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23 Companies |
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25 Mechanisms of Action |
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307 News |
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- Enrollment open: Phase I STEBVax in Healthy Adults (clinicaltrials.gov) - Nov 14, 2012
P1, N=29, Recruiting, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Active, not recruiting --> Recruiting
- Actimmune (interferon gamma-1 b) / Clinigen, Amgen
Enrollment open, IO biomarker: The Effects of Interferon-gamma on Sepsis-induced Immunoparalysis (clinicaltrials.gov) - Nov 11, 2012
P3, N=20, Recruiting, Sponsor: Radboud University
Active, not recruiting --> Recruiting Not yet recruiting --> Recruiting
- Trial completion: SEPSISPAM: Assessment of Two Levels of Arterial Pressure on Survival in Patients With Septic Shock (clinicaltrials.gov) - Nov 1, 2012
P=N/A, N=800, Completed, Sponsor: University Hospital, Angers
Not yet recruiting --> Recruiting Recruiting --> Completed
- || New P3 trial: VANCS II: Vasopressin Versus Norepinephrine for the Management of Septic Shock in Cancer Patients (clinicaltrials.gov) - Oct 29, 2012
P3, N=250, Recruiting, Sponsor: Instituto do Cancer do Estado de S
- | Enrollment open: VANCS II: Vasopressin Versus Norepinephrine for the Management of Septic Shock in Cancer Patients (clinicaltrials.gov) - Oct 28, 2012
P3, N=250, Recruiting, Sponsor: Instituto do Cancer do Estado de S
Recruiting --> Completed Not yet recruiting --> Recruiting
- Enrollment change: Ascorbic Acid (Vitamin C) Infusion in Human Sepsis (clinicaltrials.gov) - Oct 10, 2012
P1/2, N=24, Completed, Sponsor: Virginia Commonwealth University
Not yet recruiting --> Recruiting N=30 --> 24
- Trial completion: Ascorbic Acid (Vitamin C) Infusion in Human Sepsis (clinicaltrials.gov) - Oct 10, 2012
P1/2, N=24, Completed, Sponsor: Virginia Commonwealth University
N=30 --> 24 Recruiting --> Completed
- || New P3 trial: IDEAL-ICU: I.D.E.A.L.-I.C.U. (Initiation of Dialysis EArly Versus deLayed in Intensive Care Unit) (clinicaltrials.gov) - Sep 9, 2012
P3, N=824, Recruiting, Sponsor: Centre Hospitalier Universitaire Dijon
- Trial initiation date: SEREAL: Selenium Replacement and Serum Selenium Level in Severe Sepsis and Septic Shock Patients (clinicaltrials.gov) - Aug 22, 2012
P2, N=294, Not yet recruiting, Sponsor: Gil Joon Suh
Recruiting --> Completed Initiation date: May 2012 --> Sep 2012
- Clinical: Bio-clinical Evolutive Dynamic in Patients Suffering From Communitary Septic Shock (Biosepsis) (clinicaltrials.gov) - Aug 16, 2012
P=N/A, N=60, Recruiting, Sponsor: University Hospital, Grenoble
- Enrollment change: Early Warning System for Clinical Deterioration on General Hospital Wards (clinicaltrials.gov) - Jul 24, 2012
P=N/A, N=20031, Completed, Sponsor: Tom Bailey, MD
Initiation date: May 2012 --> Sep 2012 N=7300 --> 20031
- Trial completion: Early Warning System for Clinical Deterioration on General Hospital Wards (clinicaltrials.gov) - Jul 24, 2012
P=N/A, N=20031, Completed, Sponsor: Tom Bailey, MD
N=7300 --> 20031 Recruiting --> Completed
- Actimmune (interferon gamma-1 b) / Clinigen, Amgen
New P3 trial, IO biomarker: The Effects of Interferon-gamma on Sepsis-induced Immunoparalysis (clinicaltrials.gov) - Jul 23, 2012
P3, N=20, Recruiting, Sponsor: Radboud University
- | Fragmin (dalteparin sodium) / Pfizer, Eisai
New P2 trial: Heparin Anticoagulation to Improve Outcomes in Septic Shock: The HALO Pilot (clinicaltrials.gov) - Jul 22, 2012
P2, N=76, Active, not recruiting, Sponsor: University of Manitoba
- Solu-Cortef (hydrocortisone sodium succinate injection) / Pfizer
Enrollment open: ADRENAL: ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock (clinicaltrials.gov) - Jul 7, 2012
P4, N=3800, Recruiting, Sponsor: The George Institute
Recruiting --> Completed Not yet recruiting --> Recruiting
- Trial termination: COMPACT - COMbining Plasma-filtration and Adsorption Clinical Trial (clinicaltrials.gov) - Jul 4, 2012
P=N/A, N=184, Terminated, Sponsor: Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
Not yet recruiting --> Recruiting Suspended --> Terminated; The study was prematurely interrupted for futility.
