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53 Companies |
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51 Products |
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51 Products |
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62 Mechanisms of Action |
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0 Trials |
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1105 News |
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- |||| ALT 836 / ImmunityBio
Trial completion: Anti-TF Antibody (ALT-836) to Treat Septic Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Apr 13, 2015
P2, N=150, Completed, Sponsor: Altor Bioscience Corporation
Active, not recruiting --> Completed
- |||| NN1213 / Novo Nordisk
Trial completion, Gram negative: GR270773 In The Treatment Of Suspected Or Confirmed Gram-Negative Severe Sepsis In Adults (clinicaltrials.gov) - Apr 13, 2015
P2, N=1415, Completed, Sponsor: GlaxoSmithKline
Active, not recruiting --> Completed Terminated --> Completed
- Trial completion: Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes? (clinicaltrials.gov) - Apr 8, 2015
P=N/A, N=200, Completed, Sponsor: Jewish Hospital, Cincinnati, Ohio
Terminated --> Completed Not yet recruiting --> Completed
- Trial completion, Enrollment change, Trial primary completion date: Naushero Feroze Neonatal Survival Project (clinicaltrials.gov) - Apr 7, 2015
P=N/A, N=37201, Completed, Sponsor: Aga Khan University
Not yet recruiting --> Completed Recruiting --> Completed | N=16000 --> 37201 | Trial primary completion date: Jun 2012 --> Jan 2013
- Trial completion: The AVERT Sepsis Investigation (clinicaltrials.gov) - Apr 6, 2015
P=N/A, N=100, Completed, Sponsor: Christiana Care Health Services
Recruiting --> Completed | N=16000 --> 37201 | Trial primary completion date: Jun 2012 --> Jan 2013 Recruiting --> Completed
- | Cx611 / Takeda
Trial completion: CELLULA: Randomized, Parallel Group, Placebo Control, Unicentric, Interventional Study to Assess the Effect of Expanded Human Allogeneic Adipose-derived Mesenchymal Adult Stem Cells on the Human Response to Lipopolysaccharyde in Human Volunteers (clinicaltrials.gov) - Apr 3, 2015
P1, N=32, Completed, Sponsor: TiGenix S.A.U.
Recruiting --> Completed Recruiting --> Completed
- ||||||| Cresemba (isavuconazonium sulfate) / Astellas, Basilea
Trial completion: Isavuconazole (BAL8557) in the Treatment of Candidemia and Other Invasive Candida Infections (clinicaltrials.gov) - Apr 1, 2015
P3, N=450, Completed, Sponsor: Astellas Pharma Inc
Recruiting --> Completed Active, not recruiting --> Completed
- Trial completion, Trial initiation date, Monotherapy, Head-to-Head: Efficacy and Safety of Monotherapy With Noradrenaline and Terlipressin in Patients of Cirrhosis With Septic Shock Admitted to Intensive Care Unit (clinicaltrials.gov) - Mar 31, 2015
P=N/A, N=84, Completed, Sponsor: Institute of Liver and Biliary Sciences, India
Active, not recruiting --> Completed Recruiting --> Completed | Initiation date: Apr 2013 --> Oct 2012
- | Mycamine (micafungin) / Astellas
Trial completion, Trial primary completion date: EMPIRICUS: Empirical Antifungal Treatment in ICUS (clinicaltrials.gov) - Mar 24, 2015
P3, N=260, Completed, Sponsor: University Hospital, Grenoble
Recruiting --> Completed | Initiation date: Apr 2013 --> Oct 2012 Recruiting --> Completed | Trial primary completion date: Dec 2013 --> Feb 2015
- ||| Trial completion: Procalcitonin Monitoring Sepsis Study (clinicaltrials.gov) - Mar 17, 2015
P=N/A, N=858, Completed, Sponsor: Brahms AG
Recruiting --> Completed | Trial primary completion date: Dec 2013 --> Feb 2015 Recruiting --> Completed
- Enrollment change: Neutropenic Fever, Inflammatory Markers and Sepsis in Haematological Patients (clinicaltrials.gov) - Mar 11, 2015
P=N/A, N=137, Recruiting, Sponsor: Kuopio University Hospital
Recruiting --> Completed N=80 --> 137
- Enrollment change, Trial withdrawal: UARK 2009-99 A Non-interventional Observational Study of Infectious Complications in Cancer Patients (clinicaltrials.gov) - Mar 5, 2015
P=N/A, N=0, Withdrawn, Sponsor: University of Arkansas
N=80 --> 137 N=600 --> 0 | Recruiting --> Withdrawn
- Enrollment open: SEPP1B: Correlation Between PTP1B Expression and Organ Failure During Sepsis (clinicaltrials.gov) - Feb 19, 2015
P=N/A, N=54, Recruiting, Sponsor: University Hospital, Rouen
N=600 --> 0 | Recruiting --> Withdrawn Not yet recruiting --> Recruiting
- || Enrollment closed: Improving Maternal and Child Health in India: Evaluating Demand and Supply Side Strategies (IMATCHINE) (clinicaltrials.gov) - Feb 19, 2015
P=N/A, N=14990, Active, not recruiting, Sponsor: Duke University
Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting
- Trial completion, Enrollment change, Trial primary completion date: ERNIE2: Optimising Diagnosis and Antibiotic Prescribing for Acutely Ill Children in Primary Care (clinicaltrials.gov) - Feb 19, 2015
P=N/A, N=8962, Completed, Sponsor: Katholieke Universiteit Leuven
Recruiting --> Active, not recruiting Recruiting --> Completed | N=6000 --> 8962 | Trial primary completion date: Jan 2014 --> Dec 2014
- ||||||| meropenem / Generic mfg.
