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55 Companies |
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51 Products |
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51 Products |
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62 Mechanisms of Action |
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1119 News |
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- | simvastatin / Generic mfg.
Enrollment open: Statin Therapy in the Treatment of Sepsis (clinicaltrials.gov) - Oct 7, 2013
P2/3, N=60, Recruiting, Sponsor: Beth Israel Deaconess Medical Center
Active, not recruiting --> Recruiting
- ||| New P1 trial: Open Label Pharmacokinetic Study of OZ439 and Piperaquine on Administration of OZ439+TPGS Granules for Oral Suspension Alone or With Either Piperaquine Phosphate Tablets or Granules for Oral Solution in Healthy Volunteers (clinicaltrials.gov) - Oct 7, 2013
P1, N=56, Completed, Sponsor: Medicines for Malaria Venture
- Clinical: Investigate the Activity of Endotoxin in Severe Sepsis (clinicaltrials.gov) - Oct 6, 2013
P=N/A, N=60, Recruiting, Sponsor: National Taiwan University Hospital
- | hydrocortisone / Generic mfg.
Trial completion: HYPRESS: Hydrocortisone for Prevention of Septic Shock (clinicaltrials.gov) - Sep 25, 2013
P3, N=380, Completed, Sponsor: Charite University, Berlin, Germany
Active, not recruiting --> Recruiting Recruiting --> Completed
- Trial completion: Skeletal Muscle and Platelet Mitochondrial Dysfunction During Sepsis (clinicaltrials.gov) - Sep 25, 2013
P=N/A, N=50, Completed, Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Recruiting --> Completed Recruiting --> Completed
- | Trial completion: Effect of Vitamin A in the Treatment of Neonatal Sepsis and Necrotizing Enterocolitis (clinicaltrials.gov) - Sep 23, 2013
P3, N=424, Completed, Sponsor: Johns Hopkins University
Recruiting --> Completed Recruiting --> Completed
- New P2 trial: Ubiquinol (Reduced COQ10) for Patients With Sepsis (clinicaltrials.gov) - Sep 19, 2013
P2, N=38, Recruiting, Sponsor: Beth Israel Deaconess Medical Center
- Clinical: Venous Lactate in Progression to Overt Septic Shock and Mortality in Non-elderly Sepsis Patients in Emergency Department (clinicaltrials.gov) - Sep 18, 2013
P=N/A, N=400, Recruiting, Sponsor: Chulalongkorn University
- | New P1 trial: NoSIRS: Effects of Transvenous Vagus Nerve Stimulation on Immune Response: a Pilot Study (clinicaltrials.gov) - Sep 15, 2013
P1, N=22, Completed, Sponsor: Medtronic Cardiac Rhythm Disease Management
- |||| leflunomide / Generic mfg.
Enrollment open: An Open-Label, Study to Treat Patients With Renal Allograft and Polyoma BK Viruria (clinicaltrials.gov) - Sep 5, 2013
P2, N=60, Recruiting, Sponsor: Changzheng-Cinkate
Recruiting --> Completed Not yet recruiting --> Recruiting
- Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, Integrilin (eptifibatide) / Takeda
Trial suspension: Integrilin and Ilomedin in Combination in Comparison to Standard Treatment in Severe Pneumonia Patients With Severe Sepsis (clinicaltrials.gov) - Sep 3, 2013
P2, N=36, Suspended, Sponsor: Thrombologic ApS
Not yet recruiting --> Recruiting Recruiting --> Suspended
