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55 Companies |
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51 Products |
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51 Products |
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62 Mechanisms of Action |
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0 Trials |
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1119 News |
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- Clinical: Role of Beta-blockers in the Prevention on the Arisen of a Severe Sepsis (TESS) (clinicaltrials.gov) - May 24, 2012
P=N/A, N=2444, Completed, Sponsor: Rennes University Hospital
- Clinical: Membrane Shedding During Septic Shock (clinicaltrials.gov) - May 21, 2012
P=N/A, N=100, Completed, Sponsor: University Hospital, Strasbourg, France
- Enrollment change, Surgery: Pro-Calcitonin Levels Following Pediatric Cardiac Surgery (clinicaltrials.gov) - May 21, 2012
P=N/A, N=49, Completed, Sponsor: Emory University
N=500 --> 49
- Trial completion, Surgery: Pro-Calcitonin Levels Following Pediatric Cardiac Surgery (clinicaltrials.gov) - May 21, 2012
P=N/A, N=49, Completed, Sponsor: Emory University
N=500 --> 49 Active, not recruiting --> Completed
- Trial termination: Simultaneously Using Traditional Chinese Medicine (Si-Ni-Tang) to Treat Septic Shock Patients (clinicaltrials.gov) - May 20, 2012
P2, N=8, Terminated, Sponsor: Changhua Christian Hospital
Recruiting --> Terminated; The IRB considered our trial risky. Although there were debates between investigators and IRB, we terminated our trial in accordance with the suggestion of IRB.
- Enrollment change: Simultaneously Using Traditional Chinese Medicine (Si-Ni-Tang) to Treat Septic Shock Patients (clinicaltrials.gov) - May 20, 2012
P2, N=8, Terminated, Sponsor: Changhua Christian Hospital
Although there were debates between investigators and IRB, we terminated our trial in accordance with the suggestion of IRB. N=120 --> 8
- fludrocortisone / Generic mfg., hydrocortisone / Generic mfg.
Trial suspension: APROCCHS: Activated Protein C and Corticosteroids for Human Septic Shock (clinicaltrials.gov) - May 20, 2012
P3, N=1280, Suspended, Sponsor: University of Versailles
N=120 --> 8 Recruiting --> Suspended
- | New P2 trial: SEREAL: Selenium Replacement and Serum Selenium Level in Severe Sepsis and Septic Shock Patients (clinicaltrials.gov) - May 16, 2012
P2, N=294, Not yet recruiting, Sponsor: Gil Joon Suh
- |||| Enrollment open: Post Marketing Surveillance Study To Observe Safety And Efficacy Of Eraxis® IV (clinicaltrials.gov) - May 14, 2012
P4, N=3000, Enrolling by invitation, Sponsor: Pfizer
Recruiting --> Suspended Active, not recruiting --> Enrolling by invitation
- dexmedetomidine / Generic mfg.
Clinical: The Effects of Sedative on the Fluid Responsiveness in Critically Ill Patients (clinicaltrials.gov) - May 9, 2012
P1, N=100, Completed, Sponsor: Southeast University, China
Active, not recruiting --> Enrolling by invitation N=50 --> 100
- |||||| Enrollment open: CAESAR: Effect of C1-esterase Inhibitor on Systemic Inflammation in Trauma Patients With a Femur or Pelvic Fracture (clinicaltrials.gov) - May 8, 2012
P3, N=70, Recruiting, Sponsor: UMC Utrecht
N=50 --> 100 Not yet recruiting --> Recruiting
- Menveo (meningococcal-groups A, C, W-135 and Y oligosaccharide CRM197 conjugate vaccine) / GSK
New P4 trial: Understanding the Immune Response to Two Different Meningitis Vaccines (clinicaltrials.gov) - May 6, 2012
P4, N=15, Active, not recruiting, Sponsor: University of Oxford
- epinephrine / Generic mfg.
