| Urinary Tract, Sexual Organs, and Pregnancy Conditions |
| Active, not recruiting | N/A | 2874 | Europe | | Odense University Hospital | Abortion, Spontaneous | 12/31 | 12/31 | | |
| Urinary Tract, Sexual Organs, and Pregnancy Conditions |
ACTRN12620000514909p: Haemofiltration with OXiris: Multicentre Evaluation in Acute Kidney Injury (HOME-AKI). A pilot study comparing two devices used for renal replacement therapy in the intensive care unit in patients with acute kidney injury related to sepsis. |
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| Not yet recruiting | 4 | 150 | | | Melbourne Health, Baxter Healthcare Corporation | Acute Kidney Injury; Sepsis; Septic Shock | | | | |
ACTRN12620000514909: Haemofiltration with OXiris: Multicentre Evaluation in Acute Kidney Injury (HOME-AKI). A pilot study comparing two devices used for renal replacement therapy in the intensive care unit in patients with acute kidney injury related to sepsis. |
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| Not yet recruiting | 4 | 150 | | | Melbourne Health, Baxter Healthcare Corporation | Acute Kidney Injury, Sepsis, Septic Shock | | | | |
ACTRN12605000059662: Multicentre, Unblinded, Randomised, Controlled Trial of Severe Acute Renal Failure (ARF) |
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| Not yet recruiting | 4 | 1500 | | | The George Institute, NHMRC | Acute Renal Failure | | | | |
| Completed | 4 | 100 | | 1wu of EPO was Subcutaneous Injected before and 24 ;conventional therapy | 455th hospital of LPA; 455th hospital of LPA, funding of Health Bureau of Changning district, Shanghai | acute kidney injury | | | | |
| Ongoing | 4 | 100 | Europe | COSMOFER, VENOFER, MONOFER, B03AB04, , Solution for infusion in administration system, COSMOFER, VENOFER, MOnofer | Hull and East Yorkshire Hospitals NHS Trust | patients with known chonic kidney disease with functional or absolute Iron deficiency Anaemia, and are greater than 18 years will be given repleacement iron therapy accoring to current local protocols and NICE guidelines | | | | |
ChiCTR-TRC-10001166: A clinic research of Ginsenosides compound (shen-fu injection) for renal function in anaesthetic management of liver transplantation |
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| Completed | 4 | 70 | | shenfu injection 0.5ml/kg IV +1ml/kg.h continuous infusion by pump ;saline injection 0.5ml/kg IV +1ml/kg.h continuous infusion by pump | Shanghai Changzheng Hospital; Level of the institution：, Shanghai Changzheng Hospital | End-stage liver disease; liver transplantation; acute kidney injury | | | | |
2014-003589-25: Comparison between levosimendan and placebo in acute renal failure after cardiac surgery Jämförelse mellan levosimendan och placebo vid akut njursvikt efter hjärtkirurgi |
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| Ongoing | 4 | 30 | Europe | Simdax, Concentrate and solvent for solution for infusion, Simdax | Sahlgrenska Universitetssjukhuset/Sahlgrenska, Sahlgrenska Academy | Acute kidney injury postoperatively in connection with heart surgery Akut njursvikt i samband med hjärtkirurgi, Acute renal failure Akut njursvikt, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
ChiCTR-TRC-14004985: The study of the clearances of solutes by a novel mode of continuous renal replacement therapy |
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| Recruiting | 4 | 30 | | DF-HDF ;standard CVVH ;HVHF | Jinling Hospital, Nanjing; Jinling Hospital, Nanjing, None | Acute kidney injury | | | | |
2005-001986-32: Comparison of 2 contrast agents in preventing acute renal failure after angiography |
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| Ongoing | 4 | 220 | Europe | Visipaque, Niopam, Visipaque, Niopam | NHS Tayside | Peripheral vascular or renovascular disease being investigated by angiography | | | | |
2005-005809-38: Does prophylactic N acetylcysteine reduce the incidence of contrast nephropathy in patients undergoing peripheral angiography |
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| Ongoing | 4 | 40 | Europe | Fluimucil, Fluimucil | Research & Development Department, Addenbrookes Hospital | We will use N acetylcystiene prophylactically in patient undergoing peripheral angiography at the Cambridge Vascular Unit at Addenbrooke\'s Hospital in order to prevent renal injury. Patients undergoing peripheral angiography have large quanities of contrast medium injected intravenously, contrast medium is a nephrotoxic substance. Thge drug will be administrated prophylactically to aviod acute renal failure. | | | | |
2009-010190-20: DETECTION OF ACUTE RENAL FAILURE IN CRITICALLY ILL PATIENTS: A prospective evaluation of cystatin C diagnostic performance |
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| Ongoing | 4 | 40 | Europe | OMNIPAQUE, OMNIPAQUE, OMNIPAQUE | CHU Saint-Etienne | critically ill patients hospitalised in inetnsive care unit | | | | |
2008-003733-24: A randomised study to assess the effects of Epoetin Beta on renal function in patients with critical illness(with or without multi-organ failure) |
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| Ongoing | 4 | 30 | Europe | Neo-recormon, EU/1/97/031/030, Neorecormon solution for injection (pre filled syringe), Neorecormon solution for injection (pre filled syringe) | Abertawe Bro Morgannwg University NHS Trust, Abertawe Bro Morgannwyg University Health Board | Sepsis/Acute renal failure | | | | |
2013-000899-16: Investigation of the blood levels of selected antibiotics in critically ill patients undergoing dialysis |
