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51 Mechanisms of Action

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|||||||||| New P2 trial: Quit Smoking With Nicotine Patch and Exercise/Health Education (Females Only) (clinicaltrials.gov) - Jan 17, 2012
P2, N=164, Recruiting, Sponsor: Brown University

|||||||||| Enrollment closed: Curbing Tobacco Use in Suburban and Rural Schools (clinicaltrials.gov) - Jan 10, 2012
P1, N=2384, Active, not recruiting, Sponsor: M.D. Anderson Cancer Center
Recruiting --> Active, not recruiting

||||||||||  Chantix (varenicline) / Pfizer
New P2 trial:  Effects of Varenicline on Smoking Reminders (clinicaltrials.gov) -  Jan 9, 2012
P2, N=60, Recruiting,  Sponsor: University of Pennsylvania

|||||||||| Enrollment open: Adolescent Smoking Cessation in Pediatric Primary Care (clinicaltrials.gov) - Jan 9, 2012
P=N/A, N=8160, Recruiting, Sponsor: American Academy of Pediatrics
Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting

|||||||||| Trial initiation date: Impact of a Gene Test for Susceptibility to Lung Cancer in Smokers (clinicaltrials.gov) - Jan 5, 2012
P=N/A, N=80, Recruiting, Sponsor: University of Surrey
Not yet recruiting --> Recruiting Initiation date: Oct 2010 --> Sep 2011

|||||||||| Enrollment open: Impact of a Gene Test for Susceptibility to Lung Cancer in Smokers (clinicaltrials.gov) - Jan 5, 2012
P=N/A, N=80, Recruiting, Sponsor: University of Surrey
Initiation date: Oct 2010 --> Sep 2011 Not yet recruiting --> Recruiting

|||||||||| Trial withdrawal: Nicotinic Receptor Density in Smoking and Nonsmoking Schizophrenics (clinicaltrials.gov) - Dec 29, 2011
P=N/A, N=0, Withdrawn, Sponsor: National Institute on Drug Abuse (NIDA)
Not yet recruiting --> Recruiting Completed --> Withdrawn

|||||||||| Enrollment change: Nicotinic Receptor Density in Smoking and Nonsmoking Schizophrenics (clinicaltrials.gov) - Dec 29, 2011
P=N/A, N=0, Withdrawn, Sponsor: National Institute on Drug Abuse (NIDA)
Completed --> Withdrawn N=30 --> 0

|||||||||| Enrollment closed: 'Questions About Quitting' Smoking Cessation Trial (clinicaltrials.gov) - Dec 22, 2011
P=N/A, N=1865, Active, not recruiting, Sponsor: Group Health Cooperative
N=30 --> 0 Recruiting --> Active, not recruiting

||||||||||  Chantix (varenicline) / Pfizer
Enrollment closed:  An Alternative Dosing Schedule of Varenicline for Smoking Cessation (clinicaltrials.gov) -  Dec 21, 2011
P2, N=60, Active, not recruiting,  Sponsor: Roswell Park Cancer Institute
Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting

|||||||||| Trial completion: Mindfulness and Cancer Mamma - Clinical Trial MBSR Among Women Operated for Breast Cancer (clinicaltrials.gov) - Dec 21, 2011
P2/3, N=336, Completed, Sponsor: Danish Cancer Society
Recruiting --> Active, not recruiting Active, not recruiting --> Completed

|||||||||| New P1/2 trial: SSTOP: Smoking Cessation Intervention for Diabetic Patients (clinicaltrials.gov) - Dec 20, 2011
P1/2, N=72, Recruiting, Sponsor: Rhode Island Hospital

||||||||||  Chantix (varenicline) / Pfizer
Enrollment open:  EAGLES: Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders (clinicaltrials.gov) -  Dec 20, 2011
P4, N=8000, Recruiting,  Sponsor: Pfizer
Active, not recruiting --> Completed Not yet recruiting --> Recruiting

|||||||||| Trial completion: Smoking Research Study (clinicaltrials.gov) - Dec 19, 2011
P=N/A, N=88, Completed, Sponsor: Philip Morris Products S.A.
Not yet recruiting --> Recruiting Recruiting --> Completed

|||||||||| Trial completion: A Novel Treatment to Boost Quit Attempts and Cessation Among Unmotivated Smokers (clinicaltrials.gov) - Dec 7, 2011
P=N/A, N=849, Completed, Sponsor: Medical University of South Carolina
Recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion: Group Counseling for Smoking Cessation (clinicaltrials.gov) - Dec 6, 2011
P1/2, N=240, Completed, Sponsor: American University
Active, not recruiting --> Completed No longer recruiting --> Completed

|||||||||| Trial completion: Study to Evaluate the Safety and Efficacy of Dietary Supplement Anatabloc in Reducing Daily Smokers' Urge to Smoke (clinicaltrials.gov) - Dec 4, 2011
P1, N=109, Completed, Sponsor: Rock Creek Pharmaceuticals, Inc.
No longer recruiting --> Completed Active, not recruiting --> Completed