Trial initiation date: The Effects of Epinephrine in Endotoxemia in Normal Volunteers (clinicaltrials.gov) - Apr 25, 2012
P1, N=37, Completed, Sponsor: University of Medicine and Dentistry New Jersey
Not yet recruiting --> Recruiting Initiation date: Oct 2010 --> Feb 2012
- epinephrine / Generic mfg.
Enrollment change: The Effects of Epinephrine in Endotoxemia in Normal Volunteers (clinicaltrials.gov) - Apr 25, 2012
P1, N=37, Completed, Sponsor: University of Medicine and Dentistry New Jersey
Initiation date: Oct 2010 --> Feb 2012 N=60 --> 37
- epinephrine / Generic mfg.
Trial completion: The Effects of Epinephrine in Endotoxemia in Normal Volunteers (clinicaltrials.gov) - Apr 25, 2012
P1, N=37, Completed, Sponsor: University of Medicine and Dentistry New Jersey
N=60 --> 37 Active, not recruiting --> Completed
- Clinical: Evaluation of Intestinal Brush Border Enzyme Function in Critically Ill Patients (clinicaltrials.gov) - Apr 24, 2012
P=N/A, N=45, Recruiting, Sponsor: Medical University of Vienna
- Clinical: Pasteurization of Mother's Own Milk for Preterm Infants (clinicaltrials.gov) - Apr 17, 2012
P=N/A, N=303, Completed, Sponsor: Universitaire Ziekenhuizen Leuven
- lexaptepid pegol (NOX H94) / TME Pharma
Trial completion: Pharmacokinetics/Pharmacodynamics of NOX-H94 in the Human Endotoxemia Model (clinicaltrials.gov) - Apr 17, 2012
P1, N=24, Completed, Sponsor: Noxxon Pharma AG
Active, not recruiting --> Completed Active, not recruiting --> Completed
- Clinical: Procalcitonin in Cirrhotic Patients at High Risk for Sepsis (clinicaltrials.gov) - Apr 12, 2012
P=N/A, N=75, Completed, Sponsor: Prof. Facchinetti Fabio
- Enrollment open: Human Suis and Pig Diseases in Northern Vietnam (clinicaltrials.gov) - Apr 9, 2012
P=N/A, N=350, Recruiting, Sponsor: Oxford University Clinical Research Unit, Vietnam
Active, not recruiting --> Completed Active, not recruiting --> Recruiting
- Byetta (exenatide) / AstraZeneca
New P1/2 trial: Pharmacology of Exenatide in Pediatric Sepsis (clinicaltrials.gov) - Apr 8, 2012
P1/2, N=0, Withdrawn, Sponsor: Seattle Children's Hospital
- Trial initiation date: Improving Maternal and Child Health in India: Evaluating Demand and Supply Side Strategies (IMATCHINE) (clinicaltrials.gov) - Apr 4, 2012
P=N/A, N=14990, Recruiting, Sponsor: Duke University
Active, not recruiting --> Recruiting Initiation date: Nov 2011 --> Aug 2012
- Trial completion: Histone: Coagulation Factors, Cytokines and Tissue Injury Markers in Sepsis (clinicaltrials.gov) - Apr 4, 2012
P=N/A, N=500, Completed, Sponsor: University of Oklahoma
Initiation date: Nov 2011 --> Aug 2012 Recruiting --> Completed
- ||||| Trial initiation date: CAESAR: Effect of C1-esterase Inhibitor on Systemic Inflammation in Trauma Patients With a Femur or Pelvic Fracture (clinicaltrials.gov) - Apr 1, 2012
P3, N=70, Recruiting, Sponsor: UMC Utrecht
Recruiting --> Completed Initiation date: May 2011 --> Apr 2012
- Clinical: A Prospective Study of The Complement Depletion in Patients With Severe Abdominal Sepsis (clinicaltrials.gov) - Mar 28, 2012
P=N/A, N=75, Completed, Sponsor: Jinling Hospital, China
- Enrollment closed: Comparison of a Tissue Perfusion Guided Hemodynamic Protocol With a Standard Hemodynamic Protocol in Septic Shock Patients (clinicaltrials.gov) - Mar 27, 2012
P=N/A, N=128, Active, not recruiting, Sponsor: University Hospital Inselspital, Berne
Initiation date: May 2011 --> Apr 2012 Recruiting --> Active, not recruiting
- ||| Enrollment open: Detecting Infections Rapidly and Easily for Candidemia Trial (DIRECT) (clinicaltrials.gov) - Mar 25, 2012
P=N/A, N=700, Recruiting, Sponsor: T2 Biosystems
Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting
- | Trial completion: Scandinavian Starch for Severe Sepsis/Septic Shock Trial (clinicaltrials.gov) - Mar 22, 2012
P3, N=804, Completed, Sponsor: Anders Perner
Not yet recruiting --> Recruiting Active, not recruiting --> Completed
- |||||||||| meropenem / Generic mfg.
