Translocation, Genetic MOAs

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Phase N/A 1 2 3 4 Products	0	2	4	6	8	10	12	14	16	18	20



Alkylating agent




CD20 inhib




Src kinase inhib




IFNα stim




HDAC3 inhib




PDGFR inhib




c-KIT inhib




CD20 inhib




DNA inhib




GCR agon




FGFR inhib




mTOR inhib




Aurora kinase inhib




Calcineurin inhib




Hedgehog cell-signalling pathway inhib




IMPDH inhib




Immunosuppressant




SMO protein inhib




VEGFR inhib




Apoptosis stim




Aspartate-ammonia ligase inhib




Bone morphogenetic protein receptor type II mod




CD20 inhib




CTLA4 inhib




EPH receptor inhib




Fyn inhib




GM-CSF agon




GM-CSF agon




Histamine release inhib




IGF-1R inhib




Insulin receptor agon




Nerve growth factor inhib




PARP2 inhib




T-cell activation inhib




TIE-2 inhib




mTOR inhib



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