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55 Companies |
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51 Products |
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51 Products |
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62 Mechanisms of Action |
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1119 News |
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- Trial completion, Enrollment change: Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE (clinicaltrials.gov) - Dec 12, 2014
P=N/A, N=14000, Completed, Sponsor: European Society of Intensive Care Medicine
Recruiting --> Completed | N=1000 --> 14000
- Turnobi (L-citrulline intravenous) / Asklepion Pharma
Trial primary completion date: Citrulline in Severe Sepsis (clinicaltrials.gov) - Dec 10, 2014
P2, N=75, Recruiting, Sponsor: Vanderbilt University
Recruiting --> Completed | N=1000 --> 14000 Trial primary completion date: Jul 2014 --> Dec 2015
- ||| Trial completion: PROMS-01: Probiotics and Endotoxemia (clinicaltrials.gov) - Dec 10, 2014
P=N/A, N=90, Completed, Sponsor: Danisco
Trial primary completion date: Jul 2014 --> Dec 2015 Active, not recruiting --> Completed
- colistin sulphate / Generic mfg.
Trial primary completion date: Optimizing Dosing of Colistin for Infections Resistant to All Other Antibiotics, Approved NIH Protocol Dated 12.06.07(DMID Protocol #07-0036) (clinicaltrials.gov) - Dec 9, 2014
P=N/A, N=10, Active, not recruiting, Sponsor: University of Pittsburgh
Active, not recruiting --> Completed Trial primary completion date: Aug 2013 --> Dec 2014
- ||| Enrollment open: Changes in 13CO2/12CO2 Delta Value in Exhaled Breath as an Early Indicator of Infection in Adult Trauma Subjects (clinicaltrials.gov) - Dec 9, 2014
P=N/A, N=110, Recruiting, Sponsor: University of Wisconsin, Madison
Trial primary completion date: Aug 2013 --> Dec 2014 Not yet recruiting --> Recruiting
- Trial primary completion date: Study of the Impact of the Minimum Inhibitory Concentration and Susceptible Cut-off Points (CLSI, EUCAST, and Pharmacokinetics/Pharmacodynamics)in Prognosis of Bacteremia by Enterobacteriaceae (clinicaltrials.gov) - Dec 6, 2014
P=N/A, N=900, Recruiting, Sponsor: Fundación Pública Andaluza Progreso y Salud
Not yet recruiting --> Recruiting Trial primary completion date: Jun 2014 --> Dec 2014
- || Trial primary completion date: Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock (clinicaltrials.gov) - Dec 6, 2014
P=N/A, N=361, Recruiting, Sponsor: University of British Columbia
Trial primary completion date: Jun 2014 --> Dec 2014 Trial primary completion date: Dec 2014 --> Dec 2015
- Enrollment change, Trial termination: Investigate the Activity of Endotoxin in Severe Sepsis (clinicaltrials.gov) - Dec 6, 2014
P=N/A, N=2, Terminated, Sponsor: National Taiwan University Hospital
Trial primary completion date: Dec 2014 --> Dec 2015 N=60 --> 2 | Recruiting --> Terminated; The quality of Limulus Amebocyte Lysate (LAL) test was poor.
- Clinical: Assessment of Coagulation Profile and Haematopoietic Responses in Patients With Acute-on-chronic Liver Failure During Systemic Inflammatory Response (SIRS) and Sepsis (clinicaltrials.gov) - Dec 6, 2014
P=N/A, N=100, Recruiting, Sponsor: Institute of Liver and Biliary Sciences, India
- ||| Biomarker, Trial completion, Trial primary completion date: The Value of PSP in Predicting Outcome in ICU Surgical Peritonitis Patients (clinicaltrials.gov) - Dec 6, 2014
P=N/A, N=137, Completed, Sponsor: University of Magdeburg
N=60 --> 2 | Recruiting --> Terminated; The quality of Limulus Amebocyte Lysate (LAL) test was poor. Enrolling by invitation --> Completed | Trial primary completion date: Dec 2011 --> Dec 2014
- Enrollment closed: Phase I STEBVax in Healthy Adults (clinicaltrials.gov) - Dec 6, 2014
P1, N=29, Active, not recruiting, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Enrolling by invitation --> Completed | Trial primary completion date: Dec 2011 --> Dec 2014 Recruiting --> Active, not recruiting
- || vancomycin / Generic mfg.
Trial primary completion date: Bacteremia: Treatment Algorithm to Reduce the Use of Vancomycin in Adults With Blood Stream Infection (clinicaltrials.gov) - Dec 5, 2014
P2, N=500, Recruiting, Sponsor: Duke University
Recruiting --> Active, not recruiting Trial primary completion date: Apr 2015 --> Jun 2016
- Trial termination: Utility of High-Fidelity Simulation In the Education and Assessment of Residents in the Recognition and Management of the Sepsis Syndrome (clinicaltrials.gov) - Dec 5, 2014
P=N/A, N=40, Terminated, Sponsor: New York University School of Medicine
Trial primary completion date: Apr 2015 --> Jun 2016 Not yet recruiting --> Terminated; Key Personnel left institution
- piperacillin / Generic mfg.
