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13 Companies |
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19 Products |
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19 Products |
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22 Mechanisms of Action |
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0 Trials |
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57 News |
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- | Enrollment change, Trial termination, Surgery: Impact of Balanced Slat Colloid HES 130/0.42 on Coagulation Profiles in Patients Undergoing Spinal Cord Tumor Surgery (clinicaltrials.gov) - Apr 20, 2019
P=N/A, N=6, Terminated, Sponsor: Yonsei University
N=70 --> 6 | Recruiting --> Terminated; It ended early because it would not be possible to meet the target number.
- | lapatinib / Generic mfg., temozolomide / Generic mfg.
Trial completion, Trial primary completion date: Dose-Dense Temozolomide + Lapatinib for Recurrent Ependymoma (clinicaltrials.gov) - Sep 28, 2018
P2, N=58, Completed, Sponsor: National Institutes of Health Clinical Center (CC)
N=70 --> 6 | Recruiting --> Terminated; It ended early because it would not be possible to meet the target number. Active, not recruiting --> Completed | Trial primary completion date: Jan 2017 --> Jul 2018
- | Trial completion, Trial completion date: SIOP-LGG-2004: Radiation Therapy or Combination Chemotherapy in Treating Patients With Clinically or Radiologically Progressive Low-Grade Gliomas (clinicaltrials.gov) - Apr 20, 2018
P=N/A, N=3417, Completed, Sponsor: Societe Internationale d'Oncologie Pediatrique
Active, not recruiting --> Completed | Trial primary completion date: Jan 2017 --> Jul 2018 Active, not recruiting --> Completed | Trial completion date: Dec 2017 --> May 2017
- | Avastin (bevacizumab) / Roche
Trial completion, Enrollment change, Trial primary completion date: Bevacizumab and Irinotecan in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade Glioma (clinicaltrials.gov) - Sep 19, 2017
P2, N=97, Completed, Sponsor: National Cancer Institute (NCI)
Active, not recruiting --> Completed | Trial completion date: Dec 2017 --> May 2017 Active, not recruiting --> Completed | N=140 --> 97 | Trial primary completion date: Dec 2010 --> Oct 2015
- | donepezil / Generic mfg.
Trial completion, Phase classification: Donepezil in Treating Young Patients With Primary Brain Tumors Previously Treated With Radiation Therapy to the Brain (clinicaltrials.gov) - Aug 30, 2017
P, N=14, Completed, Sponsor: Wake Forest University Health Sciences
Active, not recruiting --> Completed | N=140 --> 97 | Trial primary completion date: Dec 2010 --> Oct 2015 Active, not recruiting --> Completed | Phase classification: PN/A --> P
- Phase classification: Proton Radiation Therapy for Spinal Tumors (clinicaltrials.gov) - Feb 11, 2017
P=N/A, N=0, Withdrawn, Sponsor: University of Florida
Active, not recruiting --> Completed | Phase classification: PN/A --> P Phase classification: P2 --> P=N/A
- Trial primary completion date: SIOP-LGG-2004: Radiation Therapy or Combination Chemotherapy in Treating Patients With Clinically or Radiologically Progressive Low-Grade Gliomas (clinicaltrials.gov) - Oct 17, 2016
P=N/A, N=3000, Active, not recruiting, Sponsor: Societe Internationale d'Oncologie Pediatrique
Phase classification: P2 --> P=N/A Trial primary completion date: Dec 2015 --> Dec 2017
- Recentin (cediranib) / AstraZeneca
Trial completion, Trial primary completion date: AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors (clinicaltrials.gov) - Mar 7, 2016
P1, N=55, Completed, Sponsor: National Cancer Institute (NCI)
Trial primary completion date: Dec 2015 --> Dec 2017 Active, not recruiting --> Completed | Trial primary completion date: Jan 2012 --> Jul 2015
- ||| Trial completion, Surgery: A Clinical Study of a Spine Fusion System in Vertebral Body Fusion Surgery (clinicaltrials.gov) - Dec 4, 2015
P=N/A, N=106, Completed, Sponsor: Johnson & Johnson Medical (Suzhou) Ltd.
