NYU Langone Health - Heart Rhythm Center
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 17 Trials 
60 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Chinitz, Larry
RIDGE-1, NCT06228924: Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults with PKP2 Mutation-associated ARVC

Recruiting
1
15
US
TN-401
Tenaya Therapeutics, Johns Hopkins University, Mayo Clinic
Arrhythmogenic Right Ventricular Cardiomyopathy
05/26
10/29
ERUCA, NCT04438395: Dielectric Tissue Imaging in Cavotricuspid Isthmus Ablation

Recruiting
N/A
30
US
Cardiac ablation via catheter
EPD Solutions, A Philips Company
Atrial Fibrillation and Flutter
06/22
06/22
RIDGE, NCT06311708: Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

Recruiting
N/A
200
Europe, US
Tenaya Therapeutics, University of California, San Francisco, Brigham and Women's Hospital, New York University, University of Colorado, Denver, Johns Hopkins University, The Cleveland Clinic, Mayo Clinic, Medical University of South Carolina, Hopital Louis Pradel, Istituti Clinici Scientifici Maugeri SpA, The Queen Elizabeth Hospital, St George's University Hospitals NHS Foundation Trust, Royal Brompton & Harefield NHS Foundation Trust, Barts & The London NHS Trust, Skane University Hospital, Centro Cardiologico Monzino, Hôpital Haut-Lévêque, Nantes University Hospital, Pitié-Salpêtrière Hospital, Wuerzburg University Hospital, University Hospital Muenster
Arrhythmogenic Right Ventricular Cardiomyopathy
03/30
07/30
PSOT, NCT03481413: Patient Specific Optimized Therapy Post-Market Clinical Follow-up Study

Terminated
N/A
566
Europe, US, RoW
Ablation
EPD Solutions, A Philips Company
Arrythmia
03/23
03/23
ABT-CIP-10523, NCT06707688: Abbott Medical - VERITAS Study

Active, not recruiting
N/A
458
Europe, Canada, US
Amulet™ 2 Left Atrial Appendage (LAA) Occluder
Abbott Medical Devices
Atrial Fibrillation (AF), Stoke
10/25
09/27
NCT06676072: A Study of the TactiFlex SE Catheter and Volt PFA Generator in Subjects With PAF:

Recruiting
N/A
188
Europe, US
PFA Ablation catheter
Abbott Medical Devices
Atrial Fibrillation (AF), Atrial Arrhythmia, Paroxysmal AF, Drug Refractory Paroxysmal Atrial Fibrillation
04/26
04/26
ViewFlex X FIH, NCT06772493: ViewFlex X ICE First-in-Human Study

Recruiting
N/A
200
US
ViewFlex X ICE System
Abbott Medical Devices
Cardiac Arrhythmias
12/25
12/25
ADVANTAGE AF, NCT05443594: A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects With Persistent Atrial Fibrillation

Completed
N/A
669
Europe, Canada, US
Phase 1: FARAPULSE Ablation System, Phase 2: FARAPULSE Ablation System
Boston Scientific Corporation
Persistent Atrial Fibrillation
02/25
02/25
NCT05997446: Amulet™ ADVANCE LAA

Active, not recruiting
N/A
610
US
Left atrial appendage occlusion (LAAO)
Abbott Medical Devices
Atrial Fibrillation, Stroke, Bleeding
06/27
06/27
NCT04502316: Real-World Experience - Barostim™ Advancing the Level of Clinical Evidence (REBALANCE Registry)

Active, not recruiting
N/A
5000
US
Barostim™ System
CVRx, Inc.
Heart Failure
06/28
06/28
LAAOS-4, NCT05963698: The Fourth Left Atrial Appendage Occlusion Study

Recruiting
N/A
4000
Europe, Canada, US
WATCHMAN device
Hamilton Health Sciences Corporation, McMaster University, Population Health Research Institute, Boston Scientific Corporation
Atrial Fibrillation, Stroke, Ischemic, Systemic Embolism
09/29
12/29
NCT06048731: Enlighten Study: The EV-ICD Post Approval Registry

Active, not recruiting
N/A
1000
Europe, Canada, US, RoW
Defibrillation using EV-ICD
Medtronic
Ventricular Arrhythmia, Tachycardia
05/30
10/37
Coordinator, Research
CAMPLIFE, NCT06562296: Study Evaluating Several CAMPs in Nonhealing Diabetic Foot and Venous Leg Ulcers

Active, not recruiting
4
292
US
Amnion-Intermediate-Chorion, AIC, Amnion-Chorion-Amnion, ACA, Standard of Care, SOC
Cellution Biologics, SerenaGroup, Inc., LifeCell
Diabetic Foot Ulcer, Venous Leg Ulcer
10/25
12/25
NCT05078827: Therapeutic Equivalence of Fluorouracil Cream, 5% Compared With Fluorouracil 5% Topical Cream of MylanPharmaceuticals Inc., U.S.A in the Treatment of Actinic Keratosis

Completed
3
458
US
Test Product (A): Fluorouracil Cream, 5% topical cream, Experimental, Reference Product (B): Fluorouracil 5% Topical Cream of Mylan Pharmaceuticals Inc., Morgantown, WV 26505 U.S.A., Active Comparator, Placebo Product (C): Test vehicle cream for fluorouracil 5% of Encube Ethicals Pvt. Ltd., India, Placebo Comparator
Encube Ethicals Pvt. Ltd., CBCC Global Research
Actinic Keratoses
11/22
12/22
OPERA-T, NCT05238116 / 2021-004554-32: Safety and Efficacy of PC945 (Opelconazole) in Combination With Other Antifungal Therapy for the Treatment of Refractory Invasive Pulmonary Aspergillosis ( Study)