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| Ongoing | 4 | 40 | Europe | Zyvoxid 600 mg, Meropenem Eberth 1g, Zyvoxid 600 mg (Pfizer), Meropenem Eberth 1g, Zyvoxid 600 mg (Pfizer), Meropenem Eberth 1g | Department of Pharmacy Unversitätsmedizin Mainz, Department of Pharmacy Universitätsmedizin Mainz | Sepsis and acute renal failure (ARF) are pathological entities that commonly co-exist in patients admitted to intensive care. Antibiotic dosing in septic patients with ARF can be complicated and may result in either underdosing, causing treatment failure and antibiotic resistance, or overdosing resulting in drug toxicity. The aim of this study is to collect pharmacokinetic data for evaluating underdosing or overdosing of linezolid and meropenem in patients receiving renal replacement therapy. | | | | |
ChiCTR-IPR-16010141: Comparison between different contrast media on Contrast-Induced Acute Kidney Injury in AMI patients undergoing primary percutaneous coronary intervention |
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| Recruiting | 4 | 300 | | iodixanol will be administered during PCI ;iohexol will be administered during PCI | Department of Cardiology, General Hospital of Guang Zhou Military Command; General Hospital of Guang Zhou Military Command, Project of Key Laboratory of Guangzhou medical and Internet of things | Contrast-Induced Acute Kidney Injury | | | | |
2016-004361-12: A study to assess the effect in renal function recovery of two anticoagulation strategies (ways of making blood more fluent) in critically ill patients with acute kidney failure treated with continuous renal replacement therapies. Estudio para evaluar el efecto en la recuperación de la función renal de dos estrategias de anticoagulación (formas de hacer la sangre más fluida) en pacientes críticos con insuficiencia renal aguda que necesitan tratamiento con terapias de reemplazo renal continuo. |
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| Ongoing | 4 | 44 | Europe | Anticoagulant and preservative solution for blood, Heparin sodium | Fernando Sánchez, Fernando Sánchez, Hospital Universitario de La Plana | Acute renal failure (ARF). Insuficiencia renal aguda., Acute renal failure is the inability of the kidneys to perform their functions to purify and clean the blood, and in this setting we use machines to temporarily replace renal function. La insuficiencia renal es la incapacidad de los riñones para realizar sus funciones de purificar y limpiar la sangre, por lo que se recurre a máquinas para sustituir temporalmente la función renal., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Therapeutic techniques [E02] | | | | |
ChiCTR-IPD-17010596: NGAL, KIM-1 and IL-18 for Prediction of the outcome in the patients with contrast-induced acute kidney injury and the reassessment of statins intervention |
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| Recruiting | 4 | 200 | | Intensive treatment with atorvastatin ;Conventional treatment with atorvastatin | Ningbo No. 2 Hospital; Ningbo 2nd Hospital, Medical Science and Technology in Zhejiang Province Plan (Grant No. 2015KYA200, 2015 - 2017) | contrast-induced acute kidney injury | | | | |
FER-CIT-2016-01, NCT06646328: Oxidative Stress and Circulating Nuclear DNA (cfDNA) in Acute Kidney Injury and Continuous Renal Replacement Therapies. |
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| Terminated | 4 | 20 | Europe | Central venous access, Pump-assisted circuit, Continuous renal replacement therapy, CRRT, Heparin sodium, Non-fractional heparin, Heparin, Regional citrate anticoagulation, Blood and ultrafiltrate samples | Fernando Sanchez, Hospital Universitario de la Plana, Hospital General Universitario de Castellón | Acute Kidney Injury | 04/21 | 04/21 | | |
ChiCTR1800019481: Effects of different sedation drugs on postoperative renal function of patients undergoing crdiopulmonry bypss heart surgery and its relationship with glycocalyx |
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| Recruiting | 4 | 60 | | sevoflurane ;propofol | The Affiliated Hospital of Guizhou Medical University; The Affiliated Hospital of Guizhou Medical University, Self-funding | acute kidney injury | | | | |
ChiCTR1900021798: Lithium Carbona in contrast-induced acute kidney injury: a prospective, randomized, controlled study |
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| Not yet recruiting | 4 | 200 | | Intravenous infusion of 0.9% sodium chloride injection at a rate of 1.0 ml/(kg·h) 6 h before and 12 h after contrast injection+ Lithium carbonate sustained release tablets 300mg/600mg qd oral for 3 days ;Intravenous infusion of 0.9% sodium chloride injection at a rate of 1.0 ml/(kg·h) 6 h before and 12 h after contrast injection+ placebo qd oral for 3 days | The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University, Self-supporting | Contrast induced acute kidney injury | | | | |
ChiCTR1900027602: Evaluation Effects and Safety of Using Lower Dose CTA Scan Protocol Diagnosis on Patients with the Low Extremity Peripheral Artery Disease and Chronic Kidney Disease with Contrast Induced-Acute Kidney Injury’s Risk Factor |
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| Not yet recruiting | 4 | | | | Shiyan Taihe Hospital; Shiyan Taihe Hospital, Shiyan Taihe Hospital | Lower limb artery stenosis with chronic kidney disease | | | | |
ChiCTR2000034472: Effects of Betamethasone on Renal Dysfunction in Elderly Patients During Perioperative Period: a Multicenter, Prospective, Randomized, Controlled Clinical Trial |