Trial completion, Enrollment change: Efficacy, Pharmacokinetics and Safety of Meropenem in Infants Below 90 Days With Clinical or Confirmed Late-onset Sepsis (clinicaltrials.gov) - Feb 19, 2015
P3, N=272, Completed, Sponsor: PENTA Foundation
Recruiting --> Completed | N=6000 --> 8962 | Trial primary completion date: Jan 2014 --> Dec 2014 Recruiting --> Completed | N=550 --> 272
- ||| Enrollment open: Patient Centered Cloud-based Electronic System: Ambient Warning and Response Evaluation (ProCCESs AWARE) (clinicaltrials.gov) - Feb 11, 2015
P=N/A, N=12000, Recruiting, Sponsor: Mayo Clinic
Recruiting --> Completed | N=550 --> 272 Active, not recruiting --> Recruiting
- || Enrollment change, Trial primary completion date: The Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN) (clinicaltrials.gov) - Feb 10, 2015
P=N/A, N=15000, Recruiting, Sponsor: Mayo Clinic
Active, not recruiting --> Recruiting N=5000 --> 15000 | Trial primary completion date: Jun 2015 --> Dec 2016
- Avastin (bevacizumab) / Roche
Enrollment change, Trial withdrawal, Trial primary completion date: Pilot Study of Bevacizumab (Avastin) in Patients With Septic Shock (clinicaltrials.gov) - Feb 9, 2015
P=N/A, N=0, Withdrawn, Sponsor: Beth Israel Deaconess Medical Center
N=5000 --> 15000 | Trial primary completion date: Jun 2015 --> Dec 2016 N=20 --> 0 | Not yet recruiting --> Withdrawn | Trial primary completion date: Jan 2011 --> Jan 2015
- Trial primary completion date, IO biomarker: Detection Of Monocytes/Macrophages Function And Tim-3 Expression In Septic Patients (clinicaltrials.gov) - Feb 5, 2015
P=N/A, N=1, Recruiting, Sponsor: Chinese PLA General Hospital
N=20 --> 0 | Not yet recruiting --> Withdrawn | Trial primary completion date: Jan 2011 --> Jan 2015 Trial primary completion date: Jul 2013 --> Jul 2015
- Enrollment change, Trial termination: CAESAR: Effect of C1-esterase Inhibitor on Systemic Inflammation in Trauma Patients With a Femur or Pelvic Fracture (clinicaltrials.gov) - Feb 5, 2015
P3, N=11, Terminated, Sponsor: UMC Utrecht
Trial primary completion date: Jul 2013 --> Jul 2015 N=70 --> 11 | Recruiting --> Terminated; Futility and limited feasibility
- ||| Trial completion: Venous Lactate in Progression to Overt Septic Shock and Mortality in Non-elderly Sepsis Patients in Emergency Department (clinicaltrials.gov) - Feb 5, 2015
P=N/A, N=392, Completed, Sponsor: Chulalongkorn University
N=70 --> 11 | Recruiting --> Terminated; Futility and limited feasibility Recruiting --> Completed
- Enrollment change, Trial termination, Trial primary completion date: DOVSS: Discontinuation Order of Vasopressors in Septic Shock (clinicaltrials.gov) - Jan 30, 2015
P=N/A, N=78, Terminated, Sponsor: Samsung Medical Center
Recruiting --> Completed N=134 --> 78 | Recruiting --> Terminated | Trial primary completion date: Dec 2012 --> Dec 2013; Futility by interim analysis
- || Trial primary completion date: Prevalence of CVC-associated Sepsis and Use of Blood Cultures in Berlin - Brandenburg (clinicaltrials.gov) - Jan 28, 2015
P=N/A, N=80, Recruiting, Sponsor: Charite University, Berlin, Germany
N=134 --> 78 | Recruiting --> Terminated | Trial primary completion date: Dec 2012 --> Dec 2013; Futility by interim analysis Trial primary completion date: Oct 2014 --> Jul 2015
- ||| Clinical: Epidemiology, Acute Management, and Outcomes of Patients With Sepsis Presenting to a Referral Hospital in Western Kenya (clinicaltrials.gov) - Jan 28, 2015
P=N/A, N=440, Not yet recruiting, Sponsor: Duke University
- Trial completion, Enrollment change: A Skills and Drills Intervention for Emergency Obstetrics and Neonatal Care at First Referral Units of North Karnataka (clinicaltrials.gov) - Jan 28, 2015
P=N/A, N=15018, Completed, Sponsor: Harvard School of Public Health
Trial primary completion date: Oct 2014 --> Jul 2015 Enrolling by invitation --> Completed | N=7883 --> 15018
- Enrollment change, Trial termination: Comparison of Ultrasound-guided Versus Blind Insertion of Radial Artery Catheters (clinicaltrials.gov) - Jan 26, 2015
P=N/A, N=35, Terminated, Sponsor: Yale University
Enrolling by invitation --> Completed | N=7883 --> 15018 N=75 --> 35 | Recruiting --> Terminated; Inability to recruit further.