Recruiting
3
123
Europe, Canada, US, RoW
PC945, Placebo
Pulmocide Ltd
Refractory IPA
03/26
04/26
NCT06004388: Study of Two Digital Therapeutics for the Prevention of Episodic Migraine Receiving CGRP Therapy (ReMMiD-C)

Completed
3
110
US
Click Digital Therapeutic
Click Therapeutics, Inc.
Migraine, Episodic Migraine, Headache, Headache, Migraine
05/24
06/24
SKOAP, NCT04504812: A Sequenced Strategy for Improving Outcomes in People With Knee Osteoarthritis Pain

Completed
3
1937
US
Duloxetine, Cymbalta, Intra-Articular Injection, Nerve Procedure with long acting blocks, Nerve Procedure with nerve ablation, Pain Coping Skills Training, Best Practices
Johns Hopkins University, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Pacira Pharmaceuticals, Inc
Knee Osteoarthritis
04/25
04/25
CONVOKE, NCT05838625: Study of Two Digital Therapeutics for the Treatment of Experiential Negative Symptoms of Schizophrenia

Completed
3
464
US
Digital Therapeutic
Click Therapeutics, Inc., Boehringer Ingelheim
Schizophrenia
06/25
07/25
NCT06067984: An Extension Study of a Second Course of a Digital Therapeutic for the Treatment of Experiential Negative Symptoms of Schizophrenia

Completed
3
73
US
Study App
Click Therapeutics, Inc., Boehringer Ingelheim
Schizophrenia, Negative Symptoms in Schizophrenia
06/25
08/25
ENIGMA-TRS 2, NCT07184619: Evenamide, a Glutamate Release Modulator, as Add-On to Standard of Care in Subjects With Documented Treatment-Resistant Schizophrenia

Not yet recruiting
3
400
US
Evenamide 15 mg bid, Placebo
Newron Pharmaceuticals SPA
Treatment-resistant Schizophrenia
09/26
09/26
NCT06365437: A Dose Escalation Study of TCD601 Compared to ATG in de Novo Renal Transplantation

Completed
2
33
Europe
TCD601, Siplizumab, Tacrolimus (TAC), Corticosteroids (CS), Mycophenolate Mofetil (MMF), ATG
ITB-Med LLC
Kidney Transplantation
12/24
12/24
PHYOX8, NCT05001269 / 2021-001083-16: Nedosiran in Pediatric Patients From Birth to 11 Years of Age With PH and Relatively Intact Renal Function

Completed
2
27
Europe, Canada, Japan, US, RoW
nedosiran, DCR-PHXC
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Primary Hyperoxaluria, Primary Hyperoxaluria Type 1, Primary Hyperoxaluria Type 2, Primary Hyperoxaluria Type 3
02/25
02/25
CHASE, NCT05727878: Trial to Evaluate Safety and Efficacy of KPI-012 Ophthalmic Solution in Participants With PCED

Terminated
2
103
US, RoW
KPI-012, KPI-012 Vehicle
Combangio, Inc, Kala Pharmaceuticals, Inc.
Persistent Corneal Epithelial Defect
09/25
10/25
NCT05733546: A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive Disorder

Active, not recruiting
2
102
US
Psilocybin, COMP360
COMPASS Pathways
Major Depressive Disorder
09/25
09/25
NCT04270175: Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Patients Previously Exposed to Daratumumab

Active, not recruiting
2
15
US
Daratumumab SC, Faspro, Pomalidomide, Dexamethasone
Weill Medical College of Cornell University, Janssen Scientific Affairs, LLC
Amyloid, AL Amyloidosis, Refractory AL Amyloidosis
01/26
01/28
NCT04803058: A Study of TCD601 in the Induction of Tolerance in Renal Transplantation (PERSPECTIVE)

Active, not recruiting
2
18
US, RoW
TCD601
ITB-Med LLC
Kidney Transplantation
03/27
03/30
STRIDE, NCT06025110: A Study of TCD601 (Siplizumab) in New Onset Type 1 Diabetes Patients

Terminated
2
9
Europe
TCD601, Placebo
ITB-Med LLC
Diabetes Mellitus, Type 1
07/25
07/25
ASCEND, NCT05669001: A Study of TCD601 in de Novo Renal Transplant Recipients

Active, not recruiting
2
90
US
TCD601, siplizumab, belatacept, ATG, antithymocyte globulin, TAC, tacrolimus, MPA, mycophenolic acid, Corticosteroids
ITB-Med LLC
Renal Transplantation
04/26
04/26
NCT04311632: A Dose Escalation Study in de Novo Renal Transplantation

Completed
2
13
US
TCD601, Tacrolimus (TAC), Corticosteroids (CS), Mycophenolate Mofetil (MMF), ATG
ITB-Med LLC
Kidney Transplantation
10/23
10/23
NCT04464980: Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD)

Active, not recruiting
2
1516
US
SL-BUP, sublingual buprenorphine, Suboxone, XR-BUP, extended-release buprenorphine, CAM2038, Brixadi, XR-NTX, extended-release naltrexone, Vivitrol, MM, MMR, MMD
NYU Langone Health, New York State Psychiatric Institute, Columbia University, Harvard Medical School (HMS and HSDM), Mclean Hospital, National Institute on Drug Abuse (NIDA), The Emmes Company, LLC
Opioid Use Disorder (OUD)
12/26
01/27
NCT04803006: A Study of TCD601 in the Induction of Tolerance in Renal Transplantation (PANORAMA)