Clinical: PK Analysis of Piperacillin in Septic Shock Patients (clinicaltrials.gov) - Dec 5, 2014
P=N/A, N=15, Recruiting, Sponsor: University of Aarhus
- ||| Clinical: PPV to Guide Fluid Management in the PICU (clinicaltrials.gov) - Dec 5, 2014
P=N/A, N=150, Not yet recruiting, Sponsor: University of North Carolina, Chapel Hill
- Trial completion, Trial primary completion date: Noninvasive Assessment of Tissue Perfusion Status in Critically Ill Pediatric Patients (clinicaltrials.gov) - Dec 5, 2014
P=N/A, N=46, Completed, Sponsor: University of Michigan
Not yet recruiting --> Terminated; Key Personnel left institution Recruiting --> Completed | Trial primary completion date: Mar 2014 --> Nov 2014
- ||| Trial completion: Early- and Late-onset Candidemia (clinicaltrials.gov) - Dec 5, 2014
P=N/A, N=400, Completed, Sponsor: Giovanni Di Perri
Recruiting --> Completed | Trial primary completion date: Mar 2014 --> Nov 2014 Recruiting --> Completed
- levofloxacin / Generic mfg., cloxacillin / Generic mfg.
Trial primary completion date: Efficacy of a Short-term Sequential Therapy in Non-complicated Catheter Related Bacteremia by Methicillin- Susceptible S.Aureus. (clinicaltrials.gov) - Dec 5, 2014
P3, N=154, Recruiting, Sponsor: Fundaci
Recruiting --> Completed Trial primary completion date: Jun 2014 --> Jan 2015
- Omegaven (omega-3 long-chain polyunsaturated fatty acids) / Fresenius Kabi
Enrollment open, Phase classification, Trial initiation date, Trial primary completion date: FOILED: Fish OIL Optimal dosE Determination Study (clinicaltrials.gov) - Dec 5, 2014
P2, N=21, Recruiting, Sponsor: University Hospital Carl Gustav Carus
Trial primary completion date: Jun 2014 --> Jan 2015 Not yet recruiting --> Recruiting | Phase classification: P1 --> P2 | Initiation date: Oct 2010 --> Oct 2013 | Trial primary completion date: Dec 2011 --> Dec 2015
- || Trial completion, Trial initiation date: VECTORII: In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia - VECTOR II (clinicaltrials.gov) - Dec 5, 2014
P3, N=20, Completed, Sponsor: Radboud University
Not yet recruiting --> Recruiting | Phase classification: P1 --> P2 | Initiation date: Oct 2010 --> Oct 2013 | Trial primary completion date: Dec 2011 --> Dec 2015 Not yet recruiting --> Completed | Initiation date: May 2013 --> Sep 2013
- Clinical: OFTaPLR: Optimization of Fluid Therapy in Sepsis by a Passive Leg Raising Test (clinicaltrials.gov) - Nov 28, 2014
P=N/A, N=120, Recruiting, Sponsor: Karolinska Institutet
- Trial completion: Effects of Free Fatty Acids and 3-hydroxybutyrate on Protein, Glucose, Lipid Metabolism and Intracellular Signals. (clinicaltrials.gov) - Nov 25, 2014
P=N/A, N=10, Completed, Sponsor: University of Aarhus
Not yet recruiting --> Completed | Initiation date: May 2013 --> Sep 2013 Active, not recruiting --> Completed
- Trial completion, Enrollment change: Urinary Heparanase Activity as a Predictor of Acute Kidney Injury in Critically Ill Adults (clinicaltrials.gov) - Nov 24, 2014
P=N/A, N=57, Completed, Sponsor: Denver Health and Hospital Authority
Active, not recruiting --> Completed Recruiting --> Completed | N=136 --> 57
- Trial termination, Trial primary completion date: Hyper2S: Hyperoxia and Hypertonic Saline in Septic Shock (clinicaltrials.gov) - Nov 20, 2014
P=N/A, N=441, Terminated, Sponsor: University Hospital, Angers
Recruiting --> Completed | N=136 --> 57 Active, not recruiting --> Terminated | Trial primary completion date: Jun 2014 --> Sep 2014
- || Enrollment change: VitalCare: The Prevention of Failure to Rescue Using Early Warning Scoring (clinicaltrials.gov) - Nov 20, 2014
P=N/A, N=414, Completed, Sponsor: Philips Healthcare
Active, not recruiting --> Terminated | Trial primary completion date: Jun 2014 --> Sep 2014 N=100 --> 414
- Clinical: Early Procalcitonin Kinetics During Empirical Antibiotic Therapy in Critically Ill Patients (clinicaltrials.gov) - Nov 19, 2014
P=N/A, N=209, Completed, Sponsor: Domonkos Trásy
- tranexamic acid oral / Generic mfg.
