Sjogren's Syndrome
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  • ||||||||||  Retrospective data, Review, Journal:  Sexual dysfunction in women with primary Sj (Pubmed Central) -  Jun 30, 2024   
    This updated meta-analysis underscores the importance of assessing genitourinary atrophy, disease-related psychological changes, and dyspareunia in women with pSS. It also emphasizes the need for customized therapeutic approaches to address these sexual dysfunctions effectively.
  • ||||||||||  Clinical, Journal:  Immune-mediated inflammatory diseases and periodontal disease: a bidirectional two-sample mendelian randomization study. (Pubmed Central) -  Jun 29, 2024   
    Our study has confirmed a genetic causal relationship between IMIDs and periodontal disease, thereby unveiling novel potential mechanisms underlying IMIDs and periodontal disease. This discovery is promising in fostering interdisciplinary collaboration between clinicians and stomatologists to facilitate appropriate and precise screening, prevention, and early treatment of IMIDs and periodontal disease.
  • ||||||||||  Journal, Real-world evidence, Real-world:  Clinical trial eligibility of a real-world connective tissue disease cohort: Results from the LEAP cohort. (Pubmed Central) -  Jun 27, 2024   
    In an unselected, real-world CTD cohort, up to half of patients are ineligible for clinical trials due to not meeting classification criteria, overlapping features or a lack of trials within their primary disease. To address this inequality in access to novel therapies, clinical trial design should evolve eligibility criteria in CTDs.
  • ||||||||||  Journal:  Identification of drug targets for Sj (Pubmed Central) -  Jun 27, 2024   
    Our study reveals promising therapeutic targets for the treatment of SS, providing valuable insights into targeted therapy for SS. However, further validation through future experiments is warranted.
  • ||||||||||  Retrospective data, Journal:  Decreased Risk of Osteoporosis Incident in Subjects Receiving Chinese Herbal Medicine for Sj (Pubmed Central) -  Jun 27, 2024   
    Prolonged use of CHM, especially for one year or more, markedly dwindled sequent osteoporosis risk by 71%. Integrating CHM into standard care may favor the improvement of bone function, but further well-designed randomized controlled trials to investigate the possible mechanism are needed.
  • ||||||||||  Journal:  Ocular manifestations of juvenile Sj (Pubmed Central) -  Jun 26, 2024   
    Management of keratoconjunctivitis sicca in jSjD includes improving ocular surface lubrication and decreasing inflammation. Recognition of pediatric-specific clinical features and development of universally accepted jSjD classification criteria will allow for better identification of potential participants for future jSjD studies.
  • ||||||||||  Journal:  A Case of Superficial Siderosis with Elevated Anti-Ro/SSA Antibody. (Pubmed Central) -  Jun 24, 2024   
    To our knowledge, this report is the first to discuss the presence of anti-Ro/SSA antibodies in patients with SS. The role of anti-Ro/SSA antibodies in the pathophysiology of SS remains unclear; therefore, to confirm a possible association, further research and accumulation of cases are required.
  • ||||||||||  Biomarker, Review, Journal, IO biomarker:  Identification of inflammatory markers as indicators for disease progression in primary Sj (Pubmed Central) -  Jun 23, 2024   
    These inflammatory markers can be used as prognostic indicators for disease progression in pSS. In conclusion, the results from the studies reported in this review indicate that high levels of inflammatory markers may serve as markers for disease progression of pSS, which, in turn, may be valuable in predicting disease outcome.
  • ||||||||||  bleomycin / Generic mfg.
    Journal:  Kynurenine acts as a signaling molecule to attenuate pulmonary fibrosis by enhancing the AHR-PTEN axis. (Pubmed Central) -  Jun 22, 2024   
    In conclusion, the results from the studies reported in this review indicate that high levels of inflammatory markers may serve as markers for disease progression of pSS, which, in turn, may be valuable in predicting disease outcome. Our studies not only highlighted a critical role of Trp metabolism in PF pathogenesis, but also provided compelling evidence suggesting that Kyn could serve as a promising metabolite against PF.