Active, not recruiting
2
18
US
TCD601
ITB-Med LLC
Kidney Transplantation
07/27
07/30
AURORA, NCT06453668: A Study of TCD601 (Siplizumab) in Newly Diagnosed Adult Amyotrophic Lateral Sclerosis (ALS) Patients

Active, not recruiting
1
48
Europe
TCD601, siplizumab
ITB-Med LLC
ALS
11/26
11/26
PBL-0405-01, NCT06273852: A Study of the Intratumoral Microdose Administration of PBA-0405 in Patients With Solid Tumors

Completed
1
8
US
PBA-0405, PB004.22.0405.aF
Pure Biologics S.A., Presage Biosciences
Head and Neck Squamous Cell Carcinoma, Soft Tissue Sarcoma Adult, Triple Negative Breast Cancer
03/25
03/25
MST01-AZN-05, NCT06366451: PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, Sabestomig, and AZD9592 in HNSCC

Recruiting
1
15
US
Rilvegostomig, AZD2936, Volrustomig, MEDI5752, Sabestomig, AZD7789, AZD9592, Pembrolizumab, Keytruda, MK-3475, AZD9592 + Rilvegostomig, AZD9592 + Volrustomig, AZD9592 + Sabestomig, AZD9592 + Pembrolizumab
Presage Biosciences, AstraZeneca
Head and Neck Squamous Cell Carcinoma
02/25
04/25
OP-1250-003, NCT05508906: Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer

Recruiting
1
190
US, RoW
Palazestrant, Ribociclib, KISQALI®, CDK4/6 inhibitor, Alpelisib, PIQRAY®, PI3K Inhibitor, Everolimus, mTOR inhibitor, Atirmociclib, CDK4i
Olema Pharmaceuticals, Inc., Novartis, Pfizer
Metastatic Breast Cancer, ER-positive Breast Cancer, HER2-negative Breast Cancer, Breast Cancer, Locally Advanced Breast Cancer
12/27
01/28
RAINIER, NCT06634394: APVO436 Phase 1b/2 Study in Patients With Newly Diagnosed AML

Recruiting
1
39
US
APVO436, Venetoclax, venclexta, Azacitidine, vidaza
Aptevo Therapeutics
Acute Myeloid Leukemia (AML)
10/27
03/28
NCT06798454: Single Ascending Dose Study to Evaluate Safety Tolerability, Pharmacokinetics, and Pharmacodynamics of PVT201 in Healthy Subjects and Patients (PBC/PSC)

Completed
1
24
RoW
PVT201, Navacim, Placebo, normal saline, 0.9% NaCl
Parvus Therapeutics, Inc., Avance Clinical Pty Ltd.
Primary Biliary Cholangitis (PBC)
04/25
04/25
INTASYL PH-762, NCT06014086: Intratumoral PH-762 for Cutaneous Carcinoma

Recruiting
1
30
US
PH-762
Phio Pharmaceuticals Inc., Prosoft Clinical
Squamous Cell Carcinoma of the Skin, Malignant Melanoma of Skin, Merkel Cell Carcinoma of Skin
01/26
04/26
NCT04541108: Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies

Recruiting
1
15
US
Rilvegostomig, AZD2936, Volrustomig, MEDI5752, Sabestomig, AZD7789, Pembrolizumab, Keytruda, MK-3475
Presage Biosciences, Merck Sharp & Dohme LLC
Solid Tumor
12/31
12/31
NCT06802328: Intermediate-Size Patient Population Expanded Access: Foralumab in Non-Active Secondary Progressive MS Patients

Available
N/A
US
Foralumab TZLS-401 50 µg
Tiziana Life Sciences LTD
Non-Active Secondary Progressive Multiple Sclerosis
 
 
ReMMi-D, NCT05853900: Study of Two Digital Therapeutics for the Prevention of Episodic Migraine

Completed
N/A
568
US
ReMMi-D Digital Therapeutic
Click Therapeutics, Inc.
Migraine, Episodic Migraine, Headache, Headache, Migraine
05/24
05/24
NCT06136936: A Study to Evaluate the Overall Effects of Treatment With Abbreviated CT-156 in People With Schizophrenia

Completed
N/A
53
US
CT-156-C-001
Click Therapeutics, Inc., Boehringer Ingelheim
Schizophrenia
01/24
02/24
NCT05222581: Engineering Evaluation of a Breast Pump Device

Completed
N/A
48
US
Prototypes of breast shield and Freedom Double Electric Breast Pump
Momtech Inc.
Healthy, Breast Pumping
06/24
09/24
NCT06136923: An Exploratory Study to Evaluate Attention Biases in Adults With Multiple Sclerosis, Breast Cancer, and Lung Cancer

Completed
N/A
194
US
CT-100-D-004-A, CT-100-D-004-B
Click Therapeutics, Inc.
Multiple Sclerosis, Lung Cancer, Breast Cancer
04/24
05/24
LOCAL, NCT04968847: FemaSeed Artificial Insemination Trial

Completed
N/A
314
US
FemaSeed Localized Directional Insemination
Femasys Inc.
Infertility, Male Factor
12/23
04/24
CT-100-D-003, NCT06275659: An Exploratory Study to Evaluate a Digital Intervention to Disrupt Scratching in Atopic Dermatitis and Psoriasis

