Sepsis
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  • ||||||||||  Trial completion, Enrollment change, Trial initiation date, Trial primary completion date:  Intensive Care - GLObal Study on Severe Acute Respiratory Infection (clinicaltrials.gov) -  Dec 12, 2014   
    P=N/A,  N=800, Completed, 
    Active, not recruiting --> Completed | N=4000 --> 800 | Initiation date: Nov 2013 --> Nov 2014 | Trial primary completion date: Dec 2015 --> Nov 2014
  • ||||||||||  Turnobi (L-citrulline intravenous) / Asklepion Pharma
    Trial primary completion date:  Citrulline in Severe Sepsis (clinicaltrials.gov) -  Dec 10, 2014   
    P2,  N=75, Recruiting, 
    Active, not recruiting --> Completed | N=4000 --> 800 | Initiation date: Nov 2013 --> Nov 2014 | Trial primary completion date: Dec 2015 --> Nov 2014 Trial primary completion date: Jul 2014 --> Dec 2015
  • ||||||||||  Trial completion:  PROMS-01: Probiotics and Endotoxemia (clinicaltrials.gov) -  Dec 10, 2014   
    P=N/A,  N=90, Completed, 
    Trial primary completion date: Jul 2014 --> Dec 2015 Active, not recruiting --> Completed
  • ||||||||||  Enrollment change, Trial termination:  Investigate the Activity of Endotoxin in Severe Sepsis (clinicaltrials.gov) -  Dec 6, 2014   
    P=N/A,  N=2, Terminated, 
    Trial primary completion date: Dec 2014 --> Dec 2015 N=60 --> 2 | Recruiting --> Terminated; The quality of Limulus Amebocyte Lysate (LAL) test was poor.
  • ||||||||||  Enrollment closed:  Phase I STEBVax in Healthy Adults (clinicaltrials.gov) -  Dec 6, 2014   
    P1,  N=29, Active, not recruiting, 
    N=60 --> 2 | Recruiting --> Terminated; The quality of Limulus Amebocyte Lysate (LAL) test was poor. Recruiting --> Active, not recruiting
  • ||||||||||  Biomarker, Trial completion, Trial primary completion date:  The Value of PSP in Predicting Outcome in ICU Surgical Peritonitis Patients (clinicaltrials.gov) -  Dec 6, 2014   
    P=N/A,  N=137, Completed, 
    Recruiting --> Active, not recruiting Enrolling by invitation --> Completed | Trial primary completion date: Dec 2011 --> Dec 2014
  • ||||||||||  Omegaven (omega-3 long-chain polyunsaturated fatty acids) / Fresenius Kabi
    Enrollment open, Phase classification, Trial initiation date, Trial primary completion date:  FOILED: Fish OIL Optimal dosE Determination Study (clinicaltrials.gov) -  Dec 5, 2014   
    P2,  N=21, Recruiting, 
    Not yet recruiting --> Terminated; Key Personnel left institution Not yet recruiting --> Recruiting | Phase classification: P1 --> P2 | Initiation date: Oct 2010 --> Oct 2013 | Trial primary completion date: Dec 2011 --> Dec 2015
  • ||||||||||  Trial completion:  Early- and Late-onset Candidemia (clinicaltrials.gov) -  Dec 5, 2014   
    P=N/A,  N=400, Completed, 
    Recruiting --> Completed | Trial primary completion date: Mar 2014 --> Nov 2014 Recruiting --> Completed
  • ||||||||||  Trial termination, Trial primary completion date:  Hyper2S: Hyperoxia and Hypertonic Saline in Septic Shock (clinicaltrials.gov) -  Nov 20, 2014   
    P=N/A,  N=441, Terminated, 
    Recruiting --> Completed | N=136 --> 57 Active, not recruiting --> Terminated | Trial primary completion date: Jun 2014 --> Sep 2014
  • ||||||||||  tranexamic acid oral / Generic mfg.
    Trial completion, Enrollment change:  Single Dose Enteral Tranexamic Acid in Critically Ill Patients (clinicaltrials.gov) -  Nov 19, 2014   
    P2,  N=4, Completed, 
    N=100 --> 414 Recruiting --> Completed | N=200 --> 4
  • ||||||||||  Trial completion, Enrollment change, Trial primary completion date:  SIHAM Candidemia Network:An Observational Study (clinicaltrials.gov) -  Nov 19, 2014   
    P=N/A,  N=1400, Completed, 
    Recruiting --> Completed | N=200 --> 4 Not yet recruiting --> Completed | N=2500 --> 1400 | Trial primary completion date: Mar 2012 --> Jun 2012
  • ||||||||||  Trial primary completion date:  Early PREdiction of Severe Sepsis I (ExPRES-Sepsis I) Study (clinicaltrials.gov) -  Nov 13, 2014   
    P=N/A,  N=200, Recruiting, 
    Not yet recruiting --> Recruiting Trial primary completion date: Nov 2014 --> Jul 2015
  • ||||||||||  dexmedetomidine / Generic mfg.
    Clinical:  Dexmedetomidine on Microcirculation in Septic Shock (clinicaltrials.gov) -  Oct 30, 2014   
    P4,  N=30, Recruiting, 
    Trial primary completion date: May 2015 --> May 2016 Not yet recruiting --> Recruiting
  • ||||||||||  gentamicin sulfate / Generic mfg., amoxicillin / Generic mfg.
    Trial completion, Trial primary completion date:  Neonatal Sepsis, Evaluation, Bangladesh (clinicaltrials.gov) -  Oct 30, 2014   
    P=N/A,  N=20000, Completed, 
    Recruiting --> Completed | N=6000 --> 12000 Recruiting --> Completed | Trial primary completion date: Jun 2014 --> Dec 2013
  • ||||||||||  Enrollment open:  Actigraphy to MEasuRe Intensive Care Unit Activity (clinicaltrials.gov) -  Oct 24, 2014   
    P=N/A,  N=75, Recruiting, 
    N=300 --> 30 | Recruiting --> Terminated | Trial primary completion date: Dec 2011 --> Dec 2013; Study logistics proved difficult and enrollment never moved beyond the pilot phase. Not yet recruiting --> Recruiting
  • ||||||||||  Cubicin (daptomycin) / Merck (MSD)
    Enrollment change, Trial termination:  Daptomycin + Meropenem Versus Ceftazidime in the Treatment of Nosocomial Spontaneous Bacterial Peritonitis (clinicaltrials.gov) -  Oct 17, 2014   
    P2/3,  N=32, Terminated, 
    Recruiting --> Completed | Trial primary completion date: Jul 2013 --> Apr 2014 N=60 --> 32 | Recruiting --> Terminated; Decision of independent monitoring committee after interim analysis: Risk of failure significantly higher in ceftazidime group.