|||||||||| New P1 trial: DDAT: SPECT Imaging of DAT Genotype (clinicaltrials.gov) - Dec 1, 2011
P1, N=40, Recruiting, Sponsor: University of Pennsylvania

||||||||||  methylphenidate prolonged release tablet - 12 hrs acting / Generic mfg.
Enrollment change:  Prevention of Cigarette Smoking in Attention Deficit Hyperactivity Disorder (ADHD) Youth With Concerta (clinicaltrials.gov) -  Nov 30, 2011
P4, N=203, Completed,  Sponsor: Massachusetts General Hospital
Active, not recruiting --> Completed N=164 --> 203

|||||||||| New P2 trial: Substance Treatment and HIV Testing and Referral System (clinicaltrials.gov) - Nov 30, 2011
P2, N=140, Not yet recruiting, Sponsor: Polaris Health Directions

|||||||||| New P2 trial: Interactive Voice Response Technology to Mobilize Contingency Management for Smoking Cessation (clinicaltrials.gov) - Nov 30, 2011
P2, N=90, Recruiting, Sponsor: University of Connecticut Health Center

|||||||||| Enrollment open: Emergency Department Smoking Cessation Study (clinicaltrials.gov) - Nov 30, 2011
P=N/A, N=924, Recruiting, Sponsor: University of British Columbia
N=164 --> 203 Not yet recruiting --> Recruiting

|||||||||| Enrollment closed: Impact of Smoking Cessation and ?-Tocopherol to Restore Vascular Endothelial Function (clinicaltrials.gov) - Nov 29, 2011
P1/2, N=67, Active, not recruiting, Sponsor: University of Connecticut
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting

||||||||||  bupropion / Generic mfg.
Trial completion:  Smoking Cessation Medications: Efficacy, Mechanisms and Algorithms (clinicaltrials.gov) -  Nov 28, 2011
P4, N=1504, Completed,  Sponsor: University of Wisconsin, Madison
Recruiting --> Active, not recruiting Active, not recruiting --> Completed

||||||||||  bupropion / Generic mfg.
Trial completion:  Smoking Cessation Intervention: Effectiveness in Primary Care (clinicaltrials.gov) -  Nov 28, 2011
P4, N=1346, Completed,  Sponsor: University of Wisconsin, Madison
Active, not recruiting --> Completed Active, not recruiting --> Completed

||||||||||  Chantix (varenicline) / Pfizer
Enrollment change:  Varenicline Effects on Cue Reactivity and Smoking Reward/Reinforcement (clinicaltrials.gov) -  Nov 27, 2011
P=N/A, N=163, Completed,  Sponsor: H. Lee Moffitt Cancer Center and Research Institute
Active, not recruiting --> Completed N=106 --> 163

||||||||||  Chantix (varenicline) / Pfizer
Trial completion:  Varenicline Effects on Cue Reactivity and Smoking Reward/Reinforcement (clinicaltrials.gov) -  Nov 27, 2011
P=N/A, N=163, Completed,  Sponsor: H. Lee Moffitt Cancer Center and Research Institute
N=106 --> 163 Active, not recruiting --> Completed

||||||||||  encenicline (EVP-6124) / Forum Pharmaceuticals, Mitsubishi Tanabe
New P2 trial:  A Safety and Cognitive Function Study of EVP-6124 Versus Placebo in Subjects With Nicotine Dependence (clinicaltrials.gov) -  Nov 24, 2011
P2, N=450, Recruiting,  Sponsor: A. Eden Evins

|||||||||| Trial completion: Effect of Stress-management and Biofeedback on Craving in Smoking Abstinence: A Pilot Study (clinicaltrials.gov) - Nov 24, 2011
P2, N=40, Completed, Sponsor: University Hospital, Ghent
Active, not recruiting --> Completed Not yet recruiting --> Completed

||||||||||  Chantix (varenicline) / Pfizer
Enrollment change:  Smoke-Free Living Study (clinicaltrials.gov) -  Nov 22, 2011
P1, N=100, Completed,  Sponsor: University of British Columbia
Not yet recruiting --> Completed N=81 --> 100

||||||||||  Chantix (varenicline) / Pfizer
Trial completion:  Smoke-Free Living Study (clinicaltrials.gov) -  Nov 22, 2011
P1, N=100, Completed,  Sponsor: University of British Columbia
N=81 --> 100 Recruiting --> Completed

|||||||||| New P1 trial: Safety and Pharmacodynamics of SEL-068 Vaccine in Smokers and Non-Smokers (clinicaltrials.gov) - Nov 21, 2011
P1, N=80, Active, not recruiting, Sponsor: Selecta Biosciences, Inc.

