| Wang, Yongjun NA |
FAITH, NCT05169021: Folic Acid and Intensive Antihypertensive Therapy for Hypertension With CSVD |
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| Not yet recruiting | 4 | 15000 | RoW | Amlodipine folic acid 5.8mg+intensive antihypertensive therapy, Amlodipine folic acid 5.8mg+standard antihypertensive therapy, Amlodipine+intensive antihypertensive therapy, Amlodipine+standard antihypertensive therapy, Standard antihypertensive therapy | Beijing Tiantan Hospital | Cerebral Small Vessel Diseases, Stroke | 12/24 | 12/28 | | |
| Completed | 3 | 1362 | RoW | Edaravone Dexborneol Concentrated Solution for injection, Xian Bi Xin, CFDA Approval Number H20200007, Edaravone Dexborneol placebo, Xian Bi Xin placebo | Beijing Tiantan Hospital | Acute Ischemic Stroke, Mechanical Thrombectomy, Edaravone Dexborneol, Phase III | 02/23 | 05/23 | | |
| Completed | 3 | 1412 | RoW | Injection of recombinant human tissue plasminogen kinase derivatives, Reteplase, brand name: Ruitongli, r-PA, Recombinant human tissue plasminogen activator, Alteplase, brand name: Actilyse, rt-PA | Angde Biotech Pharmaceutical Co., Ltd., Beijing Tiantan Hospital | Acute Ischemic Stroke | 06/23 | 06/23 | | |
| Completed | 3 | 516 | RoW | tenecteplase (0.25 mg/kg, Max 25 mg), standard medical treatment, Aspirin, Clopidogrel | Beijing Tiantan Hospital | Ischemic Stroke, Acute | 01/24 | 02/24 | | |
NCT05745259: Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients （3T Stroke-Ⅲ） |
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| Recruiting | 3 | 1630 | RoW | Alteplase, rt-PA, Tenecteplase, TNK-tPA | Beijing Tiantan Hospital, Jiangsu FENG HUA Biotech Pharmaceutical Co., Ltd, The Place Pharmaceutical(Jiangsu) Co., Ltd | Acute Ischemic Stroke | 11/23 | 03/24 | | |
| Completed | 3 | 1446 | NA | Recombinant Human Prourokinase for Injection (rhPro-UK), Puyouke, standard medical treatment, Aspirin, clopidogrel, anticoagulant | Beijing Tiantan Hospital | Ischemic Stroke, Mild, Thrombosis | 03/24 | 06/24 | | |
| Recruiting | 3 | 452 | RoW | Tenecteplase, rhTNK-tPA, TNK-tPA, Best Practice (which may include intravenous Alteplase), rt-PA | Beijing Tiantan Hospital | Ischemic Stroke, Acute | 02/26 | 05/26 | | |
NCT06299579: GD-11 for Injection in the Treatment of Acute Ischemic Stroke |
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| Recruiting | 3 | 980 | RoW | GD-11 for injection test group, Placebo control group | Beijing Tiantan Hospital, Jiangsu Wangao Pharmaceutical Co. ltd | Acute Ischemic Stroke | 02/25 | 12/25 | | |
| Completed | 3 | 1552 | RoW | rhPro-UK, rt-PA | Tasly Biopharmaceuticals Co., Ltd. | Acute Ischemic Stroke | 03/24 | 03/24 | | |
| Recruiting | 3 | 998 | RoW | Y-3 for injection, Placebo control group | Beijing Tiantan Hospital, NeuroDawn Pharmaceutical Co., Ltd. | Acute Ischemic Stroke | 12/24 | 07/25 | | |
NCT06522269: Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-C ) |
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| Recruiting | 3 | 1622 | RoW | Emergency Stroke Unit based on 0.23-T MRI, Standard stroke unit adherent to guidelines | Beijing Tiantan Hospital | Ischemic Stroke, Acute | 12/24 | 07/25 | | |
NCT06522282: Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-D ) |
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| Recruiting | 3 | 600 | RoW | Emergency Stroke Unit based on 0.23-T MRI, Standard stroke unit | Beijing Tiantan Hospital | Ischemic Stroke, Acute | 12/25 | 03/26 | | |
