Sjogren's Syndrome
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  • ||||||||||  cyclosporin A microemulsion / Generic mfg.
    Journal:  The effect of intense pulsed light combined with topical 0.05% cyclosporin a eyedrops in the treatment of Sj (Pubmed Central) -  May 24, 2024   
    Moreover, SIT and lid margin abnormalities significantly improved in Group C (both p?<?0.05), but not in Group S. Treatment with 0.05% CsA eyedrops plus IPL therapy could significantly reduce the issues and physical discomfort of patients with SS-DE. Registered on 20 July 2021, with the registration number ChiCTR2100049059.
  • ||||||||||  Preclinical, Journal, IO biomarker:  PANoptosis Features, a Humanized NSG Murine Model of Sjogren's Syndrome. (Pubmed Central) -  May 23, 2024   
    The expressions of p-MLKL and p-RIPK3 were increased in the SG of NSG-pSS and NSG-SLE mice. Increased expression of type I interferon-related genes, PANoptosis (apoptosis and necroptosis) were identified in the SG of this typical humanized NSG murine model of SS.
  • ||||||||||  Review, Journal:  Combination of Sj (Pubmed Central) -  May 22, 2024   
    Key Points Below, we present the first case of Sj
  • ||||||||||  Journal:  Male patients with primary Sj (Pubmed Central) -  May 22, 2024   
    Male patients with pSS have distinctive peripheral blood lymphocyte subpopulations, present with more severe clinical symptoms and immunological features, and have an unfavorable prognosis. Key Points
  • ||||||||||  Journal:  Pulmonary Hypertension in Connective Tissue Diseases Other than Systemic Sclerosis. (Pubmed Central) -  May 22, 2024   
    The importance of diagnosing PH early in symptomatic patients with non-SSc CTD is highlighted, with a review of the relevant biomarkers, imaging, and diagnostic procedures required to establish a diagnosis.Therapeutic strategies for non-SSc PH associated with CTD are explored with an in-depth review of the medical, interventional, and surgical options available to these patients, emphasizing the CTD-specific considerations that guide treatment and aid in prognosis. By identifying gaps in the current literature, we offer insights into future research priorities that may prove valuable for patients with PH associated with non-SSc CTD.
  • ||||||||||  Review, Journal:  Non-cancerous complications in HTLV-1 carriers. (Pubmed Central) -  May 22, 2024   
    While non-cancerous events linked to HTLV-1 infection are not fatal, they are likely to reduce quality of life. Large prospective studies should be conducted by international collaborators.
  • ||||||||||  Journal:  Seronegative patients with primary Sj (Pubmed Central) -  May 21, 2024   
    Data from the ANCHOR-RA study will add to the body of evidence to support recommendations for screening for RA-ILD to improve detection of this important complication of RA and enable early intervention. Our findings suggest that salivary anti-SSA/Ro antibodies are potential discriminatory biomarkers for pSS, which may also identify seronegative patients, addressing the unmet clinical need of early detection and stratification of pSS.
  • ||||||||||  Retrospective data, Review, Journal:  Disease Duration Affects the Clinical Phenotype of Primary Sj (Pubmed Central) -  May 20, 2024   
    Longer disease duration in pSS patients correlates with increased prevalence of sicca symptoms, fatigue, and arthralgia and higher positivity of autoantibodies associated with pSS. However, the prevalence of interstitial lung disease and leukopenia did not correlate with disease duration after matching for age at onset.
  • ||||||||||  cyclosporine / Generic mfg.
    Journal:  A Cross-sectional Online Questionnaire-based Survey About the Use of Compounded Medications in Veterinary Ophthalmology. (Pubmed Central) -  May 20, 2024   
    Ten to 30% of their total prescriptions were compounded ophthalmic drugs, the most common of which were tacrolimus and cyclosporine for the treatment of keratoconjunctivitis sicca. Reported advantages of treatment with a compound included the accessibility of preparations that were not commercially available and the ability to customize formulations; reported disadvantages included brief shelf life, delivery time, and cost.
  • ||||||||||  Review, Journal:  Emerging role of gut microbiota in autoimmune diseases. (Pubmed Central) -  May 20, 2024   
    Reported advantages of treatment with a compound included the accessibility of preparations that were not commercially available and the ability to customize formulations; reported disadvantages included brief shelf life, delivery time, and cost. Furthermore, we aim to summarize the impacts and potential mechanisms that underlie the interactions between the gut microbiota and the host in autoimmune diseases, primarily focusing on systemic lupus erythematosus, rheumatoid arthritis, Sj
  • ||||||||||  Enrollment open:  Investigation of the Effectiveness of Cognitive Exercise Therapy Approach in Patients With Primary Sj (clinicaltrials.gov) -  May 20, 2024   
    P=N/A,  N=54, Recruiting, 
    Furthermore, we aim to summarize the impacts and potential mechanisms that underlie the interactions between the gut microbiota and the host in autoimmune diseases, primarily focusing on systemic lupus erythematosus, rheumatoid arthritis, Sj Not yet recruiting --> Recruiting
  • ||||||||||  Journal:  Experimental interventions attenuate a conjunctival epidermal metaplasia model. (Pubmed Central) -  May 19, 2024   
    The administration of glucocorticoids or serum resulted in the downregulation of epidermal genes (DSG1, SPRR1A/B, and KRT1) and partially corrected epidermal metaplasia. Our results using an isolated conjunctival epidermal metaplasia model point toward the possibility of rationally "repurposing" clinical interventions, such as glucocorticoid, serum, or PAX6 administration, for treating epidermal metaplasia of the conjunctiva.
