Sjogren's Syndrome News

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|||||||||| A CASE OF RAPIDLY PROGRESSIVE NEURO-SJOGREN'S DISEASE RESULTING IN RESPIRATORY FAILURE (Convention Center 258 B) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1844;

|||||||||| ISOLATED NODULAR PULMONARY AMYLOIDOSIS IN A PATIENT OF SJOGREN'S DISEASE (Convention Center Exhibit Hall: Rapid Fire Area 3B) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1758;

|||||||||| A RARE PRESENTATION OF LUNG CYSTS IN A CASE WITH COMBINED RHEUMATOID ARTHRITIS AND SJOGREN'S SYNDROME (Convention Center Exhibit Hall: Poster Area 4) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1693;

|||||||||| Journal: Case Series of Changes in Greyscale and Power Doppler Signals on Salivary Gland Ultrasonography after Treatment in Patients with Sj (Pubmed Central) - Jul 31, 2024
PDs decreased, along with GS and markers of disease activity, after treatment. PDs have the potential to provide insights into glandular inflammation in real time; however, large-scale studies on their clinical usefulness are needed.

|||||||||| Retrospective data, Journal: Endometriosis and Sj (Pubmed Central) - Jul 31, 2024
PDs have the potential to provide insights into glandular inflammation in real time; however, large-scale studies on their clinical usefulness are needed. These findings support a bidirectional association between endometriosis and pSS, which may be driven by dendritic cell maturation and fibrosis signaling pathways.

|||||||||| Journal: Exome sequencing revealed variants in SGCA and SIL1 genes underlying limb girdle muscular dystrophy and Marinesco-Sj (Pubmed Central) - Jul 31, 2024
The recurrent mutations expanding the global understanding of the mutation's geographic and ethnic distribution and contributing valuable epidemiological data. The study will facilitate genetic counseling for families experiencing similar clinical features, both within Pakistani populations and in other regions.

|||||||||| Journal: Role of mucosal-associated invariant T cells dynamics in pathogenesis of Sj (Pubmed Central) - Jul 31, 2024
Tissular MAIT cells are detected in salivary glands from SS with a proinflammatory tissular cytokine environment. MAIT cells with abnormal phenotype, functions and tissular homeostasis may contribute to epithelial damage in SS.

|||||||||| Preclinical, Journal: IL-40 is up-regulated in the synovial fluid and cartilage of osteoarthritis patients and contributes to the alteration of chondrocytes phenotype in vitro. (Pubmed Central) - Jul 31, 2024
This study is the first to demonstrate the accumulation of IL-40 in OA cartilage and its up-regulation in the synovial fluid of OA patients compared to controls. In addition, extracellular IL-40 appears to play a role in promoting inflammation and cartilage destruction by driving chondrocyte behaviour towards a more aggressive phenotype.

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Journal: A case of mixed hereditary gelsolin amyloidosis and hydroxychloroquine induced myopathy. (Pubmed Central) - Jul 30, 2024
This subsequently led to targeted genetic testing, revealing an autosomal dominant c.640G?>?A pathogenic variant of the gelsolin gene. Therefore, this is a unique case of complex muscle pathology with features of a rare hereditary systemic amyloidosis an uncommon drug- induced myopathy.

|||||||||| Journal: Integrating point of care ultrasound into rheumatology practice. (Pubmed Central) - Jul 30, 2024
It discusses the potential for salivary gland ultrasound in the diagnostic workup of suspected Sjogren's syndrome. Other areas for POCRUS application such as in suspected nerve entrapment are reviewed.

|||||||||| Journal: Questionnaire survey of the application of four objective indicators necessary for standardized diagnosis of Sj (Pubmed Central) - Jul 30, 2024
SS diagnosis couldn't be estimated according to 2002 AECG criteria, assuming both labial FS and UWSF were unavailable in 156 (94.0%) patients with positive anti-SSA/Ro; or assuming either labial FS or UWSF was unavailable in 10 (6.0%) patients with negative anti-SSA/Ro. The application rates of four objective indicators necessary for SS diagnosis are low, the rate of carrying out labial gland biopsy should be increased, and the labial FS reports and UWSF test should be standardized.