NCT06414499: Teneteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-Ⅳ(TRACE Ⅳ) |
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| Recruiting | 3 | 1394 | RoW | rhTNK-tPA, Control group | Beijing Tiantan Hospital | Tenecteplase, Minor Ischemic Stroke | 07/25 | 12/25 | | |
CN-CATCH, NCT06255977: A Study Evaluating the Safety and Efficacy of Neuroprotective Peptide CN-105 Peptide in Patients With Acute Supratentorial Intracerebral Hemorrhage |
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| Recruiting | 2 | 240 | RoW | CN-105, CN-105peptide | Beijing Tiantan Hospital, SDM Bio Service Inc. | Intracerebral Hemorrhage | 05/24 | 08/24 | | |
NCT04984577: Study of Compound Edaravone Injection for Treatment of Acute Ischemic Stroke |
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| Suspended | 2 | 240 | RoW | Compound Edaravone Injection-Low dose, Compound Edaravone Injection-High dose, Edaravone Injection, Placebo injection | Nanjing Yoko Biomedical Co., Ltd. | Acute Ischemic Stroke | 12/26 | 12/26 | | |
NCT05700097: Dengzhanxixin Injection for Acute Ischemic Stroke Receiving Reperfusion Therapy |
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| Active, not recruiting | 2 | 240 | RoW | Dengzhanxixin Injection, Dengzhanxixin Zhusheye, Placebo injection, Placebo | Beijing Tiantan Hospital | Acute Ischemic Stroke | 09/23 | 12/23 | | |
NCT06202378: Safety and Efficacy of SHPL-49 Injection in Participants With Acute Ischemic Stroke |
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| Active, not recruiting | 2 | 270 | RoW | 3 ampoules of SHPL-49 Injection, 6 ampoules of SHPL-49 Injection, 0.9% Sodium Chloride Injection | Shanghai Hutchison Pharmaceuticals Limited, Beijing Tiantan Hospital | Acute Ischemic Stroke | 12/24 | 12/25 | | |
NCT06322394: BXOS110 Injection in the Treatment of Acute Ischaemic Stroke |
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| Recruiting | 2 | 300 | RoW | high-dose BXOS110, BXOS110, low-dose BXOS110, Placebo | Biocells (Beijing) Biotech Co.,Ltd | Acute Ischemic Stroke | 03/25 | 09/25 | | |
NCT05745311: Study of the KPCXM18 Injection for Treatment of Acute Ischemic Stroke |
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| Not yet recruiting | 2 | 240 | NA | The KPCXM18 injection, Placebo | Kunming Pharmaceuticals, Inc. | Acute Ischemic Stroke | 05/24 | 07/24 | | |
NCT06492239: Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-A ) |
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| Recruiting | 2 | 200 | RoW | Emergency Stroke Unit based on 0.23-T MRI, Standard stroke unit adherent to guidelines | Beijing Tiantan Hospital | Ischemic Stroke, Acute | 02/25 | 08/25 | | |
NCT06492265: Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-B ) |
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| Recruiting | 2 | 100 | RoW | Emergency Stroke Unit based on 0.23-T MRI, Standard stroke unit adherent to guidelines | Yongjun Wang | Ischemic Stroke, Acute | 02/25 | 04/25 | | |
NCT06601127: Study of Tiprogrel in the Treatment of High-risk Patients with Acute Ischemic Cerebrovascular Events (THRIVE). |
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| Not yet recruiting | 2 | 600 | RoW | Tiprogrel+Aspirin, Clopidogrel+Aspirin | Tianjin Institute of Pharmaceutical Research Co., Ltd | Ischemic Stroke | 04/26 | 06/26 | | |
NCT05686642: Efficacy and Safety of LT3001 on Treating the Acute Ischemic Stroke |