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| Recruiting | 4 | 90 | | Betamethasone 8mg intravenous drip ;Betamethasone 16mg intravenous drip ;Intravenous drip of equal amount of normal saline | The Second Xiangya Hospital of Central South University; The Second Xiangya Hospital of Central South University, Project funding | Acute Kidney injury | | | | |
ChiCTR2000034950: Clinical study of the effect of levosimendan on Cleveland score-based cardiac surgery-related AKI (CSA-AKI) |
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| Recruiting | 4 | 200 | | Levosimendan + standard inotropic medication ;standard inotropic medication | Cardiothoracic surgery ICU of the First Affiliated Hospital of Sun Yat-Sen University; The First Affiliated Hospital of Sun Yat-Sen University, Cardiovascular Multidisciplinary Integrated Thinking Research Fund，China International Medical foundation | Cardiac surgery-associated acute kidney injury | | | | |
NCT04530448: Coronavirus Induced Acute Kidney Injury: Prevention Using Urine Alkalinization |
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| Terminated | 4 | 3 | US | Sodium bicarbonate, Standard of Care | West Virginia University | COVID, Coronavirus, Coronavirus Infection, AKI, Acute Kidney Injury | 07/21 | 07/21 | | |
VIBAKI, NCT04893733: Intravenous Administration of Vitamin B Complex Improves Renal Recovery in Patients With AKI |
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| Recruiting | 4 | 180 | RoW | Vitamin B Complex, Placebo | Caja Nacional de Salud, International Society of Nephrology | Acute Kidney Injury | 09/21 | 12/21 | | |
2021-003172-13: Study of the effects of sodium-glucose cotransporter 2 inhibitors on kidney function and metabolism in patients that undergo cardiac surgery. Een studie naar de effecten van natrium-glucose cotransporter-2 remmers op de nierfunctie en het metabolisme in patiënten die een hart operatie ondergaan. |
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| Ongoing | 4 | 80 | Europe | Film-coated tablet, Jardiance | Amsterdam UMC, The European Research Executive Agency (REA) | Cardiac surgery-associated acute kidney injury cardio-chirurgie geassocieerde nierinsufficiëntie, Kidney injury occurring after cardiac surgery Nier schade die optreed na een hart operatie, Diseases [C] - Symptoms and general pathology [C23] | | | | |
ChiCTR2000040410: A Single-center, Prospective, Randomized controlled trial comparing the Effectiveness of different hydration schemes in preventing Acute kidney injury in patients unDergoing PCI |
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| Not yet recruiting | 4 | 3264 | | The dosage of iodixanol depends on the type of examination, age, weight, cardiac output and the patient's general condition and the technique used. From 12 hours before the contrast injection to 24 hours after the contrast agent is used, the oral water should be taken orally to replenish water. ;The dosage of iodixanol depends on the type of examination, age, weight, cardiac output and the patient's general condition and the technique used. From 12 hours before the contrast medium injection to 24 hours after the contrast medium is used, intravenous infusion of normal saline is used. The injecti ;The dosage of ioverol depends on the type of examination, age, weight, cardiac output and the patient's general condition and the technology used. From 12 hours before the contrast injection to 24 hours after the contrast agent is used, the oral water is used for rehydration, and the replenishment a ;The dosage of ioverol depends on the type of examination, age, weight, cardiac output, and the patient's general condition and the technique used. From 12 hours before the contrast medium injection to 24 hours after the contrast medium, normal saline is injected intravenously. Liquid flow rate ≥100ml/h. | Tianjin People's Hospital; Tianjin People's Hospital, CHINA HEALTH PROMOTION FOUNDATION | Acute Coronary Syndrome | | | | |
ChiCTR1900026747: Effect of ulinastatin on prevention of acute kidney injury after cardiac surgery: a randomised, double-blinded, placebo-controlled trial |
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| Not yet recruiting | 4 | 360 | | Intravenous injection of ulinastatin ;Placebo (0.9% normal saline) | Renji Hospital, Shanghai Jiaotong University School of Medicine; Renji Hospital, Shanghai Jiaotong University School of Medicine, self-financing | acute kidney injury | | | | |
2021-004938-11: Prevention of cardiac surgery-associated renal injury through the use of sodium-glucose cotransporter 2 inhibitors |
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| Not yet recruiting | 4 | 604 | Europe | Empagliflozin, Film-coated tablet, Jardiance 10 mg | Hospital Clínico Universitario de Valladolid, Gerencia Regional de Salud de Castilla y León | Cardiac surgery-associated acute kidney injury Fracaso renal agudo asociado a cirugía cardiaca, Renal injury due to cardiac surgery Lesión renal asociada a cirugía cardiaca, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
ChiCTR2000034544: Non-inferior study of balanced salt solution versus human albumin solution in reversing end-stage liver disease be complicated of acute kidney injury |
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| Recruiting | 4 | 114 | | balance solution ;human albumin solution | Beijing You'an Hospital Affiliated to Capital Medical University; Beijing You'an Hospital Affiliated to Capital Medical University, China Primary Heaith Care Foundation -Youan Foundation of Liver Disease and AIDS | acute kidney injury | | | | |