- cefazolin / Generic mfg.
Trial primary completion date: An Open Label Study to Describe the Pharmacokinetics of Cefazolin in Preterm Neonates (clinicaltrials.gov) - Jan 20, 2015
P1, N=12, Recruiting, Sponsor: Phillip Brian Smith
N=75 --> 35 | Recruiting --> Terminated; Inability to recruit further. Trial primary completion date: Dec 2014 --> Dec 2015
- ||||| Cresemba (isavuconazonium sulfate) / Astellas, Basilea
Enrollment closed: Isavuconazole (BAL8557) in the Treatment of Candidemia and Other Invasive Candida Infections (clinicaltrials.gov) - Jan 20, 2015
P3, N=450, Active, not recruiting, Sponsor: Astellas Pharma Inc
Trial primary completion date: Dec 2014 --> Dec 2015 Recruiting --> Active, not recruiting
- Trial completion, Trial primary completion date: Bio-clinical Evolutive Dynamic in Patients Suffering From Communitary Septic Shock (Biosepsis) (clinicaltrials.gov) - Jan 20, 2015
P=N/A, N=64, Completed, Sponsor: University Hospital, Grenoble
Recruiting --> Active, not recruiting Recruiting --> Completed | Trial primary completion date: Jun 2013 --> Oct 2012
- Trial completion, Enrollment change: SNA&Sepsis: Autonomic Nervous System Alteration Induce by Sepsis: Assessment and Prognosis Impact (clinicaltrials.gov) - Jan 20, 2015
P4, N=13, Completed, Sponsor: University Hospital, Grenoble
Recruiting --> Completed | Trial primary completion date: Jun 2013 --> Oct 2012 Recruiting --> Completed | N=30 --> 13
- New P1 trial: rTSST-1 Variant Vaccine Phase 1 First-in-man Trail (clinicaltrials.gov) - Jan 17, 2015
P1, N=46, Recruiting, Sponsor: Biomedizinische Forschungs gmbH
- Trial primary completion date: EARTH-ICU: Early Physical Therapy in Patients With Sepsis (clinicaltrials.gov) - Jan 15, 2015
P=N/A, N=36, Recruiting, Sponsor: Cliniques universitaires Saint-Luc- Universit
Recruiting --> Completed | N=30 --> 13 Trial primary completion date: Dec 2014 --> Jul 2015
- Clinical: ASSET - a Double-Blind, Randomized Placebo-Controlled Clinical Investigation With Alteco® LPS Adsorber (clinicaltrials.gov) - Jan 15, 2015
P=N/A, N=32, Not yet recruiting, Sponsor: Alteco Medical AB
- | Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie
Trial completion, Enrollment change: Safety and Tolerability of Ceftazidime-Avibactam for Pediatric Patients With Suspected or Confirmed Infections (clinicaltrials.gov) - Jan 15, 2015
P1, N=29, Completed, Sponsor: AstraZeneca
Trial primary completion date: Dec 2014 --> Jul 2015 Recruiting --> Completed | N=40 --> 29
- Trial primary completion date, Gram negative: Duration of Antibiotics for the Treatment of Gram-negative Bacilli Bacteremia (clinicaltrials.gov) - Jan 13, 2015
P=N/A, N=400, Recruiting, Sponsor: Rabin Medical Center
Recruiting --> Completed | N=40 --> 29 Trial primary completion date: Jan 2015 --> Jan 2017
- || New P3 trial: Balanced Salt Solution VS. Normal Saline Solution in Septic Shock (clinicaltrials.gov) - Jan 13, 2015
P3, N=60, Active, not recruiting, Sponsor: Ramathibodi Hospital
- Clinical: DYnAMICS: DYsphAgia In Mechanically Ventilated ICU patientS (clinicaltrials.gov) - Jan 7, 2015
P=N/A, N=2000, Not yet recruiting, Sponsor: University Hospital Inselspital, Berne
- ||| Enrollment open, Trial primary completion date: Serial Therapeutic and Antifungal Monitoring Protocol (clinicaltrials.gov) - Jan 6, 2015