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| Recruiting | 2 | 300 | RoW | LT3001 Drug:high dose, Placebo, LT3001 Drug:low dose | Shanghai Pharmaceuticals Holding Co., Ltd | Acute Ischemic Stroke | 04/25 | 07/25 | | |
NCT04590118: Allogeneic Mesenchymal Stem Cells for the Survivors of Ischemic Stroke Trial (ASSIST) |
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| Recruiting | 1/2 | 60 | RoW | it-hMSC, Placebo | Jiuzhitang Maker (Beijing) Cell Technology Co.,Ltd., Beijing Tiantan Hospital | Ischemic Stroke | 04/23 | 08/23 | | |
NCT05200728: The Tolerability, Safety, and PK Characteristics of SIM1910-09 in Healthy Chinese Volunteers |
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| Completed | 1 | 68 | RoW | SIM1910-09, AER-271, Placebo | Jiangsu Simcere Pharmaceutical Co., Ltd. | Acute Ischemic Stroke, Cerebral Edema | 03/23 | 03/23 | | |
NCT04951440: Study on the Effectiveness and Safety of Nitrone for Injection in Patients With Acute Ischemic Stroke |
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| Active, not recruiting | N/A | 200 | RoW | Nitrate ketone oxazine | Peking University Third Hospital, Capital Medical University | Acute Ischemic Stroke | 12/20 | 12/21 | | |
NCT04524624: An AI-Based CDSS for Integrated Management of Patients With Acute Ischemic Stroke(GOLDEN BRIDGE II) |
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| Not yet recruiting | N/A | 21689 | RoW | AI-based CDSS | Beijing Tiantan Hospital | Stroke | 09/22 | 06/23 | | |
NCT02147782: Clinical Observation on Bone Metabolism Induced by Chronic Renal Insufficiency |
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| Recruiting | N/A | 300 | RoW | | Shanghai University of Traditional Chinese Medicine, Anhui Provincial Hospital, Huadong Hospital, Longhua Hospital | Chronic Renal Insufficiency, Renal Osteodystrophy | 12/22 | 12/22 | | |
| Recruiting | N/A | 600 | RoW | | Shanghai University of Traditional Chinese Medicine | Family Genetic Characteristics of Osteoporosis | 09/23 | 10/23 | | |
RETRACE-II, NCT06064747: Low-Frequency REpetitive TRanscranial Magnetic Stimulation Combined With Endovascular Treatment in ACute Ischemic StrokE |
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| Not yet recruiting | N/A | 60 | RoW | LF-rTMS, Sham stimulation | Beijing Tiantan Hospital | Stroke, Acute Ischemic | 10/24 | 10/24 | | |
RETRACE-I, NCT06064734: Low-Frequency REpetitive TRanscranial Magnetic Stimulation in ACute Ischemic StrokE Within 48 Hours |
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| Not yet recruiting | N/A | 60 | RoW | LF-rTMS | Beijing Tiantan Hospital | Stroke, Acute, Stroke, Ischemic | 10/24 | 10/24 | | |
NCT04503941: Ultrasound Examination of Inguinal Lymph Node Used to Evaluate the Effect of Acupuncture on Knee Osteoarthritis |
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| Enrolling by invitation | N/A | 122 | RoW | Acupuncture treatment, False Needle treatment | Shanghai University of Traditional Chinese Medicine | Knee Osteoarthritis | 01/25 | 05/25 | | |
BTH-DREAM-PRIDE, NCT04948749: Drug Eluting Stenting and Aggressive Medical Treatment for Preventing Recurrent Stroke in Intracranial Atherosclerotic Disease Trial |
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| Recruiting | N/A | 792 | RoW | Drug Eluting Stent implantation, Maurora ® Sirolimus Eluting Stent implantation, Aggressive medical treatment, Dual antiplatelet therapy for 6 months, Risk factor management, Risk factor and life style management, Standard medical treatment, Dual antiplatelet therapy for 3 months | Beijing Tiantan Hospital | ICAD - Intracranial Atherosclerotic Disease, ICAS - Intracranial Atherosclerosis, Drug-eluting Stent, Stroke, Drug Eluting Stents (DES), Medical Treatment | 12/26 | 12/26 | | |