- Enrollment change: COMPACT - COMbining Plasma-filtration and Adsorption Clinical Trial (clinicaltrials.gov) - Jul 4, 2012
P=N/A, N=184, Terminated, Sponsor: Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
Suspended --> Terminated; The study was prematurely interrupted for futility. N=330 --> 184
- Biomarker, Enrollment change: Use of Inflammatory Biomarkers to Guide Antibiotic Therapy in Patients With Severe Infections (clinicaltrials.gov) - Jun 29, 2012
P=N/A, N=94, Completed, Sponsor: Federal University of Minas Gerais
N=330 --> 184 N=124 --> 94
- Biomarker, Trial completion: Use of Inflammatory Biomarkers to Guide Antibiotic Therapy in Patients With Severe Infections (clinicaltrials.gov) - Jun 29, 2012
P=N/A, N=94, Completed, Sponsor: Federal University of Minas Gerais
N=124 --> 94 Recruiting --> Completed
- Trial initiation date: HYSATESS-p: Hypertonic Saline and Terlipressin for Sepsis-associated Hypotension (clinicaltrials.gov) - Jun 18, 2012
P3, N=21, Terminated, Sponsor: Hospital General de Ciudad Real
Recruiting --> Completed Initiation date: Mar 2011 --> Jun 2012
- Clinical: Effects of Sedatives on Sublingual Microcirculation of Patients With Septic Shock (clinicaltrials.gov) - Jun 11, 2012
P=N/A, N=16, Completed, Sponsor: Casa de Saúde São José
- | New P2 trial: Investigating FE 202158 as Potential Primary Treatment in Patients With Early Septic Shock (clinicaltrials.gov) - Jun 4, 2012
P2, N=31, Completed, Sponsor: Ferring Pharmaceuticals
- Clinical: Red Blood Cell Transfusion Improves Perfusion Parameters in Septic Shock Patients With Hypoperfusion (clinicaltrials.gov) - Jun 3, 2012
P=N/A, N=46, Completed, Sponsor: Bruno Franco Mazza
- Enrollment change: Immune Response and Cytomegalovirus in Intensive Care Unit (ICU) Patients (clinicaltrials.gov) - May 31, 2012
P=N/A, N=29, Completed, Sponsor: Assistance Publique Hopitaux De Marseille
Initiation date: Mar 2011 --> Jun 2012 N=65 --> 29
- Trial completion: Immune Response and Cytomegalovirus in Intensive Care Unit (ICU) Patients (clinicaltrials.gov) - May 31, 2012
P=N/A, N=29, Completed, Sponsor: Assistance Publique Hopitaux De Marseille
N=65 --> 29 Recruiting --> Completed
- heparin sodium injection / Generic mfg.
Enrollment open: Safety of Heparin in Patients With Septic Shock (clinicaltrials.gov) - May 29, 2012
P2, N=100, Recruiting, Sponsor: University of Colorado, Denver
Recruiting --> Completed Not yet recruiting --> Recruiting
- Clinical: Membrane Shedding During Septic Shock (clinicaltrials.gov) - May 21, 2012
P=N/A, N=100, Completed, Sponsor: University Hospital, Strasbourg, France
- Trial termination: Simultaneously Using Traditional Chinese Medicine (Si-Ni-Tang) to Treat Septic Shock Patients (clinicaltrials.gov) - May 20, 2012
P2, N=8, Terminated, Sponsor: Changhua Christian Hospital
Recruiting --> Terminated; The IRB considered our trial risky. Although there were debates between investigators and IRB, we terminated our trial in accordance with the suggestion of IRB.
- Enrollment change: Simultaneously Using Traditional Chinese Medicine (Si-Ni-Tang) to Treat Septic Shock Patients (clinicaltrials.gov) - May 20, 2012
P2, N=8, Terminated, Sponsor: Changhua Christian Hospital
Although there were debates between investigators and IRB, we terminated our trial in accordance with the suggestion of IRB. N=120 --> 8
- fludrocortisone / Generic mfg., hydrocortisone / Generic mfg.