Active, not recruiting --> Completed | Trial primary completion date: Jan 2012 --> Jul 2015 Active, not recruiting --> Completed
- Enrollment change, Trial withdrawal, Trial primary completion date: Proton Radiation Therapy for Spinal Tumors (clinicaltrials.gov) - Aug 25, 2015
P2, N=0, Withdrawn, Sponsor: University of Florida
Active, not recruiting --> Completed N=34 --> 0 | Recruiting --> Withdrawn | Trial primary completion date: May 2025 --> Aug 2015
- Trial primary completion date: SIOP-LGG-2004: Radiation Therapy or Combination Chemotherapy in Treating Patients With Clinically or Radiologically Progressive Low-Grade Gliomas (clinicaltrials.gov) - Jun 16, 2015
P=N/A, N=3000, Active, not recruiting, Sponsor: Societe Internationale d'Oncologie Pediatrique
N=34 --> 0 | Recruiting --> Withdrawn | Trial primary completion date: May 2025 --> Aug 2015 Trial primary completion date: Dec 2014 --> Dec 2015
- Trial primary completion date, Surgery: Minimally Invasive Surgery in Treating Patients With Spinal Tumors (clinicaltrials.gov) - Jun 11, 2015
P=N/A, N=7, Terminated, Sponsor: City of Hope Medical Center
Trial primary completion date: Dec 2014 --> Dec 2015 Trial primary completion date: Mar 2015 --> Jun 2014
- | emvododstat (PTC299) / PTC Therap
Trial completion, Trial primary completion date: PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors (clinicaltrials.gov) - May 4, 2015
P1, N=28, Completed, Sponsor: Pediatric Brain Tumor Consortium
Trial primary completion date: Mar 2015 --> Jun 2014 Suspended --> Completed | Trial primary completion date: May 2012 --> Jan 2015
- |||| erlotinib / Generic mfg.
Trial completion: Erlotinib and Radiation Therapy in Treating Young Patients With Newly Diagnosed Glioma (clinicaltrials.gov) - May 2, 2015
P1/2, N=62, Completed, Sponsor: St. Jude Children's Research Hospital
Suspended --> Completed | Trial primary completion date: May 2012 --> Jan 2015 Active, not recruiting --> Completed
- Enrollment closed, Enrollment open, Surgery: A Clinical Study of a Spine Fusion System in Vertebral Body Fusion Surgery (clinicaltrials.gov) - Mar 20, 2015
P=N/A, N=106, Active, not recruiting, Sponsor: Johnson & Johnson Medical (Suzhou) Ltd.
Active, not recruiting --> Completed Recruiting --> Active, not recruiting
- Trial completion, Surgery: A Phase I/II Study of the Photon Radiosurgery System (clinicaltrials.gov) - Mar 2, 2015
P1/2, N=35, Completed, Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago
Recruiting --> Active, not recruiting Recruiting --> Completed
- lapatinib / Generic mfg., temozolomide / Generic mfg.
Trial primary completion date: Dose-Dense Temozolomide + Lapatinib for Recurrent Ependymoma (clinicaltrials.gov) - Dec 10, 2014
P2, N=50, Active, not recruiting, Sponsor: M.D. Anderson Cancer Center
Recruiting --> Completed Trial primary completion date: Jan 2015 --> Jan 2016
- Enrollment closed, Trial primary completion date: SIOP-LGG-2004: Radiation Therapy or Combination Chemotherapy in Treating Patients With Clinically or Radiologically Progressive Low-Grade Gliomas (clinicaltrials.gov) - Nov 20, 2014
P=N/A, N=3000, Active, not recruiting, Sponsor: Societe Internationale d'Oncologie Pediatrique
Trial primary completion date: Jan 2015 --> Jan 2016 Recruiting --> Active, not recruiting | Trial primary completion date: Apr 2012 --> Dec 2014
- Surgery: A Clinical Study of a Spine Fusion System in Vertebral Body Fusion Surgery (clinicaltrials.gov) - Sep 30, 2014
P=N/A, N=106, Recruiting, Sponsor: Johnson & Johnson Medical (Suzhou) Ltd.