||||||||||  ianalumab (VAY736) / Novartis
Enrollment closed:  NEPTUNUS-2: Three-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome (clinicaltrials.gov) -  Jul 29, 2024
P3, N=505, Active, not recruiting,  Sponsor: Novartis Pharmaceuticals
The application rates of four objective indicators necessary for SS diagnosis are low, the rate of carrying out labial gland biopsy should be increased, and the labial FS reports and UWSF test should be standardized. Recruiting --> Active, not recruiting

|||||||||| Review, Journal: Molecular insights into the phase transition of lysozyme into amyloid nanostructures: Implications of therapeutic strategies in diverse pathological conditions. (Pubmed Central) - Jul 29, 2024
Apart from this, we have tried to explore and advance our fundamental understanding of the complex processes involved in lysozyme aggregation. This will help the research community to lay a robust foundation for screening, designing, and formulating targeted anti-amyloid therapeutics offering improved treatment modalities and interventions not only for lysozyme-linked amyloidopathy but for a wide range of amyloid-related disorders.

|||||||||| Journal: Artesunate alleviates Sj (Pubmed Central) - Jul 28, 2024
In summary, this study highlighted the therapeutic potential of ART in SS and ART inhibited the IFN-? signaling in pDCs via the TLR-MyD88-IRF7 pathway.

|||||||||| Journal: Prevalence of Progressive Fibrosing Interstitial Lung Disease in Patients with Primary Sjogren Syndrome. (Pubmed Central) - Jul 27, 2024
In particular, UIP and NSIP showed a similar evolution towards PPF in patients with pSS; for NSIP, this behavior was more frequent than for other rheumatic diseases. Our results emphasize the importance of early recognition of PPF for timely intervention and careful follow-up.

|||||||||| Review, Journal: Role of ncRNAs in the Pathogenesis of Sj (Pubmed Central) - Jul 27, 2024
Our results emphasize the importance of early recognition of PPF for timely intervention and careful follow-up. Here we review research into the causative roles of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) on immunological responses, inflammation, and salivary gland epithelial cell function in Sj

|||||||||| Journal: Polyarthritis in Sj (Pubmed Central) - Jul 27, 2024
A ROC curve analysis showed an acceptable diagnostic accuracy in differentiating between SS-pa and SS-RA patients using a binary logistic regression model, where highly positive rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) values, kidney involvement, and anti-Ro/SS-A positivity were shown to significantly raise the odds of having RA, whereas anti-La/SS-B positivity seemed to have a protective role, since it significantly decreased the odds of having it. Further biomarkers are needed to better classify SS patient cohorts with inflammatory joint pain of different origins and, consequently, different management requirements.

|||||||||| Review, Journal: The use of stem cells in treating xerostomia: a systematic review. (Pubmed Central) - Jul 27, 2024
Further biomarkers are needed to better classify SS patient cohorts with inflammatory joint pain of different origins and, consequently, different management requirements. Although in its initial stages, the use of stem cells seems to be a promising therapy to alleviate xerostomia regardless of its cause.

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Journal: G protein-coupled receptor kinase 2 as a novel therapeutic target for gland fibrosis of Sj (Pubmed Central) - Jul 27, 2024
Although in its initial stages, the use of stem cells seems to be a promising therapy to alleviate xerostomia regardless of its cause. Around 28 days post immunization with SMG antigen, WT SS mice were treated with a specific GRK2 inhibitor paroxetine (Par, 5?mg

|||||||||| Review, Journal: Insights into the cellular basis of skin inflammation in systemic autoimmune rheumatic diseases from single-cell technologies. (Pubmed Central) - Jul 26, 2024
It is important to understand whether the pathophysiological processes underlying skin inflammation are different or shared between SARDs to develop targeted therapies. This review will discuss commonalities and differences between inflammatory skin disease in SARDs focusing on histopathology and describe newer insights obtained from single-cell technologies.