Trial suspension: APROCCHS: Activated Protein C and Corticosteroids for Human Septic Shock (clinicaltrials.gov) - May 20, 2012
P3, N=1280, Suspended, Sponsor: University of Versailles
N=120 --> 8 Recruiting --> Suspended
- | New P2 trial: SEREAL: Selenium Replacement and Serum Selenium Level in Severe Sepsis and Septic Shock Patients (clinicaltrials.gov) - May 16, 2012
P2, N=294, Not yet recruiting, Sponsor: Gil Joon Suh
- Clinical: Evaluation of Intestinal Brush Border Enzyme Function in Critically Ill Patients (clinicaltrials.gov) - Apr 24, 2012
P=N/A, N=45, Recruiting, Sponsor: Medical University of Vienna
- Byetta (exenatide) / AstraZeneca
New P1/2 trial: Pharmacology of Exenatide in Pediatric Sepsis (clinicaltrials.gov) - Apr 8, 2012
P1/2, N=0, Withdrawn, Sponsor: Seattle Children's Hospital
- Enrollment closed: Comparison of a Tissue Perfusion Guided Hemodynamic Protocol With a Standard Hemodynamic Protocol in Septic Shock Patients (clinicaltrials.gov) - Mar 27, 2012
P=N/A, N=128, Active, not recruiting, Sponsor: University Hospital Inselspital, Berne
Recruiting --> Suspended Recruiting --> Active, not recruiting
- | Trial completion: Scandinavian Starch for Severe Sepsis/Septic Shock Trial (clinicaltrials.gov) - Mar 22, 2012
P3, N=804, Completed, Sponsor: Anders Perner
Recruiting --> Active, not recruiting Active, not recruiting --> Completed
- ||||||| Trial completion: Efficacy and Safety of Drotrecogin Alfa (Activated) in Adult Patients With Septic Shock (clinicaltrials.gov) - Mar 8, 2012
P3, N=1696, Completed, Sponsor: Eli Lilly and Company
Active, not recruiting --> Completed Active, not recruiting --> Completed
- | Enrollment closed: ALBIOS: Volume Replacement With Albumin in Severe Sepsis (clinicaltrials.gov) - Feb 29, 2012
P3, N=1800, Active, not recruiting, Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Active, not recruiting --> Completed Recruiting --> Active, not recruiting
- Solu-Cortef (hydrocortisone sodium succinate injection) / Pfizer
Trial initiation date: ADRENAL: ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock (clinicaltrials.gov) - Feb 21, 2012
P4, N=3800, Recruiting, Sponsor: The George Institute
Recruiting --> Active, not recruiting Initiation date: Feb 2012 --> Jun 2012
- | New P1/2 trial: Use of PiCCO System in Critically Ill Patients With Septic Shock and Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Feb 1, 2012
P1/2, N=400, Recruiting, Sponsor: Jinhua Central Hospital
- Enrollment open: Emergency Department Management of Sepsis Patients: A Goal-Oriented Non-Invasive Sepsis Trial (clinicaltrials.gov) - Jan 16, 2012
P=N/A, N=160, Recruiting, Sponsor: National University Hospital, Singapore
Initiation date: Feb 2012 --> Jun 2012 Not yet recruiting --> Recruiting
- | Enrollment open: The Cooling And Surviving Septic Shock Study (CASS) (clinicaltrials.gov) - Jan 11, 2012
P2/3, N=560, Recruiting, Sponsor: Danish Procalcitonin Study Group
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- || New P3 trial: TRISS: Transfusion-requirements in Septic Shock Trial (clinicaltrials.gov) - Dec 1, 2011
P3, N=1000, Active, not recruiting, Sponsor: Scandinavian Critical Care Trials Group
- Trial completion: The Use of Intensive Care in Critically Ill Cancer Haematological Patients: "TRIAL-OH" (clinicaltrials.gov) - Nov 20, 2011
P=N/A, N=1011, Completed, Sponsor: Assistance Publique - Hôpitaux de Paris
Not yet recruiting --> Recruiting Recruiting --> Completed
- | Trial completion: A Study to Assess Safety,and Tolerability of 2 Doses of AZD9773 (CytoFab™) in Japanese With Severe Sepsis/Septic Shock (clinicaltrials.gov) - Nov 6, 2011
P2, N=20, Completed, Sponsor: AstraZeneca
Recruiting --> Completed Active, not recruiting --> Completed
- || New P2/3 trial: The Cooling And Surviving Septic Shock Study (CASS) (clinicaltrials.gov) - Oct 17, 2011
P2/3, N=560, Recruiting, Sponsor: Danish Procalcitonin Study Group
- Enrollment change: VaCoSS: Serial Vasopressin and Copeptin Levels in Children With Sepsis and Septic Shock (clinicaltrials.gov) - Oct 11, 2011
P=N/A, N=153, Recruiting, Sponsor: Jan Hau Lee
Active, not recruiting --> Completed N=105 --> 153
- Clinical: Preemptive Resuscitation for Eradication of Septic Shock (clinicaltrials.gov) - Oct 6, 2011
P=N/A, N=140, Recruiting, Sponsor: Christiana Care Health Services
- | Solu-Cortef (hydrocortisone sodium succinate injection) / Pfizer
New P4 trial: ADRENAL: ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock (clinicaltrials.gov) - Oct 5, 2011
P4, N=3800, Recruiting, Sponsor: The George Institute
- Clinical: High MAP in Septic Shock With Hypertension (clinicaltrials.gov) - Sep 27, 2011
P=N/A, N=24, Recruiting, Sponsor: Southeast University, China
- New P1/2 trial: Ascorbic Acid (Vitamin C) Infusion in Human Sepsis (clinicaltrials.gov) - Sep 12, 2011
P1/2, N=24, Completed, Sponsor: Virginia Commonwealth University