SAFE-PCI, NCT05037695: SGLT-2 Inhibitors in Prevention of Post-procedural Renal and Cardiovascular Complications aFter PCI Among Patients With Diabetes Mellitus and Coronary Artery Disease: a Prospective, Randomized, Pilot Study |
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| Recruiting | 4 | 40 | RoW | empagliflozin 25 MG | University of Sao Paulo General Hospital | Diabetes Mellitus, Type 2, Coronary Artery Disease, Acute Kidney Injury | 07/22 | 12/22 | | |
ChiCTR2100055100: Effect of dexmedetomidine on acute kidney injury in elderly patients after laparoscopic partial nephrectomy |
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| Recruiting | 4 | 120 | | Intravenous infusion of dexmedetomidine 0.4 ug/kg/h during surgery ;Intravenous infusion of normal saline 0.4 ug/kg/h during surgery | The Third Medical Center of PLA General Hospital; The Third Medical Center of PLA General Hospital, 2020 Capital Health Development Research Project | Acute kidney injury | | | | |
ChiCTR2000036579: Research on precision treatment strategies of anti-drug resistant bacterial infection drugs in high-risk populations of acute kidney injury |
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| Not yet recruiting | 4 | 410 | | Based on ATM-GDR recommended dosage | Jing Zhang; Huashan Hospital Affiliated to Fudan University, Promoting clinical skills and clinical innovation in municipal hospitals, a three-year action plan (2020-2022), a major clinical research project | Resistant bacterial infection | | | | |
NCT04210453: The Impact of Vitamin C on Postoperative Acute Kidney Injury in Risk Patients Undergoing Valvular Heart Surgery |
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| Recruiting | 4 | 264 | RoW | Vitamin C, Control (Normal saline) | Yonsei University | Acute Kidney Injury | 12/22 | 12/22 | | |
ChiCTR2100042967: Comparison of Iso-Osmolar Versus Low-Osmolar Contrast Agents on Contrast-Induced Acute Kidney Injury in Patients with Renal Insufficiency |
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| Recruiting | 4 | 1200 | | Iodixanol ;Low-Osmolar iodine Contrast Agents | West China Hospital, Sichuan University; West China Hospital, Sichuan University, Sichuan Red Cross Foundation | contrast-induced Acute kidney injury | | | | |
ChiCTR2100046884: Clinical study on the prevention and treatment of CRRT-associated hypophosphatemia with phosphorus replacement fluid |
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| Recruiting | 4 | 286 | | Supplement sodium glycerophosphate on the basis of conventional replacement fluid ;Conventional replacement fluid | Xinqiao Hospital of Army Medical University; Xinqiao Hospital of Army Medical University, The training program for clinical medical research of the army military medical university | acute kidney injury | | | | |
ChiCTR2100044465: Effects of sodium bicarbonate Ringer injection and sodium lactate Ringer injection on acute renal injury after major abdominal surgery: a randomized, controlled, open-label clinical study |
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| Recruiting | 4 | 3500 | | Sodium Bicarbonate Ringer’s Injection ;Sodium Lactated Ringer’s Injection | Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, China Primary Health Care Foundation | Acute kidney injury | | | | |
2022-002453-25: Study of the effects of sodium-glucose cotransporter 2 inhibitors on kidney function in patients undergoing cardiac surgery Studie naar effect van sodium-glucose cotransporter-2 inhibitoren op nierfunctie in patiënten die een hartoperatie ondergaan |
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| Ongoing | 4 | 784 | Europe | Film-coated tablet, Forxiga | Amsterdam UMC, Netherlands Organisation for Health Research and Development | Cardiac Surgery-Associated Acute Kidney Injury cardiochirurgie geassocieerde nierinsufficiëntie, Kidney failure following cardiac surgery Nierschade optredend na hartoperaties, Diseases [C] - Symptoms and general pathology [C23] | | | | |
| Recruiting | 4 | 3400 | RoW | Sodium Bicarbonate Ringer's Injection, Sodium Lactated Ringer's Injection | Tongji Hospital | Acute Kidney Injury | 06/23 | 08/23 | | |
2022-003000-32: Clinical study on the impact of albumin administration in preventing renal failure after cardiac surgery Studio clinico sull'impatto della somministrazione di albumina 20 % nel prevenire l'insufficienza renale dopo intervento di cardiochirurgia |
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| Not yet recruiting | 4 | 590 | Europe | Concentrate and solvent for concentrate for solution for infusion | Monash University | Acute kidney injury (AKI) is a common complication of cardiac surgery. AKI is defined according to KDIGO criteria in 3 severity stages.KDIGO creatinine-based criteria for diagnosis and staging of AKIStage Serum creatinineI 1.5–1.9 times baseline within 7 days; or = 26.5 µmol/l (= 0.3 mg/dl) increase within 48 hII 2.0–2.9 times baseline within 7 daysIII = 3.0 times baseline within 7 days; or Increase to = 353.6 µmol/l (= 40 mg/dl); or Initiation of renal replacement therapy Danno renale acuto associato alla cardiochirurgia. Il danno renale acuto (AKI) è una complicanza comune della cardiochirurgia. L'AKI è definito in tre stadi di gravità in accordo alle linee guida KDIGO.Creatinina sierica I 1,5-1,9 volte il basale entro 7 giorni; o = aumento di 26,5 µmol/l (= 0,3 mg/dl) entro 48 oreII 2,0–2,9 volte il basale entro 7 giorniIII = 3,0 volte il basale entro 7 giorni; o Aumento a = 353,6 µmol/l (= 40 mg/dl); o Inizio della terapia sostitutiva renale, Acute kidney injury associated with cardiac surgery causes a loss of kidney function and urine production as well as a retention of substances normally eliminated through the urine. Il danno renale acuto associato alla cardiochirurgia causa una perdita della funzionalità renale e della produzione di urine e una ritenzione delle sostanze normalmente eliminiate attraverso le urine., Diseases [C] - Symptoms and general pathology [C23] | | | | |