New P3 trial, PK/PD data: Efficacy, Pharmacokinetics and Safety of Meropenem in Infants Below 90 Days With Clinical or Confirmed Late-onset Sepsis (clinicaltrials.gov) - Mar 8, 2012
P3, N=550, Recruiting, Sponsor: PENTA Foundation
- ||||||| Trial completion: Efficacy and Safety of Drotrecogin Alfa (Activated) in Adult Patients With Septic Shock (clinicaltrials.gov) - Mar 8, 2012
P3, N=1696, Completed, Sponsor: Eli Lilly and Company
Active, not recruiting --> Completed Active, not recruiting --> Completed
- sevelamer carbonate / Generic mfg.
New P2 trial: Sevelamer for Reducing Endotoxemia and Immune Activation (clinicaltrials.gov) - Mar 1, 2012
P2, N=40, Completed, Sponsor: AIDS Clinical Trials Group
- | Enrollment closed: ALBIOS: Volume Replacement With Albumin in Severe Sepsis (clinicaltrials.gov) - Feb 29, 2012
P3, N=1800, Active, not recruiting, Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Active, not recruiting --> Completed Recruiting --> Active, not recruiting
- | Trial completion: Efficacy Study of a Facemask Device to Treat Hypotension (clinicaltrials.gov) - Feb 29, 2012
P2, N=47, Completed, Sponsor: Advanced Circulatory Systems
Recruiting --> Active, not recruiting Recruiting --> Completed
- Solu-Cortef (hydrocortisone sodium succinate injection) / Pfizer
Trial initiation date: ADRENAL: ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock (clinicaltrials.gov) - Feb 21, 2012
P4, N=3800, Recruiting, Sponsor: The George Institute
Recruiting --> Completed Initiation date: Feb 2012 --> Jun 2012
- | Trial completion: Effect of Multiple Dose Levels of SRT2379 on Endotoxin-Induced Inflammation (clinicaltrials.gov) - Feb 15, 2012
P1, N=39, Completed, Sponsor: Sirtris, a GSK Company
Initiation date: Feb 2012 --> Jun 2012 Recruiting --> Completed
- Cubicin (daptomycin) / Merck (MSD)
Trial completion: An Open Label Study to Describe the Pharmacokinetics of Daptomycin in Infants (clinicaltrials.gov) - Feb 15, 2012
P1, N=20, Completed, Sponsor: Duke University
Recruiting --> Completed Recruiting --> Completed
- Biomarker, Enrollment change: Mediators of Inflammation, Prognostic Markers and Genetic Polymorphisms in Patients With Sepsis (clinicaltrials.gov) - Feb 13, 2012
P=N/A, N=105, Completed, Sponsor: University Hospital Mannheim
Recruiting --> Completed N=300 --> 105
- Biomarker, Trial completion: Mediators of Inflammation, Prognostic Markers and Genetic Polymorphisms in Patients With Sepsis (clinicaltrials.gov) - Feb 13, 2012
P=N/A, N=105, Completed, Sponsor: University Hospital Mannheim
N=300 --> 105 Recruiting --> Completed
- Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, Integrilin (eptifibatide) / Takeda
New P2 trial: Integrilin and Ilomedin in Combination in Comparison to Standard Treatment in Severe Pneumonia Patients With Severe Sepsis (clinicaltrials.gov) - Feb 12, 2012
P2, N=36, Suspended, Sponsor: Thrombologic ApS
- Trial completion: Distribution of Haptoglobin Phenotype in Septic and Non Septic Pre-term Neonates (PTSH) (clinicaltrials.gov) - Feb 12, 2012
P=N/A, N=133, Completed, Sponsor: Irina Kessel
Recruiting --> Completed Active, not recruiting --> Completed
- fludrocortisone / Generic mfg., hydrocortisone / Generic mfg.
