Wye Valley NHS Trust
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 2 Trials 
15 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Robinson, Lisa
NCT03016533: Dolutegravir Study in HIV-1 Participants Completing IMPAACT Studies P1093 and P2019

Completed
3
101
US, RoW
Dolutegravir film-coated tablets, Dolutegravir film-coated dispersible tablets, ABC/DTG/3TC immediate release tablets, ABC/DTG/3TC film-coated dispersible tablets
ViiV Healthcare
HIV Infections
12/24
12/24
FiTNEss, NCT03720041 / 2018-003590-10: Myeloma XIV: Frailty-adjusted Therapy in Transplant Non-Eligible Patients With Newly Diagnosed Multiple Myeloma

Recruiting
3
740
Europe
R1: Ixazomib, Lenalidomide, Dexamethasone (IRD) induction therapy - reactive arm, Ninlaro, Revlimid, R1: Ixazomib, Lenalidomide, Dexamethasone (IRD) induction therapy - adaptive arm, R2: Lenalidomide plus placebo maintenance, R2: Lenalidomide + ixazomib maintenance
University of Leeds, Cancer Research UK, Takeda, Celgene
Multiple Myeloma
12/24
12/24
NCT05674656 / 2022-000829-24: Pharmacokinetics, Safety, Tolerability of Dolutegravir/Rilpivirine in Pediatrics

Recruiting
1/2
20
US
Dolutegravir/Rilpivirine FDC, JULUCA
ViiV Healthcare, Janssen Research & Development, LLC
HIV Infections
06/26
05/28
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting
N/A
958
Canada, US
Tendyne Mitral Valve System, MitraClip System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
05/24
06/28
ProRKS, NCT02780297: Prospective Research Rare Kidney Stones

Recruiting
N/A
220
Canada, US, RoW
Mayo Clinic
Hyperoxaluria, Cystinuria, Dent Disease, Lowe Syndrome, Adenine Phosphoribosyltransferase Deficiency
07/26
07/26
ALT-FLOW II, NCT05686317: Trial of the Edwards APTURE Transcatheter Shunt System

Recruiting
N/A
100
Europe, Canada, US
Edwards APTURE transcatheter shunt system, Sham procedure
Edwards Lifesciences
Heart Failure
01/26
07/30
CATALYST, NCT04226547: Amplatzer Amulet LAAO Vs. NOAC

Recruiting
N/A
2650
Europe, Canada, Japan, US, RoW
Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC
Abbott Medical Devices
Atrial Fibrillation, Stroke, Bleeding
08/27
08/30
SMARTT, NCT01310023: Surveillance Monitoring for ART Toxicities Study in HIV Uninfected Children Born to HIV Infected Women

Recruiting
N/A
5170
US
Harvard School of Public Health (HSPH), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Drug Abuse (NIDA), National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Mental Health (NIMH), National Heart, Lung, and Blood Institute (NHLBI), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute of Neurological Disorders and Stroke (NINDS), Tulane University School of Medicine, National Institute of Dental and Craniofacial Research (NIDCR), NIH Office of AIDS Research (OAR)
Antiretroviral Toxicity
07/25
07/25
AMP Up, NCT02119702: Adolescent Master Protocol for Participants 18 Years of Age and Older

Recruiting
N/A
820
US
Harvard School of Public Health (HSPH), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Drug Abuse (NIDA), National Institute of Allergy and Infectious Diseases (NIAID), NIH Office of AIDS Research (OAR), National Institute of Mental Health (NIMH), National Institute of Neurological Disorders and Stroke (NINDS), National Institute on Deafness and Other Communication Disorders (NIDCD), National Heart, Lung, and Blood Institute (NHLBI), National Institute of Dental and Craniofacial Research (NIDCR), National Institute on Alcohol Abuse and Alcoholism (NIAAA), Tulane University School of Medicine
HIV/AIDS
07/25
07/25
Ray, Biswajit
POETIC-A, NCT04584853 / 2019-003897-24: PreOperative Endocrine Therapy for Individualised Care With Abemaciclib

Recruiting
3
2032
Europe
Abemaciclib, Verzenios, Endocrine therapy (letrozole, anastrozole, exemestane or tamoxifen), Arimidex, Aromasin, Femara, or Tamoxifen
Institute of Cancer Research, United Kingdom
Breast Cancer Female
09/30
03/32
ATNEC, NCT04109079: Axillary Management in Breast Cancer Patients with Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy

Recruiting
N/A
1900
Europe
Axillary lymph node dissection, Axillary radiotherapy, Breast or chest wall radiotherapy
University Hospitals of Derby and Burton NHS Foundation Trust
Breast Cancer, Sentinel Lymph Node, Neoplasm, Breast
02/30
02/30
Small, Charlotte
NCT03653832 / 2018-001650-98: Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial)

Completed
3
1437
Europe
Dexmedetomidine, Dexdor, Clonidine, Catapres, Propofol, Diprivan
University of Edinburgh, West Hertfordshire Hospitals NHS Trust, Queen's University, Belfast, The University of Queensland, University Hospital of Wales, Edinburgh Napier University, King's College London, University of Warwick, University of Manchester, Royal Surrey County Hospital NHS Foundation Trust, University College, London, NHS Lothian, Imperial College London, University of Cambridge
Critical Illness
12/23
07/24
REMAP-CAP, NCT02735707 / 2015-002340-14: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

Recruiting
3
20000
Europe, Canada, Japan, US, RoW
Ceftriaxone, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam, Ceftaroline, Amoxicillin-clavulanate, Standard course macrolide, Extended course macrolide, No systemic corticosteroid, Fixed-duration Hydrocortisone, Shock-dependent hydrocortisone, Fixed-duration higher dose Hydrocortisone, No antiviral agent for influenza, Five-days oseltamivir, Ten-days oseltamivir, No antiviral agent for COVID-19, Lopinavir / Ritonavir, Hydroxychloroquine, Hydroxychloroquine + lopinavir/ritonavir, Ivermectin, No immune modulation for COVID-19, Interferon beta-1a, IFN-β1a, Anakinra, Tocilizumab, Sarilumab, Local standard venous thromboprophylaxis, Therapeutic dose anticoagulation, Conventional low dose thromboprophylaxis, Intermediate dose thromboprophylaxis, Continuation of therapeutic dose anticoagulation, No immunoglobulin, Convalescent plasma, Delayed administration of convalescent plasma, No vitamin C, Vitamin C, No antiplatelet, Aspirin, acetylsalicylic acid, P2Y12 inhibitor, Clopidogrel, Prasugrel, Ticagrelor, No simvastatin, Simvastatin, Eritoran, Apremilast, Clinician-preferred mechanical ventilation strategy, Protocolised mechanical ventilation strategy, No renin-angiotensin system inhibitor, Angiotensin converting enzyme inhibitor, Ramipril, Lisinopril, Perindopril, Enalapril, Trandolapril, Captopril, Angiotensin Receptor Blockers, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, ARB + DMX-200, No cysteamine, Cysteamine, Fixed-duration dexamethasone, Baloxavir Marboxil, Five-days oseltamivir + baloxavir marboxil, Ten-days oseltamivir + baloxavir marboxil, No endothelial modulator, Imatinib, No Immune Modulator for Influenza, Baricitinib, Nirmatrelvir/ritonavir, Paxlovid, Remdesivir, Nirmatrelvir/ritonavir + remdesivir
UMC Utrecht, Australian and New Zealand Intensive Care Research Centre, Medical Research Institute of New Zealand, Unity Health, Berry Consultants, Global Coalition for Adaptive Research, University of Pittsburgh Medical Center, Intensive Care National Audit & Research Centre, St. Marianna University School of Medicine, Nat Intensive Care Surveillance - MORU, National University Hospital, Singapore
Community-acquired Pneumonia, Influenza, COVID-19
02/26
02/28
Das, Kaustuv
ATNEC, NCT04109079: Axillary Management in Breast Cancer Patients with Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy

Recruiting
N/A
1900
Europe
Axillary lymph node dissection, Axillary radiotherapy, Breast or chest wall radiotherapy
University Hospitals of Derby and Burton NHS Foundation Trust
Breast Cancer, Sentinel Lymph Node, Neoplasm, Breast
02/30
02/30
Collins, Emma
NCT03653832 / 2018-001650-98: Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial)

Completed
3
1437
Europe
Dexmedetomidine, Dexdor, Clonidine, Catapres, Propofol, Diprivan
University of Edinburgh, West Hertfordshire Hospitals NHS Trust, Queen's University, Belfast, The University of Queensland, University Hospital of Wales, Edinburgh Napier University, King's College London, University of Warwick, University of Manchester, Royal Surrey County Hospital NHS Foundation Trust, University College, London, NHS Lothian, Imperial College London, University of Cambridge
Critical Illness
12/23
07/24

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