Sezary Syndrome MOAs - LARVOL Sigma

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Phase N/A 1 2 3 4 Products	0	3	6	9	12	15	18	21	24	27	30



Purinergic receptor P1 agon




CD20 inhib




CD20 inhib




DNA cross linking agent




VEGFR inhib




AKT inhib




HDAC2 inhib




VEGFR inhib




PDGFR inhib




c-KIT inhib




µ-opioid agon




GCR agon




IL-6 inhib




IFNα 2b stim




IL-2 stim




Tubulin polymerization promoter




mTOR inhib




AKT inhib




Bcl2 inhib




Bcl2 inhib




CD20 inhib




CXCR4 antag




Calcineurin inhib




IL-1β inhib




IL-6 inhib




IMPDH inhib




Immunosuppressant




Integrin inhib




NMDAR antag




PPAR α agon




Protease inhib




Proteasome inhib




T-cell activation inhib




TIE-2 inhib




TNFα inhib




Apoptosis stim




Aurora kinase A inhib




BRAF inhib




Bone morphogenetic protein receptor type II mod




CDK6 inhib




COX2 inhib




CTLA4 inhib




Cytomegalovirus replication inhib




DGAT-1 inhib




EGFR inhib




EPH receptor inhib




Endosialin inhib




Fyn inhib




GM-CSF agon




GM-CSF agon



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