Sjogren's Syndrome News

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|||||||||| PRIMARY SJOGREN'S SYNDROME () - May 29, 2024 - Abstract #EULAR2024EULAR_3118;
The presence of joint symptoms shortens the patient's path to the specialist rheumatologist. Multidisciplinary training of family physicians is necessary for timely diagnosis of primary Sjogren's syndrome.

|||||||||| PREVALENCE OF MALIGNANCIES IN PATIENTS WITH SJOGREN'S SYNDROME OVER A 10-YEAR PERIOD, DATA FROM THE GIRRCS ITALIAN COHORT () - May 29, 2024 - Abstract #EULAR2024EULAR_3117;
Notably, a high ESSDAI value and increased levels of gamma globulins were identified as associated with lymphomas and also with solid malignancies diagnosis. RF presence was significantly associated with MGUS presence but not with lymphoma diagnosis.

|||||||||| PREVALENCE AND SIGNIFICANCE OF NAILFOLD CAPILLAROSCOPY ABNORMALITIES IN PRIMARY SJOGREN'S SYNDROME COMPARED TO PRIMARY RAYNAUD PHENOMENON () - May 29, 2024 - Abstract #EULAR2024EULAR_3116;
Microvascular abnormalities were more common in patients with pSS compared to those with primary RP. pSS patients with microvascular abnormalities had more RP, anti-Ro52, ILD, and impaired lung function.

|||||||||| PREMATURE CEREBROVASCULAR EVENTS IN PRIMARY SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3115;
Our results suggest that screening for pSS in patients with stroke may be useful. Table 1.

|||||||||| PRELIMINARY DATA ON THE PREVALENCE OF PRIMARY SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3114;
Vaginal dryness seems to be uncommon in premenopausal women. In nearly half of the premenopausal women experiencing vaginal sicca symptoms or clinical signs of vaginal dryness, the diagnosis of Sj

|||||||||| Orencia (abatacept) / BMS, Bredinin (mizoribine) / Asahi Kasei, Lee's Pharm
POWER DOPPLER AND GREYSCALE CHANGES ON SALIVARY GLAND ULTRASONOGRAPHY IN SJOGREN'S DISEASE: AN OBSERVATIONAL STUDY () - May 29, 2024 - Abstract #EULAR2024EULAR_3113;
PDs correlated with ESSDAI, SSFR, SWE, and SWV. PDs presence suggests the possibility of future salivary gland structural changes.

|||||||||| MOLECULAR PROFILING OF AN EASTERN MEDITERRANEAN FAMILY REVEALS NOT ONLY KNOWN BUT ALSO NEW CANDIDATE GENETIC RISK FOR AUTOIMMUNE DISEASES () - May 29, 2024 - Abstract #EULAR2024EULAR_3110;
PRDM1, a transcription factor regulated by IRF5, has been implicated in primary SjS. In addition, RBMS3 is thought to be a new susceptibility gene for primary SjS.

|||||||||| MOLECULAR AND CELLULAR INSIGHTS OF B CELL LYMPHOMA IN PATIENTS WITH SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3109;
Digital cytometry identified differences between immune cell populations within the blood samples. Further investigation is needed to expand our understanding of the molecular mechanisms that contribute to B-cell lymphoma.

|||||||||| MICRORNAS AS POTENTIAL BIOMARKERS FOR SUBCLINICAL ATHEROSCLEROSIS IN PRIMARY SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3108;
In addition, miR-92a-3p may act as a potential biomarker for atherosclerosis and increased cardiovascular risk in pSS, as miR-92a-3p levels are elevated and correlate significantly with increased cIMT. Figure 1.

|||||||||| LINE IMMUNOASSAY VERSUS CHEMILUMINESCENCE ASSAY AND MULTIPLEXED BEAD IMMUNOASSAY FOR DETECTION OF ANTI-RO AND ANTI-LA ANTIBODIES () - May 29, 2024 - Abstract #EULAR2024EULAR_3107;
Figure 1. Automated quantitative assays, CLIA and MBI, are potential alternatives to LIA in the detection of anti-Ro and anti-La antibodies in patients with pSS.

|||||||||| KLRB1 EXPRESSION SIGNIFIES CD4+ T CELL ACTIVATION AND IS HEIGHTENED IN PRIMARY SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3105;
Automated quantitative assays, CLIA and MBI, are potential alternatives to LIA in the detection of anti-Ro and anti-La antibodies in patients with pSS. KLRB1 serves as a distinctive marker of CD4+ T cell activation phenotype, and its heightened expression within CD4+ T cells of pSS patients implies its potential role in pSS pathogenesis and its potential as a supplementary diagnostic indicator for pSS.