Trial withdrawal: Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis (clinicaltrials.gov) - Feb 9, 2012
P4, N=0, Withdrawn, Sponsor: CAMC Health System
Active, not recruiting --> Completed Terminated --> Withdrawn
- || Apolactoferrin (talactoferrin alfa) / Agennix, talactoferrin oral (oral rhLF) / Agennix
Trial suspension: OASIS: Safety and Efficacy of Talactoferrin Alfa in Patients With Severe Sepsis (clinicaltrials.gov) - Feb 1, 2012
P2/3, N=1280, Suspended, Sponsor: Agennix
Terminated --> Withdrawn Recruiting --> Suspended
- | New P1/2 trial: Use of PiCCO System in Critically Ill Patients With Septic Shock and Acute Respiratory Distress Syndrome (clinicaltrials.gov) - Feb 1, 2012
P1/2, N=400, Recruiting, Sponsor: Jinhua Central Hospital
- lexaptepid pegol (NOX H94) / TME Pharma
New P1 trial: Pharmacokinetics/Pharmacodynamics of NOX-H94 in the Human Endotoxemia Model (clinicaltrials.gov) - Jan 30, 2012
P1, N=24, Completed, Sponsor: Noxxon Pharma AG
- Cubicin (daptomycin) / Merck (MSD)
New P3 trial: DAVASAB: Daptomycin Versus Vancomycin in the Treatment of Nosocomial or Healthcare-associated MRSA Bacteremia (clinicaltrials.gov) - Jan 19, 2012
P3, N=10, Terminated, Sponsor: Assistance Publique - Hôpitaux de Paris
- Enrollment open: Emergency Department Management of Sepsis Patients: A Goal-Oriented Non-Invasive Sepsis Trial (clinicaltrials.gov) - Jan 16, 2012
P=N/A, N=160, Recruiting, Sponsor: National University Hospital, Singapore
Recruiting --> Suspended Not yet recruiting --> Recruiting
- fluconazole IV / Generic mfg.
Trial termination: A Study Of The Efficacy And Safety Of Anidulafungin Vs. Fluconazole In The Treatment Of Patients With Candidemia And/Or Other Forms Of Invasive Candidiasis (clinicaltrials.gov) - Jan 11, 2012
P3, N=17, Terminated, Sponsor: Pfizer
Not yet recruiting --> Recruiting Recruiting --> Terminated; See termination reason in detailed description.
- fluconazole IV / Generic mfg.
Enrollment change: A Study Of The Efficacy And Safety Of Anidulafungin Vs. Fluconazole In The Treatment Of Patients With Candidemia And/Or Other Forms Of Invasive Candidiasis (clinicaltrials.gov) - Jan 11, 2012
P3, N=17, Terminated, Sponsor: Pfizer
Recruiting --> Terminated; See termination reason in detailed description. N=364 --> 17
- | Enrollment open: The Cooling And Surviving Septic Shock Study (CASS) (clinicaltrials.gov) - Jan 11, 2012
P2/3, N=560, Recruiting, Sponsor: Danish Procalcitonin Study Group
N=364 --> 17 Not yet recruiting --> Recruiting
- Trial initiation date: ACT-ICU Study: Activity and Cognitive Therapy in the Intensive Care Unit (clinicaltrials.gov) - Jan 8, 2012
P1, N=90, Active, not recruiting, Sponsor: Vanderbilt University
Not yet recruiting --> Recruiting Initiation date: Nov 2010 --> Feb 2011