  • ||||||||||  rivaroxaban / Generic mfg., apixaban / Generic mfg.
    Antiphospholipid syndrome in adult male patients in Mexico. (Exhibition Hall) -  May 17, 2024 - Abstract #ISTH2024ISTH_1536;    
    Results of 66 patients (40 and 26 with primary and secondary APS, respectively), with a median age of 26.5 years-old (range: 16-57), were analyzed. Diseases associated with secondary APS included: SLE (n=9), RA (n=7), Sj
  • ||||||||||  Review, Journal:  Understanding exososmes: Part 3-therapeutic + diagnostic potential in dentistry. (Pubmed Central) -  May 17, 2024   
    Diseases associated with secondary APS included: SLE (n=9), RA (n=7), Sj In total 47 diagnostic studies revealed a role for salivary/crevicular fluid exosomes for the diagnosis of birth defects, cardiovascular disease, diabetes, gingival recession detection, gingivitis, irritable bowel syndrome, neurodegenerative disease, oral lichen planus, oral squamous cell carcinoma, oropharyngeal cancer detection, orthodontic root resorption, pancreatic cancer, periodontitis, peri-implantitis, Sj
  • ||||||||||  Journal:  Putting science to work for women's health. (Pubmed Central) -  May 17, 2024   
    Here we describe the convergence of this initiative with the National Institute of Dental and Craniofacial Research's work to advance the understanding of sex as a biological variable for conditions such as Sjogren's disease and temporomandibular disorder. This transformative approach to women's health research propels the United States toward innovative solutions, ensuring that science works for the health and well-being of every woman.
  • ||||||||||  Retrospective data, Review, Journal:  OHIP-14 Scores in Patients with Sj (Pubmed Central) -  May 17, 2024   
    Meta-analysis revealed significantly higher scores in patients with sicca syndrome compared to pSS, although salivary flow was markedly reduced in pSS. While offering supplementary information to standard tests and supporting the assessment of pSS and sicca syndrome patients, further validation is necessary to establish OHIP-14 validity in determining the impact of pSS and sicca syndrome on patients' quality of life.
  • ||||||||||  Journal:  Saliva Production and Esophageal Motility Influence Esophageal Acid Clearance Related to (Pubmed Central) -  May 16, 2024   
    While offering supplementary information to standard tests and supporting the assessment of pSS and sicca syndrome patients, further validation is necessary to establish OHIP-14 validity in determining the impact of pSS and sicca syndrome on patients' quality of life. Saliva production and motor function are both important in PSPW related pH recovery.
  • ||||||||||  Review, Journal:  Exploring Sj (Pubmed Central) -  May 15, 2024   
    This review additionally offers the ?yurvedic viewpoint on SS and its symptoms. This supplementary insight has the potential to contribute to the development of an integrated and holistic approach to managing the condition.
  • ||||||||||  hydroxychloroquine / Generic mfg.
    Review, Journal:  Hydroxychloroquine and the associated risk of arrhythmias. (Pubmed Central) -  May 15, 2024   
    This supplementary insight has the potential to contribute to the development of an integrated and holistic approach to managing the condition. Hydroxychloroquine (HCQ), which was initially used as an antimalarial drug, is now being used to treat other illnesses, especially rheumatic autoimmune disorders
  • ||||||||||  Observational data, Retrospective data, Journal:  Epidemiology of SLE in Italy: an observational study using a primary care database. (Pubmed Central) -  May 15, 2024   
    The results of this nationwide study, the first conducted in Italy, showed that the incidence of SLE has increased in Italy in recent years. Age, sex, and area of residence strongly correlate with the epidemiology of this condition.
  • ||||||||||  Journal:  Unlocking the genetic tapestry of autoimmune diseases: Unveiling common genes across multiple conditions. (Pubmed Central) -  May 15, 2024   
    This research contributes valuable insights into the molecular signatures of autoimmune diseases, highlighting the unique gene expression patterns characterizing each condition. The identification of common genes shared among different autoimmune conditions, and their potential role in mitigating the risk of rare diseases in patients with more prevalent conditions, underscores the growing significance of genetics in healthcare and the promising future of personalized medicine.
  • ||||||||||  Journal:  One case of Sj (Pubmed Central) -  May 14, 2024   
    Our findings provide novel insights into the causal influence of autoimmune diseases on specific lymphomasubtypes, though the mechanisms behind this causal relationship warrant further exploration. No abstract available
  • ||||||||||  Review, Journal:  Peripheral Nerve and Muscle Disorders Associated with Sj (Pubmed Central) -  May 14, 2024   
    Immunotherapy using corticosteroids and high-dose intravenous immunoglobulin therapy tends to elicit varied therapeutic responses depending on the peripheral neuropathy phenotype. We also discuss myositis, a possible complication of Sj