|||||||||| Journal: Investigation of pyroptosis-related hub genes and the immune microenvironment in primary Sj (Pubmed Central) - Jul 26, 2024
Besides, we identified five pyroptosis-related hub genes that might play a role in the pathogenesis of pSS. These findings could offer valuable insights for the development of novel treatment strategies for pSS.

|||||||||| Review, Journal: Advances in cellular and molecular pathways of salivary gland damage in Sj (Pubmed Central) - Jul 26, 2024
Comprehensive understanding of these mechanisms is crucial for developing targeted therapeutic interventions. Thus, this study explores the cellular and molecular mechanisms underlying SS-related salivary gland damage, aiming to propose novel targeted therapeutic approaches.

|||||||||| Retrospective data, Journal: Associations Between Obstructive Sleep Apnea Syndrome, Dry Eye Disease, and CPAP Usage Among Taiwanese Patients: A Retrospective Analysis. (Pubmed Central) - Jul 26, 2024
Patients undergoing CPAP were at greater risk of developing DED than those not undergoing CPAP (Odds ratio: 3.93, 95% confidence interval: 1.47-10.49, P = 0.006). OSA severity is associated with DED and might be attributed to the use of CPAP.

|||||||||| Journal: Acute renal failure caused by Sj (Pubmed Central) - Jul 26, 2024
We also provide a relevant analysis of SS and RA overlap syndrome treatment. We also provide a relevant analysis of SS and RA overlap syndrome treatment.

|||||||||| Preclinical, Journal: Establishment and characterization of salivary gland-specific injury in transgenic mice model. (Pubmed Central) - Jul 26, 2024
We also provide a relevant analysis of SS and RA overlap syndrome treatment. This transgenic mouse model may become a useful tool for elucidating the mechanisms involved in hyposalivation and for developing pharmaceuticals and tissue regenerative medical products for this condition.

|||||||||| Review, Journal: Update on the pathophysiology and treatment of primary Sj (Pubmed Central) - Jul 26, 2024
Indeed, several randomized controlled trials have just been completed or are poised to commence evaluating the effectiveness of novel drugs targeting both innate and adaptive immune pathways, including pro-inflammatory cytokines, the type I interferon system, B cell activation, B cell and T cell co-stimulation pathway, and ectopic germinal centre formation. Novel clinical trials are also ongoing exploring various targeted approaches (that is, IgG recycling inhibition, nuclease therapy and CAR-T cell therapy) for Sj

|||||||||| Journal: Annual trends in pain management modalities in patients with newly diagnosed autoimmune rheumatic diseases in the USA from 2007 to 2021: an administrative claims-based study. (Pubmed Central) - Jul 26, 2024
Since 2014, the use of non-opioid pain management modalities has increased or stabilised, whereas opioid and NSAID use has declined. Future studies are needed to evaluate the effectiveness of these changes, and the effects they have had on outcomes such as quality of life, disability, and function.

|||||||||| Biomarker, Journal: JAK1, SKI, ZBTB16 as potential biomarkers mediate the inflammatory response in keratoconjunctivitis sicca. (Pubmed Central) - Jul 26, 2024
The results of animal experiments showed that the transcription and expression levels of these three genes were significantly different in rat KCS tissues and normal tissues, and there were also differences in the expression of JAK1 and SKI in rat peripheral blood, as well as significant up-regulation of the expression of related inflammatory factors in KCS tissues. Through bioinformatics prediction and animal experimental validation, this study identified three differentially expressed genes in SS mediated KCS patients, which provide new potential biological targets for the diagnosis and treatment of KCS.

|||||||||| Biomarker, Journal, Circular RNA: The circular RNA hsa_circ_0045800 serves as a favorable biomarker in pathogenesis of sj (Pubmed Central) - Jul 26, 2024
Peripheral blood mononuclear cells are directly involved in the pathogenesis of pSS, and the discovery of hsa_circ_0045800 in peripheral blood mononuclear cells highlights its potential as a novel biomarker for disease activity and diagnosis in patients with pSS. Key Points

|||||||||| Journal: Causal effects of autoimmune diseases on temporomandibular disorders and the mediating pathways: a Mendelian randomization study. (Pubmed Central) - Jul 24, 2024
These findings highlight the importance for clinicians to pay more attention to patients with RA or MS when consulting for temporomandibular discomfort. The mediating role of specific immune cells is proposed but needs further investigation.