Completed
N/A
120
US
CT-100-004-A, CT-100-004-B
Click Therapeutics, Inc.
Psoriasis, Atopic Dermatitis
02/24
02/24
NCT05119842: APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study

Recruiting
N/A
30
Europe, US
APrevent® VOIS-Implant
APrevent Biotech GmbH
Paralysis, Unilateral, Vocal Cord
09/25
09/26
CoMind EFS, NCT06368648: CoMind Early Feasibility Study

Recruiting
N/A
581
US
CoMind Technologies Limited, Lindus Health
Intracranial Pressure, Intracranial Pressure Changes, Traumatic Brain Injury, Intracerebral Hemorrhage, Encephalitis, Encephalopathy, Hydrocephalus, Stroke, Autoregulation
11/26
11/26
NCT05006404: Autus Valve Pivotal Study

Recruiting
N/A
50
US
Pulmonary Valve Replacement Surgery
Autus Valve Technologies, Inc.
Congenital Heart Disease
08/26
02/36
MASTR, NCT05243966: Myriad™ Augmented Soft Tissue Reconstruction Registry

Recruiting
N/A
800
US
Myriad Matrix™ and Myriad Morcells™
Aroa Biosurgery Limited
Abdominal Wound Dehiscence, Necrotizing Soft Tissue Infection, Lower Extremity Wound, Pilonidal Sinus, Anal Fistula, Hidradenitis Suppurativa, Pressure Injury
01/28
01/29
FASTR-TEN, NCT06867185: Evaluating Therapeutic Electrical Stimulation to Improve Nerve Healing After Surgical Repair of Digital Nerve Injuries

Recruiting
N/A
60
US
Brief Electrical Stimulation Therapy, BES, Therapeutic Electrical Stimulation, Electrical Stimulation, Digital Nerve Repair, Nerve Repair
Checkpoint Surgical Inc.
Digital Nerve Injury, Nerve Injury, Nerve Reconstruction, Nerve Trauma, Digital Nerve Lesion
12/26
03/27
PVDUS-01, NCT06256575: Study of Diosmin for the Treatment of Digital Ulcers in Systemic Sclerosis

Recruiting
N/A
45
Canada
Diosmin, Vasculera, Placebo
Primus Pharmaceuticals, KGK Science Inc.
Scleroderma, Systemic, Digital Ulcer
07/27
08/27
NCT06770998: A Study of a Novel EEG Neurofeedback System for PTSD Treatment

Recruiting
N/A
250
US
EEG-neurofeedback training, Prism training, amyg-EFP training, active Prism training, Sham training, sham Prism training
Foundation for Atlanta Veterans Education and Research, Inc., GrayMatters Health Ltd., Rochester Institute of Technology, NYU Langone Health, Atlanta VA Medical Center, Birmingham VA Health Care System, Ralph H. Johnson VA Medical Center, VA Boston Healthcare System, CTP Inc, BioStats Statistical Consulting Ltd, ShareCRF, United States Department of Defense
Stress Disorders, Post-Traumatic
06/27
08/27
NCT07104396: Cogito: A Turnkey Solution for Rapidly Developing, Evaluating, Deploying, and Scaling Digital Therapeutics

Recruiting
N/A
20
US
Cogito digital therapeutics development platform
Square2 Systems, Inc., National Institute on Drug Abuse (NIDA)
Substance Use Disorders (SUDs)
08/25
08/25
LBBAP PMCF, NCT07217392: Left Bundle Branch Area Pacing (LBBAP) PMCF Study

Recruiting
N/A
200
RoW
LBBAP lead, CSP lead
Abbott Medical Devices
Bradycardia, Right Ventricular Pacing, Heart Failure, Atrial Fibrillation (AF), Cardiac Disease, Left Bundle Branch Area Pacing, Conduction System Pacing
04/27
04/27
PHONES, NCT04662320: Promoting Healing of Nerves Through Electrical Stimulation

Active, not recruiting
N/A
100
US
Checkpoint BEST System, Brief Electrical Stimulation (BES) Therapy
Checkpoint Surgical Inc., Congressionally Directed Medical Research Programs
Cubital Tunnel Syndrome, Nerve Compression, Nerve Injury, Ulnar Neuropathies
12/25
12/25
FINALE, NCT05977751: Prospective Multi-Center Trial for FemBloc Permanent Birth Control

Recruiting
N/A
573
US
FemBloc
Femasys Inc.
Contraception
12/29
06/31
PHINEST, NCT05884125: Promoting Healing of Injured Nerves With Electrical Stimulation Therapy

Recruiting
N/A
60
US
Checkpoint BEST System, Brief Electrical Stimulation (BES) Therapy
Checkpoint Surgical Inc., Congressionally Directed Medical Research Programs
Nerve Injury, Peripheral Nerve Injuries, Peripheral Nerve Injury Upper Limb, Nerve Palsy
06/27
06/27
COMPANION AI, NCT06056271: Clinical and Healthcare Outcomes From Real-World Use in the United States of a Companion AI During AF Ablation

Recruiting
N/A
400
US
AF Ablation
Volta Medical, Heart Rhythm Clinical and Research Solutions, LLC
Atrial Fibrillation
12/27
12/27
NCT05678530: Observational, Non-Interventional Study Supporting Validation of VO2Max Estimation Methods Using Results in Patients Receiving Standard of Care Cardiopulmonary Exercise Tests (CPET)

Recruiting
N/A
400
Canada, US
Prolaio
Cardiopulmonary
03/26
03/26
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Chinitz, Larry
RIDGE-1, NCT06228924: Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults with PKP2 Mutation-associated ARVC