|||||||||| KIDNEY INVOLVEMENT AND PROGRESSION IN PATIENTS WITH SYSTEMIC SCLEROSIS AND ISOLATED SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3104;
This preliminary study also highlights slight differences in renal involvement and its progression between the two groups considered. In SSc patients, creatinine levels at T0 are, on average, lower than in pSS patients possibly linked to their reduced muscle mass.

|||||||||| INVESTIGATING PERIPHERAL MICROCIRCULATION IN JUVENILE SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3103;
The reduction of capillary density, as well as microhaemorrhages at NVC analysis, are significantly associated with some clinical aspects like articular involvement and serum biomarkers (C3 reduction). The NVC is suggested as safe and further analysis in jSjS patients.

|||||||||| Kineret (anakinra) / SOBI, Ilaris (canakinumab) / Novartis
IL-1 PATHWAY IN SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3102;
at ductal epithelial cell level is quite interesting and worth of further investigation. In addition, the indirect evidence of an alteration in homeostasis and activation of SGECs following inhibition of IL-1 pathways, might suggest a role of this molecule in two of the major pathogenic mechanisms driving the development of an autoimmune epithelitis.

|||||||||| HUMORAL RESPONSES AGAINST HDL ARE LINKED TO UNFAVORABLE LIPOPROTEIN TRAITS AND LIPID SPECIES IN PRIMARY SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3101;
Anti-HDL antibodies were associated with unfavourable lipoprotein traits and major lipid classes, depending on atherosclerosis status. Anti-HDL antibodies may be considered a missing link to understand the connection between adaptive immune responses and lipid profiles in autoimmunity.

|||||||||| HOW DOES EXERCISE AFFECT DISEASE SCORES, SLEEP, DEPRESSION AND QUALITY OF LIFE IN PRIMARY SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3100;
Perhaps the reason why the relationships between exercise levels and disease activity and fatigue are not significant is because people do not know how to exercise properly. We think it is very important that patients do enough of the right kind of exercise and that they are educated about it.

|||||||||| HOMOCYSTEINE AND CAROTID INTIMA-MEDIA THICKNESS IN PRIMARY SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3099;
Patients with pSS have a higher risk for the development of subclinical atherosclerosis, as indicated by a higher value of CIMT and significant relationship between CIMT and Hcy. The results of this study suggest that routine assessment of plasma Hcy levels and measurement of CIMT would be useful to identify individuals with higher risk of accelerated atherosclerosis in patients with pSS.

|||||||||| GLYCOLYSIS EXPRESSION IN LYMPHOCYTES INFILTRATING SJOGREN'S DISEASE SALIVARY GLANDS. A PRELIMINARY ANALYSIS ON THE EXPRESSION OF THE GLUCOSE TRANSPORTER GLUT-1 () - May 29, 2024 - Abstract #EULAR2024EULAR_3097;
An increase in GLUT-1+ lymphocytes was detected according to the severity of inflammation and reached the highest levels in large, organized foci. Despite preliminary, our findings suggest that activation of glucose metabolism may be associated with tissue lymphocytes activation and proliferation.

|||||||||| Orencia (abatacept) / BMS, Rituxan (rituximab) / Roche
GLOBAL BURDEN OF SJOGREN'S DISEASE (SJD): FINDINGS FROM A SYSTEMATIC LITERATURE REVIEW (SLR) OF HUMANISTIC AND CLINICAL OUTCOMES () - May 29, 2024 - Abstract #EULAR2024EULAR_3096;
Patients with greater symptom burden (ESSPRI ?5) report significant impacts on their HRQoL related to dryness, fatigue, depression, and anxiety. Phase 3 clinical trials have so far not revealed treatments that can adequately address HRQoL or the burden of illness as measured by ESSPRI and ESSDAI.

|||||||||| EXAMINING THE RELATIONSHIP BETWEEN NEUROCOGNITIVE MANIFESTATIONS AND SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3095;
Out of the neurocognitive tests performed, DSST may be best in assessing physical and mental fatigue. DSST is commonly used in assessing cognitive function in other patients, and this result suggests that it may add value to the assessment of fatigue in patients with SJD.