|||||||||| Journal: Discovery of new myositis genetic associations through leveraging other immune-mediated diseases. (Pubmed Central) - Jul 24, 2024
Next, we colocalized IIM signals that overlapped IMD signals, and found seven potentially novel myositis associations mapped to immune-related genes, including BLK, IRF5/TNPO3, and ITK/HAVCR2, implicating a role for both B and T cells in IIM. This work proposes a new paradigm of genetic discovery in rarer diseases by leveraging information from more common IMD, and can be expanded to other conditions and traits beyond IMD.

|||||||||| Journal, IO biomarker: Modified Sanliangsan Improved Sjogren's Syndrome Complicated with Interstitial Lung Disease by Suppressing Serum MUC1 Levels. (Pubmed Central) - Jul 22, 2024
This work proposes a new paradigm of genetic discovery in rarer diseases by leveraging information from more common IMD, and can be expanded to other conditions and traits beyond IMD. Based on conventional Western medicine treatment, modified Sanliangsan can significantly improve the clinical symptoms, signs, and lung function of patients; the mechanism may be due to eugenol and related to MUC1 regulation.

|||||||||| Journal: Profiles of peripheral B cell subsets in a cohort of primary Sj (Pubmed Central) - Jul 22, 2024
Based on conventional Western medicine treatment, modified Sanliangsan can significantly improve the clinical symptoms, signs, and lung function of patients; the mechanism may be due to eugenol and related to MUC1 regulation. We identified a comprehensive B lymphocyte subset distribution profile in primary Sj

|||||||||| Journal: A scientometric and comparative study of Sjogren's syndrome research by rheumatologists and stomatologists. (Pubmed Central) - Jul 22, 2024
This study firstly reports the scientometric characteristics of SS publications by rheumatologists and stomatologists. The scale and citations of rheumatologists' publications greatly outweigh those of stomatologists, suggesting stomatologists can cooperate more with rheumatologists regarding SS research.

||||||||||  SHJ002 / Sunhawk Vision Biotech
Enrollment open:  Efficacy and Safety of SHJ002 Ophthalmic Solution in the Treatment of Corneal Erosion in Sjogren's Patients (clinicaltrials.gov) -  Jul 22, 2024
P2, N=122, Recruiting,  Sponsor: Sunhawk Vision Biotech, Inc.
The scale and citations of rheumatologists' publications greatly outweigh those of stomatologists, suggesting stomatologists can cooperate more with rheumatologists regarding SS research. Not yet recruiting --> Recruiting

|||||||||| Journal: SHED-exos promote saliva secretion by suppressing p-ERK1/2-mediated apoptosis in glandular cells. (Pubmed Central) - Jul 20, 2024
SHED-exos suppress epithelial cell death, which is responsible for promoting salivary secretion. SHED-exos inhibited inflammation-triggered epithelial cell apoptosis by suppressing p-ERK1/2 activation, which is involved in these effects.

|||||||||| Journal: Salivary glands of Sj (Pubmed Central) - Jul 20, 2024
SHED-exos inhibited inflammation-triggered epithelial cell apoptosis by suppressing p-ERK1/2 activation, which is involved in these effects. No abstract available

|||||||||| Journal: From Risk to Resilience: improved outcomes after myocardial infarction in patients with Sjogren's syndrome. (Pubmed Central) - Jul 19, 2024
No abstract available No abstract available

|||||||||| Journal: Sjogren syndrome and outcomes of acute myocardial infarction: A propensity-score matched analysis of the Nationwide Inpatient Sample 2005-2018. (Pubmed Central) - Jul 19, 2024
In conclusion, in patients admitted to US hospitals for AMI, patients with Sjogren syndrome have a lowered probability of in-hospital mortality, certain morbidities, and prolonged LOS. Further investigations should be conducted to establish a robust understanding of the associations observed.

