C-Guardians, NCT04900844: Safety and Efficacy of the CGuard™ Carotid Stent System in Carotid Artery Stenting

Active, not recruiting

N/A

317

Europe, US

CGuard Carotid Stent implantation, Carotid stenting

InspireMD

Carotid Artery Stenosis

07/22

10/25

PERFORMANCE II, NCT04201132: Protection Against Emboli During Carotid Artery Stenting Using the Neuroguard IEP System

Active, not recruiting

N/A

305

Europe, US, RoW

Carotid artery stenting with Neuroguard IEP System

Contego Medical, Inc., Yale Cardiovascular Research Group, Advance Research Associates, CardioMed Device Consultants, LLC, Iqvia Pty Ltd, Medidata Solutions

Carotid Artery Stenosis, Carotid Artery Diseases, Carotid Stenosis

10/23

12/25

NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Recruiting

N/A

1400

Europe, US, RoW

Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation

Medtronic Vascular

Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus

11/26

11/29

TARGET-IV_NA, NCT04562532: Firehawk Rapamycin Target Eluting Coronary Stent North American Trial

Active, not recruiting

N/A

1720

Europe, Canada, US

Microport Firehawk stent, MicroPort Firehawk rapamycin target eluting stent, 2nd generation DES (XIENCE family, Promus family, Resolute/Onyx family/Endeavor, and Orsiro stent)

Shanghai MicroPort Medical (Group) Co., Ltd.

Coronary Artery Disease

12/23

06/27

Short-Cut, NCT06089135: Shockwave Lithoplasty Compared to Cutting Balloon Treatment in Calcified Coronary Disease - A Randomized Controlled Trial

Recruiting

N/A

410

Intravascular Lithotripsy, Cutting Balloon

Baim Institute for Clinical Research, Robert W. Yeh, MD, Ajay Kirtane, MD, C. Michael Gibson, MS, MD, Kathleen Kearney, MD, Akiko Maehara, MD, Suzanne Baron, MD

Treatment in Calcified Coronary Disease

08/25

12/25

SPIRIT XLV PAS, NCT05423379: XIENCE Skypoint Large Vessel Post Approval Study

Active, not recruiting

N/A

102

Europe, US

XIENCE Skypoint Large Vessel Everolimus Eluting Coronary Stent System (EECSS)

Abbott Medical Devices

Coronary Artery Disease

08/25

08/27

CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting

N/A

2486

Europe, Canada, US, RoW

Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS

Mayo Clinic, National Institute of Neurological Disorders and Stroke (NINDS)

Carotid Stenosis

02/26

RECIPE, NCT04636021: Restoring Non-Emergent Cardiovascular Care in the Peri- COVID-19 Era

Recruiting

N/A

1000

COVID-19 testing

Pinnacle Health Cardiovascular Institute

Corona Virus Infection

12/21

06/22

Meise, Gretchen

C-Guardians, NCT04900844: Safety and Efficacy of the CGuard™ Carotid Stent System in Carotid Artery Stenting

Active, not recruiting

N/A

317

Europe, US

CGuard Carotid Stent implantation, Carotid stenting

InspireMD

Carotid Artery Stenosis

07/22

10/25

PERFORMANCE II, NCT04201132: Protection Against Emboli During Carotid Artery Stenting Using the Neuroguard IEP System

Active, not recruiting

N/A

305

Europe, US, RoW

Carotid artery stenting with Neuroguard IEP System

Contego Medical, Inc., Yale Cardiovascular Research Group, Advance Research Associates, CardioMed Device Consultants, LLC, Iqvia Pty Ltd, Medidata Solutions

Carotid Artery Stenosis, Carotid Artery Diseases, Carotid Stenosis

10/23

12/25

NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Recruiting

N/A

1400

Europe, US, RoW

Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation

Medtronic Vascular

Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus

11/26

11/29

TARGET-IV_NA, NCT04562532: Firehawk Rapamycin Target Eluting Coronary Stent North American Trial

Active, not recruiting

N/A

1720

Europe, Canada, US

Microport Firehawk stent, MicroPort Firehawk rapamycin target eluting stent, 2nd generation DES (XIENCE family, Promus family, Resolute/Onyx family/Endeavor, and Orsiro stent)

Shanghai MicroPort Medical (Group) Co., Ltd.