  • ||||||||||  Biomarker, Review, Journal, IO biomarker:  Sicca syndrome/Sj (Pubmed Central) -  Jun 21, 2024   
    Dryness symptoms are more acute in the former than in iSjD, with predominance of xerostomia over xerophthalmia, and partial/complete response to glucocorticoids. Dryness symptoms in ICI-treated patients warrant prompt SjD investigation.
  • ||||||||||  Journal, Metastases:  Advanced Atrioventricular Block in Athletes: Prevalence and Role of Anti-Ro/Sj (Pubmed Central) -  Jun 20, 2024   
    Our study provides evidence that advanced AVB occurs in young athletes, in most cases associated with anti-Ro/SSA antibodies blocking L-type calcium channels. These findings may open new avenues for immunomodulating therapies to reduce the risk of life-threatening events in athletes, avoiding or delaying pacemaker implantation.
  • ||||||||||  Uplizna (inebilizumab-cdon) / Mitsubishi Tanabe, Amgen
    Journal:  A case report of AQP4-IgG-seropositive refractory neuromyelitis optica spectrum disorder patient with Sj (Pubmed Central) -  Jun 20, 2024   
    After receiving two 300?mg injections of inebilizumab, not only the symptoms of NMOSD improved significantly, but also the symptoms of concurrent SS and pancytopenia. In the cases of AQP4-IgG seropositive NMOSD who have recurrent episodes and are comorbid with other autoimmune disorders, inebilizumab may be a good choice.
  • ||||||||||  dazodalibep (HZN-4920) / Amgen
    Clinical, P2 data, Journal:  CD40 ligand antagonist dazodalibep in Sj (Pubmed Central) -  Jun 19, 2024   
    P2
    In summary, DAZ appears to be a potential new therapy for SjD and its efficacy implies an important role for the CD40/CD40 ligand pathway in its pathogenesis. ClinicalTrials.gov identifier: NCT04129164 .
  • ||||||||||  Journal:  Invisible, Uncontrollable, Unpredictable: Illness Experiences in Women with Sj (Pubmed Central) -  Jun 19, 2024   
    SS disease experience has a strong imprint on emotional well-being and sense of self-control among middle-aged women. Understanding SS impacts on women's lives is important to better understand the disease and contribute to recognizing potential areas of management and social support in relevant windows of opportunity within the health-disease continuum.
  • ||||||||||  Review, Journal:  Depressive Disorder and Dermatological Autoimmune Diseases. (Pubmed Central) -  Jun 19, 2024   
    A particular reciprocal correlation of depressive disorders with psoriasis, atopic dermatitis, alopecia areata, impetigo, lupus and systemic scleroderma was found. One possible explanation for the co-occurrence of the above diseases is that the inflammatory theory may be applicable to depression, the various elements of which also apply to autoimmune diseases.
  • ||||||||||  tamoxifen / Generic mfg.
    Journal:  Deleting Mitochondrial Superoxide Dismutase 2 in Salivary Gland Ductal Epithelial Cells Recapitulates Non-Sj (Pubmed Central) -  Jun 19, 2024   
    To address this question, we created mice with a tamoxifen-inducible conditional knockout (KO) of a critical antioxidant enzyme, superoxide dismutase 2 (Sod2), in the salivary glands (i-sg-Sod2 KO mice)...These data demonstrate that although localized oxidative stress in salivary gland ductal cells was insufficient for SjD development, it induced glandular dysfunction. The i-sg-Sod2 KO mouse resembles patients classified as non-Sj
  • ||||||||||  Journal:  Acquired Fanconi syndrome in mixed cryoglobulinemia patients: a single-center case series. (Pubmed Central) -  Jun 18, 2024   
    Despite the lack of causal evidence, the coexistence of Fanconi syndrome and tubulointerstitial injury is also noteworthy in patients with cryoglobulinemia, underscoring the importance of thorough evaluation and tailored management in patients presenting with overlapping renal manifestations. Key Points
  • ||||||||||  Journal:  Blood-Derived Eye Drops for the Treatment of Corneal Neuropathic Pain. (Pubmed Central) -  Jun 18, 2024   
    Future directions for clinical practice and research involve standardizing preparation protocols, establishing treatment guidelines, elucidating underlying mechanisms, conducting long-term clinical trials, and implementing cost-effective measures such as scaling up manufacturing. With ongoing advancements, blood-derived eye drops hold promise as a valuable therapeutic option for patients suffering from NCP.