NCT03522688: Impact of Dexmedetomidine on Acute Kidney Injury Following Living Donor Liver Transplantation |
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| Active, not recruiting | 4 | 214 | RoW | Dexmedetomidine, precedex, Normal saline | Asan Medical Center, Kyongbo Pharmaceutical | Acute Kidney Injury, Liver Diseases | 07/23 | 07/24 | | |
NCT04558359: Renin and Renal Biomarker Response to Angiotensin II |
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| Completed | 4 | 30 | US | Standard of Care, Angiotensin II | Alexander Flannery | Septic Shock, Acute Kidney Injury | 07/23 | 07/23 | | |
RADIAL-CKD, NCT02933892: Benefit of Transradial Approach in Chronic Kidney Disease Population Undergoing Cardiac Catheterization |
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| Recruiting | 4 | 100 | US | Cardiac Catheterization | Texas Tech University Health Sciences Center | Chronic Kidney Disease, Acute Kidney Injury, Heart Disease | 08/24 | 12/24 | | |
| Enrolling by invitation | 4 | 30 | US | Angiotensin II, Norepinephrine, Vasopressin, Epinephrine | University of California, Los Angeles | Cirrhosis, Liver, End Stage Liver DIsease, Acute Kidney Injury, Liver Transplant; Complications | 09/24 | 12/24 | | |
NCT04602767: Low Dose Vasopressin vs Phenylephrine in Cardiac Surgery |
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| Recruiting | 4 | 300 | US | Vasopressin, Pitressin, Phenylephrine, Neosynephrine | Thomas Jefferson University | Acute Kidney Injury | 05/24 | 10/24 | | |
| Completed | 4 | 155 | RoW | Empagliflozin 25 MG, Jardiance 25 mg | University of Sao Paulo General Hospital | Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury | 01/24 | 01/24 | | |
NCT03810417: Preop Digifab in CABG to Reduce Ouabain Levels and Prevent AKI |
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| Completed | 4 | 250 | US | Digoxin Antibodies Fab Fragments, Placebo | University of Maryland, Baltimore | Acute Kidney Injury | 04/24 | 04/24 | | |
| Recruiting | 4 | 200 | US | Ketamine, Propofol | Mayo Clinic | Cardiac Surgery | 12/24 | 12/24 | | |
| Suspended | 4 | 250 | US | Dapagliflozin 10mg Tab | Albert Einstein Healthcare Network | Acute Kidney Injury, Percutaneous Coronary Intervention | 06/25 | 06/25 | | |
| Terminated | 4 | 105 | US | AlloSure, PAXGene | George Washington University, CareDx, VirginiaBio Analytics, LLC | Kidney Injury, Kidney Failure, Kidney Failure, Chronic, Kidney Failure, Acute, Kidney Diseases, Kidney Transplant Rejection, Kidney Transplant Infection, Kidney Transplant; Complications, Kidney Disease, Chronic, Kidney Ischemia | 12/22 | 12/22 | | |
ChiCTR2100052127: Effect of different administration methods of polymyxin E on renal function in patients with severe pulmonary infection. |
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| Not yet recruiting | 4 | 90 | | None ;None | Xinyang Central Hospital; Xinyang Central Hospital, Self-funded and fund financing. | Pulmonary infection | | | | |
PAUSE-CRRT, NCT06229990: Protocol Based-furosemide Stress Test Versus Standard Care to Evaluate Renal Recovery During Continuous Renal Replacement Therapy |
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| Recruiting | 4 | 40 | RoW | Furosemide Injection, Furosemide stress test | Chiang Mai University | Acute Kidney Injury | 06/24 | 06/24 | | |
NCT06154226: Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor |
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| Recruiting | 4 | 100 | US | Pantoprazole, Famotidine | The University of Texas Health Science Center, Houston, Society of Cardiovascular Anesthesiologists | Acute Kidney Injury | 12/24 | 02/25 | | |
| Active, not recruiting | 4 | 140 | RoW | use of florescein | Saglik Bilimleri Universitesi | Contrast-induced Nephropathy, Acute Kidney Injury | 08/24 | 12/24 | | |
| Not yet recruiting | 4 | 156 | RoW | Nafamostat Mesylate, Nafamostat, Nafamostat Mesylate for Injection, NM, Unfractionated Heparin, heparin, UFH | Shen Lei | Sepsis | 04/27 | 04/27 | | |
NCT06108362: Effect of Terlipressin on the Incidence of Early Postoperative Acute Kidney Injury in Liver Transplantation Patients |
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| Recruiting | 4 | 104 | RoW | Terlipressin, Glypressin, normal saline, normal sodium | Beijing Tsinghua Chang Gung Hospital | Acute Kidney Injury, Liver Transplant; Complications | 06/24 | 06/24 | | |
NCT06521697: Effects of Minimal-Flow Sevoflurane and Multimodal Analgesia in Head and Neck Cancer Surgery |
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| Not yet recruiting | 4 | 60 | NA | Multimodal analgesia using dexmedetomidine-ketamine-lidocaine mixture, Multimodal analgesia, Minimal flow sevoflurane | National Taiwan University Hospital | Head and Neck Cancer, Anesthesia, Renal Protection, Acute Kidney Injury, Multimodal Analgesia | 06/25 | 12/25 | | |
| Completed | 4 | 620 | | | Monash Health, Monash Health, Institutional funds from the Department of Surgery, School of Clinical Sciences, Monash University., The Prince of Wales Hospital Foundation, Commonwealth Serum Laboratory (CSL-Behring – Australia) | acute kidney injury, cardiac surgery | | | | |