Recruiting
1
15
US
TN-401
Tenaya Therapeutics, Johns Hopkins University, Mayo Clinic
Arrhythmogenic Right Ventricular Cardiomyopathy
05/26
10/29
ERUCA, NCT04438395: Dielectric Tissue Imaging in Cavotricuspid Isthmus Ablation

Recruiting
N/A
30
US
Cardiac ablation via catheter
EPD Solutions, A Philips Company
Atrial Fibrillation and Flutter
06/22
06/22
RIDGE, NCT06311708: Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

Recruiting
N/A
200
Europe, US
Tenaya Therapeutics, University of California, San Francisco, Brigham and Women's Hospital, New York University, University of Colorado, Denver, Johns Hopkins University, The Cleveland Clinic, Mayo Clinic, Medical University of South Carolina, Hopital Louis Pradel, Istituti Clinici Scientifici Maugeri SpA, The Queen Elizabeth Hospital, St George's University Hospitals NHS Foundation Trust, Royal Brompton & Harefield NHS Foundation Trust, Barts & The London NHS Trust, Skane University Hospital, Centro Cardiologico Monzino, Hôpital Haut-Lévêque, Nantes University Hospital, Pitié-Salpêtrière Hospital, Wuerzburg University Hospital, University Hospital Muenster
Arrhythmogenic Right Ventricular Cardiomyopathy
03/30
07/30
PSOT, NCT03481413: Patient Specific Optimized Therapy Post-Market Clinical Follow-up Study

Terminated
N/A
566
Europe, US, RoW
Ablation
EPD Solutions, A Philips Company
Arrythmia
03/23
03/23
ABT-CIP-10523, NCT06707688: Abbott Medical - VERITAS Study

Active, not recruiting
N/A
458
Europe, Canada, US
Amulet™ 2 Left Atrial Appendage (LAA) Occluder
Abbott Medical Devices
Atrial Fibrillation (AF), Stoke
10/25
09/27
NCT06676072: A Study of the TactiFlex SE Catheter and Volt PFA Generator in Subjects With PAF:

Recruiting
N/A
188
Europe, US
PFA Ablation catheter
Abbott Medical Devices
Atrial Fibrillation (AF), Atrial Arrhythmia, Paroxysmal AF, Drug Refractory Paroxysmal Atrial Fibrillation
04/26
04/26
ViewFlex X FIH, NCT06772493: ViewFlex X ICE First-in-Human Study

Recruiting
N/A
200
US
ViewFlex X ICE System
Abbott Medical Devices
Cardiac Arrhythmias
12/25
12/25
ADVANTAGE AF, NCT05443594: A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects With Persistent Atrial Fibrillation

Completed
N/A
669
Europe, Canada, US
Phase 1: FARAPULSE Ablation System, Phase 2: FARAPULSE Ablation System
Boston Scientific Corporation
Persistent Atrial Fibrillation
02/25
02/25
NCT05997446: Amulet™ ADVANCE LAA

Active, not recruiting
N/A
610
US
Left atrial appendage occlusion (LAAO)
Abbott Medical Devices
Atrial Fibrillation, Stroke, Bleeding
06/27
06/27
NCT04502316: Real-World Experience - Barostim™ Advancing the Level of Clinical Evidence (REBALANCE Registry)

Active, not recruiting
N/A
5000
US
Barostim™ System
CVRx, Inc.
Heart Failure
06/28
06/28
LAAOS-4, NCT05963698: The Fourth Left Atrial Appendage Occlusion Study

Recruiting
N/A
4000
Europe, Canada, US
WATCHMAN device
Hamilton Health Sciences Corporation, McMaster University, Population Health Research Institute, Boston Scientific Corporation
Atrial Fibrillation, Stroke, Ischemic, Systemic Embolism
09/29
12/29
NCT06048731: Enlighten Study: The EV-ICD Post Approval Registry

Active, not recruiting
N/A
1000
Europe, Canada, US, RoW
Defibrillation using EV-ICD
Medtronic
Ventricular Arrhythmia, Tachycardia
05/30
10/37
Coordinator, Research
CAMPLIFE, NCT06562296: Study Evaluating Several CAMPs in Nonhealing Diabetic Foot and Venous Leg Ulcers

Active, not recruiting
4
292
US
Amnion-Intermediate-Chorion, AIC, Amnion-Chorion-Amnion, ACA, Standard of Care, SOC
Cellution Biologics, SerenaGroup, Inc., LifeCell
Diabetic Foot Ulcer, Venous Leg Ulcer
10/25
12/25
NCT05078827: Therapeutic Equivalence of Fluorouracil Cream, 5% Compared With Fluorouracil 5% Topical Cream of MylanPharmaceuticals Inc., U.S.A in the Treatment of Actinic Keratosis

Completed
3
458
US
Test Product (A): Fluorouracil Cream, 5% topical cream, Experimental, Reference Product (B): Fluorouracil 5% Topical Cream of Mylan Pharmaceuticals Inc., Morgantown, WV 26505 U.S.A., Active Comparator, Placebo Product (C): Test vehicle cream for fluorouracil 5% of Encube Ethicals Pvt. Ltd., India, Placebo Comparator
Encube Ethicals Pvt. Ltd., CBCC Global Research
Actinic Keratoses
11/22
12/22
OPERA-T, NCT05238116 / 2021-004554-32: Safety and Efficacy of PC945 (Opelconazole) in Combination With Other Antifungal Therapy for the Treatment of Refractory Invasive Pulmonary Aspergillosis ( Study)