Trial completion, Enrollment change: Single Dose Enteral Tranexamic Acid in Critically Ill Patients (clinicaltrials.gov) - Nov 19, 2014
P2, N=4, Completed, Sponsor: San Diego Veterans Healthcare System
N=100 --> 414 Recruiting --> Completed | N=200 --> 4
- Trial completion, Enrollment change, Trial primary completion date: SIHAM Candidemia Network:An Observational Study (clinicaltrials.gov) - Nov 19, 2014
P=N/A, N=1400, Completed, Sponsor: Society of Indian Human & Animal Mycologist
Recruiting --> Completed | N=200 --> 4 Not yet recruiting --> Completed | N=2500 --> 1400 | Trial primary completion date: Mar 2012 --> Jun 2012
- Biomarker, Trial primary completion date: Neutrophil Gelatinase Associated Lipocalin (NGAL) in Urine: Can This Prove to be a Biomarker for Acute Kidney Injury in Patients With Sepsis? (clinicaltrials.gov) - Nov 18, 2014
P=N/A, N=40, Recruiting, Sponsor: Sygehus Lillebaelt
Not yet recruiting --> Completed | N=2500 --> 1400 | Trial primary completion date: Mar 2012 --> Jun 2012 Trial primary completion date: Jul 2014 --> Jun 2015
- Enrollment open: Early Goal Directed Therapy in Sepsis by Emergency Medical Services (clinicaltrials.gov) - Nov 16, 2014
P=N/A, N=200, Recruiting, Sponsor: Massachusetts General Hospital
Trial primary completion date: Jul 2014 --> Jun 2015 Not yet recruiting --> Recruiting
- || Trial primary completion date: Early PREdiction of Severe Sepsis I (ExPRES-Sepsis I) Study (clinicaltrials.gov) - Nov 13, 2014
P=N/A, N=200, Recruiting, Sponsor: University of Edinburgh
Not yet recruiting --> Recruiting Trial primary completion date: Nov 2014 --> Jul 2015
- Trial primary completion date: Immune Response of Patients With Chronic, Staphylococcus Aureus-infected Wounds (clinicaltrials.gov) - Nov 5, 2014
P=N/A, N=76, Recruiting, Sponsor: Centre Hospitalier Universitaire de Nīmes
Trial primary completion date: Nov 2014 --> Jul 2015 Trial primary completion date: May 2015 --> May 2016
- dexmedetomidine / Generic mfg.
Clinical: Dexmedetomidine on Microcirculation in Septic Shock (clinicaltrials.gov) - Oct 30, 2014
P4, N=30, Recruiting, Sponsor: Southeast University, China
Trial primary completion date: May 2015 --> May 2016 Not yet recruiting --> Recruiting
- Trial completion, Enrollment change: Improved Accessibility of EmONC Services for Maternal and Newborn Health: a Community Based Project (clinicaltrials.gov) - Oct 30, 2014
P=N/A, N=12000, Completed, Sponsor: Aga Khan University
Not yet recruiting --> Recruiting Recruiting --> Completed | N=6000 --> 12000
- gentamicin sulfate / Generic mfg., amoxicillin / Generic mfg.
Trial completion, Trial primary completion date: Neonatal Sepsis, Evaluation, Bangladesh (clinicaltrials.gov) - Oct 30, 2014
P=N/A, N=20000, Completed, Sponsor: International Centre for Diarrhoeal Disease Research, Bangladesh
Recruiting --> Completed | N=6000 --> 12000 Recruiting --> Completed | Trial primary completion date: Jun 2014 --> Dec 2013
- Enrollment change, Trial termination, Trial primary completion date: PIN-UP: Validation Study of Combined Positron Emission Tomography/Computer Tomography to Diagnose Infection and Inflammation (clinicaltrials.gov) - Oct 28, 2014
P=N/A, N=30, Terminated, Sponsor: Odense University Hospital
Recruiting --> Completed | Trial primary completion date: Jun 2014 --> Dec 2013 N=300 --> 30 | Recruiting --> Terminated | Trial primary completion date: Dec 2011 --> Dec 2013; Study logistics proved difficult and enrollment never moved beyond the pilot phase.