||||||||||  Hetlioz (tasimelteon) / Vanda
New P1 trial:  Effects of Smoking, Age and Body Size on Pharmacokinetics, Safety and Tolerability on Tasimelteon in Healthy Subjects (clinicaltrials.gov) -  Nov 20, 2011
P1, N=60, Completed,  Sponsor: Vanda Pharmaceuticals

||||||||||  Chantix (varenicline) / Pfizer
New P4 trial:  Sympathovagal Balance in Smoking Cessation (clinicaltrials.gov) -  Nov 16, 2011
P4, N=85, Active, not recruiting,  Sponsor: Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH

|||||||||| New P4 trial: Emerging Adults Who Use Alcohol and Marijuana (clinicaltrials.gov) - Nov 15, 2011
P4, N=500, Recruiting, Sponsor: Butler Hospital

||||||||||  aspirin / Generic mfg., clopidogrel / Generic mfg., prasugrel / Generic mfg.
Trial completion:  The Influence of Smoking Status on Prasugrel and Clopidogrel Treated Subjects Taking Aspirin and Having Stable Coronary Artery Disease (clinicaltrials.gov) -  Nov 8, 2011
P4, N=110, Completed,  Sponsor: Daiichi Sankyo Inc.
Recruiting --> Completed Recruiting --> Completed

||||||||||  Chantix (varenicline) / Pfizer
Enrollment open:  Varenicline In-Patient Study (clinicaltrials.gov) -  Nov 7, 2011
P2, N=80, Recruiting,  Sponsor: Stanford University
Recruiting --> Completed Not yet recruiting --> Recruiting

||||||||||  budesonide / Generic mfg.
Trial completion:  Budesonide in Treating Patients With Lung Nodules at High Risk of Developing Lung Cancer (clinicaltrials.gov) -  Nov 3, 2011
P2, N=225, Completed,  Sponsor: M.D. Anderson Cancer Center
Not yet recruiting --> Recruiting Active, not recruiting --> Completed

|||||||||| Trial completion: The Effectiveness of Smoking Cessation Guidelines in the Emergency Department (clinicaltrials.gov) - Nov 2, 2011
P=N/A, N=789, Completed, Sponsor: University of Iowa
Active, not recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Enrollment change: Tobacco Cessation Via Doctors of Chiropractic (clinicaltrials.gov) - Oct 24, 2011
P=N/A, N=201, Completed, Sponsor: Oregon Research Institute
Active, not recruiting --> Completed N=1530 --> 201

|||||||||| Trial completion: Tobacco Quitlines:Adjunct to Dental Office Tobacco Intervention (clinicaltrials.gov) - Oct 24, 2011
P2, N=2177, Completed, Sponsor: Oregon Research Institute
N=1530 --> 201 Recruiting --> Completed

|||||||||| New P1 trial, Metastases: Enhanced Quitline Intervention in Smoking Cessation for Patients With Non-Metastatic Lung Cancer (clinicaltrials.gov) - Oct 20, 2011
P1, N=10, Active, not recruiting, Sponsor: Comprehensive Cancer Center of Wake Forest University

|||||||||| Trial completion: Physiological, Cognitive and Cerebral Activity Changes as a Function of Cigarette Smoking (With or Without Nicotine) and Tobacco Abstinence (clinicaltrials.gov) - Oct 20, 2011
P=N/A, N=125, Completed, Sponsor: National Institute on Drug Abuse (NIDA)
Recruiting --> Completed Recruiting --> Completed

|||||||||| Trial completion: PHD2: Tobacco Cessation Via Public Health Dental Clinics (clinicaltrials.gov) - Oct 20, 2011
P2, N=2637, Completed, Sponsor: Oregon Research Institute
Recruiting --> Completed Active, not recruiting --> Completed

|||||||||| Trial completion: Tobacco Cessation Via Doctors of Chiropractic (clinicaltrials.gov) - Oct 20, 2011
P=N/A, N=201, Completed, Sponsor: Oregon Research Institute
Active, not recruiting --> Completed Recruiting --> Completed

||||||||||  Chantix (varenicline) / Pfizer
New P4 trial:  EAGLES: Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders (clinicaltrials.gov) -  Oct 19, 2011
P4, N=8000, Recruiting,  Sponsor: Pfizer

|||||||||| Enrollment closed: Supplemental Nicotine Administration for Smoking Cessation in Posttraumatic Stress Disorder (PTSD) (clinicaltrials.gov) - Oct 18, 2011
P=N/A, N=81, Active, not recruiting, Sponsor: Duke University
Recruiting --> Completed Recruiting --> Active, not recruiting

|||||||||| New P1 trial: Cell Phone-Based Expert Systems for Smoking Cessation (clinicaltrials.gov) - Oct 17, 2011
P1, N=446, Completed, Sponsor: VA Pacific Islands Health Care System

||||||||||  Chantix (varenicline) / Pfizer
Trial completion:  Combination of Nicotine Replacement Therapy (NRT) and Varenicline to Increase Cessation of Tobacco (CONVICT Study) (clinicaltrials.gov) -  Oct 17, 2011
P3, N=117, Completed,  Sponsor: Queen Mary University of London
Recruiting --> Active, not recruiting Recruiting --> Completed

|||||||||| New P2 trial: Development of Positive Psychotherapy for Smoking Cessation (clinicaltrials.gov) - Oct 12, 2011
P2, N=80, Active, not recruiting, Sponsor: Brown University