Coronary Artery Disease

12/23

06/27

ADVENT PAS, NCT06431815: ADVENT Post Approval Study

Recruiting

N/A

220

Canada, US, RoW

FARAPULSE™ Pulsed Field Ablation System, FARAWAVE™ Pulsed Field Ablation Catheter

Boston Scientific Corporation

Paroxysmal Atrial Fibrillation

10/28

10/29

NCT05966662: Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO)

Active, not recruiting

N/A

145

IVL with Shockwave C2+ 2Hz Coronary IVL Catheter

Shockwave Medical, Inc.

Coronary Artery Disease, Myocardial Infarction

01/25

12/25

ADVENT LTO, NCT06526546: ADVENT Trial Long Term Outcomes Evaluating Atrial Fibrillation Progression Study

Enrolling by invitation

N/A

583

Boston Scientific Corporation

Paroxysmal Atrial Fibrillation

07/25

10/25

AIM HIGHer, NCT05064709: Assessment of CCM in HF With Higher Ejection Fraction

Recruiting

N/A

1500

Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System, CCM Group (CCM ON), OPTIMIZER™ Smart Mini System, Sham Group (CCM OFF)

Impulse Dynamics

Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mid Range Ejection Fraction, Heart Failure With Moderately Reduced Ejection Fraction, Diastolic Heart Failure

02/26

ROADSTER 3, NCT05365490: Post-approval Study of Transcarotid Artery Revascularization in Standard Risk Patients With Significant Carotid Artery Disease

Active, not recruiting

N/A

344

Transcarotid Artery Revascularization (TCAR), Carotid Revascularization, Carotid Artery Stenting

Silk Road Medical

Carotid Artery Diseases

09/25

CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting

N/A

2486

Europe, Canada, US, RoW

Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS

Mayo Clinic, National Institute of Neurological Disorders and Stroke (NINDS)

Carotid Stenosis

02/26

NCT03970343: Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy

Recruiting

N/A

620

OPTIMIZER Smart System

Impulse Dynamics

Heart Failure

03/26

LeAAPS, NCT05478304: Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial

Recruiting

N/A

6500

Europe, Canada, US, RoW

AtriClip LAA Exclusion System

AtriCure, Inc., Population Health Research Institute

Ischemic Stroke, Systemic Embolism

12/31

04/32

Yeh, Robert

AGENT IDE, NCT04647253: A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis (ISR)

Active, not recruiting

600

AGENT DCB, PTCA balloon catheter

Boston Scientific Corporation

In-Stent Restenosis

10/23

09/27

AGENT IDE, NCT06492174: A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis (ISR) - Long Lesion Cohort

Active, not recruiting

AGENT DCB 40 mm

Boston Scientific Corporation

In-Stent Restenosis

12/25

12/27

PROGRESS CTO, NCT02061436: Prospective Global Registry for the Study of Chronic Total Occlusion Intervention

Recruiting

N/A

2000

Europe, Canada, US, RoW

Minneapolis Heart Institute Foundation

Coronary Artery Disease

01/24

VITALYST EFS, NCT06132568: VITALYST Early Feasibility Study in High-Risk PCI Patients

Completed

N/A

Europe, US

VITALYST System, Percutaneous Mechanical Circulatory Support

Boston Scientific Corporation

High-risk Percutaneous Coronary Intervention, Heart Disease, Coronary

10/24

01/25

SAFE-PAD, NCT04496544: Safety Assessment of Femoropopliteal Endovascular Treatment With PAclitaxel-coated Devices ( Study)

Completed

N/A

168553

Retrospective data collection

Beth Israel Deaconess Medical Center, Medtronic, Philips Healthcare, Bard Peripheral Vascular, Inc., Boston Scientific Corporation, Cook Medical