- Trial completion: Treatment of Type-1 Hepatorenal Syndrome Associated With Sepsis (clinicaltrials.gov) - Aug 28, 2013
P=N/A, N=18, Completed, Sponsor: Hospital Clinic of Barcelona
Recruiting --> Suspended Not yet recruiting --> Completed
- Trial completion: REAMICHOC: Acute Kidney Injury in Septic Critically Ill Patients : Are Aminoglycosides Really Harmful? (clinicaltrials.gov) - Aug 26, 2013
P=N/A, N=317, Completed, Sponsor: Université Victor Segalen Bordeaux 2
Not yet recruiting --> Completed Not yet recruiting --> Completed
- Cubicin (daptomycin) / Merck (MSD)
Trial termination: DAVASAB: Daptomycin Versus Vancomycin in the Treatment of Nosocomial or Healthcare-associated MRSA Bacteremia (clinicaltrials.gov) - Aug 22, 2013
P3, N=10, Terminated, Sponsor: Assistance Publique - Hôpitaux de Paris
Not yet recruiting --> Completed Recruiting --> Terminated; lack of inclusion
- Cubicin (daptomycin) / Merck (MSD)
Enrollment change: DAVASAB: Daptomycin Versus Vancomycin in the Treatment of Nosocomial or Healthcare-associated MRSA Bacteremia (clinicaltrials.gov) - Aug 22, 2013
P3, N=10, Terminated, Sponsor: Assistance Publique - Hôpitaux de Paris
Recruiting --> Terminated; lack of inclusion N=332 --> 10
- Enrollment open: German Lactat Clearance in Severe Sepsis (clinicaltrials.gov) - Aug 20, 2013
P=N/A, N=300, Recruiting, Sponsor: RWTH Aachen University
N=332 --> 10 Not yet recruiting --> Recruiting
- Enrollment change: Comparison of Infection Rates Among Patients Using Two Catheter Access Devices (clinicaltrials.gov) - Aug 18, 2013
P=N/A, N=10000, Completed, Sponsor: Emory University
Not yet recruiting --> Recruiting N=7500 --> 10000
- Trial completion: Comparison of Infection Rates Among Patients Using Two Catheter Access Devices (clinicaltrials.gov) - Aug 18, 2013
P=N/A, N=10000, Completed, Sponsor: Emory University
N=7500 --> 10000 Not yet recruiting --> Completed
- | levofloxacin / Generic mfg., cloxacillin / Generic mfg.
Enrollment open: Efficacy of a Short-term Sequential Therapy in Non-complicated Catheter Related Bacteremia by Methicillin- Susceptible S.Aureus. (clinicaltrials.gov) - Aug 15, 2013
P3, N=154, Recruiting, Sponsor: Fundaci
Not yet recruiting --> Completed Active, not recruiting --> Recruiting
- Menveo (meningococcal-groups A, C, W-135 and Y oligosaccharide CRM197 conjugate vaccine) / GSK
Enrollment closed: Understanding the Immune Response to Two Different Meningitis Vaccines (clinicaltrials.gov) - Aug 11, 2013
P4, N=15, Active, not recruiting, Sponsor: University of Oxford
Active, not recruiting --> Recruiting Recruiting --> Active, not recruiting
- | chlorhexidine gluconate / Generic mfg.
New P4 trial: Efficacy of 2% Chlorhexidine Gluconate in 70% Alcohol Compare 10% Povidone Iodine in Blood Culture in Children (clinicaltrials.gov) - Aug 7, 2013
P4, N=1269, Completed, Sponsor: Thammasat University
- Enrollment open, Review: Outcomes of Severe Sepsis Patients in Surgical Intensive Care Units (clinicaltrials.gov) - Aug 6, 2013
P=N/A, N=1100, Recruiting, Sponsor: National Taiwan University Hospital
Recruiting --> Active, not recruiting Not yet recruiting --> Recruiting
- | dabigatran etexilate / Generic mfg., argatroban / Generic mfg., enoxaparin sodium / Generic mfg.