NCT06570187: The Effect of Dexmedetomidine on the Renal Functions in Septic Critically Ill Patients |
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| Recruiting | 4 | 128 | RoW | Dexmedetomidine, Propofol | Cairo University | Sepsis, Septic Shock, Acute Kidney Injury | 10/26 | 10/26 | | |
NCT06622291: Perioperative Nitric Oxide Prevents Acute Kidney Injury in Acute Type a Aortic Dissection Patients |
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| Enrolling by invitation | 4 | 216 | RoW | Nitric Oxide, Placebo | Beijing Anzhen Hospital | Acute Kidney Injury, Nitrous Oxide, Acute Type a Aortic Dissection | 10/25 | 06/26 | | |
HALT, NCT06535945: Influence of Human Albumin Supplementation on Kidney Dysfunction After Liver Transplantation |
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| Not yet recruiting | 4 | 400 | Europe | Albumin administration | Rennes University Hospital, Ministry of Health, France | Liver Transplantation, Acute Kidney Injury | 06/28 | 06/28 | | |
ChiCTR2300070064: Effificacy of Sodium Tanshinone IIA Sulfonate combined with hydration pretreatment for prevention of contrast-induced acute kidney injury in patients after percutaneous coronary intervention |
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| Not yet recruiting | 4 | 400 | | STS 80 mg,was diluted in 250 mL of 0.9% saline and administered intravenously over 2 hours period before and 3 days after the operation ;only received hydration | The First Affiliated Hospital of He'nan University; The First Affiliated Hospital of He'nan University, None | contrast-induced acute kidney injury | | | | |
ChiCTR2300076484: A cohort study of the protective effect of daglipzin on acute kidney injury after coronary angiography in patients with diabetes mellitus |
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| Not yet recruiting | 4 | 1020 | | None; None | Beijing Hospital; Beijing Hospital, National High Level Hospital Clinical Research Funding | CI-AKI | | | | |
ChiCTR2400079751: Prospective, randomised, controlled, open clinical study of sodium bicarbonate Ringer injection vs saline hydration for the prevention of acute kidney injury after contrast media in patients with chronic kidney disease |
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| Not yet recruiting | 4 | 160 | | hydrated by Sodium bicarbonate Ringer injection; hydrated by saline (medicine) | Department of Emergency, Shandong Provincial Hospital; Shandong Provincial Hospital, Horizontal research | acute kidney injury after contrast media | | | | |
| Recruiting | 4 | 856 | Canada | 20-25% Albumin fluid (100 mL), 0.9% Normal Saline (100 mL) | Ottawa Hospital Research Institute, The Physicians' Services Incorporated Foundation, The Kidney Foundation of Canada, The Ottawa Hospital Academic Medical Organization (TOHAMO) Innovation Fund Grant., Canadian Institutes of Health Research (CIHR), Canadian Blood Services, Héma-Québec | Acute Kidney Injury, Renal Replacement Therapy, Hypotension, Critical Illness | 08/25 | 10/25 | | |
NCT05540184: Allopurinol and Trimetazidine as a Preventive of Acute Kidney Injury in PCI Patients |
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| Recruiting | 4 | 124 | RoW | Trimetazidine 35 mg, Vastarel MR, Allopurinol 300 MG, Zyloric 300mg, Normal saline, 0.9 NS | Beni-Suef University, Cairo University | AKI - Acute Kidney Injury | 09/25 | 09/25 | | |
| Recruiting | 4 | 784 | Europe | Dapagliflozin 10 MG Oral Tablet [Farxiga], Farxiga, SGLT2i, Sodium glucose co-transporter-2 inhibitor, Placebo | Amsterdam UMC, ZonMw: The Netherlands Organisation for Health Research and Development | Acute Kidney Injury, Cardiac Surgery, Sodium-Glucose Transporter 2 Inhibitor | 08/25 | 10/25 | | |
Tinza-SLEDD, NCT03614741: Efficacy, Safety and Pharmacokinetics of Tinzaparin During Slow Low Efficient Daily Dialysis in Intensive Care Patients |
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| Recruiting | 4 | 60 | Europe | Tinzaparin continuous infusion, Tinzaparin bolus | Tampere University Hospital | Acute Kidney Injury, Renal Replacement Therapy, Anticoagulants | 12/25 | 12/25 | | |
NCT05429515: Effect of HFR-SUPRA in the Treatment of Multiple Myeloma-related Acute Kidney Injury |
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| Not yet recruiting | 4 | 50 | NA | HFR-SUPRA, haemodiafiltration with ultrafiltrate regeneration by adsorption on resin, hemodialysis, Chemotherapy | Peking Union Medical College Hospital, Bellco Hoxen Medical (Shanghai) Co., Ltd | Multiple Myeloma, Acute Kidney Injury, Hemodiafiltration With Ultrafiltrate Regeneration (HFR) | 07/32 | 12/32 | | |
ChiCTR2300074837: A clinical study of complications in patients with coronary heart disease |
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| Recruiting | 4 | 300 | | Standard hydration regimen was given before and after angiography according to the guidelines. At the same time, ulinastatin 20wu was given intravenously 1 day before angiography, and ulinastatin 20wu was continued to be given twice a day after angiography for 2 days.; Before angiography, 1000ml of 0.9% sodium chloride injection was administered intravenously (completed within 12 hours); After contrast examination, 1000ml of 0.9% sodium chloride injection was administered (completed within 12 hours) | Chinese PLA General Hospital; Chinese PLA General Hospital, Self-funding | coronary heart disease, contrast-associated acute kidney injury | | | | |
| Recruiting | 3/4 | 200 | | | Dr. Matthew Brain, Alfred Hospital, Alfred Hospital Small Project Grant - $10,000 | Acute Kidney Injury, Renal Replacement Therapy | | | | |