- Trial primary completion date: Proton Radiation Therapy for Spinal Tumors (clinicaltrials.gov) - Sep 28, 2014
P2, N=34, Recruiting, Sponsor: University of Florida
Recruiting --> Active, not recruiting | Trial primary completion date: Apr 2012 --> Dec 2014 Trial primary completion date: May 2024 --> May 2025
- Enrollment change: Talotrexin in Treating Young Patients With Recurrent Solid Tumors or Leukemia That is Recurrent or Does Not Respond to Treatment (clinicaltrials.gov) - Aug 8, 2014
P1, N=0, Withdrawn, Sponsor: Children's Oncology Group
Trial primary completion date: May 2024 --> May 2025 N=36 --> 0
- Enrollment change, Trial primary completion date: Valproic Acid in Treating Young Patients With Recurrent or Refractory Solid Tumors or CNS Tumors (clinicaltrials.gov) - Aug 7, 2014
P1, N=26, Completed, Sponsor: Children's Oncology Group
N=36 --> 0 N=18 --> 26 | Trial primary completion date: Sep 2011 --> Oct 2007
- | Trial completion: Valproic Acid in Treating Young Patients With Recurrent or Refractory Solid Tumors or CNS Tumors (clinicaltrials.gov) - Aug 5, 2014
P1, N=26, Completed, Sponsor: Children's Oncology Group
N=18 --> 26 | Trial primary completion date: Sep 2011 --> Oct 2007 Active, not recruiting --> Completed
- Enrollment open, Trial primary completion date, Surgery: Impact of Balanced Slat Colloid HES 130/0.42 on Coagulation Profiles in Patients Undergoing Spinal Cord Tumor Surgery (clinicaltrials.gov) - Jul 30, 2014
P=N/A, N=70, Recruiting, Sponsor: Yonsei University
Active, not recruiting --> Completed Not yet recruiting --> Recruiting | Trial primary completion date: Jul 2014 --> Jul 2015
- Trial termination, Surgery: Minimally Invasive Surgery in Treating Patients With Spinal Tumors (clinicaltrials.gov) - Jul 8, 2014
P=N/A, N=7, Terminated, Sponsor: City of Hope Medical Center
Not yet recruiting --> Recruiting | Trial primary completion date: Jul 2014 --> Jul 2015 Recruiting --> Terminated; Lack of subject response
- Enrollment change, Trial termination, Surgery: Minimally Invasive Surgery in Treating Patients With Spinal Tumors (clinicaltrials.gov) - Jul 8, 2014
P=N/A, N=7, Terminated, Sponsor: City of Hope Medical Center
Recruiting --> Terminated; Lack of subject response N=30 --> 7 | Recruiting --> Terminated; Lack of subject response
- ||| carboplatin / Generic mfg., temozolomide / Generic mfg., vincristine / Generic mfg.
Trial completion: Carboplatin, Vincristine, and Temozolomide in Treating Children With Progressive and/or Symptomatic Low-Grade Glioma (clinicaltrials.gov) - Jul 2, 2014
P=N/A, N=66, Completed, Sponsor: Children's Oncology Group
N=30 --> 7 | Recruiting --> Terminated; Lack of subject response Active, not recruiting --> Completed
- veliparib (ABT-888) / AbbVie
Trial completion, PARP Biomarker: ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors (clinicaltrials.gov) - Jun 19, 2014
P1, N=31, Completed, Sponsor: National Cancer Institute (NCI)
Active, not recruiting --> Completed Active, not recruiting --> Completed
- veliparib (ABT-888) / AbbVie
Enrollment change, PARP Biomarker: ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors (clinicaltrials.gov) - Apr 20, 2014
P1, N=31, Active, not recruiting, Sponsor: National Cancer Institute (NCI)
Active, not recruiting --> Completed N=24 --> 31
- Avastin (bevacizumab) / Roche
Enrollment change: Bevacizumab and Irinotecan in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade Glioma (clinicaltrials.gov) - Apr 20, 2014
P2, N=140, Active, not recruiting, Sponsor: National Cancer Institute (NCI)
N=24 --> 31 N=97 --> 140
- | Trial completion: Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors (clinicaltrials.gov) - Apr 13, 2014
P1, N=94, Completed, Sponsor: Children's Oncology Group
N=97 --> 140 Recruiting --> Completed
- erlotinib / Generic mfg.
Enrollment change: Erlotinib and Radiation Therapy in Treating Young Patients With Newly Diagnosed Glioma (clinicaltrials.gov) - Mar 26, 2014
P1/2, N=62, Active, not recruiting, Sponsor: St. Jude Children's Research Hospital
Recruiting --> Completed N=80 --> 62
- | megestrol / Generic mfg.
Trial completion: Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment (clinicaltrials.gov) - Feb 22, 2014
P2, N=70, Completed, Sponsor: University of South Florida
N=80 --> 62 Active, not recruiting --> Completed
- | Istodax (romidepsin) / Astellas, BMS
Trial completion: FR901228 in Treating Children With Refractory or Recurrent Solid Tumors or Leukemia (clinicaltrials.gov) - Feb 22, 2014
P1, N=30, Completed, Sponsor: National Cancer Institute (NCI)
Active, not recruiting --> Completed No longer recruiting --> Completed
- | temozolomide / Generic mfg.
Trial completion, Surgery: Chemotherapy and Radiation Therapy After Surgery in Treating Children With Newly Diagnosed Astrocytoma, Glioblastoma Multiforme, Gliosarcoma, or Diffuse Intrinsic Pontine Glioma (clinicaltrials.gov) - Feb 22, 2014
P2, N=170, Completed, Sponsor: Children's Oncology Group
No longer recruiting --> Completed Active, not recruiting --> Completed
- | Zokinvy (lonafarnib) / Eiger
Trial completion: SCH 66336 in Treating Children With Recurrent or Progressive Brain Tumors (clinicaltrials.gov) - Feb 19, 2014
P1, N=53, Completed, Sponsor: Pediatric Brain Tumor Consortium
Active, not recruiting --> Completed No longer recruiting --> Completed
- lapatinib / Generic mfg., temozolomide / Generic mfg.