- New P1 trial: A Trial on Different Dosages of Vitamin D in Preterm Infants With Late-onset Sepsis (clinicaltrials.gov) - Oct 24, 2014
P1, N=50, Recruiting, Sponsor: Mansoura University Children Hospital
- Enrollment open: Actigraphy to MEasuRe Intensive Care Unit Activity (clinicaltrials.gov) - Oct 24, 2014
P=N/A, N=75, Recruiting, Sponsor: Vanderbilt University
N=300 --> 30 | Recruiting --> Terminated | Trial primary completion date: Dec 2011 --> Dec 2013; Study logistics proved difficult and enrollment never moved beyond the pilot phase. Not yet recruiting --> Recruiting
- Trial termination, Trial primary completion date: Administration of Protein C Concentrates in Adult Critically Ill Septic Patients (clinicaltrials.gov) - Oct 23, 2014
P3, N=0, Terminated, Sponsor: Università Vita-Salute San Raffaele
Not yet recruiting --> Recruiting Recruiting --> Terminated | Trial primary completion date: May 2015 --> Oct 2014
- Enrollment change, Trial withdrawal: System-level Monitoring of Immune Activation Concerning Susceptibility to Sepsis in Trauma Patients (clinicaltrials.gov) - Oct 22, 2014
P=N/A, N=0, Withdrawn, Sponsor: Universitätsmedizin Mannheim
Recruiting --> Terminated | Trial primary completion date: May 2015 --> Oct 2014 N=30 --> 0 | Not yet recruiting --> Withdrawn
- dexmedetomidine / Generic mfg.
Clinical: Dexmedetomidine on Microcirculation in Septic Shock (clinicaltrials.gov) - Oct 22, 2014
P4, N=30, Not yet recruiting, Sponsor: Southeast University, China
- Trial completion, Trial primary completion date: Immune Activation, Hypoxia and Vasoreaction in Sepsis of Pulmonary Versus Abdominal Origin (clinicaltrials.gov) - Oct 22, 2014
P=N/A, N=20, Completed, Sponsor: Universitätsmedizin Mannheim
N=30 --> 0 | Not yet recruiting --> Withdrawn Recruiting --> Completed | Trial primary completion date: Jul 2013 --> Apr 2014
- Surgery, Bariatric surgery: Transluminal or Percutaneous Endoscopic Drainage and Debridement of Abcesses After Bariatric Surgery (clinicaltrials.gov) - Oct 17, 2014
P=N/A, N=9, Completed, Sponsor: Erasme University Hospital
- | Solu-Cortef (hydrocortisone sodium succinate injection) / Pfizer
New P4 trial: Hyperglycemia and Effects of Daily 100 mg Versus 200 mg of Hydrocortisone Therapy in Patients With Septic Shock (clinicaltrials.gov) - Oct 17, 2014
P4, N=80, Recruiting, Sponsor: Srinakharinwirot University
- || hydrocortisone / Generic mfg.
New P3 trial: Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock (clinicaltrials.gov) - Oct 17, 2014
P3, N=84, Completed, Sponsor: Nanjing PLA General Hospital
- Enrollment open: PRODA: Procalcitonin-guided Treatment on Duration of Antibiotic Therapy and Cost in Septic Patients (clinicaltrials.gov) - Oct 17, 2014
P=N/A, N=50, Recruiting, Sponsor: Seoul National University Hospital
Recruiting --> Completed | Trial primary completion date: Jul 2013 --> Apr 2014 Not yet recruiting --> Recruiting
- Cubicin (daptomycin) / Merck (MSD)
Enrollment change, Trial termination: Daptomycin + Meropenem Versus Ceftazidime in the Treatment of Nosocomial Spontaneous Bacterial Peritonitis (clinicaltrials.gov) - Oct 17, 2014
P2/3, N=32, Terminated, Sponsor: University of Padova
Not yet recruiting --> Recruiting N=60 --> 32 | Recruiting --> Terminated; Decision of independent monitoring committee after interim analysis: Risk of failure significantly higher in ceftazidime group.
- | New trial: Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness: A Pilot RCT (clinicaltrials.gov) - Oct 11, 2014
P=N/A, N=115, Recruiting, Sponsor: Sunnybrook Health Sciences Centre
N=60 --> 32 | Recruiting --> Terminated; Decision of independent monitoring committee after interim analysis: Risk of failure significantly higher in ceftazidime group. Not yet recruiting --> Recruiting
- ||| Clinical: Changes in 13CO2/12CO2 Delta Value in Exhaled Breath as an Early Indicator of Infection in Adult Trauma Subjects (clinicaltrials.gov) - Oct 11, 2014
P=N/A, N=110, Not yet recruiting, Sponsor: University of Wisconsin, Madison
- Enrollment change, Trial termination, Trial primary completion date: Safety and Efficacy Study of Ethanol Locking to Prevent Central Line Infection in Premature Neonates (clinicaltrials.gov) - Oct 4, 2014
P=N/A, N=10, Terminated, Sponsor: East Carolina University
Not yet recruiting --> Recruiting N=150 --> 10 | Recruiting --> Terminated | Trial primary completion date: Dec 2012 --> Jun 2011; Primary investigator relocated