| Recruiting | N/A | 50000 | RoW | | Shanghai University of Traditional Chinese Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Dongzhimen Hospital, Beijing, The First Affiliated Hospital of Guangzhou University of TCM, Guangdong Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Changchun University of Chinese Medicine, Gansu Provincial Hospital, Guangzhou Kingmed Diagnostics Co., Ltd., Shandong Provincial Hospital of Traditional Chinese Medicine, Yunnan Provincial Hospital of Traditional Chinese Medicine, Shenzhen Pingle Orthopedic Hospital, First People's Hospital of Nankang District, Ganzhou City | Osteoporosis | 10/26 | 10/28 | | |
| Wang, Yilong |
PERFORM, NCT05583266: Efficacy of Pentoxifylline on Cerebrovascular Function in Patients With Cerebral Small Vessel Disease |
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| Not yet recruiting | 4 | 80 | RoW | Pentoxifylline sustained-release tablets, Pentoxifylline sustained-release tablets placebo | Beijing Tiantan Hospital, CSPC Ouyi Pharmaceutical Co., Ltd. | Cerebral Small Vessel Diseases | 03/23 | 03/24 | | |
NCT05578521: CerebrAlcare Pills on CereBral Small VesseL DiseasE（CABLE） |
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| Active, not recruiting | 4 | 114 | RoW | Cerebralcare pills, Cerebralcare pills placebo | Beijing Tiantan Hospital, Tasly Pharmaceutical Group Co., Ltd | Cerebral Small Vessel Diseases | 12/23 | 03/24 | | |
STRATEGY, NCT05310968: Study on Tirofiban With Aspirin in the Treatment of Acute Penetrating Artery Territory Infarction |
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| Recruiting | 4 | 970 | RoW | Tirofiban hydrochloride sodium chloride injection, Tirofiban hydrochloride sodium chloride injection placebo, Aspirin | Beijing Tiantan Hospital, GrandPharma (China) Co., Ltd. | Branch Atheromatous Disease | 06/24 | 09/24 | | |
| Completed | 3 | 4810 | RoW | Early antihypertensive treatment, Delayed antihypertensive treatment | Tulane University, Beijing Tiantan Hospital, Soochow University | Acute Ischemic Stroke | 10/22 | 01/23 | | |
| Active, not recruiting | 3 | 6100 | RoW | Intensive antiplatelet, Dual antiplatelet, Standard antiplatelet, Aspirin, Immediate high-intensity statin, Immediate Atorvastatin, Delayed high-intensity statin, Delayed Atorvastatin | Beijing Tiantan Hospital, Ministry of Science and Technology of the People's Republic of China | Acute Stroke, Transient Ischemic Attack | 01/23 | 10/23 | | |
EMPHASIS, NCT05836740: Efficacy and Safety of Minocycline in Patients With Moderate to Severe Acute Ischemic Stroke |
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| Recruiting | 3 | 1672 | RoW | Minocycline hydrochloride capsule, Placebo capsules of Minocycline hydrochloride capsules | Beijing Tiantan Hospital, NeuroDawn Pharmaceutical Co., Ltd. | Ischemic Stroke, Acute | 03/24 | 10/24 | | |
TAPIS, NCT06316570: Ticagrelor With Aspirin Dual Antiplatelet Therapy Combined With Intravenous Thrombolysis for Ischemic Stroke |
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| Recruiting | 3 | 1380 | RoW | Early Dual Antiplatelet Therapy, Ticagrelor and Aspirin, Placebo, Placebo of Ticagrelor and Aspirin | Beijing Tiantan Hospital | Ischemic Stroke, Acute | 12/25 | 12/26 | | |