|||||||||| Journal: AutoDock and molecular dynamics-based therapeutic potential prediction of flavonoids for primary Sj (Pubmed Central) - Jul 19, 2024
The therapeutic effect of apigenin on dry mouth in pSS models was further validated. In conclusion, these results indicate the estrogenic and pSS therapeutic potential of apigenin, naringenin, and daidzein.

|||||||||| Journal: Integrative multi-omics analysis reveals cellular and molecular insights into primary Sj (Pubmed Central) - Jul 19, 2024
CTSS and GSTO1 show promise as diagnostic biomarkers and potential therapeutic targets for pSS. Further investigations are warranted to elucidate the underlying mechanisms and develop targeted therapies for this complex autoimmune disease.

|||||||||| Journal: Soluble CD72, is a T-cell activator probably via binding to CD6 in homeostasis and autoimmunity. (Pubmed Central) - Jul 19, 2024
The sCD72-CD6 axis on activated CD4+T cells is probably a new signaling pathway in the induction of immune-mediated diseases. Therefore, targeting sCD72 may become a valuable therapeutic tool in some autoimmune disorders.

||||||||||  ianalumab (VAY736) / Novartis
Trial primary completion date:  NEPTUNUS-2: Three-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome (clinicaltrials.gov) -  Jul 19, 2024
P3, N=489, Recruiting,  Sponsor: Novartis Pharmaceuticals
Therefore, targeting sCD72 may become a valuable therapeutic tool in some autoimmune disorders. Trial primary completion date: Mar 2026 --> May 2025

|||||||||| Journal: MiR-23b-3p alleviates Sj (Pubmed Central) - Jul 18, 2024
The study concludes that miR-23b-3p alleviates SS by targeting SOX6 and inhibiting the NF-?B signaling pathway. The miR-23b-3p/SOX6 axis represents a promising avenue for the development of novel therapeutic strategies for SS.

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Review, Journal: Sjogren's Antibodies and Neonatal Lupus: A Scoping Review. (Pubmed Central) - Jul 18, 2024
The miR-23b-3p/SOX6 axis represents a promising avenue for the development of novel therapeutic strategies for SS. Regarding medical management, hydroxychloroquine

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Journal: Sicca syndrome as complication of COVID-19 infection: A case report. (Pubmed Central) - Jul 18, 2024
He continued on 200?mg/day of hydroxychloroquine, along with tear drops until now with remission...The sequela of this infection is not understood, with limited data in the literature. Future prospective cohort studies are needed to reveal the impact of these features on oral health.

|||||||||| Journal: Chronic interstitial lung disease associated with systemic lupus erythematosus: A multicentric study of 89 cases. (Pubmed Central) - Jul 17, 2024
ILD is a rare manifestation of SLE with good overall prognosis but with possible risk of ILD progression. Patients with SLE-ILD frequently have another connective tissue disease.

|||||||||| Journal, Causal relationship, Immune cell: The causal relationship between immune cells and Sj (Pubmed Central) - Jul 17, 2024
Twenty-three immune cells showed a reverse causal relationship with SS. These findings demonstrate the influence of immune cells on SS risk and the effects of SS on immune cells, providing new clues for further research on the mechanisms underlying SS.

|||||||||| Retrospective data, Journal: Clinical characteristics and labial gland pathological features in children with systemic lupus erythematosus complicated by Sj (Pubmed Central) - Jul 17, 2024
The SLE-SS children with an FS?4 are more likely to experience musculoskeletal involvement. However, FS is not associated with disease activity or other significant organ damage.

|||||||||| Late Breaking Abstract - Deep-learning Algorithm FibroNet to Identify Fibrotic Primary Sj (PS-30; Poster board no. 17) - Jul 16, 2024 - Abstract #ERS2024ERS_5797;
The diagnostic performance was similar to that of pulmonologists with ILD experience, and slightly inferior to that of radiologists with ILD experience. Conclusions We developed a deep learning model (FibroNet) that uses chest HRCT images to identify F-pSS-ILD, which can identify fibrotic types, including not only UIP but also fNSIP.



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