Recruiting
3
123
Europe, Canada, US, RoW
PC945, Placebo
Pulmocide Ltd
Refractory IPA
03/26
04/26
NCT06004388: Study of Two Digital Therapeutics for the Prevention of Episodic Migraine Receiving CGRP Therapy (ReMMiD-C)

Completed
3
110
US
Click Digital Therapeutic
Click Therapeutics, Inc.
Migraine, Episodic Migraine, Headache, Headache, Migraine
05/24
06/24
SKOAP, NCT04504812: A Sequenced Strategy for Improving Outcomes in People With Knee Osteoarthritis Pain

Completed
3
1937
US
Duloxetine, Cymbalta, Intra-Articular Injection, Nerve Procedure with long acting blocks, Nerve Procedure with nerve ablation, Pain Coping Skills Training, Best Practices
Johns Hopkins University, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Pacira Pharmaceuticals, Inc
Knee Osteoarthritis
04/25
04/25
CONVOKE, NCT05838625: Study of Two Digital Therapeutics for the Treatment of Experiential Negative Symptoms of Schizophrenia

Completed
3
464
US
Digital Therapeutic
Click Therapeutics, Inc., Boehringer Ingelheim
Schizophrenia
06/25
07/25
NCT06067984: An Extension Study of a Second Course of a Digital Therapeutic for the Treatment of Experiential Negative Symptoms of Schizophrenia

Completed
3
73
US
Study App
Click Therapeutics, Inc., Boehringer Ingelheim
Schizophrenia, Negative Symptoms in Schizophrenia
06/25
08/25
ENIGMA-TRS 2, NCT07184619: Evenamide, a Glutamate Release Modulator, as Add-On to Standard of Care in Subjects With Documented Treatment-Resistant Schizophrenia

Not yet recruiting
3
400
US
Evenamide 15 mg bid, Placebo
Newron Pharmaceuticals SPA
Treatment-resistant Schizophrenia
09/26
09/26
NCT06365437: A Dose Escalation Study of TCD601 Compared to ATG in de Novo Renal Transplantation

Completed
2
33
Europe
TCD601, Siplizumab, Tacrolimus (TAC), Corticosteroids (CS), Mycophenolate Mofetil (MMF), ATG
ITB-Med LLC
Kidney Transplantation
12/24
12/24
PHYOX8, NCT05001269 / 2021-001083-16: Nedosiran in Pediatric Patients From Birth to 11 Years of Age With PH and Relatively Intact Renal Function

Completed
2
27
Europe, Canada, Japan, US, RoW
nedosiran, DCR-PHXC
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Primary Hyperoxaluria, Primary Hyperoxaluria Type 1, Primary Hyperoxaluria Type 2, Primary Hyperoxaluria Type 3
02/25
02/25
CHASE, NCT05727878: Trial to Evaluate Safety and Efficacy of KPI-012 Ophthalmic Solution in Participants With PCED

Terminated
2
103
US, RoW
KPI-012, KPI-012 Vehicle
Combangio, Inc, Kala Pharmaceuticals, Inc.
Persistent Corneal Epithelial Defect
09/25
10/25
NCT05733546: A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive Disorder

Active, not recruiting
2
102
US
Psilocybin, COMP360
COMPASS Pathways
Major Depressive Disorder
09/25
09/25
NCT04270175: Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Patients Previously Exposed to Daratumumab

Active, not recruiting
2
15
US
Daratumumab SC, Faspro, Pomalidomide, Dexamethasone
Weill Medical College of Cornell University, Janssen Scientific Affairs, LLC
Amyloid, AL Amyloidosis, Refractory AL Amyloidosis
01/26
01/28
NCT04803058: A Study of TCD601 in the Induction of Tolerance in Renal Transplantation (PERSPECTIVE)

Active, not recruiting
2
18
US, RoW
TCD601
ITB-Med LLC
Kidney Transplantation
03/27
03/30
STRIDE, NCT06025110: A Study of TCD601 (Siplizumab) in New Onset Type 1 Diabetes Patients

Terminated
2
9
Europe
TCD601, Placebo
ITB-Med LLC
Diabetes Mellitus, Type 1
07/25
07/25
ASCEND, NCT05669001: A Study of TCD601 in de Novo Renal Transplant Recipients

Active, not recruiting
2
90
US
TCD601, siplizumab, belatacept, ATG, antithymocyte globulin, TAC, tacrolimus, MPA, mycophenolic acid, Corticosteroids
ITB-Med LLC
Renal Transplantation
04/26
04/26
NCT04311632: A Dose Escalation Study in de Novo Renal Transplantation

Completed
2
13
US
TCD601, Tacrolimus (TAC), Corticosteroids (CS), Mycophenolate Mofetil (MMF), ATG
ITB-Med LLC
Kidney Transplantation
10/23
10/23
NCT04464980: Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD)

Active, not recruiting
2
1516
US
SL-BUP, sublingual buprenorphine, Suboxone, XR-BUP, extended-release buprenorphine, CAM2038, Brixadi, XR-NTX, extended-release naltrexone, Vivitrol, MM, MMR, MMD
NYU Langone Health, New York State Psychiatric Institute, Columbia University, Harvard Medical School (HMS and HSDM), Mclean Hospital, National Institute on Drug Abuse (NIDA), The Emmes Company, LLC
Opioid Use Disorder (OUD)
12/26
01/27
NCT04803006: A Study of TCD601 in the Induction of Tolerance in Renal Transplantation (PANORAMA)