|||||||||| DYSREGULATION OF TREG CELLS IN PATIENTS WITH PRIMARY SJOGREN'S SYNDROME () - May 29, 2024 - Abstract #EULAR2024EULAR_3094;
DSST is commonly used in assessing cognitive function in other patients, and this result suggests that it may add value to the assessment of fatigue in patients with SJD. These findings implied that Tregs in pSjS exhibit a more significant dysregulation than HCs and may contribute the pathogenesis.

|||||||||| DIAGNOSTIC PROTEIN BIOMARKERS IN SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3093;
SS and MGSB+ groups of patients showed significant higher levels of ICAM1 in saliva compared to the control group. The analysis of this protein in saliva could be useful for the early diagnosis of SS patients.

|||||||||| DIAGNOSTIC PERFORMANCE OF MAJOR SALIVARY GLAND ULTRASOUND FOR DIAGNOSIS OF SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3092;
The analysis of this protein in saliva could be useful for the early diagnosis of SS patients. In our routine clinical practice, the diagnostic performance of SGU is good, superior to sialometry, although the latter is included in the ACR/EULAR criteria for SS and the SGU not.

|||||||||| DIAGNOSING SJOGREN'S SYNDROME: A MULTI-MODAL DEEP LEARNING APPROACH WITH HISTOPATHOLOGIC IMAGES AND CLINICAL DATA () - May 29, 2024 - Abstract #EULAR2024EULAR_3091;
P=N/A
This study successfully demonstrates the potential of integrating clinical data and histopathological images to obtain significant diagnostic accuracy. This approach paves the way for more reliable and reproducible diagnoses of Sj

|||||||||| DESCRIPTION OF THE CLINICAL, HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL CHARACTERISTICS OF PATIENTS WITH SICCA SYNDROME WITH MINOR SALIVARY GLAND BIOPSY AND FOCUS SCORE ?1 () - May 29, 2024 - Abstract #EULAR2024EULAR_3090;
2:1. A higher frequency of glandular atrophy was found in patients with SS and polyautoimmunity, as well as in patients with other autoimmune diseases.

|||||||||| CORRELATION BETWEEN OXFORD GRADING OF CORNEAL STAINING SCORE AND SICCA TEST INCLUDED IN ACR-EULAR 2016 CLASSIFICATION CRITERIA FOR PRIMARY SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3089;
Corneal damage found by OGS does not seem to be related with oral dryness measured by salivary flow. OGS could play a role in identifying patients with severe eye dryness during the pSS diagnostic process.

|||||||||| COMPARISON OF FATIGUE AND ASSOCIATED FACTORS AMONG PATIENTS WITH PRIMARY AND SECONDARY SJOGREN'S SYNDROME AND PATIENTS WITH CONNECTIVE TISSUE DISEASE WITHOUT SJOGREN'S SYNDROME () - May 29, 2024 - Abstract #EULAR2024EULAR_3088;
Independent risk factors for fatigue in pSS patients included female gender, fibromyalgia, arthritis, subjective pain, and dryness, differing somewhat from sSS patients. Proper management of arthritis and fibromyalgia could ameliorate fatigue in pSS patients.

|||||||||| COMPARISON BETWEEN CLINICAL AND IMMUNOLOGIC PROFILES IN SJOGREN'S SYNDROME PATIENTS WITH AND WITHOUT CHRONIC KIDNEY DISEASE () - May 29, 2024 - Abstract #EULAR2024EULAR_3087;
The majority of pSS patients has remained normal renal function. Impaired renal function and comorbidity such as diabetes and hypertension could be a risk factor for CKD development in pSS patients, suggesting the need for regular renal function monitoring.

|||||||||| CLINICAL SIGNIFICANCE OF MerTK AND Tyro3 LEVELS IN THE MINOR SALIVARY GLANDS OF PATIENTS WITH SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3086;
Among TAM receptors, MerTK within the lymphocytic infiltrates of SS patients was associated with several laboratory features of the disease, clinical disease activity, and organ damage. Thus, MerTK levels may be a useful marker to predict the prognosis of patients with SS.

|||||||||| CENTRAL NERVOUS SYSTEM INVOLVEMENT IN PRIMARY SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3084;
CNS involvement in pSS is rare and reported in small numbers because it can be seen in different patterns and resembles variable neurological clinical pictures. In order to better determine treatment response, options, and prognosis, studies with a larger patient group and collaboration between neurology and rheumatology for patient follow-up are needed.

|||||||||| CANCER FREQUENCY IN CLOSE RELATIVES OF PATIENTS WITH SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3083;
No study was found in the literature that investigated the incidence of cancer in close relatives of SjS patients. There is a need for larger population-based studies on this topic to clarify this association.