New P2 trial: Direct Thrombin Inhibitors Versus LMWH in Staphylococcus Aureus Bacteraemia (clinicaltrials.gov) - Jul 28, 2013
P2, N=80, Recruiting, Sponsor: Universitaire Ziekenhuizen Leuven
- || Enrollment change: Procalcitonin Monitoring Sepsis Study (clinicaltrials.gov) - Jul 24, 2013
P=N/A, N=800, Recruiting, Sponsor: Brahms AG
Not yet recruiting --> Recruiting N=360 --> 800
- | Enrollment change: Efficacy Study of a Facemask Device to Treat Hypotension (clinicaltrials.gov) - Jul 23, 2013
P2, N=47, Completed, Sponsor: Advanced Circulatory Systems
N=360 --> 800 N=34 --> 47
- Enrollment open: Lung and Systemic Inflammation in the Critically Ill Patient (clinicaltrials.gov) - Jul 18, 2013
P=N/A, N=18, Recruiting, Sponsor: Rigshospitalet, Denmark
N=34 --> 47 Not yet recruiting --> Recruiting
- |||| Trial completion: A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFab™) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock (clinicaltrials.gov) - Jul 18, 2013
P2b, N=300, Completed, Sponsor: AstraZeneca
Not yet recruiting --> Recruiting Active, not recruiting --> Completed
- || Cubicin (daptomycin) / Merck (MSD)
New P3 trial, Monotherapy: Efficacy of Daptomycin Plus Fosfomycin Versus Daptomycin for Treatment of MRSA Bacteremia (clinicaltrials.gov) - Jul 10, 2013
P3, N=206, Recruiting, Sponsor: Miquel Pujol
- Trial completion: Infected Elders in the Emergency Department: Outcomes and Processes of Care (clinicaltrials.gov) - Jul 10, 2013
P=N/A, N=213, Completed, Sponsor: Ohio State University
Active, not recruiting --> Completed Active, not recruiting --> Completed
- New P3 trial: Cholecalciferol Supplementation for Sepsis in the ICU (clinicaltrials.gov) - Jul 9, 2013
P3, N=30, Recruiting, Sponsor: Massachusetts General Hospital
- Cubicin (daptomycin) / Merck (MSD)
Trial termination: STOP-NT: Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients (clinicaltrials.gov) - Jul 7, 2013
P4, N=100, Terminated, Sponsor: Henry Ford Health System
Active, not recruiting --> Completed Recruiting --> Terminated; Independent biostatistician recommended early termination of the trial due to low probability of success.
- Cubicin (daptomycin) / Merck (MSD)
Enrollment change: STOP-NT: Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients (clinicaltrials.gov) - Jul 7, 2013
P4, N=100, Terminated, Sponsor: Henry Ford Health System
Recruiting --> Terminated; Independent biostatistician recommended early termination of the trial due to low probability of success. N=130 --> 100
- | Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie
New P1 trial: Safety and Tolerability of Ceftazidime-Avibactam for Pediatric Patients With Suspected or Confirmed Infections (clinicaltrials.gov) - Jul 7, 2013
P1, N=40, Recruiting, Sponsor: AstraZeneca
- Trial completion: Zinc and Inflammation in Sepsis (clinicaltrials.gov) - Jul 3, 2013
P=N/A, N=39, Completed, Sponsor: University of Aberdeen
N=130 --> 100 Recruiting --> Completed
- | Trial completion: SISPCT: Placebo Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis (clinicaltrials.gov) - Jun 27, 2013
P3, N=1180, Completed, Sponsor: Kompetenznetz Sepsis
Recruiting --> Completed Active, not recruiting --> Completed
- Trial completion, IO biomarker: The Effects of Immunostimulation With GM-CSF or IFN-y on Immunoparalysis Following Human Endotoxemia (clinicaltrials.gov) - Jun 25, 2013
P=N/A, N=18, Completed, Sponsor: Radboud University
Active, not recruiting --> Completed Active, not recruiting --> Completed
- Trial completion: Investigation of the Accuracy of Temporal Artery Thermometers (clinicaltrials.gov) - Jun 17, 2013
P=N/A, N=385, Completed, Sponsor: Bispebjerg Hospital
Active, not recruiting --> Completed Recruiting --> Completed
- Clinical: Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes? (clinicaltrials.gov) - Jun 13, 2013
P=N/A, N=100, Active, not recruiting, Sponsor: Jewish Hospital, Cincinnati, Ohio
- chlorhexidine gluconate / Generic mfg.