ACTRN12622001467729: Investigating the effect of a new agent on heart disease and kidney function in people who have recovered from acute kidney injury |
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| Recruiting | 3 | 60 | | | The George Institute for Global Health, National Heart Foundation of Australia, The George Institute for Global Health | Heart disease, Acute kidney injury | | | | |
2018-000487-28: ntravenous amino acid therapy for kidney protection in cardiac surgery: a multi-centre randomised blinded placebo controlled clinical trial Amminoacidi endovenosi come nefroprotezione in cardiochirurgia: uno studio multicentrico randomizzato in doppio cieco |
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| Ongoing | 3 | 3500 | Europe | ISOPURAMIN, GLAMIN, [020580155], [032105037], Solution for infusion, ISOPURAMIN - 10 % SOLUZIONE PER INFUSIONE 20 FLACONI 500 ML, GLAMIN - FLACONE 500 ML | OSPEDALE SAN RAFFAELE, Grant Ministeriale | Patients undergoing cardiac surgery at risk for developing acute kidney injury Pazienti sottoposti a intervento di cardiochirurgia a rischio di sviluppare insufficienza renale acuta, Patients undergoing cardiac surgery at risk for developing acute kidney injury Pazienti sottoposti a intervento di cardiochirurgia a rischio di sviluppare insufficienza renale acuta, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
NCT04258423: Everolimus Plus Mycophenolic Acid for Kidney Preservation in Liver Transplant Recipients With Impaired Kidney Function |
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| Terminated | 3 | 4 | US | Tacrolimus, Prograf, Everolimus, Zortress | Indiana University | Kidney Failure | 06/20 | 06/20 | | |
2021-003088-87: Reduction of occurence of Acute Kidney Injury through administration of angiotensin-II Reduktion des Auftretens einer akuten Nierenschädigung durch die Gabe von Glutamin |
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| Not yet recruiting | 3 | 64 | Europe | Concentrate for solution for infusion, GIAPREZA 2.5 mg/ml concentrate for solution for infusion angiotensin II | Westfälische Wilhelms-Universität Münster, Deutsche Forschungsgemeinschaft | Cardiac surgical patients at high risk for AKI Herzchirurgische Patienten mit hohem Risiko für die Entwicklung einer AKI, Cardiac surgical patients at high risk for acute kidney injury Herzchirurgische Patienten mit einem hohen Risiko für die Entwicklung einer akuten Nierenschädigung, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Therapeutic techniques [E02] | | | | |
NCT04655716: Urine Alkalinisation to Prevent AKI in COVID-19 |
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| Active, not recruiting | 3 | 80 | Europe | Sodium Bicarbonate 150Meq/L/D5W Inj, 8.4% sodium bicarbonate intravenous form | Guy's and St Thomas' NHS Foundation Trust | Covid19 | 06/22 | 12/22 | | |
NEB-HF, NCT04465123: Early Sequential Nephron Blockade in Acute Heart Failure Patients: A Randomised, Controlled Study |
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| Recruiting | 3 | 100 | RoW | Spironolactone or hydrochlorothiazide, Aldactone, HCTZ, Thiazide, Placebo | Chiang Mai University | Acute Heart Failure, Acute Kidney Injury | 07/22 | 12/22 | | |
2019-004625-24: Study to Investigate the Efficacy and Safety of Alkaline Phosphatase in Patients With Sepsis-Associated Acute Kidney Injury |
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| Not yet recruiting | 3 | 1600 | Europe, RoW | Recombinant Human Alkaline Phosphatase, recAP, Solution for infusion | AM-Pharma B.V., AM-Pharma B.V. | Sepsis-associated acute kidney injury, Sepsis-associated acute kidney injury, Body processes [G] - Immune system processes [G12] | | | | |
NCT03877081: Effect of Probiotics and Prebiotics in Renal Function in Septic Acute Kidney Injury Patients |
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| Recruiting | 3 | 90 | RoW | Probiotics, Placebo | Hospital Civil de Guadalajara | Acute Kidney Injury, Probiotics, Sepsis | 09/22 | 02/23 | | |
| Completed | 3 | 64 | Europe | Angiotensin II, Control | Westfälische Wilhelms-Universität Münster, German Research Foundation | Cardiac Surgery, Vasoplegia, Hyperreninemia | 12/22 | 03/23 | | |
NCT04685174: Intraoperative NIRS of Transplanted Kidney for Prediction of Acute and Sub-acute Injury |
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| Not yet recruiting | 3 | 60 | NA | Invos Model 5100C Cerebral/Somatic Oximeter | Tel-Aviv Sourasky Medical Center | Graft Failure | 01/23 | 03/23 | | |
NCT03897335: Preventing Acute Kidney Injury (AKI) in Pediatric Patients |
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| Recruiting | 3 | 80 | US | Aminophylline, Placebo, Normal Saline | Le Bonheur Children's Hospital | Acute Kidney Injury | 02/23 | 02/24 | | |
2020-000414-16: Impact of a treatment with angiotensin receptor blocker on outcome after acute kidney injury in patients discharged from the ICU “START-or-NOT trial”.A prospective, randomized, double blinded, multicenter study Impact d’un traitement par inhibiteur des récepteurs de l’angiotensine 2 sur le pronostic après une insuffisance rénale aigue en réanimation. Étude multicentrique, randomisée, en double aveugle. Étude START-or-NOT |
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| Terminated | 3 | 500 | Europe | Coated tablet, IRBESARTAN EG 150 mg | APHP, DGOS | Acute kidney injury Insuffisance rénale, Body processes [G] - Physiological processes [G07] | | | | |
| Active, not recruiting | 3 | 32 | US | Ravulizumab | Brigham and Women's Hospital | Covid19, Thrombotic Microangiopathies, Acute Kidney Injury | 05/23 | 11/23 | | |