Active, not recruiting
2
18
US
TCD601
ITB-Med LLC
Kidney Transplantation
07/27
07/30
AURORA, NCT06453668: A Study of TCD601 (Siplizumab) in Newly Diagnosed Adult Amyotrophic Lateral Sclerosis (ALS) Patients

Active, not recruiting
1
48
Europe
TCD601, siplizumab
ITB-Med LLC
ALS
11/26
11/26
PBL-0405-01, NCT06273852: A Study of the Intratumoral Microdose Administration of PBA-0405 in Patients With Solid Tumors

Completed
1
8
US
PBA-0405, PB004.22.0405.aF
Pure Biologics S.A., Presage Biosciences
Head and Neck Squamous Cell Carcinoma, Soft Tissue Sarcoma Adult, Triple Negative Breast Cancer
03/25
03/25
MST01-AZN-05, NCT06366451: PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, Sabestomig, and AZD9592 in HNSCC

Recruiting
1
15
US
Rilvegostomig, AZD2936, Volrustomig, MEDI5752, Sabestomig, AZD7789, AZD9592, Pembrolizumab, Keytruda, MK-3475, AZD9592 + Rilvegostomig, AZD9592 + Volrustomig, AZD9592 + Sabestomig, AZD9592 + Pembrolizumab
Presage Biosciences, AstraZeneca
Head and Neck Squamous Cell Carcinoma
02/25
04/25
OP-1250-003, NCT05508906: Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer

Recruiting
1
190
US, RoW
Palazestrant, Ribociclib, KISQALI®, CDK4/6 inhibitor, Alpelisib, PIQRAY®, PI3K Inhibitor, Everolimus, mTOR inhibitor, Atirmociclib, CDK4i
Olema Pharmaceuticals, Inc., Novartis, Pfizer
Metastatic Breast Cancer, ER-positive Breast Cancer, HER2-negative Breast Cancer, Breast Cancer, Locally Advanced Breast Cancer
12/27
01/28
RAINIER, NCT06634394: APVO436 Phase 1b/2 Study in Patients With Newly Diagnosed AML

Recruiting
1
39
US
APVO436, Venetoclax, venclexta, Azacitidine, vidaza
Aptevo Therapeutics
Acute Myeloid Leukemia (AML)
10/27
03/28
NCT06798454: Single Ascending Dose Study to Evaluate Safety Tolerability, Pharmacokinetics, and Pharmacodynamics of PVT201 in Healthy Subjects and Patients (PBC/PSC)

Completed
1
24
RoW
PVT201, Navacim, Placebo, normal saline, 0.9% NaCl
Parvus Therapeutics, Inc., Avance Clinical Pty Ltd.
Primary Biliary Cholangitis (PBC)
04/25
04/25
INTASYL PH-762, NCT06014086: Intratumoral PH-762 for Cutaneous Carcinoma

Recruiting
1
30
US
PH-762
Phio Pharmaceuticals Inc., Prosoft Clinical
Squamous Cell Carcinoma of the Skin, Malignant Melanoma of Skin, Merkel Cell Carcinoma of Skin
01/26
04/26
NCT04541108: Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies

Recruiting
1
15
US
Rilvegostomig, AZD2936, Volrustomig, MEDI5752, Sabestomig, AZD7789, Pembrolizumab, Keytruda, MK-3475
Presage Biosciences, Merck Sharp & Dohme LLC
Solid Tumor
12/31
12/31
NCT06802328: Intermediate-Size Patient Population Expanded Access: Foralumab in Non-Active Secondary Progressive MS Patients

Available
N/A
US
Foralumab TZLS-401 50 µg
Tiziana Life Sciences LTD
Non-Active Secondary Progressive Multiple Sclerosis
 
 
ReMMi-D, NCT05853900: Study of Two Digital Therapeutics for the Prevention of Episodic Migraine

Completed
N/A
568
US
ReMMi-D Digital Therapeutic
Click Therapeutics, Inc.
Migraine, Episodic Migraine, Headache, Headache, Migraine
05/24
05/24
NCT06136936: A Study to Evaluate the Overall Effects of Treatment With Abbreviated CT-156 in People With Schizophrenia

Completed
N/A
53
US
CT-156-C-001
Click Therapeutics, Inc., Boehringer Ingelheim
Schizophrenia
01/24
02/24
NCT05222581: Engineering Evaluation of a Breast Pump Device

Completed
N/A
48
US
Prototypes of breast shield and Freedom Double Electric Breast Pump
Momtech Inc.
Healthy, Breast Pumping
06/24
09/24
NCT06136923: An Exploratory Study to Evaluate Attention Biases in Adults With Multiple Sclerosis, Breast Cancer, and Lung Cancer

Completed
N/A
194
US
CT-100-D-004-A, CT-100-D-004-B
Click Therapeutics, Inc.
Multiple Sclerosis, Lung Cancer, Breast Cancer
04/24
05/24
LOCAL, NCT04968847: FemaSeed Artificial Insemination Trial

Completed
N/A
314
US
FemaSeed Localized Directional Insemination
Femasys Inc.
Infertility, Male Factor
12/23
04/24
CT-100-D-003, NCT06275659: An Exploratory Study to Evaluate a Digital Intervention to Disrupt Scratching in Atopic Dermatitis and Psoriasis