|||||||||| CAN SALIVARY CARCIOEMBRYONIC ANTIGEN BE USEFUL FOR THE DIAGNOSIS OF SJOGREN'S SYNDROME () - May 29, 2024 - Abstract #EULAR2024EULAR_3082;
Patients with Sjogren's syndrome have significantly higher concentrations of CEA compared to healthy controls and patients with osteoarthritis and rheumatoid arthritis. CEA could be a useful laboratory parameter in the future for diagnosing Sjogren's syndrome.

|||||||||| CAN MEASURES OF HABITUAL ACTIVITY INTENSITY STRATIFY PRIMARY SJOGREN'S SYNDROME PARTICIPANTS WITH PERSISTENT FATIGUE? INSIGHTS FROM THE BRC TOOLS STUDY () - May 29, 2024 - Abstract #EULAR2024EULAR_3081;
This analysis has shown that the persistently fatigued participants tended to spend more time sedentary compared to the non-persistent group, but this separation was not statistically significant. Therefore, future research should explore more nuanced measures to investigate the relationships between habitual movement, other physiological signals, and fatigue in PSS.

|||||||||| methotrexate / Generic mfg.
ASSOCIATIONS AMONG PATIENT EMPOWERMENT, PATIENT ENGAGEMENT, PATIENT ACTIVATION AND CLINICAL MANIFESTATIONS IN PRIMARY SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3079;
Therefore, future research should explore more nuanced measures to investigate the relationships between habitual movement, other physiological signals, and fatigue in PSS. In addition, treatment protocols including steroids (30mg daily dose) (n=6; 29.83

|||||||||| ASSOCIATION OF A DIAGNOSTIC DELAY AND POOR GENERAL HEALTH STATUS AND GENERAL PERFORMANCE IN PRIMARY SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3078;
In addition, treatment protocols including steroids (30mg daily dose) (n=6; 29.83 The study highlights a significant 6.3-year delay from symptom onset to Sj

|||||||||| ASSOCIATION BETWEEN HISTOPATHOLOGICAL FINDINGS OF SALIVARY GLAND AND CLINICAL FEATURES IN PATIENTS WITH DRYNESS () - May 29, 2024 - Abstract #EULAR2024EULAR_3077;
The presence and extent of non-specific histopathologic findings in salivary gland in patients with SS were not different from those in patients with dryness due to other causes. However, in patients with SS, the extent of these findings may associate with autoantibodies, inflammatory levels, as well as glandular function.

|||||||||| ANTICENTROMERE ANTIBODIES IN THE SETTING OF SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3076;
However, when compared to SSc patients, ACA+ pSS patients display a less severe vascular profile, resulting in an intermediate clinical phenotype between limited cutaneous scleroderma and pSS. ACA presence in pSS patients may play a pivotal role in clinical features across disease settings.

|||||||||| ANTI-RO52 AUTOANTIBODIES PREDICT SJ () - May 29, 2024 - Abstract #EULAR2024EULAR_3075;
Furthermore, we observed a correlation between increased IgG (>15mg/ml), SS and dry mouth and having anti-Ro52. Stratification of SS patients shows that they drive the correlation, but as the risk between dry mouth and anti-ro52 remains, we argue that some SS patients are undiagnosed in the PBC cohort.

|||||||||| ANALYSIS OF THE PROTEOME IN MINOR SALIVARY GLANDS FROM SJOEGREN'S SYNDROME PATIENTS () - May 29, 2024 - Abstract #EULAR2024EULAR_3074;
The total number of proteins identified in our analysis exceeds that of previous studies and allows us to provide the first list of differentially expressed proteins in MSG tissues in SjS and controls that correlate with SjS-relevant measures. Our results indicate that MSG tissues from patients with different levels of lymphocyte infiltration and salivary gland dysfunction differ in the protein expression profiles.

|||||||||| AI-ENABLED TISSUE CLASSIFIER FOR SJOGREN'S DISEASE SALIVARY GLAND IDENTIFIES KEY HISTOLOGICAL FEATURES IMPORTANT FOR UNDERSTANDING DISEASE MANIFESTATION () - May 29, 2024 - Abstract #EULAR2024EULAR_3073;
Though the AI-Tissue classifier produced here would not outperform a trained pathologist in accuracy, it is much faster and much more cost effective to run. Therefore, this algorithm in combination with current focus scores (and other clinical data) could provide novel insights and key findings for both clinicians and researchers concerning SJD progression, severity, or other meaningful metrics.