GABRIEL, NCT05513807: Graft Acute Kidney Injury: Vitamin B3 to Facilitate Renal Recovery In the Early Life of a Transplant |
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| Completed | 3 | 204 | Europe | Nicotinamide treatment, NICOBION, Placebo treatment | Assistance Publique - Hôpitaux de Paris, Institut National de la Santé Et de la Recherche Médicale, France, Centre National de la Recherche Scientifique, France | Delayed Graft Function | 02/24 | 06/24 | | |
| Recruiting | 3 | 310 | Europe | Nicotinamide treatment, placebo treatment | Centre Hospitalier Universitaire, Amiens, Centre Hospitalier de Dieppe, Centre Hospitalier d'Abbeville, Centre Hospitalier de Laon, University Hospital, Caen, Centre Hospitalier de Cherbourg, University Hospital, Rouen, Centre Hospitalier de Roubaix, Centre Hospitalier de Bethune, Hôpital Saint Philibert, Lomme, Tourcoing Hospital, Centre Hospitalier de Valenciennes, Centre Hospitalier Arras, Centre Hospitalier de Lens, Centre Hospitalier de Calais | Acute Kidney Injury, Septic Shock, Nicotinamide, Mortality | 10/23 | 01/24 | | |
| Recruiting | 3 | 50 | US | Dialysis | Fresenius Medical Care North America | Acute Kidney Injury, ESRD | 11/24 | 03/25 | | |
MGHK23, NCT02836899: Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction. |
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| Active, not recruiting | 3 | 250 | US | Nitric Oxide, Placebo | Massachusetts General Hospital, Ichinose, Fumito, M.D., Ph.D., Massachusetts General Hospital, Kenneth, Shelton, M.D., Massachusetts General Hospital, Kacmarek, Robert M., Ph.D., Massachusetts General Hospital, Sundt, Thoralf M., M.D., Massachusetts General Hospital, Villavicencio-Theoduloz, Mauricio A., M.D., Massachusetts General Hospital, Thompson, Boyd Taylor, M.D., Massachusetts General Hospital, Bonventre, Joseph V., M.D., Brigham Women Hospital, Shann, Kenneth G., Massachusetts General Hospital, Zapol, Warren M., M.D., Marrazzo, Francesco, M.D., Massachusetts General Hospital, Spina, Stefano, M.D., Massachusetts General Hospital, Zadek, Francesco, M.D., Massachusetts General Hospital, Rezoagli, Emanuele, M.D., Massachusetts General Hospital, National Heart, Lung, and Blood Institute (NHLBI) | Acute Kidney Injury | 11/23 | 11/23 | | |
| Completed | 3 | 63 | US | Acute normovolemic hemodilution (ANH) | University of California, Los Angeles | Cardiac Surgery, Acute Kidney Injury, Congenital Heart Disease, Aortic Surgery | 05/23 | 06/23 | | |
| Recruiting | 3 | 272 | Europe | 56 days of weight-adjusted L-Carnitine treatment, 10 days of intravenous placebo (isotonic saline) | Centre Hospitalier Universitaire de Nīmes | Severe Sepsis, Shock, Septic, Acute Kidney Injury | 05/25 | 05/26 | | |
NCT05613361: The Effect of Curcumin Against Colistin-induced Nephrotoxicity |
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| Recruiting | 3 | 214 | RoW | Colistin, Curcumin | October 6 University, Cairo University | Acute Kidney Injury, Drug-Induced Nephropathy | 04/24 | 10/24 | | |
| Recruiting | 3 | 460 | RoW | Paracetamol, Acetyl-Para-Aminophenol (APAP), Acetaminophen, Mechanical antipyresis | University of British Columbia, Mahidol Oxford Tropical Medicine Research Unit, Kinshasa Medical Oxford Research Unit | Severe Malaria, Malaria,Falciparum, Acute Kidney Injury, Paracetamol | 06/24 | 11/25 | | |
NCT06344442: Low-dose Arginine-vasopressin Supplementation on Post-transplant Acute Kidney Injury After Liver Transplantation (AVENIR Trial) |
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| Not yet recruiting | 3 | 304 | Europe | Arginine vasopressin, Norepinephrine | Assistance Publique - Hôpitaux de Paris | Acute Kidney Injury Post Liver Transplantation | 06/26 | 06/26 | | |
| Terminated | 3 | 365 | Europe | Plasmalyte Viaflo, NaCl 0.9% | Assistance Publique - Hôpitaux de Paris | Severe Trauma Patients, Acute Kidney Injury | 08/23 | 08/23 | | |
| Not yet recruiting | 3 | 100 | NA | Desmopressin Injectable Solution, DDAVP, Tranexamic Acid Injectable Product, Cyklokapron, Placebo | Population Health Research Institute | Chronic Kidney Diseases, Acute Kidney Injury, Bleeding, Surgery | 12/25 | 03/26 | | |
NCT04216927: NO During CPB in Neonates to Reduce Risk of AKI |
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| Recruiting | 3 | 40 | US | Nitric Oxide, Oxygen | Children's Hospital Medical Center, Cincinnati, Mallinckrodt, Indiana University | AKI, CHD - Congenital Heart Disease, Surgery | 12/24 | 06/25 | | |
| Recruiting | 3 | 300 | US | Melatonin, Placebo Capsule | Rutgers, The State University of New Jersey | Acute Kidney Injury, Adverse Drug Event | 06/26 | 12/26 | | |
PAN-AKI, NCT06615102: Reducing Cardiac-surgery Associated Acute Kidney Injury Occurence by Administering Angiotensin II |
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| Not yet recruiting | 3 | 1022 | NA | Angiotensin II, Noradrenalin | Universität Münster, German Research Foundation | Cardiac Surgery, Vasoplegia | 01/27 | 04/27 | | |
| Recruiting | 3 | 736 | Europe, Canada, Japan, US, RoW | Placebo, Ravulizumab | Alexion Pharmaceuticals, Inc. | Chronic Kidney Disease, CKD, Cardiac Disease, Cardiopulmonary Bypass | 05/26 | 02/27 | | |
NCT05399537: Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT |
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| Recruiting | 3 | 40 | US | Prismocitrate 18 | Baxter Healthcare Corporation | Regional Citrate Anticoagulation (RCA), Continuous Renal Replacement Therapy (CRRT), Acute Kidney Injury (AKI) | 09/25 | 09/25 | | |