P=N/A, N=60, Recruiting, Sponsor: T2 Biosystems
Trial primary completion date: Jan 2015 --> Jan 2017 Not yet recruiting --> Recruiting | Trial primary completion date: Dec 2014 --> Apr 2015
- Trial completion, Enrollment change: Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit (clinicaltrials.gov) - Jan 6, 2015
P=N/A, N=124, Completed, Sponsor: National Taiwan University Hospital
Not yet recruiting --> Recruiting | Trial primary completion date: Dec 2014 --> Apr 2015 Recruiting --> Completed | N=280 --> 124
- | Cx611 / Takeda
New P1 trial: CELLULA: Randomized, Parallel Group, Placebo Control, Unicentric, Interventional Study to Assess the Effect of Expanded Human Allogeneic Adipose-derived Mesenchymal Adult Stem Cells on the Human Response to Lipopolysaccharyde in Human Volunteers (clinicaltrials.gov) - Jan 2, 2015
P1, N=32, Recruiting, Sponsor: TiGenix S.A.U.
- | New P2 trial: Changes in Exhaled 13CO2/12CO2 Breath Delta Value as an Early Indicator of Infection in ICU Patients (clinicaltrials.gov) - Dec 30, 2014
P2, N=110, Not yet recruiting, Sponsor: Isomark, LLC
- || Trial primary completion date: IRAMST: Inflammatory Response After Muscle and Skeleton Trauma (clinicaltrials.gov) - Dec 24, 2014
P=N/A, N=90, Recruiting, Sponsor: University of Ulm
Recruiting --> Completed | N=280 --> 124 Trial primary completion date: Oct 2014 --> Oct 2015
- New P1/2 trial: DAMSEL2: Dose Assessment of Melatonin in Sepsis Trial (clinicaltrials.gov) - Dec 19, 2014
P1/2, N=50, Active, not recruiting, Sponsor: University of Aberdeen
- Trial completion, Trial primary completion date: AMFAS: Study of the Function of Cells Involved in Inflammation in the Lungs of Those With Acute Lung Injury and Sepsis (clinicaltrials.gov) - Dec 19, 2014
P=N/A, N=80, Completed, Sponsor: Emory University
Trial primary completion date: Oct 2014 --> Oct 2015 Active, not recruiting --> Completed | Trial primary completion date: Dec 2013 --> Sep 2012
- Trial completion: Serum CD14 and CD88 Mointoring in ICU (clinicaltrials.gov) - Dec 17, 2014
P=N/A, N=80, Completed, Sponsor: Tanta University
Active, not recruiting --> Completed | Trial primary completion date: Dec 2013 --> Sep 2012 Recruiting --> Completed
- Trial completion: Serum STREM and MNDA Mointoring in ICU (clinicaltrials.gov) - Dec 17, 2014
P=N/A, N=120, Completed, Sponsor: Tanta University
Recruiting --> Completed Recruiting --> Completed
- Trial completion, Trial primary completion date: Cholecalciferol Supplementation for Sepsis in the ICU (clinicaltrials.gov) - Dec 17, 2014
P3, N=30, Completed, Sponsor: Massachusetts General Hospital
Recruiting --> Completed Recruiting --> Completed | Trial primary completion date: Mar 2014 --> Aug 2014
- Enrollment open: Adsorbtion of Cytokines Early in Septic Shock: the ACESS Study (clinicaltrials.gov) - Dec 13, 2014
P=N/A, N=20, Recruiting, Sponsor: Domonkos Tr
Recruiting --> Completed | Trial primary completion date: Mar 2014 --> Aug 2014 Active, not recruiting --> Recruiting
- Trial completion, Enrollment change: Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE (clinicaltrials.gov) - Dec 12, 2014
P=N/A, N=14000, Completed, Sponsor: European Society of Intensive Care Medicine
Active, not recruiting --> Recruiting Recruiting --> Completed | N=1000 --> 14000