Completed
N/A
120
US
CT-100-004-A, CT-100-004-B
Click Therapeutics, Inc.
Psoriasis, Atopic Dermatitis
02/24
02/24
NCT05119842: APrevent-VOIS-Implant-002 - a Two-Part, Open-Label, Non-Randomized Multicenter Study

Recruiting
N/A
30
Europe, US
APrevent® VOIS-Implant
APrevent Biotech GmbH
Paralysis, Unilateral, Vocal Cord
09/25
09/26
CoMind EFS, NCT06368648: CoMind Early Feasibility Study

Recruiting
N/A
581
US
CoMind Technologies Limited, Lindus Health
Intracranial Pressure, Intracranial Pressure Changes, Traumatic Brain Injury, Intracerebral Hemorrhage, Encephalitis, Encephalopathy, Hydrocephalus, Stroke, Autoregulation
11/26
11/26
NCT05006404: Autus Valve Pivotal Study

Recruiting
N/A
50
US
Pulmonary Valve Replacement Surgery
Autus Valve Technologies, Inc.
Congenital Heart Disease
08/26
02/36
MASTR, NCT05243966: Myriad™ Augmented Soft Tissue Reconstruction Registry

Recruiting
N/A
800
US
Myriad Matrix™ and Myriad Morcells™
Aroa Biosurgery Limited
Abdominal Wound Dehiscence, Necrotizing Soft Tissue Infection, Lower Extremity Wound, Pilonidal Sinus, Anal Fistula, Hidradenitis Suppurativa, Pressure Injury
01/28
01/29
FASTR-TEN, NCT06867185: Evaluating Therapeutic Electrical Stimulation to Improve Nerve Healing After Surgical Repair of Digital Nerve Injuries

Recruiting
N/A
60
US
Brief Electrical Stimulation Therapy, BES, Therapeutic Electrical Stimulation, Electrical Stimulation, Digital Nerve Repair, Nerve Repair
Checkpoint Surgical Inc.
Digital Nerve Injury, Nerve Injury, Nerve Reconstruction, Nerve Trauma, Digital Nerve Lesion
12/26
03/27
PVDUS-01, NCT06256575: Study of Diosmin for the Treatment of Digital Ulcers in Systemic Sclerosis

Recruiting
N/A
45
Canada
Diosmin, Vasculera, Placebo
Primus Pharmaceuticals, KGK Science Inc.
Scleroderma, Systemic, Digital Ulcer
07/27
08/27
NCT06770998: A Study of a Novel EEG Neurofeedback System for PTSD Treatment

Recruiting
N/A
250
US
EEG-neurofeedback training, Prism training, amyg-EFP training, active Prism training, Sham training, sham Prism training
Foundation for Atlanta Veterans Education and Research, Inc., GrayMatters Health Ltd., Rochester Institute of Technology, NYU Langone Health, Atlanta VA Medical Center, Birmingham VA Health Care System, Ralph H. Johnson VA Medical Center, VA Boston Healthcare System, CTP Inc, BioStats Statistical Consulting Ltd, ShareCRF, United States Department of Defense
Stress Disorders, Post-Traumatic
06/27
08/27
NCT07104396: Cogito: A Turnkey Solution for Rapidly Developing, Evaluating, Deploying, and Scaling Digital Therapeutics

Recruiting
N/A
20
US
Cogito digital therapeutics development platform
Square2 Systems, Inc., National Institute on Drug Abuse (NIDA)
Substance Use Disorders (SUDs)
08/25
08/25
LBBAP PMCF, NCT07217392: Left Bundle Branch Area Pacing (LBBAP) PMCF Study

Recruiting
N/A
200
RoW
LBBAP lead, CSP lead
Abbott Medical Devices
Bradycardia, Right Ventricular Pacing, Heart Failure, Atrial Fibrillation (AF), Cardiac Disease, Left Bundle Branch Area Pacing, Conduction System Pacing
04/27
04/27
PHONES, NCT04662320: Promoting Healing of Nerves Through Electrical Stimulation

Active, not recruiting
N/A
100
US
Checkpoint BEST System, Brief Electrical Stimulation (BES) Therapy
Checkpoint Surgical Inc., Congressionally Directed Medical Research Programs
Cubital Tunnel Syndrome, Nerve Compression, Nerve Injury, Ulnar Neuropathies
12/25
12/25
FINALE, NCT05977751: Prospective Multi-Center Trial for FemBloc Permanent Birth Control

Recruiting
N/A
573
US
FemBloc
Femasys Inc.
Contraception
12/29
06/31
PHINEST, NCT05884125: Promoting Healing of Injured Nerves With Electrical Stimulation Therapy

Recruiting
N/A
60
US
Checkpoint BEST System, Brief Electrical Stimulation (BES) Therapy
Checkpoint Surgical Inc., Congressionally Directed Medical Research Programs
Nerve Injury, Peripheral Nerve Injuries, Peripheral Nerve Injury Upper Limb, Nerve Palsy
06/27
06/27
COMPANION AI, NCT06056271: Clinical and Healthcare Outcomes From Real-World Use in the United States of a Companion AI During AF Ablation

Recruiting
N/A
400
US
AF Ablation
Volta Medical, Heart Rhythm Clinical and Research Solutions, LLC
Atrial Fibrillation
12/27
12/27
NCT05678530: Observational, Non-Interventional Study Supporting Validation of VO2Max Estimation Methods Using Results in Patients Receiving Standard of Care Cardiopulmonary Exercise Tests (CPET)

Recruiting
N/A
400
Canada, US
Prolaio
Cardiopulmonary
03/26
03/26

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