ESPRIT, NCT05836753: Efficacy and Safety of Sarecycline in Patients With Acute Ischemic Stroke After Reperfusion Therapy |
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| Recruiting | 2 | 120 | RoW | Sarecycline Tablet, Placebo tablets of Sarecycline tablets | Beijing Tiantan Hospital, NeuroDawn Pharmaceutical Co., Ltd. | Ischemic Stroke, Acute | 11/23 | 12/23 | | |
NCT06138834: EFfects of Y-6 SUblingual Tablets foR PaTients With AcUte Ischemic StRokE (FUTURE) |
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| Not yet recruiting | 2 | 300 | NA | Low-dose Y-6 sublingual tablets, High-dose Y-6 sublingual tablets, Low-dose Cilostazol, High-dose Cilostazol, Placebo | Beijing Tiantan Hospital, NeuroDawn Pharmaceutical Co., Ltd. | Acute Ischemic Stroke, Large Vessel Occlusion, Reperfusion | 11/24 | 01/25 | | |
CRYSTAL, NCT05836766: Cilostazol Dexborneol Versus Placebo for Microcirculation Dysfunction After Reperfusion Therapy in Patients With Acute Ischemic Stroke With Large Vessel Occlusion |
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| Recruiting | 2 | 120 | RoW | Y-6 sublingual tablets, Placebo tablets of Y-6 sublingual tablet | Beijing Tiantan Hospital, NeuroDawn Pharmaceutical Co., Ltd. | Acute Ischemic Stroke, Reperfusion, Large Vessel Occlusion | 07/24 | 08/24 | | |
| Not yet recruiting | 2 | 192 | RoW | Aleeto, Placebo | Beijing Tiantan Hospital | Acute Ischemic Stroke | 11/25 | 01/26 | | |
| Not yet recruiting | 2 | 328 | RoW | Estradiol Gel, Estradiol Placebo Gel, Progesterone Soft Capsule, Progesterone Placebo Soft Capsule | Beijing Tiantan Hospital | Cerebral Small Vessel Diseases, Postmenopausal Symptoms, Mild Cognitive Impairment, White Matter Hyperintensity | 06/25 | 10/25 | | |
| Not yet recruiting | 1 | 24 | RoW | Aleeto, intravenous injection, intrathecal injection | Beijing Tiantan Hospital | Amyotrophic Lateral Sclerosis | 10/24 | 10/24 | | |
NCT05903690: Safety and Tolerability of RAG-17 in the Treatment of Amyotrophic Lateral Sclerosis Patients With SOD1 Gene Mutation |
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| Enrolling by invitation | 1 | 6 | RoW | RAG-17 | Beijing Tiantan Hospital, Ractigen Therapeutics | Gene Mutation | 02/24 | 02/24 | | |
NCT06596681: A Study of the Safety and Tolerability of GA in the Treatment of Patients with Refractory Neuropathic Pain |
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| Not yet recruiting | 1 | 6 | NA | GA+clozapine | Beijing Tiantan Hospital | Pain, Intractable | 12/25 | 06/26 | | |
| Not yet recruiting | 1 | 12 | RoW | Tofacitinib tablets | Beijing Tiantan Hospital, Turing-Darwin Laboratory; West Institute of Computing Technology, Chongqing, China | Amyotrophic Lateral Sclerosis | 12/25 | 06/26 | | |
NCT06556394: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RAG-17 in Subjects With Amyotrophic Lateral Sclerosis (ALS) With Superoxide Dismutase Type 1 (SOD1) Gene Mutation |
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| Recruiting | 1 | 32 | RoW | RAG-17, Placebo | Ractigen Therapeutics. | Amyotrophic Lateral Sclerosis | 02/26 | 04/26 | | |
SPRITE, NCT06765733: The Study of Safety and Preliminary Efficacy of Aleeto in Patients with MultIple System Atrophy |
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| Not yet recruiting | 1 | 20 | RoW | Aleeto | Beijing Tiantan Hospital | Multiple System Atrophy - Parkinsonian Subtype (MSA-P), Multiple System Atrophy, MSA | 08/25 | 04/26 | | |