Peripheral Arterial Disease, Paclitaxel Adverse Reaction, Safety Issues

03/24

06/24

TARGET-IV_NA, NCT04562532: Firehawk Rapamycin Target Eluting Coronary Stent North American Trial

Active, not recruiting

N/A

1720

Europe, Canada, US

Microport Firehawk stent, MicroPort Firehawk rapamycin target eluting stent, 2nd generation DES (XIENCE family, Promus family, Resolute/Onyx family/Endeavor, and Orsiro stent)

Shanghai MicroPort Medical (Group) Co., Ltd.

Coronary Artery Disease

12/23

06/27

Short-Cut, NCT06089135: Shockwave Lithoplasty Compared to Cutting Balloon Treatment in Calcified Coronary Disease - A Randomized Controlled Trial

Recruiting

N/A

410

Intravascular Lithotripsy, Cutting Balloon

Baim Institute for Clinical Research, Robert W. Yeh, MD, Ajay Kirtane, MD, C. Michael Gibson, MS, MD, Kathleen Kearney, MD, Akiko Maehara, MD, Suzanne Baron, MD

Treatment in Calcified Coronary Disease

08/25

12/25

NCT06662500: FORWARD CAD IDE Study

Recruiting

N/A

158

Intravascular Lithotripsy

Shockwave Medical, Inc.

Coronary Arterial Disease (CAD)

08/26

07/28

MAGICAL ISR, NCT05908331: MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions

Recruiting

N/A

492

Sirolimus Drug Coated Balloon, Plan balloon Angioplasty (POBA)

Concept Medical Inc., Cardiovascular Research Foundation, New York

In-Stent Restenosis, Cardiovascular Diseases, Coronary Artery Disease

09/25

07/28

PROTECT IV, NCT04763200: Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function

Recruiting

N/A

1252

Europe, Canada, US

Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®, IABP Intra-aortic balloon pump

Abiomed Inc.

Left Ventricular Dysfunction, Coronary Artery Disease

03/26

10/27

Reitman, Arthur

AGENT IDE, NCT06492174: A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis (ISR) - Long Lesion Cohort

Active, not recruiting

AGENT DCB 40 mm

Boston Scientific Corporation

In-Stent Restenosis

12/25

12/27

Levisay, Justin

AGENT IDE, NCT06492174: A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis (ISR) - Long Lesion Cohort

Active, not recruiting

AGENT DCB 40 mm

Boston Scientific Corporation

In-Stent Restenosis

12/25

12/27

NCT02661451: Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

Active, not recruiting

N/A

178

Europe, Canada, US

SAPIEN 3 THV, Optimal Heart Failure Therapy

Cardiovascular Research Foundation, New York, Cardialysis BV, Avania

Aortic Valve Stenosis

02/23

02/25

NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

Active, not recruiting

N/A

1948

Canada, US

ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL

Boston Scientific Corporation

Aortic Stenosis

06/24

09/34

DTU-STEMI, NCT03947619: Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction: the STEMI-DTU Trial

Active, not recruiting

N/A

527

Europe, Canada, US

Impella CP® placement prior to reperfusion with Primary PCI

Abiomed Inc.

ST Elevation (STEMI) Myocardial Infarction of Anterior Wall

09/24

10/30

MITRAL-II, NCT04408430: The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter VaLves).

Active, not recruiting

N/A

185

US, RoW

Transseptal ViMAC, ViMAC

Mayra Guerrero

Mitral Annular Calcification, Mitral Stenosis, Mitral Regurgitation, Mitral Valve Disease

12/26

12/30

NCT03142152: The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR

Recruiting

N/A

300

Europe, Canada, US

Carillon Mitral Contour System, Carillon, Percutaneous mitral valve repair, Guideline Directed Heart Failure Medication

Cardiac Dimensions, Inc.

Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases

12/26

12/30

Witherow, Megan

No trials found

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