- |||||||||| mycophenolate mofetil / Generic mfg.
Retrospective data, Journal: Clinical Characteristics and Outcomes of Interstitial Lung Disease in Primary Sj (Pubmed Central) - May 13, 2024
Mycophenolate mofetil (MMF) was the most frequently used steroid sparing agent, in 25 patients (75.7%)...Presence of sicca symptoms [91.5% vs 8.7% (p<0.001)], NSIP pattern of ILD [90% vs 10% (p = 0.002)], and absence of Raynaud's phenomenon [91.7% vs 8.3% (p<0.001)] were significantly associated with responder status when compared to non-responders. ILD in primary Sj
- |||||||||| Review, Journal: Chemokines and lymphocyte homing in Sj (Pubmed Central) - May 13, 2024
These findings have led to the development of antibodies to cell adhesion molecules, antagonists of chemokines and their receptors, compounds interfering with chemokine receptor signaling, and gene therapies targeting chemokines and their receptors, providing new targets for the treatment of SS in humans. The aim of this study was to explore the relationship between lymphocyte homing and the pathogenesis of SS, and to provide a review of recent studies addressing lymphocyte homing in targeted therapy for SS.
- |||||||||| Review, Journal, Heterogeneity: Heterogeneity of macrophage activation syndrome and treatment progression. (Pubmed Central) - May 13, 2024
The aim of this study was to explore the relationship between lymphocyte homing and the pathogenesis of SS, and to provide a review of recent studies addressing lymphocyte homing in targeted therapy for SS. MAS can occur in various AIIRDs, including but not limited to systemic juvenile idiopathic arthritis (sJIA), adult-onset Still's disease (AOSD), systemic lupus erythematosus (SLE), Kawasaki disease (KD), juvenile dermatomyositis (JDM), rheumatoid arthritis (RA), and Sj
- |||||||||| New trial, HEOR, Biopsy: Evaluation of Biopsychosocial Features, Pain, Fatigue, Quality of Life, Swallowing, and Disease-Specific Symptoms in Patients With Primer Sjogren's Syndrome (clinicaltrials.gov) - May 13, 2024
P=N/A, N=150, Not yet recruiting,
- |||||||||| Journal: Clinical Profile of Patients with Primary Sj (Pubmed Central) - May 11, 2024
The non-identified ANA-positive patients featured mostly a clinical phenotype similar to that of the ANA-negative patients. On the other hand, the non-identified ANA-positive patients were mainly distinguished from the ANA-negative patients by a greater proportion of RF positivity and the need for corticosteroid use due to articular involvement.
- |||||||||| Review, Journal: Implications of innate lymphoid cells in oral diseases. (Pubmed Central) - May 11, 2024
Recently, there has been a growing interest in the role of ILCs in oral diseases. This review outlines the classifications and the major characteristics of ILCs, and then comprehensively expatiates the research on ILCs in oral cancer, primary Sjogren's syndrome, periodontal diseases, oral lichen planus, oral candidiasis, Behcet's disease, and pemphigus vulgaris, aiming at summarising the implications of ILCs in oral diseases and providing new ideas for further research.
- |||||||||| Journal: KLRB1 defines an activated phenotype of CD4+ (Pubmed Central) - May 11, 2024
This review outlines the classifications and the major characteristics of ILCs, and then comprehensively expatiates the research on ILCs in oral cancer, primary Sjogren's syndrome, periodontal diseases, oral lichen planus, oral candidiasis, Behcet's disease, and pemphigus vulgaris, aiming at summarising the implications of ILCs in oral diseases and providing new ideas for further research. KLRB1 is a characteristic molecule of the CD4+
- |||||||||| ulinastatin injection / Generic mfg.
Journal: Clinical manifestations of chronic pancreatitis in English cocker spaniels. (Pubmed Central) - May 10, 2024
English cocker spaniels with CP show clinical similarities to humans with IgG4-RD and common involvement of other organs. Clinicians should evaluate affected Cocker Spaniels for proteinuria, keratoconjunctivitis sicca, and other potential immune-mediated diseases.