Enrollment closed: Dose-Dense Temozolomide + Lapatinib for Recurrent Ependymoma (clinicaltrials.gov) - Dec 8, 2013
P2, N=50, Active, not recruiting, Sponsor: M.D. Anderson Cancer Center
No longer recruiting --> Completed Recruiting --> Active, not recruiting
- || carboplatin / Generic mfg., temozolomide / Generic mfg., vincristine / Generic mfg.
Enrollment closed: Carboplatin, Vincristine, and Temozolomide in Treating Children With Progressive and/or Symptomatic Low-Grade Glioma (clinicaltrials.gov) - Oct 24, 2013
P=N/A, N=66, Active, not recruiting, Sponsor: Children's Oncology Group
Recruiting --> Active, not recruiting Completed --> Active, not recruiting
- Enrollment open: Proton Radiation Therapy for Spinal Tumors (clinicaltrials.gov) - Jun 20, 2013
P2, N=34, Recruiting, Sponsor: University of Florida
Completed --> Active, not recruiting Not yet recruiting --> Recruiting
- RG4733 / Roche
Trial termination: Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia (clinicaltrials.gov) - Apr 30, 2013
P1/2, N=129, Terminated, Sponsor: National Cancer Institute (NCI)
Not yet recruiting --> Recruiting Active, not recruiting --> Terminated
- || carboplatin / Generic mfg., temozolomide / Generic mfg., vincristine / Generic mfg.
Enrollment change: Carboplatin, Vincristine, and Temozolomide in Treating Children With Progressive and/or Symptomatic Low-Grade Glioma (clinicaltrials.gov) - Mar 6, 2013
P=N/A, N=66, Active, not recruiting, Sponsor: Children's Oncology Group
Active, not recruiting --> Terminated N=50 --> 66
- donepezil / Generic mfg.
Enrollment change: Donepezil in Treating Young Patients With Primary Brain Tumors Previously Treated With Radiation Therapy to the Brain (clinicaltrials.gov) - Jan 23, 2013
P=N/A, N=14, Active, not recruiting, Sponsor: Comprehensive Cancer Center of Wake Forest University
N=50 --> 66 N=35 --> 14
- Trial termination: APPROACH-001: Bone Graft Materials Observational Registry (clinicaltrials.gov) - Jan 16, 2013
P=N/A, N=329, Terminated, Sponsor: Apatech, Inc.
N=35 --> 14 Recruiting --> Terminated; Parent sponsor company (Baxter Healthcare) company cut funding
- veliparib (ABT-888) / AbbVie
Enrollment closed, PARP Biomarker: ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors (clinicaltrials.gov) - Jan 10, 2013
P1, N=31, Active, not recruiting, Sponsor: National Cancer Institute (NCI)
Recruiting --> Terminated; Parent sponsor company (Baxter Healthcare) company cut funding Recruiting --> Active, not recruiting
- Recentin (cediranib) / AstraZeneca
Enrollment closed: AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors (clinicaltrials.gov) - Nov 8, 2012
P1, N=52, Active, not recruiting, Sponsor: National Cancer Institute (NCI)
Recruiting --> Active, not recruiting Completed --> Active, not recruiting
- Trial withdrawal, Surgery: Robotic-Assisted Surgery in Treating Patients With Spine Tumors (clinicaltrials.gov) - Nov 7, 2012
P=N/A, N=0, Withdrawn, Sponsor: City of Hope Medical Center
Completed --> Active, not recruiting Not yet recruiting --> Withdrawn
- Enrollment change, Surgery: Robotic-Assisted Surgery in Treating Patients With Spine Tumors (clinicaltrials.gov) - Nov 7, 2012
P=N/A, N=0, Withdrawn, Sponsor: City of Hope Medical Center
Not yet recruiting --> Withdrawn N=10 --> 0
- Zolinza (vorinostat) / Merck (MSD)
Trial completion: Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors (clinicaltrials.gov) - Oct 23, 2012
P1, N=27, Completed, Sponsor: National Cancer Institute (NCI)
N=10 --> 0 Active, not recruiting --> Completed
- Trial termination, Surgery, Metastases: Beta-Tricalcium Phosphate Bone Graft in Treating Patients Undergoing Surgery For Metastatic Spine Cancer (clinicaltrials.gov) - Aug 9, 2012
P1, N=1, Terminated, Sponsor: University of Southern California
Active, not recruiting --> Completed Recruiting --> Terminated; Lack of funding
- Enrollment change, Surgery, Metastases: Beta-Tricalcium Phosphate Bone Graft in Treating Patients Undergoing Surgery For Metastatic Spine Cancer (clinicaltrials.gov) - Aug 9, 2012
P1, N=1, Terminated, Sponsor: University of Southern California
Recruiting --> Terminated; Lack of funding N=20 --> 1