Enrollment closed: Multicenter Blood Culture Quality Improvement (clinicaltrials.gov) - Jun 10, 2013
P=N/A, N=33000, Active, not recruiting, Sponsor: Vanderbilt University
Recruiting --> Completed Recruiting --> Active, not recruiting
- Trial completion: PREMIUM Registry: PRognostic HEModynamIc Profiling in the AcUtely Ill EMergency Department Patient (clinicaltrials.gov) - Jun 10, 2013
P=N/A, N=514, Completed, Sponsor: Henry Ford Health System
Recruiting --> Active, not recruiting Recruiting --> Completed
- || levofloxacin / Generic mfg., cloxacillin / Generic mfg.
New P3 trial: Efficacy of a Short-term Sequential Therapy in Non-complicated Catheter Related Bacteremia by Methicillin- Susceptible S.Aureus. (clinicaltrials.gov) - Jun 9, 2013
P3, N=154, Recruiting, Sponsor: Fundaci
- Trial completion: Serum TNF-a in Comparison to Sequential Organ Failure Assessment (SOFA) Score Monitoring in Critically Ill Patients (clinicaltrials.gov) - Jun 5, 2013
P=N/A, N=90, Completed, Sponsor: Tanta University
Recruiting --> Completed Not yet recruiting --> Completed
- Inomax (nitric oxide) / Mallinckrodt
Enrollment change: Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis (clinicaltrials.gov) - Jun 2, 2013
P3, N=49, Completed, Sponsor: National Institute of General Medical Sciences (NIGMS)
Not yet recruiting --> Completed N=138 --> 49
- Inomax (nitric oxide) / Mallinckrodt
Trial completion: Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis (clinicaltrials.gov) - Jun 2, 2013
P3, N=49, Completed, Sponsor: National Institute of General Medical Sciences (NIGMS)
N=138 --> 49 Recruiting --> Completed
- New P1 trial: CIPNM: The Impact of IVIG Treatment on Critical Illness Polyneuropathy and/or Myopathy in Patients With MOF and SIRS/Sepsis (clinicaltrials.gov) - Jun 2, 2013
P1, N=38, Terminated, Sponsor: Medical University of Vienna
- || cefazolin / Generic mfg., vancomycin / Generic mfg.
Clinical data, New P3 trial, Head-to-Head: Neonatal Suspected Sepsis Treated With Cefazolin or Vancomycin (clinicaltrials.gov) - May 30, 2013
P3, N=109, Completed, Sponsor: Hospital Italiano de Buenos Aires
- Enrollment closed: Effects of Free Fatty Acids and 3-hydroxybutyrate on Protein, Glucose, Lipid Metabolism and Intracellular Signals. (clinicaltrials.gov) - May 23, 2013
P=N/A, N=10, Active, not recruiting, Sponsor: University of Aarhus
Recruiting --> Completed Recruiting --> Active, not recruiting
- Byetta (exenatide) / AstraZeneca
Trial withdrawal: Pharmacology of Exenatide in Pediatric Sepsis (clinicaltrials.gov) - May 23, 2013
P1/2, N=0, Withdrawn, Sponsor: Seattle Children's Hospital
Recruiting --> Active, not recruiting Not yet recruiting --> Withdrawn
- Byetta (exenatide) / AstraZeneca
Enrollment change: Pharmacology of Exenatide in Pediatric Sepsis (clinicaltrials.gov) - May 23, 2013
P1/2, N=0, Withdrawn, Sponsor: Seattle Children's Hospital
Not yet recruiting --> Withdrawn N=100 --> 0
- || New P3 trial: The Effect of Semi-quantitative Procalcitonin Assay to The Adequacy of Empirical Antibiotics and Mortality in Septic Patients (clinicaltrials.gov) - May 22, 2013
P3, N=205, Completed, Sponsor: Indonesia University