- |||||||||| Journal: Causal association between autoimmune liver disease and Sj (Pubmed Central) - May 9, 2024
However, no reliable causal relationship was found between SS and the risk of PBC or PSC. These findings contribute to elucidating the potential pathogenic mechanisms of the disease and are of significant importance for the management of patients with PBC and PSC.
- |||||||||| Review, Journal: Multifaceted role of TRIM21 in inflammation. (Pubmed Central) - May 8, 2024
The current research has shown that the antiviral action of TRIM mostly depends on their role as E3-ubiquitin ligases and a significant portion of the TRIM family mediates the transmission of innate immune cell signals and the subsequent production of cytokines. We highlighted the function of TRIM family members in various inflammatory diseases.
- |||||||||| Review, Journal: Primary nasopharyngeal carcinoma with Sj (Pubmed Central) - May 8, 2024
The study concludes that for patients with an immune condition, exhibiting symptoms like headaches or cranial nerve issues, or in cases where nasopharyngeal carcinoma is suspected, early testing through cerebrospinal fluid mNGS or EBV DNA is recommended. This approach facilitates risk assessment, prognosis determination, and the creation of individualized treatment plans.
- |||||||||| deferoxamine / Generic mfg.
The Scientific and Clinical Potentials of Imaging Cytotoxic T-Cells Using Zr-89 Crefmirlimab Berdoxam (Exhibit Hall D - Science Pavilion (Convention Center); Screen 21; In-Person Only) - May 8, 2024 - Abstract #SNMMI2024SNMMI_672;
Data of its use from more than 270 patients has demonstrated fast blood clearance and favorable tissue penetration for a wide range of applications in clinical research and potential noninvasive clinical applications in oncology and beyond. Advanced reconstruction algorithms as well as the use of total body PET scanners further allow reducing the injected activity to 0.
- |||||||||| Journal: Clinical Performance of Immunonephelometric Assay and Chemiluminescent Immunoassay for Detection of IgG Subclasses in Chinese. (Pubmed Central) - May 6, 2024
We review demographic, genetic, biochemical and clinical information from all documented cases in the existing literature, focusing on the global distribution of cases, the features of the syndrome, its variable presentation, new potential identifying features and the significance of measuring GBA2 enzyme activity. The CLIA and the Siemens immunonephelometric assay appeared to have good consistency with comparable diagnostic value in detecting IgGSc, especially IgG4, and IgG1 that can accurately identify IgG4-RD or pSS in clinical practice.
- |||||||||| Journal: Implications of IFN? SNP rs2069705 in Primary Sj (Pubmed Central) - May 6, 2024
gene emerges as a pivotal element in pSS susceptibility, primarily by augmenting IFN? transcription, activating the JAK/STAT1 pathway, and leading to B lymphocyte infiltration in the exocrine glands.
- |||||||||| mycophenolate mofetil / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Journal: A Rare Presentation: Bilateral Necrotizing Scleritis in Primary Sj (Pubmed Central) - May 6, 2024
Further, this case report addresses a gap in the existing literature concerning pSS-related scleritis. It also emphasizes the crucial role of a rheumatologist in the comprehensive management of this condition.
- |||||||||| Journal, Machine learning: WGCNA and machine learning analysis identifi ed SAMD9 and IFIT3 as primary Sj (Pubmed Central) - May 6, 2024
In the investigation of pSS public datasets, our study revealed two potential critical mediators in the pathological process of pSS salivary glands, namely SAMD9 and IFIT3. Furthermore, we put forth a hypothesis regarding the ceRNA network and made predictions regarding potential therapeutic drugs targeting these two genes.
- |||||||||| hydrocortisone / Generic mfg.