  • ||||||||||  Review, Journal, Biopsy:  Salivary gland biopsy as a prognostic tool in Sj (Pubmed Central) -  Jun 17, 2024   
    Thus, a salivary gland biopsy should be offered to all patients and included in routine practice, even when not strictly required for diagnostic purposes. More advanced analysis techniques of the tissue, including immunohistochemistry and 'omics' should be further explored in longitudinal studies to boost the ability to further stratify and predict disease evolution.
  • ||||||||||  Review, Journal:  Does ultrasound elastography have a role as a diagnostic method for Sj (Pubmed Central) -  Jun 16, 2024   
    More advanced analysis techniques of the tissue, including immunohistochemistry and 'omics' should be further explored in longitudinal studies to boost the ability to further stratify and predict disease evolution. This systematic review suggests that the assessment of salivary glands using USE is a useful diagnostic tool for SjS.
  • ||||||||||  Journal, IO biomarker:  Reconstruction of Sj (Pubmed Central) -  Jun 15, 2024   
    These data suggest that the anti-dsRNA antibodies and, TCR recognizing the gut microbiota involved in the development of sialadenitis like SS. Thus, our model provides a novel strategy for defining the roles of autoreactive TCR and autoantibodies in the development and pathogenesis of SS.
  • ||||||||||  Journal:  Primary Sjogren syndrome - A bibliometric analysis via CiteSpace. (Pubmed Central) -  Jun 14, 2024   
    Notably, an article published in the Annals of Rheumatic Diseases in 2017 garnered significant attention by being cited a remarkable 304 times. The bibliometric analysis reveals that key areas of research in pSS encompass investigating pathogenesis; advancing and applying targeted biological agents; and establishing treatment and diagnostic standards.
  • ||||||||||  Journal:  Palisaded neutrophilic granulomatous dermatitis associated with Sj (Pubmed Central) -  Jun 14, 2024   
    The bibliometric analysis reveals that key areas of research in pSS encompass investigating pathogenesis; advancing and applying targeted biological agents; and establishing treatment and diagnostic standards. No abstract available
  • ||||||||||  Preclinical, Journal:  In Vivo Human Lacrimal Gland Imaging Using an Ultrasound Biomicroscopy. (Pubmed Central) -  Jun 13, 2024   
    However, further investigations are required to confirm this observation. Lacrimal gland imaging using UBM has both advantages of optical coherence tomography and sonography, and could be useful for evaluating dry eye syndrome.
  • ||||||||||  Review, Journal:  Disorders with Ophthalmic and Thoracic Involvement. (Pubmed Central) -  Jun 13, 2024   
    The current challenge is to enrich conventional medicine with CAM that is effective and safe through supervised programs to move toward an integrative medicine. The authors describe a spectrum of these conditions based on their underlying cause.
  • ||||||||||  Journal:  Approach to non-compressive myeloneuropathy through a rendezvous of 11 cases from an Indian backdrop. (Pubmed Central) -  Jun 11, 2024   
    Differential identification of these disorders needs an in-depth perception of the mode of onset of symptoms, the course of progression of the disease, the pattern of myelopathic/neuropathic findings, and recognition of other neurological or systemic manifestations. For untroubled understanding, etiologies of myeloneuropathies should be subdivided into a few broad categories, e.g., metabolic (nutritional), toxic (toxin-induced), infectious, inflammatory (immune-mediated), paraneoplastic, and hereditary disorders.
  • ||||||||||  Journal, HEOR, Real-world evidence, Real-world:  Primary Sj (Pubmed Central) -  Jun 5, 2024   
    According to results of this population-based study, the prevalence of pSS in Italy appears to be consistent with the definition of rare disease. Patients with pSS have higher pharmacological, in-hospital and outpatient specialist care needs, leading to three-times higher overall cost for the INHS, compared to the general population.