| Active, not recruiting | N/A | 100 | RoW | | Beijing Tiantan Hospital | Cerebral Small Vessel Diseases, Hereditary | 07/27 | 07/27 | | |
NCT03703635: Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis |
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| Active, not recruiting | N/A | 512 | RoW | intracranial balloon angioplasty, aggressive medical management | Ministry of Science and Technology of the People´s Republic of China | Intracranial Artery Stenosis | 05/23 | 05/25 | | |
NCT05849805: Y-3 Injection Through Skull Bone Marrow in the Treatment of Acute Malignant Middle Cerebral Artery Infarction (SOLUTION) |
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| Completed | N/A | 20 | RoW | Intracalvaria bone marrow injection, Conventional treatment | Beijing Tiantan Hospital | Stroke, Acute Ischemic | 11/23 | 01/24 | | |
SOLUTION-2, NCT06374667: The Efficacy and Safety of Y-3 Intracalvariosseous Injection Versus Intravenous Injection in the Treatment of Acute Large Hemispheric Infarction |
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| Recruiting | N/A | 134 | RoW | Y-3 ICO injection, Y-3 intravenous injection, Conventional treatment | yilong Wang | Stroke, Acute Ischemic, Blood-Brain Barrier | 03/26 | 03/27 | | |
| Recruiting | N/A | 3500 | RoW | Without any intervention | Beijing Tiantan Hospital, Beijing Daxing District People Hospital | Cerebral Microvascular Dysfunction, Cerebral Small Vessel Diseases, Cognitive Dysfunction, Cerebrovascular Disorders, Cardiovascular Diseases, Population | 03/32 | 10/32 | | |
| Not yet recruiting | N/A | 1000 | RoW | Amyotrophic Lateral Sclerosis | yilong Wang | Amyotrophic Lateral Sclerosis | 12/24 | 12/24 | | |
MODEST, NCT06077305: A Registry Study of Microcirculation Disorder After Cerebral Small Vessel Disease and Ischemic Stroke |
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| Not yet recruiting | N/A | 20000 | RoW | | Beijing Tiantan Hospital | Cerebral Small Vessel Diseases, Ischemic Stroke | 10/26 | 12/26 | | |
| Recruiting | N/A | 200 | RoW | | Beijing Tiantan Hospital | X-linked Adrenoleukodystrophy | 12/28 | 12/28 | | |
| Jiang, Ping |
NCT06426056: Nab-Paclitaxel Plus Cisplatin With Concurrent Radiotherapy for Patients With Locally Advanced Cervical Cancer: A Multicentre, Single-arm, Phase II Trial. |
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| Not yet recruiting | 2 | 64 | NA | radiotherapy, RT, Nab paclitaxel, paclitaxel for injection (albumin bound), Cisplatin | Peking University Third Hospital, Jilin Provincial Tumor Hospital, Affiliated Hospital of Hebei University, Hebei Medical University Fourth Hospital | Cervical Cancer | 09/25 | 10/28 | | |
NCT05879796: Envafolimab Combined With Endostar and Concurrent Chemoradiotherapy for Locally Advanced Primary Cervical Cancer |
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| Not yet recruiting | N/A | 30 | NA | cis-platinum, Cisplatin, radiation, External beam radiotherapy, Brachytherapy, Envafolimab Injection, KN035, Recombinant Human Endostatin Injection, endostar | Peking University Third Hospital | Cervical Cancer | 05/24 | 05/26 | | |
NCT06699979: Multi-omics Study of Early-stage Lung Cancer with Distinct Phenotypes |
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| Recruiting | N/A | 300 | RoW | | Central South University | Lung Cancer Associated with Cystic Airspaces, Multiple Primary Lung Cancers, Non-Small Cell Lung Cancer | 12/25 | 12/27 | | |