|||||||||| A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED CLINICAL TRIAL OF FISH OIL (OMEGA 3) IN SJOGREN'S SYNDROME PATIENTS IN ERBIL-IRAQ () - May 29, 2024 - Abstract #EULAR2024EULAR_3071;
P2/3
Omega 3 was effective in improving Dry mouth symptoms, dry eye symptoms especially (itching, mucous discharge & photophobia) of Sjogren's syndrome patients, and Sialometry test was significantly improved and normalized in Omega 3 treated group in comparison to Placebo Group. The Schirmer test improved significantly during last visit in comparison to baseline in both groups, but it was slightly better in Omega 3 compared to placebo group, without significant differences.

|||||||||| PRECISION UNVEILED: TUNISIAN INNOVATIONS IN AI-ASSISTED ULTRASONOGRAPHY FOR ENHANCED SJOGREN'S SYNDROME DIAGNOSIS () - May 29, 2024 - Abstract #EULAR2024EULAR_3070;
However, they do not capture all of its particular texture. In fact, the gland has a distinct texture and a unique structure, clearly differentiating it from other areas of the image.

|||||||||| Rituxan (rituximab) / Roche
DESCRIPTION OF THE USE OF RITUXIMAB OFF-LABEL - EXPERIENCE OF A CENTER SPECIALIZED IN RHEUMATOLOGY () - May 29, 2024 - Abstract #EULAR2024EULAR_3059;
The increased prescription of RTX is due to high disease activity in the reported cases. The highest percentage of patients prescribed off-label RTX was female.

|||||||||| TRENDS IN LYMPHOMA PREVALENCE AND HOSPITAL OUTCOMES AMONG PATIENTS WITH UNDERLYING SYSTEMIC LUPUS ERYTHEMATOSUS: INSIGHTS FROM THE NATIONAL INPATIENT SAMPLE DATABASE () - May 29, 2024 - Abstract #EULAR2024EULAR_3049;
This rise lacks a clear explanation. Possible reasons might include the persistent nature of lupus unaffected by medications, the heightened risk of malignancies due to immunosuppressive drugs, the common association of lupus with Sjogren syndrome strongly linked to lymphomas, or a combination of these factors.

|||||||||| 30-DAY READMISSION IN PATIENTS WITH SEPTIC ARTHRITIS AND IDENTIFYING INDEPENDENT PREDICTORS ASSOCIATED WITH READMISSION: INSIGHTS FROM NATIONAL READMISSION DATABASE () - May 29, 2024 - Abstract #EULAR2024EULAR_2991;
It is crucial to carefully examine independent predictors of readmissions associated in regards to septic Arthritis. Although it was a limitation that only 2019 data was used, but still smoking was a risk factor for recurrent admissions and readmissions was least in patients who had highest income bracket.

||||||||||  Olumiant (baricitinib) / Eli Lilly
Enrollment closed:  Efficacy and Safety of Baricitinib in Sjogren's Syndrome (clinicaltrials.gov) -  May 29, 2024
P2, N=90, Active, not recruiting,  Sponsor: Peking Union Medical College Hospital
Although it was a limitation that only 2019 data was used, but still smoking was a risk factor for recurrent admissions and readmissions was least in patients who had highest income bracket. Recruiting --> Active, not recruiting

|||||||||| Journal: Case 325: Persistent Craniopharyngeal Canal. (Pubmed Central) - May 28, 2024
The patient received fluconazole, ceftriaxone, vancomycin, and metronidazole. Follow-up MRI was performed after 2 weeks.

|||||||||| Journal: Clinical importance of anti-Ro52 antibody for polymyositis and dermatomyositis. (Pubmed Central) - May 28, 2024
Anti-Ro52 Ab were frequently positive in PM/DM and anti-Ro52 Ab-positive patients showed significantly higher rates of anti-ARS Ab positivity and ILD, GC-resistant cardiomyopathy, concomitant use of immunosuppressants, and higher levels of CRP. Anti-Ro52 Ab may be useful as a severity marker in PM/DM.

|||||||||| Journal: Predicting the risk of primary Sj (Pubmed Central) - May 28, 2024
m7G regulators play an important role in the development of PSS. Our study of m7G-realted genes may inform future immunotherapy strategies for PSS.

|||||||||| Journal: Interstitial lung disease and associated factors in patients with Sj (Pubmed Central) - May 26, 2024
This may be related to older age, higher smoking rate, and longer nicotine consumption in men. Age, smoking, and severity of lung involvement are more important than inflammation status and autoantibodies for prognosis.



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