Unraveling Secondary Adrenal Insufficiency and an Invasive Pituitary Macroadenoma in a COVID-19 Positive Patient (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_263;
The coexistence of COVID-19 adds a layer of complexity to the clinical scenario, necessitating a comprehensive approach to both infectious and endocrine management. Timely recognition, appropriate endocrine assessment, and targeted interventions, such as hydrocortisone replacement and surgical resection, are crucial for optimizing outcomes in patients with this intricate interplay of pituitary pathology and infectious states
- |||||||||| Journal: Unusual presentation of Sjogren's syndrome during pregnancy: a case report. (Pubmed Central) - May 4, 2024
This case underscores that prompt recognition and management are paramount to prevent life-threatening complications in pregnant patients with autoimmune disease. This report sheds light on the unique challenge of managing hypokalaemic quadriparesis in the context of Sjogren's syndrome during pregnancy.
- |||||||||| triamcinolone acetonide / Generic mfg., famotidine / Generic mfg., pentoxifylline / Generic mfg.
Plasma Cell Mucositis: A case report () - May 2, 2024 - Abstract #INDERCOS2024INDERCOS_239;
In the past, the patient was prescribed with topical analgesics, topical antibacterial and antifungal sprays, oral pentoxifylline and famotidine with no improvement.The patient was evaluated in another hospital with the same complaints and had a incisional biopsy with preliminary diagnosis of lichenoid drug reaction and squamous cell carcinoma which resulted with no spesific diagnosis...Immunohistologic studies revealed kappa and lambda light chains were positive with mild predominancy of kappa light chain which showed no clonality After the diagnosis, intralesional triamcinolone acetonide (2.5 mg/mL) was performed once... PCM is chronic and majority of the cases are associated with autoimmunity mediated disease such as Rheumatoid Arthritis, Diabetes Mellitus,Psoriasis and Sj
- |||||||||| Orencia (abatacept) / BMS, Rituxan (rituximab) / Roche
AUTOANTIBODIES AND PRECISION MEDICINE (HALL A) - May 1, 2024 - Abstract #AUTO2024AUTO_507;
However, a more powerful definition of individual phenotypes compatible with the concept of Precision Medicine should combine autoantibodies with a host of other biomarkers, including gene polymorphism, epigenetic markers, microRNA, and microbiome. The availability of multiplex assays and the use of artificial intelligence and machine learning should contribute to the integration of these data into useful information for the management of individual patients.
- |||||||||| AUTOANTIBODIES TARGETING G PROTEIN-COUPLED RECEPTORS IN SJ (Station 07) - May 1, 2024 - Abstract #AUTO2024AUTO_467;
Additionally, reactivity of GPCR-autoantibodies may correlate with disease characteristics, such as neurological involvement.conclusions : Autoantibodies against the muscarinic receptors (M1-M5) and the chemokine receptor CXCR3 are associated with pSS including its Ro/SSA negative subset. These autoantibodies could be helpful in diagnosing this subset of pSS patients and may have pathogenic relevance since they are associated with few disease manifestations.
- |||||||||| UPDATE ON CHECKPOINT INHIBITORS INDUCED AUTOIMMUNITY (HALL A) - May 1, 2024 - Abstract #AUTO2024AUTO_446;
An update of the rheumatic syndromes associated with CPIs will be presented including PMR-like syndromes. RA-like syndromes, myositis, Sicca syndrome, vasculitis, as well as other systemic manifestations including sarcoidosis or sarcoid-like reactions, and occasional cases of systemic sclerosis or scleroderma-like reactions, subacute cutaneous lupus erythematosus as well as SLE.
- |||||||||| ANTINUCLEAR ANTIBODIES PROFILE IN 6759 PATIENTS WITH PSYCHIATRIC DISORDERS (Station 04) - May 1, 2024 - Abstract #AUTO2024AUTO_429;
Totally 32 ANA positive patients were diagnosed with autoimmune diseases, including 19 SLE cases, 9 autoimmune encephalitis, 3 Sjogren's syndrome including 1 autoimmune hemolytic anemia, and 1 immune enteritis. conclusions : ANAs are the common autoantibodies in patients with psychiatric disorders, such as schizophrenia and depression, a part of them combined with autoimmune diseases.
|
